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Search Results: 1 - 10 of 9526 matches for " Anne-Sofie Bliddal Mortensen "
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Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease
Ulla Feldt-Rasmussen,Anne-Sofie Bliddal Mortensen,?se Krogh Rasmussen,Malene Boas,Linda Hilsted,Katharina Main
Journal of Thyroid Research , 2011, DOI: 10.4061/2011/598712
Abstract: Physiological changes during gestation are important to be aware of in measurement and interpretation of thyroid function tests in women with autoimmune thyroid diseases. Thyroid autoimmune activity is decreasing in pregnancy. Measurement of serum TSH is the first-line screening variable for thyroid dysfunction also in pregnancy. However, using serum TSH for control of treatment of maternal thyroid autoimmunity infers a risk for compromised foetal development. Peripheral thyroid hormone values are highly different among laboratories, and there is a need for laboratory-specific gestational age-related reference ranges. Equally important, the intraindividual variability of the thyroid hormone measurements is much narrower than the interindividual variation (reflecting the reference interval). The best laboratory assessment of thyroid function is a free thyroid hormone estimate combined with TSH. Measurement of antithyroperoxidase and/or TSH receptor antibodies adds to the differential diagnosis of autoimmune and nonautoimmune thyroid diseases. 1. Introduction Diagnosing maternal thyroid dysfunction during all stages of pregnancy is very important for the outcome for both mother and foetus [1, 2]. Women with hypothyroidism treated insufficiently with levothyroxine (high serum concentration of thyrotropin (TSH) or serum free thyroxine (T4) in the low normal range) deliver babies with significantly lower IQ and/or other inhibited neuropsychological development [3, 4]. Such offspring outcome has even been demonstrated in women with a serum concentration of T4 in the low normal range during pregnancy [5]. Prevalence of autoimmune thyroid disease (AITD) is high in women of reproductive age, whether or not they are pregnant [6]. AITD not only affects fertility [6], but may also lead to a decreased thyroid reserve with decreased availability of thyroxine. This is particularly important in the first half of pregnancy, in which the foetal development depends on the delivery of thyroxine from the mother [7, 8]. Although autoimmune thyrotoxicosis, Graves’ disease, is rare in pregnant women, transfer of TSH receptor antibodies, which can be either stimulating or blocking, may give rise to foetal and neonatal thyrotoxicosis or hypothyroidism, respectively [9, 10]. As a natural consequence of the importance of thyroid hormones for foetal brain development much focus has been given to diagnosing both overt and subclinical (or mild) thyroid dysfunction as early as possible in pregnant women, recently resulting in international consensus guidelines [10]. Although the
Review of Sigmund Oehrl. Vierbeinerdarstellungen auf schwedischen Runensteinen: Studien zur nord-germanischen Tier- und Fesselungsikonografie. Erg nzungsb nde zum Real-lexikon der Germanischen Altertumskunde 72. Berlin and New York: Walter de Gruyter, 2011.
Anne-Sofie Gr?slund
Futhark : International Journal of Runic Studies , 2012,
Abstract:
Effects of ischemic pre- and postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver
Anders R Knudsen, Anne-Sofie Kannerup, Henning Gr?nb?k, Kasper J Andersen, Peter Funch-Jensen, Jan Frystyk, Allan Flyvbjerg, Frank V Mortensen
Comparative Hepatology , 2011, DOI: 10.1186/1476-5926-10-3
Abstract: 28 rats were randomized into five groups: control; ischemia/reperfusion; ischemic preconditioning (IPC); ischemic postconditioning (IPO); combined IPC and IPO. IPC consisted of 10 min of ischemia and 10 min of reperfusion. IPO consisted of three cycles of 30 sec. reperfusion and 30 sec. of ischemia.HIF-1α mRNA expression was significantly increased after liver ischemia compared to controls (p = 0.010). HIF-1α mRNA expression was significantly lower in groups subjected to IPC or combined IPC and IPO when compared to the ischemia/reperfusion group (p = 0.002). VEGF-A mRNA expression increased in the ischemia/reperfusion or combined IPC and IPO groups when compared to the control group (p < 0.05).Ischemic conditioning seems to prevent HIF-1α mRNA induction in the rat liver after ischemia and reperfusion. This suggests that the protective effects of ischemic conditioning do not involve the HIF-1 system. On the other hand, the magnitude of the HIF-1α response might be a marker for the degree of I/R injuries after liver ischemia. Further studies are needed to clarify this issue.Colorectal cancer is a leading form of cancer in the Western world. Approximately 50% of patients with this disease have, or will eventually develop, liver metastases. Surgical removal of those metastases remains the treatment of choice, with a five year survival rate of 37%-58% after resection [1-3]. Major hemorrhage and blood transfusion during liver resection is related to an increase in morbidity and mortality [4-6]. Vascular clamping is a frequently used method for reducing blood loss [7]. Several studies have shown that the normal livers tolerate periods of continuous warm ischemia up to 90 min and intermittent warm ischemia up to 120 min [8-10].However, ischemia/reperfusion (I/R) injury of the liver is an unfortunate side effect of this method, ranging from slightly elevated liver enzymes to acute liver failure [11]. Ischemic pre- or postconditioning (IPC or IPO), defined as brief periods of
Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: New hornblende and muscovite 40Ar/39Ar cooling ages in the central Rinkian fold belt, West Greenland
Sidgren, Anne-Sofie,Page, Laurence,Garde, Adam A.
