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Search Results: 1 - 10 of 151 matches for " Anthelmintic "
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Utiliza??o de fenbendazole e da associa??o febantel, pamoato de pirantel e praziquantel no controle de oxiurídeos em gerbis
Machado, H.H.S.;Gomes, F.F.;Fiuza, V.R.S.;Toledo, R.S.;de Oliveira, F. C.R.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2007, DOI: 10.1590/S0102-09352007000100045
Abstract: eighteen jirds were equally distributed in two treated and one control groups. the commercial products to the fenbendazole base (10mg) and the association of febantel (1.5mg), pirantel (1.44mg) and praziquantel (0.5mg) were orally administred in the concentration of 0.1ml in each group. the effectiveness of febendazole against oxiurids was 81.8%, 65.0 and 38.7% and for the association of febantel, pirantel and praziquantel was 72.7%, 73.8% and 51.0% on days 7, 14 and 21, respectively. three applications of that dose of the tested medications, within intervals of 10 days, associated to hygiene, are recommended.
Comparison of the Anthelmintic Efficacy of Three Commercial Products against Ascarids and Capillaria SPP. in Fighting Cocks  [PDF]
Froylán Ibarra-Velarde, Cristina Guerrero-Molina, Yolanda Vera-Montenegro, Yazmín Alcalá-Canto, Evangelina Romero-Callejas
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.23020
Abstract: The aim of the present study was to evaluate the anthelmintic efficacy of three commercial compounds against ascarids and Capillaria spp. in naturally infected fighting cocks from Mexico. First experiment.- Forty cocks were selected on the basis of eggs per gram (EPG) counts quantified by the McMaster method. On day 0 the birds were divided into four groups of 10 cocks, each subjected to the treatments. Group 1 received a single oral dose of 1 mg of ivermectin, 25 mg of praziquantel and 40 mg of fenbendazole given in tablets according to body weight (b.w). Group 2 was treated with a single oral dose of 1 mg of ivermectin, 25 mg of praziquantel and 40 mg of fenbendazole given in tablets/b.w. but formulated with a different excipient. Group 3 received a single tablet containing 0.2 mg of abamectin and 30 mg of albendazole. Group 4 served as a non-treated control. Fecal analyses were carried out on days 0 (day of treatment), 7, 14, 21 and 28, being collected from the floor where the cocks were individually caged. Efficacy was measured on the percentage of egg reduction from day 0 with respect the EPG counts from the control group. In a second experiment the study was similarly performed using another cock-farm located at approximately 300 km away from the first one. Results indicated an overall efficacy of 100%, 94.0% and 100% for groups 1, 2 and 3 in the first experiment and 100%, 100%, 100% for groups 1, 2 and 3 of the 2nd experiment, respectively. It is concluded that all drugs used exerted high efficacy in fighting cocks naturally infected with helminths.
Pharmacognostical Standardisation of the Roots of Ziziphus oenoplia(L.)Mill.(Rhamnaceae)
D.Jaison,K.Dhunmati,Kousalya M,Yaseen AM
International Journal For Pharmaceutical Research Scholars , 2013,
Abstract: Ziziphus oenoplia Linn., Mill, is a commonly occurring thorny shrub found to have many uses such as anthelmintic, antiseptic, hepatoprotective, stomachalgia, digestive etc. It is also used in ascaris infection and healing of wounds. The plant is reported to possess alkaloids, tannins and carbohydrates. Alkaloids have also been reported to posses many biological activities like anticancer, hepatoprotective, antihelmintic etc. Therefore, this plant offers much scope to investigators on different perspectives such as Pharmacognosy, Phytochemistry and Pharmacology. The following studies highlight the botanical as well as phytochemical constituents, macroscopic, microscopic and preliminary studies of roots. These observations will help in the botanical identification and the standardization of drug in crude form and also to distinguish the drug from its adulterants. Hopefully, this little work will help to inform the people who are not aware of the plant Ziziphus oenoplia Linn., mill (Rhamnaceae) which has multi-farious beneficial properties for medicine, agriculture and husbandry.
