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Search Results: 1 - 10 of 150512 matches for " Anthony; F Greaves "
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Significado clínico y frecuencia de la alteración genético/molecular 11q23/MLL en lactantes con leucemia aguda en Chile
Cabrera C,María Elena; Campbell B,Myriam; Quintana,Juan; Undurraga S,María Soledad; Ford,Anthony A; Greaves,Mel F;
Revista médica de Chile , 2001, DOI: 10.4067/S0034-98872001000600006
Abstract: background: acute leukemia (al) in infants generally shows distinctive biologic features and has a poor prognosis. aim: to study the frequency of the cytogenetic alteration of11q23 chromosome or the recombination of mll gene in infants less than 18 months old, with acute leukemia. patients and methods: we analyzed 37 cases of al in infants less than 18 months of age diagnosed in chile from 1989 to 1999. the clinical features and cytogenetic/molecular defects of 11q23mll gene rearrangement and their influence in prognosis were determined. results: there were 18 cases of acute lymphoblastic leukemia (all) characterized by female sex (67%) high presenting leukocyte count (median 99 x109/l), blast cells with a cd10 negative phenotype (50%) and 11q23/mll rearrangement (39%). molecular abnormalities of 11q23 were significantly associated with adverse prognosis, with an event free survival (efs) of only 14 ± 12%. interestingly, infants with germ line 11q23 had a very good outcome with an efs of 73 ± 11% (p<0.025). there were 19 cases of acute myeloblastic leukemia (aml) characterized by male sex (63%) high leukocyte count (median 93 x 109/l), fab-ms morphology (53%) and 11q23/mll rearrangement (53%). efs was very poor, 20 ± 9% and 33±4% for rearranged and germinal group respectively (p=ns), due to a high mortality rate during the first month of diagnosis. conclusions: these findings demonstrate that chilean all infants with 11q23 abnormalities have a very poor prognosis. however those with germinal state can enjoy a prolonged disease free survival with the current treatment protocols (rev méd chile2001; 129: 634-642)
Leucemia linfoma T del adulto en Chile.: Estudio clínico-patológico y molecular de 26 pacientes
Cabrera C,M Elena; Labra G,Silvia; Meneses C,Pedro; Matutes,Estella; Cartier R,Luis; M Ford,Anthony; F Greaves,Melvyn;
Revista médica de Chile , 1999, DOI: 10.4067/S0034-98871999000800007
Abstract: background: adult t cell leukemia lymphoma is a lymphoproliferative syndrome etiologically associated to human t cell lymphotropic virus type i. aim: to describe the clinical and laboratory features of 26 caucasian chilean patients, with htlv-i positive adult t-cell leukemia lymphoma (atll). material and methods: diagnostic criteria included clinical features, cell morphology, immunophenotype, htlv-i serology and/or dna analysis by southern blot or pcr. results: according to the clinical presentation, 12 cases had the acute atll form, 6 had a lymphoma, 4 the chronic form and 4 had smoldering atll. the median presentation age was 50 years, younger than the japanese patients, but significantly older than patients from other south american countries (eg brasil, jamaica, colombia). the main clinical features: lymphadenopathy, skin lesions and hepatosplenomegaly, were similar in frequency to those of patients from other countries, except for the high incidence of associated neurological disease. tropical spastic paraparesis (tsp) in our series of atll, was seen in one third of the patients (8/26). a t-cell immunophenotype was shown in all 26 cases and htlv-i serology was positive in 25/26 patients. molecular analysis on the seronegative patient showed clonal integration of proviral htlv-i dna into the lymphocytes dna, and thus he may have been a poor responder to the retroviral infection. proviral dna integration was also demonstrated in 15/16 patients being clonal in 10, polyclonal in 3 (all smoldering cases) and oligoclonal in one. conclusions: atll in chile has similar clinical and laboratory features than the disease in other parts of the world, except for a younger age than japanese patients but older than those from other latin american countries and a high incidence of patients with associated tsp. detailed morphological and immunophenotypic analysis of the abnormal circulating lymphocytes, together with the documentation of htlv-i by serology and/or dna analysis
Maximally reliable spatial filtering of steady state visual evoked potentials
Jacek P. Dmochowski,Alex S. Greaves,Anthony M. Norcia
Quantitative Biology , 2014,
Abstract: Due to their high signal-to-noise ratio (SNR) and robustness to artifacts, steady state visual evoked potentials (SSVEPs) are a popular technique for studying neural processing in the human visual system. SSVEPs are conventionally analyzed at individual electrodes or linear combinations of electrodes which maximize some variant of the SNR. Here we exploit the fundamental assumption of evoked responses -- reproducibility across trials -- to develop a technique that extracts a small number of high SNR, maximally reliable SSVEP components. This novel spatial filtering method operates on an array of Fourier coefficients and projects the data into a low-dimensional space in which the trial-to-trial spectral covariance is maximized. When applied to two sample data sets, the resulting technique recovers physiologically plausible components (i.e., the recovered topographies match the lead fields of the underlying sources) while drastically reducing the dimensionality of the data (i.e., more than 90% of the trial-to-trial reliability is captured in the first four components). Moreover, the proposed technique achieves a higher SNR than that of the single-best electrode or the Principal Components. We provide a freely-available MATLAB implementation of the proposed technique, herein termed "Reliable Components Analysis".
