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Search Results: 1 - 10 of 13860 matches for " Anna Kozak "
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Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke
Livia S Machado, Anna Kozak, Adviye Ergul, David C Hess, Cesario V Borlongan, Susan C Fagan
BMC Neuroscience , 2006, DOI: 10.1186/1471-2202-7-56
Abstract: Both MMP-2 and MMP-9 were elevated in the ischemic tissue as compared to the contra-lateral hemisphere after 3 hours occlusion and 21 hours survival (p < 0.0001 for MMP-9). Intraperitoneal minocycline at 45 mg/kg concentration twice a day (first dose immediately after the onset of reperfusion) significantly reduced gelatinolytic activity of ischemia-elevated MMP-2 and MMP-9 (p < 0.0003). Treatment also reduced protein concentration of both enzymes (p < 0.038 for MMP-9 and p < 0.018 for MMP-2). In vitro incubation of minocycline in concentrations as low as 0.1 μg/ml with recombinant MMP-2 and MMP-9 impaired enzymatic activity and MMP-9 was more sensitive at lower minocycline concentrations (p < 0.05).Minocycline inhibits enzymatic activity of gelatin proteases activated by ischemia after experimental stroke and is likely to be selective for MMP-9 at low doses. Minocycline is a potential new therapeutic agent to acute treatment of ischemic stroke.Matrix metalloproteases (MMPs) are a family of zinc dependent proteases responsible for the extracellular matrix turnover and degradation of bioactive proteins. In cerebral ischemia, MMPs 2 and 9, also designated as gelatinases A (72 kDa) and B (92 kDa) have been identified to mediate the degradation of the basal lamina [1,2] and hemorrhagic transformation [3]. MMPs 2 and 9 have been shown to be elevated a few hours after ischemia [4] and to maintain increased activity for days after the onset [2,5]. The inhibition of these enzymes by specific class inhibitors reverts breakdown of laminin [6] and prevents increased barrier permeability, edema, and hemorrhage after ischemic stroke [7-9]. The development of MMP inhibitors as therapeutic agents has been limited by their poor solubility.Minocycline is a commonly used semi-synthetic tetracycline with anti-inflammatory and anti-apoptotic properties [10,11]. Minocycline interferes with MMP activity [12,13] and has been shown to be neuroprotective in cerebral ischemia [14] and in oth
Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke
Alex K Harris, Adviye Ergul, Anna Kozak, Livia S Machado, Maribeth H Johnson, Susan C Fagan
BMC Neuroscience , 2005, DOI: 10.1186/1471-2202-6-49
Abstract: Anti-PMN treatment caused successful depletion of neutrophils in treated animals. There was no difference in either infarct volume or hemorrhage between control and PMN depleted animals. While there were significant increases in gelatinase (MMP-2 and MMP-9) expression and activity and edema formation associated with ischemia, neutrophil depletion failed to cause any change.The main finding of this study is that, in the absence of circulating neutrophils, MMP-2 and MMP-9 expression and activity are still up-regulated following focal cerebral ischemia. Additionally, neutrophil depletion had no influence on indicators of ischemic brain damage including edema, hemorrhage, and infarct size. These findings indicate that, at least acutely, neutrophils are not a significant contributor of gelatinase activity associated with acute neurovascular damage after stroke.The matrix metalloproteinases (MMPs) are a family of some 23 zinc dependent proteases that, collectively, possess the ability to degrade nearly every component of the extra-cellular matrix [1-3]. The activity of the MMPs is tightly controlled through proteolytic activation of the zymogen forms and stoichiometric binding of tissue inhibitors of metalloproteinases (TIMPs). The MMPs play an important role in many physiological processes due to their inherent ability to remodel tissues [2,3]. However, in disease states such as vascular disease and stroke, the MMPs may become deleterious due to dysregulation and can result in tissue injury and inflammation. Specifically, the MMPs may be involved in the degradation of the basal lamina in reperfusion injury resulting in disruption of the blood brain barrier and hemorrhagic transformation [4].Recently, several lines of evidence have demonstrated the involvement of the MMPs in cerebral ischemia. Studies in rat, mouse, and baboon models have shown that MMP-9 is up-regulated following transient focal ischemia [5-8]. Additionally, Asahi et al. have shown that MMP-9 knockout as
Potrzeba wsparcia psychicznego kobiet w okresie oczekiwania na operacj ginekologiczn
Celina ?epecka-Klusek,Anna B. Pilewska-Kozak,Kinga Syty,Grzegorz Jakiel
Przegl?d Menopauzalny , 2010,
Abstract: Aim: The aim of this study was to examine whether and what is the relationship between age of women andthe need for emotional support while awaiting the scheduled gynaecological surgery. Material and methods: The study comprised 272 women who, within 2 months of 2008, underwent plannedgynaecological surgeries in one of four selected hospitals in Lublin and Warsaw. The research tool was a questionnairedesigned specifically for this study. The main study was preceded by a pilot study carried out among25 women, the results of which were excluded from this study. Results: In nearly half (45.6%) of the respondents the suggestion of surgery induced negative feelings, suchas fear, distrust and objections. Most women (72.8%) feared most the detection (or confirmation) of malignancy.Others were afraid of pain, complications, loss of femininity and/or fertility. Psychological support from theothers was expected by 87.9% of respondents. The waiting time for surgery was adequate in the subjective assessmentof the majority (79.0%). The division of women on grounds of age adopted in this study, differentiatedsignificantly most of the studied characteristics of respondents, with the exception of demographic data. Conclusions: 1. Older women (> 49 years) more often than the younger (aged ≤ 49 years), feel fear of detection(or confirmation) of malignant neoplasm, find the waiting time for surgery appropriate and expect supportprimarily from medical staff. 2. Older women less likely than younger ones can expect – in their view – theassistance and support of families.
