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Search Results: 1 - 10 of 32381 matches for " Antonio Curcio "
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The margination propensity of spherical particles for vascular targeting in the microcirculation
Francesco Gentile, Antonio Curcio, Ciro Indolfi, Mauro Ferrari, Paolo Decuzzi
Journal of Nanobiotechnology , 2008, DOI: 10.1186/1477-3155-6-9
Abstract: In the early diagnosis, treatment and imaging of diseases, as cancer and cardiovascular, the use of microparticles and nanoparticles is emerging as a powerful tool [1,2]. These are sufficiently small 'vectors' of therapeutic or/and imaging agents to be systemically administered, transported by the blood flow along the circulatory system and eventually recognize the diseased microenvironment (diseased cells). A nanoparticle comprises an internal core with the active agents and an external coating whit tailored physico-chemical properties. The interaction of the vectors with the biological target (diseased cell) is generally governed by specific forces, mediated by the formation and destruction of molecular bonds [3], and by non-specific interactions regulated by short ranged forces as van der Waals, electrostatic and steric [4].Two different delivery strategies are currently under investigation and development: a passive targeting of the diseased microenvironment relying on the permeability of the blood vessels (enhanced retention and permeability effect), and an active targeting of the diseased microvasculature relying on the recognition of specific molecules overexpressed at the site of interest [5]. It is known that tumor microvessels exhibit a significant increase in permeability to large molecules with intercellular openings and intercellular gaps as large as a micron [6], which could be crossed by sufficiently small particles. However the level of permeability is strongly dependent on the type of tumor, the site where the tumor is developing, the state of the tumor and the therapeutic treatment, and significant differences can be observed between human and xenografts tumors [7]. In addition to this, diseases other than cancer do no show any significant vessel permeability, thus making a passive targeting strategy non appropriate. On the other hand, a growing body of evidences support the idea that specific molecules are overexpressed at the surface of a disease
A influência das características pedológicas na produtividade de acácia-negra (Acacia mearnsii), Butiá, RS Influence of soil characteristics on black-wattle (Acacia mearnsii ) productivity, in Butiá, RS
Marcos Fernando Gluck Rachwal,Gustavo Ribas Curcio,Renato Antonio Dedecek
Pesquisa Florestal Brasileira , 2010, DOI: 10.4336/2012.pfb.56.53
Abstract: O desenvolvimento da acácia-negra é diferenciado em solos com características distintas. Para avaliar esta influência, foram quantificados os parametros de crescimento e a produ o de madeira, em cinco classes de solos com diferentes características morfológicas, químicas e físicas, em povoamentos comerciais com sete anos de idade, da SETA S.A., no Município de Butiá, RS. Investigou-se o crescimento da acácia em Argissolo Vermelho, Argissolo Vermelho-Amarelo, Cambissolo, Neossolo Litólico e Neossolo Regolítico. Foram realizadas análises químicas e granulométricas nos horizontes superficiais e subsuperficiais dos solos e físico-hídricas apenas no horizonte superficial. Nas árvores, determinaram-se DAP, altura, espessura de casca e volume de madeira. Nos Argissolos Vermelho e Vermelho-Amarelo e no Cambissolo, que ofereceram maiores reservas de nutrientes e maior profundidade efetiva, a produ o de madeira por hectare foi 30 % superior àquela produzida nos Neossolos Litólico e Regolítico que, além de mais rasos, apresentaram condi es químicas menos favoráveis. Black-wattle growth is different on soils with distinct characteristics. To evaluate this influence, plant growth and wood production variables were quantified on black wattle growing on five soil classes with different morphological, physical and chemical characteristics, on SETA S.A. commercial plantation at seven years of age, on Butiá County, RS. It was measured the black wattle growth on the following soil classes Argissolo Vermelho (Alfisol), Argissolo Vermelho-Amarelo (Alfisol), Cambissolo (Inceptisol), Neossolo Litólico (Entisol) e Neossolo Regolítico (Entisol). Soil chemical and texture analyses were performed on surface and subsurface horizons, and physical analyses, just on soil surface horizon. On plants, it was measured DBH, total height, bark thickness and estimated the wood volume. On both Alfisols (Red and Red Yellow) and on Inceptisol, that presented higher nutrient content and effective soil depth, wood production was 30 % greater than on both Entisols, that were shallower and with less appropriate chemical characteristics.
Incentivos y desincentivos de la industria farmacéutica privada para la I+D de nuevos medicamentos
Curcio, Pasqualina Curcio;
Cadernos de Saúde Pública , 2008, DOI: 10.1590/S0102-311X2008001000017
Abstract: the authors present a model with factors that influence research and development decisions by the pharmaceutical industry: risk of disease transmission and possibility of control; case-fatality and the presence of cure or treatments; income; number of persons who demand the medicine; and opportunity costs for the company. companies tend to invest in markets with inelastic demand (highly contagious diseases with no possibility of controlling transmission and/or very lethal diseases without treatment) and/or where there is a large population or high per capita income. companies tend not to invest in markets where marginal costs exceed marginal income, particularly when costs increase permanently as a consequence of rising opportunity costs generated by foregoing profit in other markets. in such cases, policies to subsidize r&d are not effective, and policies must be orientated towards strengthening basic and applied research by public institutions.
