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Search Results: 1 - 10 of 1053 matches for " Antonella Marte "
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Onabotulinumtoxin A for Treating Overactive/Poor Compliant Bladders in Children and Adolescents with Neurogenic Bladder Secondary to Myelomeningocele
Antonio Marte
Toxins , 2013, DOI: 10.3390/toxins5010016
Abstract: This retrospective study was performed to verify the efficacy and safety of Onabotulinumtoxin A (BTX-A) in treating children with neurogenic bladder (NB) secondary to myelomeningocele (MMC) with detrusor overactivity/low compliance. From January 2002 to June 2011, 47 patients out of 68 with neuropathic bladder were selected (22 females, 25 males, age range 5–17 years; mean age 10.7 years at first injection). They presented overactive/poor compliant neurogenic bladders on clean intermittent catheterization, and were resistant or non compliant to pharmacological therapy. Ten patients presented second to fourth grade concomitant monolateral/bilateral vesicoureteral reflux (VUR). All patients were incontinent despite catheterization. In the majority of patients Botulinum-A toxin was administered under general/local anesthesia by the injection of 200 IU of toxin, without exceeding the dosage of 12IU/kg body weight, diluted in 20 cc of saline solution in 20 sites, except in the periureteral areas. Follow-up included clinical and ultrasound examination, urodynamics performed at 6, 12 and 24 weeks, and annually thereafter. Seven patients remained stable, 21 patients required a second injection after 6–9 months and 19 a third injection. VUR was corrected, when necessary, in the same session after the BT-A injection, by 1–3 cc of subureteral Deflux ?. Urodynamic parameters considered were leak point pressure (LPP), leak point volume (LPV) and specific volume at 20 cm H 2O pressure. The results were analyzed using the Wilcoxon test. All patients experienced a significant 66.45% average increase of LPV (Wilcoxon paired rank test = 7169 × 10 ?10) and a significant 118.57% average increase of SC 20 (Wilcoxon paired rank test = 2.466 × 10 ?12). The difference between preoperative and postoperative LPP resulted not significant (Wilcoxon paired rank test = 0.8858) No patient presented severe systemic complications; 38/47 patients presented slight hematuria for 2–3 days. Two patients had postoperative urinary tract infection. All patients were hospitalized for 24 h with catheterization. Thirty-eight out of 47 patients achieved dryness between CIC; nine patients improved their incontinence but still need pads. Ten patients have resumed anticholinergic agents. Our results suggest that the use of BTX-A is safe and effective in patients with MMC with a positive effect on their dryness and quality of life.
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
Maria D. Cirnaru,Antonella Marte,Luca Murru,Luigi Bubacco,Michela Matteoli,Ernesto Fedele,Carlo Sala,Maria Passafaro,Elisa Greggio,Franco Onofri,Giovanni Piccoli
Frontiers in Molecular Neuroscience , 2014, DOI: 10.3389/fnmol.2014.00049
Abstract: Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. Robust evidence suggests that LRRK2 acts at the synaptic site as a molecular hub connecting synaptic vesicles to cytoskeletal elements via a complex panel of protein-protein interactions. Here we investigated the impact of pharmacological inhibition of LRRK2 kinase activity on synaptic function. Acute treatment with LRRK2 inhibitors reduced the frequency of spontaneous currents, the rate of synaptic vesicle trafficking and the release of neurotransmitter from isolated synaptosomes. The investigation of complementary models lacking LRRK2 expression allowed us to exclude potential off-side effects of kinase inhibitors on synaptic functions. Next we studied whether kinase inhibition affects LRRK2 heterologous interactions. We found that the binding among LRRK2, presynaptic proteins and synaptic vesicles is affected by kinase inhibition. Our results suggest that LRRK2 kinase activity influences synaptic vesicle release via modulation of LRRK2 macro-molecular complex.
