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Search Results: 1 - 10 of 586 matches for " Annica Vlad-Fiegen "
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The Wnt Pathway Target Gene CCND1 Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480  [PDF]
Annica Vlad-Fiegen, Natalie Veronika Freytag, Susanne Dorn, Oliver Müller, Sonja Eberth
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.412017
Abstract: Mutations leading to constitutive activation of the Wnt pathway and its target genes are frequently observed in cancer. The Wnt pathway promotes cell proliferation and increasing evidence supports its role also in cancer cell metabolism. This study aims to elucidate the role of the Wnt/β-catenin target gene CCND1 in these processes in colorectal cancer. We analyzed whether knock-down of CCND1 affects cell cycle progression and energy metabolism in a colorectal cancer cell line. Down-regulation of CCND1 led to retardation of the cell cycle. The proportion of cells in the G0 phase increased, while the amount of cells in the S- and G2/M phase decreased. Interestingly, knock-down of CCND1 changed the perinuclear localization of mitochondria into a homogeneous distribution within the cytosol. In addition CCND1 knock-down led to an increase of the intracellular ATP level indicating that cyclin D1 reduced mitochondrial activity. Our findings suggest that in addition to its role in cell cycle regulation, the Wnt target gene CCND1 regulates mitochondrial localization and inhibits mitochondrial activity in colorectal cancer cells.
A Meaningful Life for Older Persons Receiving Municipal Care—Unit Leaders’ Perspectives  [PDF]
Annica Kihlgren
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.511110
Abstract: Introduction: In Sweden, new national guidelines for elderly care have been introduced containing core values and local guarantees of dignity that highlight the need for dignity, well-being and the organisation of the older person’s daily life, so it is perceived as meaningful. Unit leaders play a crucial role in health care organisations when guidelines are to be implemented. Aim: The aim was therefore to describe unit leaders’ experiences about what constituted a meaningful daily life for older persons receiving municipal care and the opportunities and obstacles that might exist. Method: Repeated interviews using reflective conversations with nine leaders were performed and analysed with qualitative content analysis. Results: Unit leaders felt a shared vision regarding a meaningful life was needed. Daily routines and habits that promoted independence, a feeling of community together with familiarity with the job, and got the little extra from knowledgeable staff were important. The historical collective paradigm in elderly care needed to be abandoned in favour of one promoting more individualism. Fundamental was the courage to ask the older person what was important and dared to follow through to “Give power to the older person to decide what care to be given”. Conclusion: Organisational conditions affect unit leaders’ ability to succeed in the implementation of the work. Further studies are required regarding the nature of the support that the unit leaders need to succeed in their work.
Experiencing Participation in Health Care: “Through the Eyes of Older Adults”  [PDF]
Samal Algilani, Inger James, Annica Kihlgren
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.61007
Abstract: Background: Patient participation is well understood by health care professionals but not many studies have focused on the older adults and their perceptions of patient participation. Aim and Objectives: To report an analysis of the concept of participation from the perspective of the older adult. Design: Concept analysis. Methods: An integrative review approach was undertaken and the searches were limited from January 2003 to December 2014, guiding question was; “what constitutes patient participation according to the older adult?” Results: Through the eyes of the older adults, a two-way communication should be initiated by the staff. Equality and sharing power between older adults and staffs was perceived as a precondition. Been given time was an essential issue, implying that older adults wished to have enough time from staffs and be in the right context surrounded by the appropriate environment in order to experience participation. Conclusion: In order to experience participation for older adults, it is important that the health care professionals are aware of how and in what ways they can contribute to participation among older adults. The need or wish to create participation is not enough; the health care professional needs to see and understand participation through the older adult’s eyes. Thus, a person-centered nursing approach is relevant for the health care professional in order to both give and maintain the experience of participation to the older adult.
