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Search Results: 1 - 10 of 234018 matches for " Anne-Marie C Dingemans "
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MicroRNA Expression and Clinical Outcome of Small Cell Lung Cancer
Jih-Hsiang Lee, Johannes Voortman, Anne-Marie C. Dingemans, Donna M. Voeller, Trung Pham, Yisong Wang, Giuseppe Giaccone
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021300
Abstract: The role of microRNAs in small-cell lung carcinoma (SCLC) is largely unknown. miR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types. However, its therapeutic implication has never been studied in SCLC, a cancer type with frequent dysfunction of p53. We investigated the expression of a panel of 7 microRNAs (miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a) in 31 SCLC tumors, 14 SCLC cell lines, and 26 NSCLC cell lines. We observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines. The expression of the 7 microRNAs was unrelated to SCLC patients' clinical characteristics and was neither prognostic in term of overall survival or progression-free survival nor predictive of treatment response. Overexpression or downregulation of miR-34a did not influence SCLC cell viability. The expression of these 7 microRNAs also did not predict in vitro sensitivity to cisplatin or etoposide in SCLC cell lines. Overexpression or downregulation of miR-34a did not influence sensitivity to cisplatin or etoposide in SCLC cell lines. In contrast to downregulation of the miR-34a target genes cMET and Axl by overexpression of miR-34a in NSCLC cell lines, the intrinsic expression of cMET and Axl was low in SCLC cell lines and was not influenced by overexpression of miR-34a. Our results suggest that the expression of the 7 selected microRNAs are not prognostic in SCLC patients, and miR-34a is unrelated to the malignant behavior of SCLC cells and is unlikely to be a therapeutic target.
Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer
Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen, Victor L Thijssen
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-152
Abstract: A retrospective study was performed on frozen primary tumors of 68 early stage non-small cell lung cancer patients with a follow up of at least 10 years. From all tumor tissues, RNA was isolated and reverse transcribed into cDNA. qPCR was used to generate mRNA expression profiles including integrins alpha1, 2, 3, 4, 5, 6, 7, 11, and V as well as integrins beta1, 3, 4, 5, 6, and 8.The expression levels of integrins alpha5, beta1 and beta3 predicted overall survival and disease free survival in early stage NSCLC patients. There was no association between integrin expression and lymph node metastases. Comparison between the histological subtypes revealed a distinct integrin signature for squamous cell carcinoma while the profiles of adenocarcinoma and large cell carcinoma were largely the same.Integrin expression in NSCLC is important for the development and behavior of the tumor and influences the survival of the patient. Determining the integrin expression profile might serve as a tool in predicting the prognosis of individual patients.Lung cancer is the most common cause of cancer related death in Europe, accounting for one-fifth of the total number of cancer deaths[1]. The prognosis of patients with non-small cell lung cancer (NSCLC), which constitutes 80% of all lung cancers, is poor, even in patients with early stage disease[2]. The five year survival rate of patients with resected NSCLC is between 50-60%, and 50-60% of patients will have disease recurrence within 2 years[3]. Recently, it has been shown that adjuvant chemotherapy improves overall and disease-free survival in patients with resected stage stage II-IIIa NSCLC, but not all patients benefit[3]. Thus, selection of patients with high risk of recurrence is warranted.An important predictor of poor prognosis in patients with NSCLC is early distant metastasis[2]. When cancer cells become metastatic, they develop altered affinity and avidity for the extracellular matrix (ECM). This phenotypic change is partl
Scaling up kangaroo mother care in South Africa: 'on-site' versus 'off-site' educational facilitation
Anne-Marie Bergh, Elise van Rooyen, Robert C Pattinson
Human Resources for Health , 2008, DOI: 10.1186/1478-4491-6-13
Abstract: Thirty-six hospitals in the Provinces of Gauteng and Mpumalanga in South Africa were targeted to implement kangaroo mother care and participated in the trial. The hospitals were paired with respect to their geographical location and annual number of births. One hospital in each pair was randomly allocated to receive either 'on-site' facilitation (Group A) or 'off-site' facilitation (Group B). Hospitals in Group A received two on-site visits, whereas delegates from hospitals in Group B attended one off-site, 'hands-on' workshop at a training hospital. All hospitals were evaluated during a site visit six to eight months after attending an introductory workshop and were scored by means of an existing progress-monitoring tool with a scoring scale of 0–30. Successful implementation was regarded as demonstrating evidence of practice (score >10) during the site visit.There was no significant difference between the scores of Groups A and B (p = 0.633). Fifteen hospitals in Group A and 16 in Group B demonstrated evidence of practice. The median score for Group A was 16.52 (range 00.00–23.79) and that for Group B 14.76 (range 07.50–23.29).A previous trial illustrated that the implementation of a new health care intervention could be scaled up by using a carefully designed educational package, combined with face-to-face facilitation by respected resource persons. This study demonstrated that the site of facilitation, either on site or at a centre of excellence, did not influence the ability of a hospital to implement KMC. The choice of outreach strategy should be guided by local circumstances, cost and the availability of skilled facilitators.Implementing and scaling up new health care interventions is very challenging and often demands intensive training or retraining, especially when the objective is to reach a health system on a provincial or national level. According to a systematic review of interventions by Grimshaw et al., the successful implementation of a programme de
Size and shape information serve as labels in the alarm calls of Gunnison's prairie dogs Cynomys gunnisoni
C. N. SLOBODCHIKOFF, William R. BRIGGS, Patricia A DENNIS, Anne-Marie C. HODGE
Current Zoology , 2012,
Abstract: Some animals have the capacity to produce different alarm calls for terrestrial and aerial predators. However, it is not clear what cognitive processes are involved in generating these calls. One possibility is the position of the predator: Anything on the ground receives a terrestrial predator call, and anything in the air receives an aerial predator call. Another possibility is that animals are able to recognize the physical features of predators and incorporate those into their calls. As a way of elucidating which of these mechanisms plays a primary role in generating the structure of different calls, we performed two field experiments with Gunnison’s prairie dogs. First, we presented the prairie dogs with a circle, a triangle, and a square, each moving across the colony at the same height and speed. Second, we presented the prairie dogs with two squares of differing sizes. DFA statistics showed that 82.6 percent of calls for the circle and 79.2 percent of the calls for the triangle were correctly classified, and 73.3 percent of the calls for the square were classified as either square or circle. Also, 100 percent of the calls for the larger square and 90 percent of the calls for the smaller square were correctly classified. Because both squares and circles are features of terrestrial predators and triangles are features of aerial predators, our results suggest that prairie dogs might have a cognitive mechanism that labels the abstract shape and size of different predators, rather than the position of the predator [Current Zoology 58 (5): 741-748, 2012].
Osteosarcoma Models: From Cell Lines to Zebrafish
Alexander B. Mohseny,Pancras C. W. Hogendoorn,Anne-Marie Cleton-Jansen
Sarcoma , 2012, DOI: 10.1155/2012/417271
Abstract: High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic. Early onset, most often lack of a predisposing condition or lesion, only infrequent (<2%) prevalence of inheritance, extensive genomic instability, and a wide histological heterogeneity are just few factors to mention that make osteosarcoma difficult to study. Therefore, it is sensible to design and use models representative of the human disease. Here we summarize multiple osteosarcoma models established in vitro and in vivo, comment on their utilities, and highlight newest achievements, such as the use of zebrafish embryos. We conclude that to gain a better understanding of osteosarcoma, simplification of this extremely complex tumor is needed. Therefore, we parse the osteosarcoma problem into parts and propose adequate models to study them each separately. A better understanding of osteosarcoma provides opportunities for discovering and assaying novel effective treatment strategies.
Auditory Processing in High-Functioning Adolescents with Autism Spectrum Disorder
Anne-Marie R. DePape, Geoffrey B. C. Hall, Barbara Tillmann, Laurel J. Trainor
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044084
Abstract: Autism Spectrum Disorder (ASD) is a pervasive developmental disorder including abnormalities in perceptual processing. We measure perception in a battery of tests across speech (filtering, phoneme categorization, multisensory integration) and music (pitch memory, meter categorization, harmonic priming). We found that compared to controls, the ASD group showed poorer filtering, less audio-visual integration, less specialization for native phonemic and metrical categories, and a higher instance of absolute pitch. No group differences were found in harmonic priming. Our results are discussed in a developmental framework where culture-specific knowledge acquired early compared to late in development is most impaired, perhaps because of early-accelerated brain growth in ASD. These results suggest that early auditory remediation is needed for good communication and social functioning.