Geological Survey of Denmark and Greenland Bulletin , 2006,
Abstract: The Palaeoproterozoic Rinkian fold belt in West Greenland consists of reworked Archaean basement,mainly orthogneiss, and the unconformably overlying Palaeoproterozoic Karrat Group. Both parts were intensely deformed and metamorphosed at around 1.87 Ga, at which time the crustal anatecticPr ven igneous complex was emplaced into the northern part of the belt. Seven new hornblende and muscovite 40Ar/39Ar cooling ages are presented from the central–northern parts of the Rinkian foldbelt. Four 40Ar/39Ar hornblende ages ranging from 1795 ± 3 to 1782 ± 3 Ma were obtained from amphibolite and hornblendite enclaves in the Archaean orthogneiss, and two from relict dyke fragments in the latter that may be of Palaeoproterozoic age. Three 40Ar/39Ar muscovite ages of 1681 ± 6Ma, 1686 ± 3 Ma and 1676 ± 3 Ma were obtained from samples of Karrat Group metagreywacke,andalusite schist and metasiltstone. The new 40Ar/39Ar ages, from hornblende and muscovite respectively,are very uniform and probably unrelated to local metamorphic grade and structural history,and are interpreted as regional late orogenic cooling ages. The new hornblende ages are significantly older than those previously obtained from the central and northern parts of the adjacent Nagssugtoqidianorogen to the south, and point to different uplift histories, which may suggest that the orogeny was not synchronous in the two regions.
Blood pressure, cardiorespiratory fitness and body mass: Results from the Troms Activity Study
Aina Emaus,Tom Wilsgaard,Anne-Sofie Furberg,Inger Thune
Norsk Epidemiologi , 2011,
Abstract: Aims: Modifiable lifestyle factors, as cardiorespiratory fitness (CRF) and body mass, may prevent hypertension. However, it remains unclear whether blood pressure is associated with CRF, independently of body mass index (BMI). Thus, the purpose was to study the relationship between CRF, body composition and blood pressure among 40-44 year old men and women. Methods: During 2007-2008, 12,900 men and women aged 30-85 years attended the sixth survey of the Troms study. Blood pressure (mm Hg), height (cm) and weight (kg) were measured and body mass index (BMI kg/m2) was estimated. In a sub-study, the Troms Activity Study, CRF [VO2max (ml/kg/min)] was objectively measured using a treadmill test among 313 healthy men and women aged 40-44 years. Results: Among men and women participating in both studies, the mean BMI was 27.1 kg/m2 for men and 25.1 kg/m2 for women. Mean arterial blood pressure (MAP) was 92.4 mm Hg for men and 86.0 mm Hg for women. The proportion defined as pre-hypertensive/hypertensive (systolic/diastolic blood pressure > 120/80) were 33% and 56% for women and men, respectively. The proportion of low, medium and high CRF for both sexes combined differed significantly (p < 0.0001) by BMI level (< 25 or ≥ 25 kg/m2). Increased fitness tended to reduce blood pressure among overweight and obese men (p trend = 0.03), whereas increased fitness tended to reduce blood pressure among normal weighted women (p trend = 0.01). Conclusion: Among healthy 40-44 year old men and women in this study, BMI was positively associated and CRF was negatively associated with blood pressure. Moreover, our results suggest that BMI may be a more important factor than CRF in predicting systolic blood pressure in both sexes. However, cardiorespiratory fitness and weight control may both be important targets for prevention of hypertension
Cardiac troponin I levels in canine pyometra
Ragnvi Hagman, Anne-Sofie Lagerstedt, Boel A Fransson, Annika Bergstr?m, Jens H?ggstr?m
Acta Veterinaria Scandinavica , 2007, DOI: 10.1186/1751-0147-49-6
Abstract: Preoperative plasma levels of cTnI were investigated in 58 female dogs with pyometra and 9 controls. The value of physical examination findings, haematological, serum biochemical and pro-inflammatory (CRP and TNF-α) parameters as possible predictors of increased cTnI levels was also evaluated.Seven dogs with pyometra (12%) and one control dog (11%) had increased levels of cTnI. In the pyometra group, the levels ranged between 0.3–0.9 μg l-1 and in the control dog the level was 0.3 μg l-1. The cTnI levels did not differ significantly between the two groups. No cardiac abnormalities were evident on preoperative physical examinations. Four of the pyometra patients died within two weeks of surgery, of which two were examined post mortem. In one of these cases (later diagnosed with myocarditis and disseminated bacterial infection) the cTnI levels increased from 0.9 μg l-1 preoperatively to 180 μg l-1 the following day when also heart arrhythmia was also detected. The other patient had cTnI levels of 0.7 μg l-1 with no detectable heart pathology post mortem. CTnI increase was not associated with presence of SIRS. There was a trend for the association of cTnI increase with increased mortality. No preoperative physical examination findings and few but unspecific laboratory parameters were associated with increased cTnI levels.Increased cTnI levels were observed in 12% of the dogs with pyometra. The proportions of dogs with cTnI increase did not differ significantly in the pyometra group compared with the control group. CTnI increase was not associated with presence of SIRS. A trend for association of cTnI increase and mortality was observed. Preoperative physical examination findings and included laboratory parameters were poor predictors of increased cTnI levels.Pyometra is a common reproductive disorder which affects nearly one fourth of all female dogs before they reach ten years of age [1]. The disease generates clinical signs associated with infection and inflammation