Scleromyxedema - problemy diagnostyczne
Agata Sosnowska,Karina Kozak-Gawron,Magdalena Sporek-Oso?kowska,Anna Lis
Clinical Dermatology , 2004,
Abstract: Przedstawiono przypadek scleromyxedema z towarzysz c monoklonaln gammapati i zaburzeniami psychicznymi. Opisujemy post powanie diagnostyczne w aspekcie ustalonych kryteriów rozpoznania, ró nicowanie z twardzin uk adow oraz problemy terapeutyczne.
Visualizing Adaptation of Genotypes with a Ternary Plot
Kozak,Marcin;
Chilean journal of agricultural research , 2010, DOI: 10.4067/S0718-58392010000400010
Abstract: adaptation can be studied through various methods, some of which are based on adaptation or stability measures while others on complex models and graphs. in this adaptation measure based on quantiles is presented; the measure is three-dimensional and can be pictured with a ternary (trilinear) plot. a simple algorithm for constructing such a plot is presented and the interpretation of the plot is discussed. by means of this graphical tool one can picture and interpret the specific and wide adaptation of genotypes to environments, offering complementary information to that of other methods of analyzing genotype-by-environment data.
Manuel Puig, la política, el umbral
Kozak,Claudia;
Ciencia, docencia y tecnolog?-a , 2011,
Abstract: the article reads in manuel puig's literature a notion of politics beyond usual political discourses. taking as a point of departure textual procedures which work with "folds", "inbetweens" and "thresholds", concerning particularly the use of intimate genres and spatial procedures, politics appears as a destabilization of discourses within themselves, doubting about certainty, and building new worlds which point to the transformation of status quo. the analysis focuses on three novels (kiss of spider woman, pubis angelical and eternal curse on the reader of these pages) written during the 20th century seventies, which all along with the buenos aires affair make up the "political cycle" within manuel puig's fiction, seeking how they build impolitical community.
Analyzing one-way experiments: a piece of cake of a pain in the neck?
Kozak, Marcin;
Scientia Agricola , 2009, DOI: 10.1590/S0103-90162009000400020
Abstract: statistics may be intricate. in practical data analysis many researchers stick to the most common methods, not even trying to find out whether these methods are appropriate for their data and whether other methods might be more useful. in this paper i attempt to show that when analyzing even simple one-way factorial experiments, a lot of issues need to be considered. a classical method to analyze such data is the analysis of variance, quite likely the most often used statistical method in agricultural, biological, ecological and environmental studies. i suspect this is why this method is quite often applied inappropriately: since the method is that common, it does not require too much consideration-this is how some may think. an incorrect analysis may provide false interpretation and conclusions, so one should pay careful attention to which approach to use in the analysis. i do not mean that one should apply difficult or complex statistics; i rather mean that one should apply a correct method that offers what one needs. so, various problems concerned with the analysis of variance and other approaches to analyze such data are discussed in the paper, including checking within-group normality and homocedasticity, analyzing experiments when any of these assumptions is violated, outliers presence, multiple comparison procedures, and other issues.
Basic principles of graphing data
Kozak, Marcin;
Scientia Agricola , 2010, DOI: 10.1590/S0103-90162010000400017
Abstract: data visualization is a very important aspect of data analysis and of presentation. focusing on the latter, this paper discusses various elements of constructing graphs for publications. bad and good graphs are compared, and a checklist with graphical elements to be used while creating graphs is proposed.
Alternative business models for forest - dependent communities in Africa: A pragmatic consideration of small - scale enterprises and a path forward
RA Kozak
Madagascar Conservation & Development , 2009,
Abstract: The dominant mode of business practice in the African forest sector – especially in the high forest cover regions – comes in the form of concessionaires operating on publicly held lands. Increasingly, however, the concession - based model is being challenged. Is it socially and environmentally sustainable? Does it lead to positive socio - economic outcomes for forest dependent communities? While this paper does not attempt to answer these questions head - on, it does put forward four alternative business models that could serve to reduce poverty and improve social conditions among rural forest - dwelling Africans: 1) small and medium - sized enterprises; 2) community forest enterprises; 3) business associations; and 4) alliances with concessionaires. Definitions of the four business models are provided, and some key considerations for each are discussed. The paper concludes by providing recommendations for civil society, governments, economic actors, communities, and other stakeholders interested in catalyzing and creating an enabling environment for these sorts of business alternatives to succeed in the forested regions of Africa. Namely, there is a need to collect and disseminate quantitative data on the socio - economic contributions that small - scale enterprises can make, devise appropriate interventions that take into account the highly variable socio - political landscapes of Africa, and develop business plans grounded in solid, marketable value propositions.
Strategic management competitiveness of a higher education
Kozak, Оlena
Socìal?no-ekonomì?nì Problemì ì Der?ava , 2012,
Abstract: The article highlights the main areas of strategic development of a university. Perfect educational and social infrastructure will improve the educational and scientific activities of an institution. Providing the educational process with highly-qualified scientific and pedagogical workers will allow to improve the quality of educational programs and will contribute to the final product of universities. Implementation of a flexible specialties system in the educational process, meeting the requirements of the labor market and international quality standards of training will lead to the growth in graduates employment level and competitiveness of the university. The method of SWOT-analysis aimed at proper evaluation of the functioning area of an educational institution is proposed to apply. The factors influencing the consumers of educational services behavior and the factors affecting the possible university entrants’ choice are determined. The information strategy concerning the universities competitiveness is considered.
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