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Search Results: 1 - 10 of 6499 matches for " Anthony Balducci "
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Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI)
Anthony Balducci, Brooke M Helfer, Eric T Ahrens, Charles F O'Hanlon, Amy K Wesa
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-24
Abstract: Collagen-induced arthritis in rats, a model with many similarities to human RA, was used to study the ability of the PFC contrast agent to reveal the accumulation of inflammation over time using 19F MRI. Disease progression in the rat hind limbs was monitored by caliper measurements and 19F MRI on days 15, 22 and 29, including the height of clinically symptomatic disease. Na?ve rats served as controls. The capacity of the PFC contrast agent and 19F MRI to assess the effectiveness of therapy was studied in a cohort of rats administered oral prednisolone on days 14 to 28.Quantification of 19F signal measured by MRI in affected limbs was linearly correlated with disease severity. In animals with progressive disease, increases in 19F signal reflected the ongoing recruitment of inflammatory cells to the site, while no increase in 19F signal was observed in animals receiving treatment which resulted in clinical resolution of disease.These results indicate that 19F MRI may be used to quantitatively and qualitatively evaluate longitudinal responses to a therapeutic regimen, while additionally revealing the recruitment of monocytic cells involved in the inflammatory process to the anatomical site. This study may support the use of 19F MRI to clinically quantify and monitor the severity of inflammation, and to assess the effectiveness of treatments in RA and other diseases with an inflammatory component.
TREATMENT OF CANCER IN THE OLDER AGED PERSON
Lodovico Balducci
Mediterranean Journal of Hematology and Infectious Diseases , 2010, DOI: 10.4084/mjhid.2011.
Abstract: Cancer is a disease of aging . Currently 50% of all malignancies occur in individuals 65 and over and by the year 2030 older individuals will account for 70% of all neoplasms. With the aging of the population the management of cancer in the older person with chemotherapy is beoming increasingly common. This treatment may be safe and effective if some appropriate measures are taken, including, an assessment of the physiologic age of each patient, modification of doses according to the renal function, use of meyelopoietic growth factors prophylactically in presence of moderately toxic chemotherapy, and provision of an adequate caregiver. Cure, prolongation of survival, and symptom palliation are universal goals of medical treatment. Prolongation of active life expectancy should be added to the treatment goal of the older aged person .
E-journals: archiviazione e "conservazione" a lungo termine
Antonio Balducci
Bollettino del CILEA , 2007, DOI: 10.1472/bc.v107i0.1354
Abstract: A workshop about e-journal archiving and long term preservation took place in London on the 27th of march 2007. Some projects by independent institutions and institutional libraries have been presented; the point of view of publishers was considered as well. The critical issues have been highlighted and problems and advantages of the different solutions have been discussed. Il 27 marzo 2007 si è svolto a Londra un workshop sul tema della archiviazione e conservazione a lungo termine delle riviste elettroniche. Sono state presentate alcune iniziative da parte di enti indipendenti e di biblioteche istituzionali; è stato tenuto in considerazione anche il punto di vista degli editori. Si sono evidenziati i punti critici e sono stati discussi pregi e difetti delle varie soluzioni.
Il convegno Scienza & Media 2006
Antonio Balducci
Bollettino del CILEA , 2007, DOI: 10.1472/bc.v105i0.1322
Abstract: Il 28 e 29 settembre 2006 si è svolta a Venezia la prima edizione del Convegno Scienza e Media. Lo scopo era un confronto sul ruolo dei media, dei quotidiani, dell’impresa, delle biblioteche accademiche e della scuola in Italia sul tema della divulgazione della scienza e della conoscenza. The 28th and 29th september 2006 took place in Venice the 1st edition of the Conference Scienza e Media. The aim was to discuss about the role of media, of newspapers, of corporate, of academic libraries and of schools in Italy on the subject of the scholarly and science dissemination.
CROSSREF: Annual Meeting 2005
Antonio Balducci
Bollettino del CILEA , 2006, DOI: 10.1472/bc.v101i0.1246
Abstract: Londra, Annual Meeting CROSSREF 2005: presentazione dello stato dell’arte di CROSSREF dal punto di vista finanziario, tecnico, commerciale; valutazioni di utenti che fanno uso del sistema CROSSREF e del DOI per il linking; particolare attenzione al tema della Digital Preservation. London: Annual Meeting CROSSREF 2005: overview of CROSSREF with financial, technical and commercial updates; comments of customers using CROSSREF system and DOI for the linking; particular attention given to the Digital Preservation issue.