Risk Factors for High Endoparasitic Burden and the Efficiency of a Single Anthelmintic Treatment of Danish Horses
MM Larsen, S Lendal, M Chriél, SN Olsen, H Bj?rn
Acta Veterinaria Scandinavica , 2002, DOI: 10.1186/1751-0147-43-99
Abstract: In Danish horses resistance to benzimidazole products in the Cyathostominea spp. has been reported twice [2,3] and resistance to pyrantel is suspected [3]. Anthelmintic resistance (AR) is regarded as an increasing problem worldwide, but the factors that contribute to the development of AR are often speculative. Epi-demiological techniques have enhanced the ability to study the complex interactions between factors that may contribute to the occurrence of AR. High frequency of treatment [15], repeated use of anthelmintics with the same mode of actions [7], the generation intervals of the parasites [4] are factors which have been associated with the risk of development of AR in production animals. A low efficiency of a drug might be an indication that AR has developed. Some parasites survive treatment, what facilitates selection of AR parasites [13]. This makes it necessary to investigate the association between AR and management strategies, which potentially could contribute to its development. Factors previously identified in other production animals are also expected to be important for the development of AR in the horses, but as horses often are handled as a companion animal other factors might contribute to the development of AR.The objective of this study was 1) to identify risk factors associated with high endoparasite burden and 2) to evaluate the efficiency of a single anthelmintic treatment of Danish horses.In 1994 veterinarians from "The Danish Horse Practising Veterinarian Society" were contacted, and 22 veterinarians entered the survey and selected large (>15 horses) horse herds among their clients. In 1995 a questionnaire was sent to the selected herd owners. Sixty-eight herd owners answered the questionnaire, and 56 of the selected herds with a total of 903 horses entered a Faecal Egg Count Reduction (FECR) test [3].In 1997 the herd owners were interviewed with the aim of validating the questionnaire [10].Initially bivariate analyses were performed, and
Atividade ovicida de dois fármacos em caprinos naturalmente parasitados por nematódeos gastrintestinais, RS, Brasil
Mattos, Mary Jane Tweedie de;Schmidt, Ver?nica;Bastos, Cristine Dossin;
Ciência Rural , 2000, DOI: 10.1590/S0103-84782000000500026
Abstract: the efficacy of the anthelmintics levamisole in two different doses (8mg/kg and 11mg/kg) and closantel (10mg/kg) were compared against gastrointestinal nematodes in naturally infected goats. the reduction on the faecal egg count was 93.23% in the group treated with levamisole at the dose of 8mg/kg, 91.25% in the group treated with the dose of 11mg/kg and 70.42% in the group treated with closantel. the anthelmintic levamisole was effective against haemonchus spp., ostertagia spp., cooperia spp and oesophagostomum spp. however, closantel wasn't effective against cooperia spp and oesophagostomum spp.
A??o anti-helmíntica de extratos brutos de Andira anthelmia (Vell.) Macbr. e Andira fraxinifolia Benth., em camundongos naturalmente infectados por Vampirolepis nana e Aspiculuris tetraptera
Parasitología latinoamericana , 2003, DOI: 10.4067/S0717-77122003000100004
Abstract: the anthelmintic activity of the crude extracts of fresh and dry leaf, trunk bark and root bark of the species andira anthelmia and andira fraxinifolia. was evaluated in the species vampirolepis nana and aspiculuris tetraptera. doses of 8 g/kg/day were utilized for the leaves and trunk bark, and 1, 2, 4 and 8 g/kg/day for the root bark for the a. anthelmia, and doses of 8 g/kg/day were utilized for leaves and root bark, and of 4, 8 and 16 g/kg/day for tree bark, for the a. fraxinifolia. the dose of 8 g/kg/day of the crude extract of the fresh and dry leaf, the trunk bark and root bark, of the a. anthelmia, when compared, did not present any significant difference in the percentage elimination of v. nana, 14.9%, 16.4%, 6.3%, 17.9%, respectively. the same occurred when compared with the control group (7.4%). the doses of 2 and 4 g/kg/day, 49.4% and 42.7, respectively, were significantly more active for v. nana, in comparison with the other anatomical parts and the control group, and did not present any difference in relation to the mebendazole. the 2 g/kg/day dose was significantly more active for a. tetraptera (63.2%), in comparison with the leaves, with the root bark for the doses of 1 and 4 g/kg/day, and with the control group, 1.2%, 1.7%, 31.7%, 15.3%, 0.1%, respectively. however, it did not present any significant difference in relation to nitroscanate, this being less active than mebendazole. although the 8 g/kg/day dose for the tree bark presented a higher percentage elimination of v. nana (37.5%), no statistical difference was observed, when compared with the other doses, anatomical parts, the control group and the mebendazole. similarly, no significant difference was observed in the percentage elimination of a. tetraptera. the results suggested the crude extract of the root bark of the a. anthelmia as a promising anthelmintic, requiring further studies, due to the high toxicity presented
Atividade ovicida e larvicida in vitro do óleo essencial de Eucalyptus globulus sobre Haemonchus contortus
Macedo, Iara T. F.;Bevilaqua, Claudia M. L.;Oliveira, Lorena M. B. de;Camur?a-Vasconcelos, Ana L. F.;Vieira, Luiz da S.;Oliveira, Fabrício R.;Queiroz-Junior, Eudson M.;Portela, Bruno G.;Barros, Renata S.;Chagas, Ana C. S.;
Revista Brasileira de Parasitologia Veterinária , 2009, DOI: 10.4322/rbpv.01803011
Abstract: the objective of this work was to evaluate ovicidal and larvicidal effects of eucalyptus globulus essential oil (egeo) on haemonchus contortus. the chemical composition determination of egeo was through gas chromatography and mass spectrometry. egg hatch test (eht) was performed in concentrations 21.75; 17.4; 8.7; 5.43 e 2.71 mg.ml-1. in larval development test (ldt) were used the concentrations 43.5; 21.75; 10.87; 5.43 e 2.71 mg.ml-1. each trial was conducted by negative control with tween 80 (3%) and positive control, 0.02 mg.ml -1 of thiabendazole in eht and 0.008 mg.ml-1 of ivermectin in ldt. the maximum effectiveness of egeo on eggs was 99.3% in concentration of 21.75 mg.ml-1 and on larvae was 98.7% in concentration 43.5 mg.ml-1. the concentration of egeo that inhibits 50% of the eggs and larvae was 8.3 and 6.92 mg.ml-1, respectively. the oil chemical analysis identified as main component the monoterpen 1,8-cineol. egeo presented ovicidal and larvicidal activities in vitro, revealing a good potential for use in the control of sheep and goat gastrointestinal nematodes.