Predictive and Prognostic Protein Biomarkers in Epithelial Ovarian Cancer: Recommendation for Future Studies
Cécile Le Page,David G. Huntsman,Diane M. Provencher,Anne-Marie Mes-Masson
Cancers , 2010, DOI: 10.3390/cancers2020913
Abstract: Epithelial ovarian cancer is the most lethal gynecological malignancy. Due to its lack of symptoms, this disease is diagnosed at an advanced stage when the cancer has already spread to secondary sites. While initial rates of response to first treatment is >80%, the overall survival rate of patients is extremely low, mainly due to development of drug resistance. To date, there are no reliable clinical factors that can properly stratify patients for suitable chemotherapy strategies. Clinical parameters such as disease stage, tumor grade and residual disease, although helpful in the management of patients after their initial surgery to establish the first line of treatment, are not efficient enough. Accordingly, reliable markers that are independent and complementary to clinical parameters are needed for a better management of these patients. For several years, efforts to identify prognostic factors have focused on molecular markers, with a large number having been investigated. This review aims to present a summary of the recent advances in the identification of molecular biomarkers in ovarian cancer patient tissues, as well as an overview of the need and importance of molecular markers for personalized medicine in ovarian cancer.
Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population
Marion Chauvenet, Vanessa Cottet, C?me Lepage, Valérie Jooste, Jean Faivre, Anne-Marie Bouvier
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-282
Abstract: Between 1976 and 2005, 17,028 new cases were registered by the Burgundy digestive cancer registry. The mean variations in age-standardized incidence rates were estimated using a Poisson regression adjusted for age for each gender and location. The cumulative risk by birth cohort of developing a cancer over the age range 0-74 years was estimated using an age-cohort model.Incidence rates for right and left colon cancers increased more rapidly in males (respectively +11.7% and +10.3% on average by 5-year period) than in females (respectively +5.9% and +6.1%). It remained stable for sigmoid cancers in males (-0.1%) and decreased in females (-5.2%). It also decreased for rectal cancers both in males (-2.7%) and in females (-2.0%). The cumulative risk increased from 3.9% for males born around 1900 to 4.9% for those born around 1930 and then slightly decreased (4.5% among those born around 1950). It remained at the same level for females born around 1900 (2.7%) as for those born around 1930 (2.7%) and then slightly increased (2.9%) for those born around 1950. For right colon cancers, the cumulative risk increased strikingly in successive birth cohorts from 0.53% to 1.2% in males and 0.55% to 0.77% in females. The corresponding cumulative risks for the left colon were 0.24% and 0.42% in males and 0.14% and 0.29% in females. For sigmoid cancer, they decreased from 1.59% to 1.08% in males, and 0.88% to 0.80% in females.Temporal variations in incidence rates of colorectal cancers differed according to subsite, suggesting different aetiological factors and implications for diagnosis and screening strategies. Total colonoscopy must be the preferred strategy in high-risk groups or after a positive faecal occult blood test.In France, colorectal cancer is currently the third most common cancer in men and the second in women [1]. In 2005, the number of new cases was estimated to be 37,413 for both genders with age-standardized rates of 37.7/100,000 in males and 24.5/100,000 in femal
Représentation du corps et de l'alimentation chez une population de femmes de plus de 75 ans.
Costalat-Founeau, Anne-Marie,Picot, M-C,Hauchard, D.,Klimekova, M.
Papers on Social Representations , 2002,
Abstract:
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
Sarver Aaron L,Thayanithy Venugopal,Scott Milcah C,Cleton-Jansen Anne-Marie
Orphanet Journal of Rare Diseases , 2013, DOI: 10.1186/1750-1172-8-7
Abstract: Background Deregulation of microRNA (miRNA) transcript levels has been observed in many types of tumors including osteosarcoma. Molecular pathways regulated by differentially expressed miRNAs may contribute to the heterogeneous tumor behaviors observed in naturally occurring cancers. Thus, tumor-associated miRNA expression may provide informative biomarkers for disease outcome and metastatic potential in osteosarcoma patients. We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma. Methods Human and canine osteosarcoma patient’s samples with clinical follow-up data were used in this study. We used bioinformatics and comparative genomics approaches to identify miRNA based prognostic biomarkers in osteosarcoma. Kaplan-Meier survival curves and Whitney Mann U tests were conducted for validating the statistical significance. Results Here we show that an inverse correlation exists between aggressive tumor behavior (increased metastatic potential and accelerated time to death) and the residual expression of 14q32 miRNAs (using miR-382 as a representative of 14q32 miRNAs) in a series of clinically annotated samples from human osteosarcoma patients. We also show a comparable decrease in expression of orthologous 14q32 miRNAs in canine osteosarcoma samples, with conservation of the inverse correlation between aggressive behavior and expression of orthologous miRNA miR-134 and miR-544. Conclusions We conclude that downregulation of 14q32 miRNA expression is an evolutionarily conserved mechanism that contributes to the biological behavior of osteosarcoma, and that quantification of representative transcripts from this family, such as miR-382, miR-134, and miR-544, provide prognostic and predictive markers that can assist in the management of patients with this disease.
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