Proprietà significative degli oggetti digitali di cui tener conto nelle strategie di archiviazione
Antonio Balducci
Bollettino del CILEA , 2008, DOI: 10.1472/bc.v0i111.1413
Abstract: Il 7 aprile 2008 si è svolto a Londra un workshop sulle proprietà degli oggetti digitali di cui è importante tener conto quando si definisce una strategia di archiviazione. Sono stati presentati alcuni modelli per definire e misu rare queste proprietà, e alcuni casi d’uso. Il tema è di particolare interesse nell’ambito delle attività di CILEA Digi tal Library, che ha tra i suoi scopi principali l’archiviazione a lungo termine dei dati. A workshop concerning the “significant properties of digital objects” that should be preserved took place in London on the 7th of april 2008. Some theoretical models created to establish in the different situations what are the main properties to preserve, and some use cases, have been presented. The issue is topic for the CILEA Digital Librar ies activities, which has the long-term preservation among its focus activities.
Imaging Neuroinflammation In Vivo in a Neuropathic Pain Rat Model with Near-Infrared Fluorescence and 19F Magnetic Resonance
Kiran Vasudeva, Karl Andersen, Bree Zeyzus-Johns, T. Kevin Hitchens, Sravan Kumar Patel, Anthony Balducci, Jelena M. Janjic, John A. Pollock
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090589
Abstract: Chronic neuropathic pain following surgery represents a serious worldwide health problem leading to life-long treatment and the possibility of significant disability. In this study, neuropathic pain was modeled using the chronic constriction injury (CCI). The CCI rats exhibit mechanical hypersensitivity (typical neuropathic pain symptom) to mechanical stimulation of the affected paw 11 days post surgery, at a time when sham surgery animals do not exhibit hypersensitivity. Following a similar time course, TRPV1 gene expression appears to rise with the hypersensitivity to mechanical stimulation. Recent studies have shown that immune cells play a role in the development of neuropathic pain. To further explore the relationship between neuropathic pain and immune cells, we hypothesize that the infiltration of immune cells into the affected sciatic nerve can be monitored in vivo by molecular imaging. To test this hypothesis, an intravenous injection of a novel perfluorocarbon (PFC) nanoemulsion, which is phagocytosed by inflammatory cells (e.g. monocytes and macrophages), was used in a rat CCI model. The nanoemulsion carries two distinct imaging agents, a near-infrared (NIR) lipophilic fluorescence reporter (DiR) and a 19F MRI (magnetic resonance imaging) tracer, PFC. We demonstrate that in live rats, NIR fluorescence is concentrated in the area of the affected sciatic nerve. Furthermore, the 19F MRI signal was observed on the sciatic nerve. Histological examination of the CCI sciatic nerve reveals significant infiltration of CD68 positive macrophages. These results demonstrate that the infiltration of immune cells into the sciatic nerve can be visualized in live animals using these methods.
Nuovi parametri nelle analisi statistiche di accesso alle risorse elettroniche digitali
Domenico Dellisanti,Antonio Balducci
Bollettino del CILEA , 2005, DOI: 10.1472/bc.v95idicembre.1160
Abstract: Nell’ambito del consueto appuntamento annuale con Bibliocom, rassegna delle professioni, dei prodotti e dei servizi per la gestione dell’informazione e della conoscenza, svoltosi a Roma dal 27 al 29 ottobre, si è tenuto un seminario organizzato dal CASPUR,"La biblioteca digitale: statistiche d’uso. Studi ed esperienze a confronto". Il CILEA, all’interno dello stesso, ha presentato uno studio su nuovi parametri da utilizzarsi nelle analisi statistiche di accesso alle risorse elettroniche.
8th Meeting of Southern European Libraries' Consortia (SELL): stato dell’arte e nuove proposte consortili
Antonio Balducci,Agnese Perrone,Manuela Sofia
Bollettino del CILEA , 2008, DOI: 10.1472/bc.v0i111.1414
Abstract: L’8° incontro SELL (Southern European Libraries Link) si è tenuto presso l’Università di Trieste il 30-31 Maggio 2008. L’organizzazione dell’evento è stata svolta dal CILEA ed ha coinvolto i rappresentanti di diversi paesi, quali Portogallo, Spagna, Italia, Grecia, Turchia e Francia. I temi principali affrontati quest’anno hanno riguardato: local loading; ERMS; gestione dei backfiles; e strumenti per la gestione delle statistiche. The 8th annual SELL (Southern European Libraries Link) meeting took place on May the 30th and 31st 2008 at the University of Trieste. The meeting was organised by CILEA and it involved the following participants Portu gal, Spain, Italy, Greece, Turkey and France. The main themes discussed during the 2008 meeting are: Local Loading; ERMS; Management of backfiles and instruments to manage the usage statistics.
A Review of the Impact of Requirements on Software Project Development Using a Control Theoretic Model  [PDF]
Anthony White
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.39099
Abstract: Software projects have a low success rate in terms of reliability, meeting due dates and working within assigned budgets with only 16% of projects being considered fully successful while Capers Jones has estimated that such projects only have a success rate of 65%. Many of these failures can be attributed to changes in requirements as the project progresses. This paper reviews several System Dynamics models from the literature and analyses the model of Andersson and Karlsson, showing that this model is uncontrollable and unobservable. This leads to a number of is-sues that need to be addressed in requirements acquisition.
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