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Valery Korzhik,,Anton Ushmotkin,,Artem Razumov,,Guillermo Morales-Luna
International Journal of Computer Science & Applications , 2010,
Merging Effluent Discharge Plumes from Multiport Diffusers on a Sloping Beach  [PDF]
Anton Purnama
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.31004
Abstract: Multiport diffusers are the effective engineering devices installed at the marine outfall systems for the steady discharge of effluent streams from the modern coastal plants, such as municipal sewage treatment, power generation and seawater desalination. A far field mathematical model using a two-dimensional advection-diffusion equation is presented for continuous discharges of effluent streams from multiple outfalls on a uniformly sloping beach with a current parallel to the shoreline. The analytical solutions are illustrated graphically to replicate and capture the merging process of effluent plumes in shallow coastal waters, and then asymptotic approximation will be made to the maximum shoreline’s concentration to formulate effluent discharge plume dilution from a multiport diffuser.
Effluent Discharges from Two Outfalls on a Sloping Beach  [PDF]
Anton Purnama
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.519295
Abstract: A marine outfall is a long pipeline that continuously discharges large amounts of effluent streams into the sea. As the number of marine outfalls along the coastal areas is growing, a far field mathematical model with two point sources on a sloping beach is used to assess the coastal water quality following discharges from two outfalls. Asymptotic approximation will be made to the concentration at the beach to measure how well the effluent plumes are mixed and diluted in the coastal waters. The result found agrees with the engineering practice of installing a two-port diffuser at the end of a single outfall to minimize its potential environment impacts.
The Calculation of Stress-Strain State of Anisotropic Composite Finite-Element Area with Different Boundary Conditions on the Surface  [PDF]
Bergulyov Anton
World Journal of Mechanics (WJM) , 2014, DOI: 10.4236/wjm.2014.41004

The numerical analytic research approach of stress-strain state of anisotropic composite finite element area with different boundary conditions on the surface, is represented below. The problem is solved by using a spatial model of the elasticity theory. Differential equation system in partial derivatives reduces to one-dimensional problem using spline collocation method in two coordinate directions. Boundary problem for the system of ordinary higher-order differential equation is solved by using the stable numerical technique of discrete orthogonalization.

Planck Constant as Adiabatic Invariant Characterized by Hubble’s and Cosmological Constants  [PDF]
Anton Lipovka
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.25009

Within the framework of Einstein-Cartan-Shr?dinger formalism with asymmetric connections, the Planck constant is calculated from the first principles (from geometry of our Universe), as the adiabatic invariant of electromagnetic field on the Riemann-Cartan manifold. The Planck constant, calculated with actually measured cosmological parameters, coincide with that one, measured in laboratory with precision up to the second digit. The non-local generalization of quantum theory is suggested. The fundamental sense of the Quantum Theory is discussed, and physical sense of the cosmological constant is revealed. Within the mentioned framework, the quantum theory is naturally unified with gravity.