La investigación y desarrollo de la vacuna del sida: Costo de oportunidad para la industria farmacéutica privada
Curcio Curcio,Pascualina;
Revista Venezolana de Economía y Ciencias Sociales , 2009,
Abstract: investment by the pharmaceutical industry in r&d for the aids vaccine represented only 10% of total resources invested for this purpose in 2004. this article argues that consumers? income levels are not a significant factor determining investment decisions, nor do intellectual property rights produce any incentive. there are other factors related to the demand for the vaccine and the market performance of antiretrovirals which exert influence on the industry decisions. the extraordinary benefits obtained by the industry within antiretroviral markets (due to monopoly conditions) represent an opportunity cost within the vaccine market which is permanently increasing. these high opportunity costs mean that the industry does not find investment in r & d at all attractive. push and pull policies are not appropriate to encourage the industry; they have to be directed to regulating the antiretroviral sale monopoly and to strengthening the capacity of public and non profit institutions in order for them to develop the vaccine.
Los derechos de propiedad intelectual y el mercado de medicamentos para el tratamiento del HIV-SIDA
Curcio Curcio,Pasqualina;
Revista Venezolana de Economía y Ciencias Sociales , 2007,
Abstract: the creation of monopolies on the basis of conceding exclusive rights for the production and commercialization of products is prejudicial in the case of those whose demand is inelastic, as is the case of medicine for treating aids. the monopoly that exists in the pharmaceutical industry raises prices, restricts production and allows only 20% of the cases to be treated. the author offers a proposal designed to increase the regulation of the industry with a view to responding to the demand while, at the same time, allowing the industry to cover its research and development costs and remain profitable
Isolation and Characterization of Human Dental Pulp Derived Stem Cells by Using Media Containing Low Human Serum Percentage as Clinical Grade Substitutes for Bovine Serum
Federico Ferro, Renza Spelat, Antonio Paolo Beltrami, Daniela Cesselli, Francesco Curcio
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048945
Abstract: Adult stem cells have been proposed as an alternative to embryonic stem cells to study multilineage differentiation in vitro and to use in therapy. Current culture media for isolation and expansion of adult stem cells require the use of large amounts of animal sera, but animal-derived culture reagents give rise to some questions due to the real possibility of infections and severe immune reactions. For these reasons a clinical grade substitute to animal sera is needed. We tested the isolation, proliferation, morphology, stemness related marker expression, and osteoblastic differentiation potential of Dental Pulp Stem Cells (DPSC) in a chemically defined medium containing a low percentage of human serum, 1.25%, in comparison to a medium containing 10% Fetal Bovine Serum (FBS). DPSCs cultured in presence of our isolation/proliferation medium added with low HS percentage were obtained without immune-selection methods and showed high uniformity in the expression of stem cell markers, proliferated at higher rate, and demonstrated comparable osteoblastic potential with respect to DPSCs cultured in 10% FBS. In this study we demonstrated that a chemically defined medium added with low HS percentage, derived from autologous and heterologous sources, could be a valid substitute to FBS-containing media and should be helpful for adult stem cells clinical application.
MANEJO DOS RESíDUOS DA COLHEITA DE ACáCIA-NEGRA (Acacia mearnsii DE WILD) E A SUSTENTABILIDADE DO SíTIO
Marcos Fernando Gluck Rachwal,Renato Antonio Dedecek,Gustavo Ribas Curcio,Augusto A. Simon
Ciência Florestal , 2007,
Abstract: A acácia-negra se adapta a inúmeras condi es ambientais por ser uma espécie pioneira de crescimento rápido. Este trabalho foi realizado em povoamentos comerciais puros de acácia-negra de propriedade da TANAGRO S.A., no município de Piratini, RS, em cinco classes de solos, com plantas de mesma procedência, constituindo cada qual um tratamento. Em cada solo, foram avaliados o crescimento em DAP, altura e produ o de biomassa aérea. Os solos foram caracterizados química, física e morfologicamente em seus horizontes superficiais. Nas plantas, foram determinado o estado nutricional dos diferentes compartimentos, o teor de tanino na casca e o teor de lignina e extrativos totais no tronco. O Neossolo Litólico eutrófico produziu o maior volume de troncos comerciais, enquanto o Neossolo Litólico álico foi o menos produtivo, mostrando a grande importancia da fertilidade do solo na produtividade da acácia negra, sobretudo, o teor de P e as satura es por bases e por alumínio trocável. Se os resíduos n o forem queimados, a quantidade de macronutrientes devolvida ao solo (por galhos, flor, folhas e vagens) é maior que a quantidade de macronutrientes exportada, com a retirada apenas do tronco comercial e casca, nos solos menos produtivos, confirmando que se trata de espécie recuperadora de solo. Nos solos com maior volume de troncos comerciais produzidos, a quantidade de cálcio e magnésio exportada foi maior do que a devolvida ao solo pelos resíduos da colheita. A concentra o de tanino na casca da acácia-negra foi maior em condi es adversas de solo, mas a maior produ o de casca em solos melhores compensa esse fato.