Effects of CO2 Injection on the Seismic Velocity of Sandstone Saturated with Saline Water  [PDF]
Marte Gutierrez, Daisuke Katsuki, Abdulhadi Almrabat
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.325093
Abstract: Geological sequestration (GS) of carbon dioxide (CO2) is considered as one of the most promising technologies to reduce the amount of anthropogenic CO2 emission in the atmosphere. To ensure success of CO2 GS, monitoring is essential on ascertaining movement, volumes and locations of injected CO2 in the sequestration reservoir. One technique is to use time-lapsed seismic survey mapping to provide spatial distribution of seismic wave velocity as an indicator of CO2 migration and volumes in a storage reservoir with time. To examine the use of time-lapsed seismic survey mapping as a monitoring tool for CO2 sequestration, this paper presents mathematical and experimental studies of the effects of supercritical CO2 injection on the seismic velocity of sandstone initially saturated with saline water. The mathematical model is based on poroelasticity theory, particularly the application of the Biot-Gassmann substitution theory in the modeling of the acoustic velocity of porous rocks containing two-phase immiscible pore fluids. The experimental study uses a high pressure and high temperature triaxial cell to clarify the seismic response of a sample of Berea sandstone to supercritical CO2 injection under deep saline aquifer conditions. Measured ultrasonic wave velocity changes during CO2 injection in the sandstone sample show the effects of pore fluid distribution in the seismic velocity of porous rocks. CO2 injection was shown to decrease the P-wave velocity with increasing CO2 saturation whereas the S-wave velocity was almost constant. The results confirm that the Biot-Gassmann theory can be used to model the changes in the acoustic P-wave velocity of sandstone containing different mixtures of supercritical CO2 and saline water provided the distribution of the two fluids in the sandstone pore space is accounted for in the calculation of the pore fluid bulk modulus. The empirical relation of Brie et al. for the bulk modulus of mixtures of two-phase immiscible fluids, in combination with the Biot-Gassmann theory, was found to satisfactorily represent the pore-fluid dependent acoustic P-wave velocity of sandstone.
Virologic and Immunologic Response to cART by HIV-1 Subtype in the CASCADE Collaboration
Giota Touloumi, Nikos Pantazis, Marie-Laure Chaix, Heiner C. Bucher, Robert Zangerle, Anne-Marte Bakken Kran, Rodolphe Thiebaut, Bernard Masquelier, Claudia Kucherer, Antonella d'Arminio Monforte, Laurence Meyer, Kholoud Porter, for CASCADE Collaboration in EuroCoord
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071174
Abstract: Background We aimed to compare rates of virologic response and CD4 changes after combination antiretroviral (cART) initiation in individuals infected with B and specific non-B HIV subtypes. Methods Using CASCADE data we analyzed HIV-RNA and CD4 counts for persons infected ≥1996, ≥15 years of age. We used survival and longitudinal modeling to estimate probabilities of virologic response (confirmed HIV-RNA <500 c/ml), and failure (HIV-RNA>500 c/ml at 6 months or ≥1000 c/ml following response) and CD4 increase after cART initiation. Results 2003 (1706 B, 142 CRF02_AG, 55 A, 53 C, 47 CRF01_AE) seroconverters were included in analysis. There was no evidence of subtype effect overall for response or failure (p = 0.075 and 0.317, respectively) although there was a suggestion that those infected with subtypes CRF01_AE and A responded sooner than those with subtype B infection [HR (95% CI):1.37 (1.01–1.86) and 1.29 (0.96–1.72), respectively]. Rates of CD4 increase were similar in all subtypes except subtype A, which tended to have lower initial, but faster long-term, increases. Conclusions Virologic and immunologic response to cART was similar across all studied subtypes but statistical power was limited by the rarity of some non-B subtypes. Current antiretroviral agents seem to have similar efficacy in subtype B and most widely encountered non-B infections in high-income countries.
Sex Differences in Neural Activation to Facial Expressions Denoting Contempt and Disgust
André Aleman, Marte Swart
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003622
Abstract: The facial expression of contempt has been regarded to communicate feelings of moral superiority. Contempt is an emotion that is closely related to disgust, but in contrast to disgust, contempt is inherently interpersonal and hierarchical. The aim of this study was twofold. First, to investigate the hypothesis of preferential amygdala responses to contempt expressions versus disgust. Second, to investigate whether, at a neural level, men would respond stronger to biological signals of interpersonal superiority (e.g., contempt) than women. We performed an experiment using functional magnetic resonance imaging (fMRI), in which participants watched facial expressions of contempt and disgust in addition to neutral expressions. The faces were presented as distractors in an oddball task in which participants had to react to one target face. Facial expressions of contempt and disgust activated a network of brain regions, including prefrontal areas (superior, middle and medial prefrontal gyrus), anterior cingulate, insula, amygdala, parietal cortex, fusiform gyrus, occipital cortex, putamen and thalamus. Contemptuous faces did not elicit stronger amygdala activation than did disgusted expressions. To limit the number of statistical comparisons, we confined our analyses of sex differences to the frontal and temporal lobes. Men displayed stronger brain activation than women to facial expressions of contempt in the medial frontal gyrus, inferior frontal gyrus, and superior temporal gyrus. Conversely, women showed stronger neural responses than men to facial expressions of disgust. In addition, the effect of stimulus sex differed for men versus women. Specifically, women showed stronger responses to male contemptuous faces (as compared to female expressions), in the insula and middle frontal gyrus. Contempt has been conceptualized as signaling perceived moral violations of social hierarchy, whereas disgust would signal violations of physical purity. Thus, our results suggest a neural basis for sex differences in moral sensitivity regarding hierarchy on the one hand and physical purity on the other.