SCUBA Observations of Dust around Lindroos Stars: Evidence for a Substantial Submillimetre Disc Population
M. C. Wyatt,W. R. F. Dent,J. S. Greaves
Physics , 2003, DOI: 10.1046/j.1365-8711.2003.06595.x
Abstract: We have observed 22 Lindroos stars with SCUBA on the JCMT to search for evidence of dust discs. Stars in this sample are the less massive companions of B-type primaries and have ages of 10-170Myr. Dust was detected around three of these stars (HD74067, HD112412 and HD99803B). The emission around HD74067 is centrally peaked and is approximately symmetrically distributed out to ~70". This emission either arises from a two component disc, one circumstellar and the other circumbinary with dust masses of 0.3 and >27Mearth respectively, or an unrelated background object. The other two detections we attribute to circumsecondary discs with masses of 0.04 and 0.3Mearth; a circumprimary disc is also present around HD112413 with a similar mass to that around the companion HD112412. Cross-correlation of our sample with the IRAS catalogs only showed evidence for dust emission at 25um and 60um toward one star (HD1438); none of the sub-mm detections were evident in the far-IR data implying that these discs are cold (<40K assuming beta=1). Our sub-mm detections are some of the first of dust discs surrounding evolved stars that were not detected by IRAS or ISO and imply that 9-14% of stars could harbour previously undetected dust discs that await discovery in unbiased sub-mm surveys. If these discs are protoplanetary remnants, rather than secondary debris discs, dust lifetime arguments show that they must be devoid of small <0.1mm grains. Thus it may be possible to determine the origin of these discs from their spectral energy distributions. The low dust masses for this sample support the picture that protoplanetary dust discs are depleted to the levels of the brightest debris discs (~1Mearth) within 10Myr.
Pharmacogenetics in the Management of Coumarin Anticoagulant Therapy: The Way Forward or an Expensive Diversion?
Mike Greaves
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020342
Abstract:
Gunshot bullet embolus with pellet migration from the left brachiocephalic vein to the right ventricle: a case report
Nicholas Greaves
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2010, DOI: 10.1186/1757-7241-18-36
Abstract: The diagnosis and management of penetrating wounds of the great vessels continues to be a major surgical challenge. Their presentation varies from moribund patients to completely stable ones in whom the diagnosis is often missed unless subtle clues are noted [1]. This case study documents the conservative management of a patient who developed a venous bullet embolus after being shot with a shotgun. We aim to review some of the literature on bullet emboli to raise awareness of their existence, investigation and management. With the amount of gun crime increasing the likelihood of seeing such a case is higher. Such a complication can have significant morbidity and mortality unless detected early. Written informed consent was obtained from the patient for publication of this case report.A 16 year old male presented to our emergency department having been the victim of a 'drive-by' shooting. He was haemodynamically stable with shotgun wounds to the left side of the head and neck. Primary and secondary surveys were essentially normal barring superficial wounds but a CT trauma series was performed to look for occult injuries and establish pellet trajectories. The report confirmed over 70 lead density pellets scattered throughout the sub-cutaneous tissues of the left head, neck and shoulder. It also revealed a single pellet in the right atrium in the absence of any cardiac or mediastinal injury (see figure 1). However, there was evidence of damage to the left brachiocephalic vein with extravasation of contrast. The most plausible explanation for the intra-cardiac pellet was intra-vascular migration from the left brachiocephalic vein to the heart via the superior vena cava.Given the nature of his injuries the patient was moved to HDU for observation and on day 2 went to theatre for debridement and exploration of neck and facial wounds. Conservative management with antibiotics and serial scanning to monitor further bullet migration was favoured over surgical extraction for t
Pharmacogenetics in the management of coumarin anticoagulant therapy: the way forward or an expensive diversion?
Greaves Mike
PLOS Medicine , 2005,
Abstract:
Ashok Bery. Cultural Translation and Postcolonial Poetry
Sara GREAVES
E-rea : Revue électronique d’études sur le Monde Anglophone , 2009,
Abstract: This book explores and develops the fruitful and currently popular paradigm of translation as a metaphor, or at least as a far more elastic, extensive term than its common usage allows. It does not seek to dazzle, but invites the reader to an engaging, clearly-stated discussion of a number of poets loosely grouped under the umbrella-heading “postcolonial”: some are longstanding familiars such as Nobel Prize-winner Seamus Heaney or Louis MacNeice, slightly unexpected in this context, some are ...
Gullah, African Continuities, and their Representation in Dash’s Daughters of the Dust
Dara Greaves
The English Languages : History, Diaspora, Culture , 2010,
Abstract: This article examines Julie Dash's 1992 film Daughters of the Dust in relation to linguistic debates about the Gullah language. Dash's emphasis on Gullah culture's African continuities resembles a body of linguistic scholarship stressing African retentions in the Gullah language. Problematically, most theories of African linguistic continuity rely on troubling assumptions about authenticity and temporality, positioning Gullah as a pure preservation of African languages, and thereby implying that it embodies an earlier stage of linguistic development. Yet, this paper argues that Dash acknowledges Gullah's African continuities without perpetuating ideological assumptions about authenticity and temporal development. Dash creates characters from divergent cultural and linguistic backgrounds, who speak different levels of dialect and demonstrate a range of stylistic variation within the Gullah language. In doing so, the film rejects simple conceptions of African continuity and authenticity in favour of theories of linguistic and cultural convergence, componentiality, and flexibility.
Book Reviews - Heaven on Earth. A Journal Through Shari'a Law from the Deserts of Ancient Arabia to the Streets of the Modern Muslim World. By Sadakat Kadri.
Sheldon Greaves
Journal of Strategic Security , 2012,
Abstract:
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