Nature of the Quantum Potential  [PDF]
Anton Lipovka
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.45098
Abstract: In this paper we suggested a natural interpretation of the de Broglie-Bohm quantum potential, as the energy due to the oscillating electromagnetic field (virtual photon) coupled with moving charged particle. Generalization of the Schrödinger equation is obtained. The wave function is shown to be the eigenfunction of the Sturm-Liouville problem in which we expand virtual photon to include it implicitly into consideration. It is shown that the non-locality of quantum mechanics is related only with virtual photon. As an example, the zero-energy of harmonic oscillator is obtained from classical equations.
Confiscation and Criminal Assets Recovery—Review of Bosnian Law  [PDF]
Anton Girginov
Beijing Law Review (BLR) , 2017, DOI: 10.4236/blr.2017.83015
Abstract: This paper deals with the legal frameworks in Bosnia and Herzegovina {BiH} for confiscation and criminal assets recovery. It contains proposals for improvement of local laws regulating domestic activities and international judicial cooperation for confiscation and criminal assets recovery. The presentation is in pursuit of two goals: increase the efficiency of confiscation in BiH and intensify international legal contacts of BiH with other countries for the purpose of depriving offenders of their wealth and deter them from committing new crimes. Several legislative proposals are made, namely: abandon the crime-related confiscation and adopt the unexplained wealth confiscation, create two domestic rules: for international sharing of crime-conditioned assets and for confiscation on foreign requests of assets when the conditioning crime is beyond the applicability of the local criminal law. Also, it is argued that BiH is in need of submitting a declaration to European Convention on Mutual Assistance in Criminal Matters and the Second Additional Protocol thereto. This declaration should state that BiH accepts letters rogatory from Parties to the Convention through the EUROJUST channel.
Suppression of immunity by some pesticides, xenobiotics, and industrial chemicals. In vitro model  [PDF]
Ilia Brondz, Anton Brondz
Journal of Biophysical Chemistry (JBPC) , 2011, DOI: 10.4236/jbpc.2011.23028
Abstract: In recent years, attention has focused on suppression of immunity in immunocompromised patients. The definition of immunocompromise is impairment of the immune system caused by a disease or treatment. In addition to disease and treatment, other factors such as exposure to pesticides or toxic chemicals can damage the immune system. An in vitro test was used to assess the ability of monochloroacetic acid (MCA) (CAS number 79-11-8), dichloroacetic acid (DCA) (CAS number 79-43-6), trichloroacetic acid (TCA) (CAS number 76-03-9), and 2,2- dichloropropionic acid sodium salt (2,2-DCPANa, Dalapon) (CAS number 127-20-8) to suppress bacteriolysis by hen egg white lysozyme (HEWL). The system for bacteriolysis of Gram-negative bacteria Actinobacillus, Haemophilus, and Pasteurella in Tris-maleate buffer supplemented with EDTA and HEWL developed by Brondz et al. [1–4] was used to monitor bacteriolysis of Gram-negative bacteria in the Actinobacillus–Haemophilus–Pasteurella group. The halogenated acetic acid DCA is produced as a toxic artifact of the degradation of TCA and by disinfection of drinking and pool water and industrial waste. Nearly all humans consume DCA in drinking water during their lifetime; the concentration of DCA in drinking water can be higher than that associated with the upper-bound excess life-time cancer risk of 10–4 (40μg/L) [5]. Lysozyme found in tears, saliva, nasal secretions, and excretions from all mucous membranes can break down the cell walls of bacteria and destabilize bacterial membranes. Lysozyme is involved in innate (nonspecific) immunity; the innate immune system is the first line of defense against invading organisms. Actinobacillus actinomy- cetemcomitans (ATCC29522), a Gram-negative bacterium whose primary ecological niche is the respiratory tract and oral cavity, provided the peptidoglycan substrate for HEWL. The optical density (OD) of a standardized suspension of A. actinomycetemcomitans decreased from 100% (OD 0.6 at 540 nm) to 23.5% after exposure to EDTA/HEWL for 50 min. After 50 min of exposure to 10.0 mg/mL of MCA, DCA, TCA, or 2,2-DCPANa as a supplement, EDTA/HEWL-induced lysis of A. actinomycetemcomitans decreased to 66.3%, 66.8%, 65.7%, and 73.6%, respectively. The aim of the presented study was the development of a model for measuring possible immunotoxic effects of chemicals, degradation products, xenobiotics and metabolites by these chemicals on the immune system. The method used is an in vitro bacteriolysis of Gram- negative bacterium induced by HEWL, described previously
Recent enhancement of the immunity in AIDS and other immunocompromised patients by hyperforin an antibiotic from Hypericum perforatum L. (in vitro model) part I  [PDF]
Ilia Brondz, Anton Brondz
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.34037
Abstract: Today, Hypericum perforatum L. is probably one of the best-characterized medicinal plants, and hyperforin is its best-characterized constituent. Extracts from H. perforatum are widely used as antidepressants; however, less attention has been given to other properties of hyperforin, such as antitumor, fungicidal, antiviral and antibacterial action, or its possible use as a substance with immunomodulation properties. The present study summarizes results that describe the influence of hyperforin as an immunomodulation agent on phagocytosis and the breakdown of Escherichia coli by human polymorphonuclear neutrophils (PMNs). Hyperforin at 1 - 100 μg/mL concentrations was found to have a major influence on phagocytosis and the breakdown of E. coli by PMNs in vitro. A 100 μg/mL solution of hyperforin increased the uptake of non-opsonized E. coli almost 50-fold, and the uptake of IgG-opsonized E. coli more than threefold; on the other hand, the uptake of serum-opsonized bacteria was reduced to approximately 60% of that of the control. Hyperforin seems to bind to both PMNs and E. coli and acts like an opsonin. The elimination of remnants of IgG-opsonized E. coli from the PMNs was stimulated by hyperforin, while the elimination of remnants from non-op-so nized and serum-opsonized material was unaffected by the drug. Hyperforin exhibited clear immunomodulation ability as a phagocytosisstimulating agent. Hyperforin is probably inactive against human immunodeficiency virus (HIV) and most Gram-negative bacteria. However, it can protect acquired immunodeficiency syndrome (AIDS) patients and other immunocompromised patients by its antibacterial activity against Gram-positive bacteria and by enhancement of phagocytosis of Gram-positive and Gram-negative bacteria; some Gram-negative bacteria, such as Neisseria, are sensitive to hyperforin. Hyperforin has the ability to penetrate the blood-brain barrier (BBB) and blood-testis barrier (BTB) and is a valuable antibacterial agent against meningitis and gonorrhea. These properties of hyperforin are important for an antibiotic with immunomodulation activity in the struggle against the growing mortality in AIDS patients as a result of opportunistic bacteria, as recently shown by Bekondi et al. (2006, Int. J. Infect. Dis. 10, 387-395). It could also help to combat primary and opportunistic pathogens associated with meningitis in adults' relation to HIV serostatus.
Supercritical Fluid Chromatography—Mass Spectrometry (SFC-MS) and MALDI-TOF-MS of Heterocyclic Compounds with Trivalent and Pentavalent Nitrogen in Cough Relief Medical Forms Tuxi and Cosylan  [PDF]
Ilia Brondz, Anton Brondz
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.312A115