Antibiotic prescription in intensive care units in Latin America
Curcio,Daniel J;
Revista argentina de microbiolog?-a , 2011,
Abstract: the intensive care units (icus) are often considered as the epicenters of antibiotic resistance. therefore, the total antibiotic consumption is approximately ten fold greater in icu wards than in general hospital wards. the aim of this study was to evaluate the current use of antibiotics in latin american icus. three cross-sectional (one-day point) prevalence studies were undertaken in 43 latin american icus. of 1644 patients admitted, 688 received antibiotic treatment on the days of the study (41.8 %) and, 392 cases (57 %) were due to nosocomial-acquired infections. of all infections, 22 % (151/688) corresponded to septic shock; and 22 % (151/688) to nosocomial pneumonia (50/151 [33 %], ventilator-associated pneumonia). in 485 patients (70.5 %), cultures were performed before starting antibiotic treatment. the most common microorganisms isolated were extended-spectrum ?-lactamase enterobacteriaceae, (30.5 %), and pseudomonas aeruginosa (17 %). carbapenems (imipenem or meropenem) were the antibiotics most frequently prescribed (151/688, 22 %), followed by vancomycin (103/688, 15 %), piperacillin-tazobactam (86/688, 12.5 %) and broad-spectrum cephalosporins (mainly cefepime) (83/688, 12 %). in summary, carbapenems were the most frequent antibiotics prescribed in latin american icus. this practice seems justified for the high rates of esbl-producing gram-negatives found in our patients. beyond this reason, the problem of bacterial resistance in la requires that physicians improve the use of carbapenems. the high prevalence of carbapenem-resistant a. baumannii and p. aeruginosa in the region, along with the prevalence of carbapenem-resistant enterobacteriaceae, have increased markedly. a comprehensive evidence-based stewardship program based on local antimicrobial use and resistance problems should be implemented in our clinical settings.
Rea??o de coaglutina??o estafilocócica na identifica??o de micoplasmas
Timenetsky, Jorge;Curcio, Melissa;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1993, DOI: 10.1590/S0036-46651993000600012
Abstract: staphylococcal coagglutination was used as method for a rapid identification of mycoplasmas that could be performed by non specialized laboratories. suspensions of staphylococcus aureus (cowan i) sensitized with rabbit antibodies against nctc mycoplasma strains have identified these microorganisms and the strains isolated from humans, cell cultures rats and mice in concentrated suspensions from cultures of 4.0 ml. fourty eight strains of m.pulmonis, 6 of m. arthritidis, 8 of m.arginini, 3 of m.orale, 15 of a.laidlawii, 8 of m.hominis and 3 of m.pneumomae were identified by staphylococcal coagglutination and confirmed by growth inhibition test. optimal parameters of coagglutination were established and the stability of the conjugates were preserved for 90 days when added with acetyl cistein. the reaction was visualized without optical resources. the sera were previously absorved with heterologous nctc strains and with the pellet of the steril broth.
Compreens o de Leitura: Adequa o do Exame de Proficiência a realidade dos Programas de Pós-gradua o
Maria Helena Curcio Celia
Ilha do Desterro , 2008,
Abstract: O objetivo deste trabalho é propor um formato alternativo para uma prova de proficiência em inglês, que tradicionalmente avaliava a compreens o da leitura através da tradu o. A popula o desta pesquisa constitui-se dos alunos de pós-gradua o da Universidade Federal do Rio Grande do Sul(UNCE) que prestam exame de proficiência em leitura em língua inglesa. s o aproximadamente 400 alunos que se apresentam anualmente para fazer o teste, que acontece no final de cada semestre. Sua idade média é 27 anos. A maioria é falante nativo de português, mas alguns tem o espanhol como língua materna. Todos tem curso de gradua o completo e est o matriculados num dos 29 programas de pós-gradua o da UFRGS. A amostra é formada pelos candidatos que realizaram as provas de 27 de novembro de 1982, 25 de junho de 1983, 26 de novembro de 1983'e 22 de setembro de 1984, aos quais foram aplicados, respectivamente, o teste-piloto e o formato alternativo (19 e 29 versies e 39 versa°, revisada). N o foram controladas as variáveis sexo e nivel sócio-econ mico. Este trabalho esta organizado em 4 partes. Na 1a, estabelece- se o construto teórico adotado, tendo em vista leitura testes de compreens o da leitura. Na 2a, trata-se do teste-piloto, explicando-se sua constru o e aplica o, bem como analisando-se os resultados obtidos. A análise de necessidades e da situa o alvo é o assunto da 3a parte. O item 4 apresenta o formato alternativo e comenta os resultados da aplica o de suas duas primeiras vers es. Além disso, justifica-se a cria o de sua 3a vers o (revisada) e analisam-se seus resultados.
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