A new resorbable device for ligation of blood vessels - A pilot study
Odd V H?glund, Ragnvi Hagman, Kerstin Olsson, Jonas Mindemark, Niklas Borg, Anne-Sofie Lagerstedt
Acta Veterinaria Scandinavica , 2011, DOI: 10.1186/1751-0147-53-47
Abstract: The device was manufactured by injection moulding of polydioxanone, a resorbable polymer used for suture materials. Polydioxanone with inherent viscosities of 1.9 dL/g and 1.3 dL/g were tested. The device consisted of a perforated flexible band which could be pulled through a case with a locking mechanism. After a first version of the device had been tested, some improvements were made. The locking case was downsized, corners were rounded off, the band was made thicker and the mould was redesigned to produce longer devices. Tensile tests were performed with the second version.The first version of the device was used to ligate the ovarian pedicle in a euthanized dog and to test echogenicity of the device with ultrasound. Compression of vessels of the ovarian pedicle was examined by histology. Both versions of the device were tested for haemostasis of and tissue grip on renal arteries in six anaesthetised pigs.The tensile strength of the flexible band of the devices with inherent viscosity of 1.9 dL/g was 50.1 ± 5.5 N (range 35.2-62.9 N, n = 11) and the devices with inherent viscosity of 1.3 dL/g had a tensile strength of 39.8 ± 8.1 N (range 18.6-54.2 N, n = 11). Injection moulding of the polymer with lower inherent viscosity resulted in a longer flow distance.Both versions of the device had an effective tissue grip and complete haemostasis of renal arteries was verified. The device attached to the ovarian pedicle could be seen with ultrasound, and vessel compression and occlusion were verified by histology.Tests of functionality of the device showed complete haemostasis and good tissue grip. Devices with a band of sufficient length were easily applied and tightened in tissue.Bleeding associated with surgery is a potentially serious complication. Haemostasis to prevent blood loss is commonly achieved by tying a surgical thread around the blood vessel. Vessels localized deep in the abdomen can be difficult to ligate [1]. A device that enables secure ligatures that are
Calibrating and adjusting expectations in life: A grounded theory on how elderly persons with somatic health problems maintain control and balance in life and optimize well-being
Anne-Sofie Helvik,Valentina Cabral Iversen,Randi Steiring,Lillemor R-M Hallberg
International Journal of Qualitative Studies on Health & Well-Being , 2011, DOI: 10.3402/qhw.v6i1.6030
Abstract: Aim: This study aims at exploring the main concern for elderly individuals with somatic health problems and what they do to manage this. Method: In total, 14 individuals (mean = 74.2 years; range = 68–86 years) of both gender including hospitalized and outpatient persons participated in the study. Open interviews were conducted and analyzed according to grounded theory, an inductive theory-generating method. Results: The main concern for the elderly individuals with somatic health problems was identified as their striving to maintain control and balance in life. The analysis ended up in a substantive theory explaining how elderly individuals with somatic disease were calibrating and adjusting their expectations in life in order to adapt to their reduced energy level, health problems, and aging. By adjusting the expectations to their actual abilities, the elderly can maintain a sense of that they still have the control over their lives and create stability. The ongoing adjustment process is facilitated by different strategies and result despite lower expectations in subjective well-being. The facilitating strategies are utilizing the network of important others, enjoying cultural heritage, being occupied with interests, having a mission to fulfill, improving the situation by limiting boundaries and, finally, creating meaning in everyday life. Conclusion: The main concern of the elderly with somatic health problems was to maintain control and balance in life. The emerging theory explains how elderly people with somatic health problems calibrate their expectations of life in order to adjust to reduced energy, health problems, and aging. This process is facilitated by different strategies and result despite lower expectation in subjective well-being.