Alkaloids are natural, semisynthetic or synthetic organic compounds, normally polar with basic chemical properties and containing at least one nitrogen atom in a heterocyclic ring. Some synthetic or semisynthetic substances resemble the alkaloid architecture. Trivalent nitrogen in these substances is normal; however, some natural and semisynthetic alkaloids have pentavalent nitrogen. The drug pholcodine is a derivative of morphine. Pholcodine has very little addiction- developing effect. It is a semisynthetic alkaloid that was first synthesized in 1950 by Chabrier et al. Pholcodine possesses antitussive (cough relief) properties similar to codeine, morphine and ethylmorphine. The drug was used in liquid formulations as Tuxi and Tuxi Forte, and it is in present use in Tuxidrin as liquid mixture and in tablet form. Pholcodine is an Active Pharmacological Ingredient (API) in tablets and liquid mixtures. Leiras International and Weifa in Norway manufacture medical forms with pholcodine. Several impurities in pholcodine were described by J. Roe in 1997 and by Denk et al. in 2000 and 2002. In addition, several degradation products may be formed in liquid formulations under storage. Some of these products are related not to the original production of pholcodine but rather to its oxidation under storage. The appearance of degradation products strongly depends on the storage temperature and pH of the liquid phase. Pholcodine-N-oxide and pholcodine-N,N-dioxide are among the degradation (oxidation) products; pholcodine can also degrade to morphine. There is little information about the toxicity of the N-oxide and no information on the N,N-di- oxide of pholcodine. In this study, the fact that morphine is generated during the storage of formulations containing pholcodine is presented. Another antitussive mixture under the name Cosylan was analyzed to examine the oxidation of ethylmorphine to ethylmorphine-N-oxide. Ethylmorphine is the API in Cosylan.

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