El imaginario de la ciudad venezolana: de 1958 a la metrópoli parroquiana. Aproximación desde la historia cultural urbana
Almandoz Marte,Arturo;
Cuadernos de Geografía - Revista Colombiana de Geografía , 2011,
Abstract: on the basis of the theoretical and methodological postulates of cultural history, narrative, and micro-history, as well as of the emerging field of urban cultural history, the article addresses the representation of the city and of urbanization in venezuelan literature. as part of a larger-scale project on the 20th century, the article focuses on the two decades following the overthrow of the pérez jiménez, dictatorship in 1958, which were characterized by democratic reconstruction and intense urban growth. the primary sources used are essays and novels.
Entre guerra fría y tercer mundo: Urbanización y subdesarrollo en Latinoamérica, 1960-1980
Almandoz Marte,Arturo;
Argos , 2010,
Abstract: framed within the economic, political and social relationship between industrialization and urbanization, the article aims at illustrating how the imbalance between the latter and the productive system explains latin america?s failed development between the cuban revolution and the alliance for progress, by the early 1960s, and the failure of modernization, by the late 1970s. the article relies on the premise that urbanization and development studies have often lacked historical perspective, so an overall approach of political, economic and intellectual changes is necessary, all of which ought to provide a long-term view as a possible contribution of this research
Entre guerra fría y tercer mundo: Urbanización y subdesarrollo en Latinoamérica, 1960-1980 Entre guerra fria e terceiro mondo: Urbaniza o e subdesenvolvimento em América Latina, 1960-1980 Between Cold War and Third World: Urbanization and underdevelopment in Latin America, 1960-1980
Arturo Almandoz Marte
Argos , 2010,
Abstract: Enmarcado por la relación económica, política y social entre industrialización y urbanización, el artículo trata de ilustrar cómo el desbalance de ésta con respecto al aparato productivo explica en buena medida el desarrollo fallido en Latinoamérica entre la Revolución cubana y la Alianza para el Progreso, a comienzos de los a os sesenta, y el fracaso de la modernización, a finales de los setenta. Se parte de la premisa de que los estudios de urbanización y desarrollo han carecido con frecuencia de perspectiva histórica, por lo que hace falta una aproximación panorámica de cambios políticos, económicos e intelectuales, todos los cuales provean una visión de larga duración como posible contribución de esta investigación No contexto dela rela o econ mica, política e social entre industrializa o e urbaniza o, este artigo tenta de ilustrar como o desequilibro de esta com rela o ao aparato produtivo explica em boa medida o desenvolvimento truncado da América Latina entre a Revolu o cubana e a Alian a para o Progresso, nos come os dos anos sessenta, e o fracasso da moderniza o, as finais dos setenta. O artigo parte da premissa de que os estudos de urbaniza o e desenvolvimento têm com freqüência carecida duma abordagem panoramica das mudan as políticas, econ micas e intelectuais, as quais fornecem uma vis o de longa dura o como possível contribui o desta pesquisa Framed within the economic, political and social relationship between industrialization and urbanization, the article aims at illustrating how the imbalance between the latter and the productive system explains Latin America’s failed development between the Cuban Revolution and the Alliance for Progress, by the early 1960s, and the failure of modernization, by the late 1970s. The article relies on the premise that urbanization and development studies have often lacked historical perspective, so an overall approach of political, economic and intellectual changes is necessary, all of which ought to provide a long-term view as a possible contribution of this research
MAKING - an International Conference on Materiality and Knowledge
Marte S?reb? Gulliksen
FORMakademisk , 2011,
Alternative theoretical and methodological approaches for exploring higher education in Art and Crafts
Marte S?reb? Gulliksen
FORMakademisk , 2010,
Abstract: This article presents and discusses approaches for exploring higher education in Art and Crafts. The concepts exploring versus research and the different foci in an insider perspective versus an outsider perspective introduces the theme. An insider perspective is said to be a useful starting point for inquiry, referring to Frayling’s trichotomy research into, research on and research through from 1993. The field of higher education in Art and Crafts education is shortly presented as comprising two main areas of knowledge: knowledge of education, and knowledge about the different subject areas within Art and Crafts. Both theory and practice are a part of these areas of knowledge. As higher education in Art and Crafts is a making profession, the most prominent challenge when exploring this today is thus said to be to develop research based knowledge on Education in Art and Crafts as a making discipline. Two keywords are deemed to be useful in approaching this theme: Mode 2 knowledge production and transdisciplinarity. The article concludes with describing specific ways of doing this today from within the context of application. Two examples of large research projects in Scandinavia are presented as examples of such projects.
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