Early sexual behaviour and Chlamydia trachomatis infection – a population based cross-sectional study on gender differences among adolescents in Norway
Gravningen Kirsten,Furberg Anne-Sofie,Simonsen Gunnar Skov,Wilsgaard Tom
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-319
Abstract: Background Early sexual behaviour has been shown to differ significantly between genders, but few studies have addressed this topic to explain the commonly observed differences in chlamydia rates between adolescent girls and boys. Our study aimed to determine chlamydia prevalence in adolescents aged 15–20 years in a high-incidence area in Norway, and to identify gender-specific early sexual behaviours associated with infection. Methods A population based cross-sectional study was conducted among all high school students in five towns in Finnmark county in 2009, using a web-based questionnaire and real-time Chlamydia trachomatis PCR in first-void urine samples (participation rate 85%, 800 girls/818 boys, mean age 17.2 years). Crude and multivariable logistic regression models were applied with chlamydia test result as dependent variable. Results Prevalence of chlamydia infection was 5.7% (95% confidence interval, CI, 4.4–7.3%). Girls were twice as likely to be infected as boys (7.3%, 5.3–9.7 vs 3.9%, 2.3–6.0). Girls reported earlier sexual debut, older partners, higher lifetime number of partners, and were poorer condom users. In girls, higher maternal education (odds ratio, OR, 2.2, 95% CI 1.1–4.4), ≥2 sexual partners past 6 months (OR 3.6, 1.8–7.3), and partner meeting venue at a private party, bar or disco (OR 5.0, 1.1–22.7) increased the odds of infection in the multivariable model. In boys, condom use at first intercourse (OR 0.06, 0.01–0.42) decreased the odds of infection, while having an older last sexual partner (OR 3.7, 1.3–11.0) increased the odds. In all participants, the risk of infection increased if residence outside the family home during school year (OR 2.0, 1.2–3.6), and decreased if condom was used at last intercourse (OR 0.2, 0.1–0.8). Conclusions We detected significant gender differences in chlamydia prevalence and sexual behaviours, and accordingly differing independent risk factors for chlamydia infection. We suggest that accumulation of essentially different experiences in the early sexually active years contribute to gender disparities in chlamydia risk in individuals this age. Gender-specific approaches may be the best alternative to control chlamydia infection in age group 15–20 years.
Nursing Home Admission during the First Year after Hospitalization – The Contribution of Cognitive Impairment
Anne-Sofie Helvik, Randi Helene Skancke, Geir Selb?k, Knut Engedal
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086116
Abstract: Objective The importance of cognitive and physical functioning for nursing home admission among medically hospitalized older patients is rarely studied in a one-year follow-up perspective. This study aims to explore the association between patient characteristics and nursing home admission within one year after hospitalization in persons 65 years or more. Design A one-year longitudinal study. Methods We included 463 (234 women) persons aged 65 years or more from internal medical wards in a rural area of Norway. Cognitive function was assessed using the Mini Mental State Examination; physical and instrumental functional status was assessed using the physical self-maintenance scale and instrumental activities of daily living scale of Lawton and Brody. Comorbidity was measured with the Charlson index. Admission to nursing home within one year (yes versus no) was analyzed using logistic regression analysis and Cox proportional hazard regression analysis. Results The mean age of the sample was 80.5 (SD 7.4) years, mean Mini Mental State Examination score was 24.1 (SD 3.8) (maximum score is 30). In adjusted analysis participants with cognitive impairment (a Mini Mental State Examination score <25) or impaired physical functioning at baseline had higher risk of admission to nursing home within one year (OR 3.0, 95%CI 1.5–6.2 and OR 3.5, 95%CI 1.8–9.6, respectively). The time before admission was also associated with cognitive impairment and impaired physical functioning in the adjusted analysis (HR 2.6 95%CI 1.4–4.8 and HR 3.7, 95%CI 1.5–8.9, respectively). Conclusion Impaired cognitive and physical functioning increased the risk for nursing home admission within one year after hospitalization. However, putative regressors, such as education and social network were not included in the analysis.
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