Simultaneous Hashing of Multiple Messages  [PDF]
Shay Gueron, Vlad Krasnov
Journal of Information Security (JIS) , 2012, DOI: 10.4236/jis.2012.34039
Abstract: We describe a method for efficiently hashing multiple messages of different lengths. Such computations occur in various scenarios, and one of them is when an operating system checks the integrity of its components during boot time. These tasks can gain performance by parallelizing the computations and using SIMD architectures. For such scenarios, we compare the performance of a new 4-buffers SHA-256 S-HASH implementation, to that of the standard serial hashing. Our results are measured on the 2nd Generation Intel? CoreTM Processor, and demonstrate SHA-256 processing at effectively ~5.2 Cycles per Byte, when hashing from any of the three cache levels, or from the system memory. This represents speedup by a factor of 3.42x compared to OpenSSL (1.0.1), and by 2.25x compared to the recent and faster n-SMS method. For hashing from a disk, we show an effective rate of ~6.73 Cycles/Byte, which is almost 3 times faster than OpenSSL (1.0.1) under the same conditions. These results indicate that for some usage models, SHA-256 is significantly faster than commonly perceived.
Stimulation of Striking Roots at the Cuttings of Laurel Tree (Laurus nobilis) with the Aid of Bioactive Substances of the Radistim Type
Mariana VLAD,I. VLAD
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 2008,
Abstract: The laurel tree was first appraised as a decorative plant because of its persistent, glossy and agreeably nuanced leaves , as well as by its small yellow flowers grouped in panicles of an attractive aspect. This paper followed the effect of radistim on striking roots at the cuttings of Laurus nobilis, observing a considerably increase of the rate of striking roots as well as an enhancement of the quality of the rooting process proved through the number of roots per cutting. The stimulation of the laurel tree cuttings root striking with the aid of the bio-stimulators of the radistim 2 type ensures a superior vegetation potential for the newly formed plants. The work method elaborated at the glass houses complex of Oradea, may contribute to the extension of the laurel tree as a culture in Romania.
Being a Next of Kin—Experiences of Burden and Quality of Life  [PDF]
Elisabeth Liedstr?m, Annica Kihlgren, Kirsti Skovdahl, Jenny Windahl
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.44032
Abstract:

Aim and Objectives: To increase the understanding of next of kin’s life situation in the context of supporting persons who are long term ill, disabled and/or older by describing their experienced burden and quality of life and also the relationship between QoL, burden and socioeconomic variables. Methods: Cross-sectional, descriptive and correlative design. Eighty-four next of kin answered two questionnaires: the Caregiver Burden Scale and the Subjective Quality of Life. Results: Next of kin experienced a high burden in their life situation although they, at the same time, experienced a good quality of life. In the results gender differences were found. Females next of kin to a higher extent were disappointed, more emotionally involved, and they also estimated their economic situation as more unsatisfactory than the males next of kin. Conclusion: Healthcare personnel meet next of kin, persons in need of care, within all healthcare and social care in society. Therefore it is important to have a general knowledge and ability to understand the next of kin’s life situation, thus making it possible to focus the nursing interventions on individual support regardless of the care receiver’s diagnosis.

Referrals to Emergency Departments— The Processes and Factors That Influence Decision-Making among Community Nurses  [PDF]
Annica Kihlgren, Helena Sunvisson, Kristina Ziegert, Anna-Greta Mamhidir
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.45042
Abstract:

The aim of the study was to describe the basis on which municipal care registered nurses (RN) make decisions and their experiences when referring older persons from nursing homes to emergency departments (EDs). RNs in the community are to ensure that older adults receive good care quality in nursing home. This study used a descriptive design with a qualitative content analysis. The analysis of the data from the 13 interviews revealed one theme “Shared responsibilities in the best interests of the older person reduce feelings of insufficiency”. The content was formulated, which revealed the RNs’ feelings, reasoning and factors influencing them and their actions in the decision-making situation, before the patients were referred to an emergency department. Complex illnesses, non-adapted organizations, considerations about what was good and right in order to meet the older person’s needs, taking account of her/his life-world, health, well-being and best interests were reported. Co-worker competencies and open dialogues in the “inner circle” were crucial for the nurses’ confidence in the decision. Hesitation to refer was associated with previous negative reactions from ED professionals. The RN sometimes express that they lacked medical knowledge and were uncertain how to judge the acute illness or changes. Access to the “outer circle”, i.e. physicians and hospital colleagues, was necessary to counteract feelings of insecurity about referrals. When difficult decisions have to be made, not only medical facts but also relationships are of importance. To strengthen the RNs’ and staff members’ competence by means of education seems to be important for avoiding unnecessary referrals. Guidelines and work routine need to be more transparent and referrals due to the lack of resources are not only wasteful but can worsen the older persons’ health.