Effectiveness of Asteraceae extracts on Trichostrongylidae eggs development in sheep
Krychak-Furtado, Silvana;Silva, Ana Luisa Palhano;Miguel, Obdulio Gomes;Dias, Josiane de Fátima Gaspari;Miguel, Marilis Dallarmi;Costa, Sonia Soares;Negrelle, Raquel Rejane Bonato;
Revista Brasileira de Parasitologia Veterinária , 2011, DOI: 10.1590/S1984-29612011000300007
Abstract: data on in vitro evaluation of extracts of three species of the asteraceae family on the development of trichostrongylidae eggs in sheep are presented. egg hatchability was tested using herbal extracts prepared in a soxhlet extractor, and using hydrolate prepared by means of hydrodistillation. the laboratory tests showed that the ethanol extract from flowers of the species aster lanceolatus presented high activity against trichostrongylidae eggs development in sheep, inhibiting larva formation by 91% within 48 hours, and maintaining similar rates after 72 hours.
Avalia??o in vitro dos efeitos do óleo da semente de Carapa guianensis Aubl. sobre larvas de nematóides gastrintestinais de caprinos e ovinos
Farias, M.P.O;Teixeira, W.C;Wanderley, A.G;Alves, L.C;Faustino, M.A.G;
Revista Brasileira de Plantas Medicinais , 2010, DOI: 10.1590/S1516-05722010000200015
Abstract: this study aimed to evaluate the in vitro action of carapa guianensis (andiroba) seed oil on the cultivation of larvae from gastrointestinal nematodes of goats and sheep. five andiroba oil dilutions (100, 50, 30, 25, and 10%) were assayed, with three replicates per treatment, using tween 80 as surfactant. three control groups were formed: a negative control (distilled water), another negative control (distilled water + tween 80) and a positive control (doramectin). the activity of andiroba on the eggs from gastrointestinal nematodes was obtained by calculating larva reduction percentages per gram of feces. in goats, a highly effective reduction in the total number of larvae was detected for treatments 100, 50 and 30%, with null means for all nematode genera. in sheep, a highly effective reduction in the total number of larvae was observed for all treatments, with null means for treatments 100, 50 and 30%. such results indicate that carapa guianensis (andiroba) seed oil has in vitro activity against larvae from gastrointestinal nematodes of goats and sheep.
Anthelmintic resistance
Cernea M.,,Anca M?rculescu,,Veturia Ileana Nueleanu
Medicamentul Veterinar , 2007,
Abstract: A thoroughgoing study on resistance was achieved for the first time in insecticides, later on finding that, this can be extended also in anthelmintic substances. The resistance to anthelmintics evolved gradually from a simple medical curiosity, to an important economic problem. Many factors contribute to the appearance of resistance to anthelmintic substances. After epidemiological studies on various helmintic populations, it was concluded that there are four essential and distinguish factors that induce the appearance of parasitic resistance: operational factors, genetic factors, biological and ecological factors. In the last two decades there were conceived many tests to give emphasis to the phenomenon of resistance, but very few were accepted and validated at an international level. The motivation for this phenomenon consist in the fact that every of this methods have a certain sensibility, feasibility and profitableness. All these tests have positive aspects, and few negative aspects, that make themhard to be utilized (apparatus and high costs) or there are not enough sensible, so the obtained results are difficult to be interpreted. The use of molecular technique for the diagnosis of resistance to anthelmintics does not represent a viable option in the present, because the data about the intimate molecular mechanisms of resistance to anthelmintics are very few and there are not confirmed by the clinical reality.
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