Topological Aspects of the Product of Lattices
Carmen Vlad
International Journal of Mathematics and Mathematical Sciences , 2011, DOI: 10.1155/2011/920737
Abstract: Let be an arbitrary nonempty set and a lattice of subsets of such that , . ( ) denotes the algebra generated by , and ( ) denotes those nonnegative, finite, finitely additive measures on ( ). In addition, ( ) denotes the subset of ( ) which consists of the nontrivial zero-one valued measures. The paper gives detailed analysis of products of lattices, their associated Wallman spaces, and products of a variety of measures. 1. Introduction It is well known that given two measurable spaces and measures on them, we can obtain the product measurable space and the product measure on that space. The purpose of this paper is to give detailed analysis of product lattices and their associated Wallman spaces and to investigate how certain lattice properties carry over to the product lattices. In addition, we proceed from a measure theoretic point of view. We note that some of the material presented here has been developed from a filter approach by Kost, but the measure approach lends to a generalization of measures and to an easier treatment of topological style lattice properties. 2. Background and Notations In this section we introduce the notation and terminology that will be used throughout the paper. All is fairly standard, and we include it for the reader’s convenience. Let be an arbitrary nonempty set and a lattice of subsets of such that , . A lattice is a partially ordered set any two elements ( ) of which have both and . denotes the algebra generated by ; is the algebra generated by ; is the lattice of all countable intersections of sets from ; is the lattice of arbitrary intersections of sets from ; is the smallest class closed under countable intersections and unions which contains . 2.1. Lattice Terminology The lattice is called: -lattice if is closed under countable intersections; complement generated if implies , , (where prime denotes the complement); disjunctive if for and such that there exists with and ; separating (or ) if and implies there exists such that , ; if for and there exist such that , , and ; normal if for any with there exist with , , and ; compact if for any collection of sets of with , there exists a finite subcollection with empty intersection; countably compact if for any countable collection of sets of with , there exists a finite subcollection with empty intersection. 2.2. Measure Terminology denotes those nonnegative, finite, finitely additive measures on . A measure is called: -smooth on if for all sequences of sets of with , ; -smooth on if for all sequences of sets of with , , that is, countably additive. -regular if for
An Adaption of the Jaynes Decision Algorithm
Vlad Tarko
Entropy , 2007, DOI: 10.3390/e9010027
Abstract: There are two types of decisions: given the estimated state of affairs, one decidesto change oneself in a certain way (that is best suited for the given conditions); given whatone is, one decides to change the state of affairs in a certain way (that is best suited for whatone wants for oneself). Jaynes' approach to decision theory accounts only for the first type ofdecisions, the case when one is just an observer of the external world and the decisiondoesn't change the world. However, many decisions involve the wish to transform theexternal environment. To account for this we need to add an additional step in Jaynes'proposed algorithm.
The World Trade Center Attack: Is critical care prepared for terrorism?
Vlad Kvetan
Critical Care , 2001, DOI: 10.1186/cc1061
Abstract: The question of whether the US critical care system is ready to handle various types of disasters is mentioned periodically [1]. Intensivists do not usually receive in-depth instruction in disaster medicine, even though they have increasing roles in managing hospital resources. The practice of limiting the training of critical care physicians to geographically described intensive care units (ICUs) only is questionable.At Montefiore Medical Center, our academic service has organized a number of missions and fielded functional specialized units for situations from earthquakes and burns disasters to mass military mobilization during the Gulf War [2,3]. Since disaster situations provide large experience in syndrome medicine (such as crush and blast injuries, inhalation burns, and toxicological threats), the state of the art in critical care response has been described elsewhere [4]. Critical care is clearly both flexible and interdisciplinary, and it adapts to many environments [5].Over the past 15 years, there has been increased collaboration between intensivists from countries that see a large number of suicide bombing attacks, as well as with intensivists in the US uniformed services who are increasingly involved in disaster response, ranging from joint exercises to mixed field teams. Yet our preparedness, as a specialty, for a major terrorist incident remains limited.Such an incident occurred on 11 September 2001 in New York City. Our team was notified during morning ICU rounds that the World Trade Center was under attack. An Incident Command Center was immediately established for the control of communication and authority. All ICU personnel at home were contacted and asked to report in for a staff meeting. The directors of critical care, emergency, and operating rooms immediately triaged all monitored beds and identified that 35 Level 1 ICU beds and 25 recovery room beds were available, in addition to the emergency room and operating room resources. No surgical cas
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