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Search Results: 1 - 10 of 21691 matches for " Anna Gabriel Copeland "
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Participation and the role of Public Space
Anna Gabriel Copeland
Public Space : the Journal of Law and Social Justice , 2008,
Abstract: This article examines participatory rights as human rights and considers their importance to the lives of children and young people. It argues that a broad definition of participation needs to be used which takes us from 'round tables' to understanding that young people participate in many different ways. It points out that failure to recognise and respect the many varied ways that children and young people choose to participate results in a breach of their human rights. It shows how our socio-legal system operates to permit and support these breaches of the rights of children and young people, resulting in their alienation from civic society.
Comparison of two methods of measurement of maximal respiratory pressures in health and cystic fibrosis  [PDF]
Theodore Dassios, Anna Katelari, Stavros Doudounakis, Gabriel Dimitriou
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68A2006
Abstract: Introduction: Respiratory muscle strength can be assessed by static mouth measurements of maximal inspiratory pressure (Pimax) and maximal expiratory pressure (Pemax). Impaired respiratory muscle strength is common in neuromuscular and obstructive pulmonary disease such as Cystic Fibrosis (CF). Maximal respiratory pressures can easily be measured with a portable manometer on the bedside and in the community. Our objective was to compare maximal respiratory pressures as measured by standard laboratory equipment and the portable mouth pressure meter Micro RPM. Methods: Pimax and Pemax were assessed in 296 healthy subjects and patients with CF with the Micro RPM and standard laboratory equipment. The Micro RPM measures and digitally displays maximal respiratory pressures after averageing over a one second period. Standard laboratory equipment consisted of a differential pressure transducer, whose amplified signals were analyzed by Lab-VIEW software. Each subject performed at least five reproducible maneuvers after familiarizing with the equipment. Results: The Micro RPM accurately measured maximal inspiratory and maximal expiratory pressures both in healthy individuals as well as in patients with CF. Mean difference (standard deviation) of the methods was 1.37 (17.73) cm H2O for Pimax maneuvers and 1.84 (9.09) cm H2O for Pemax maneuvers. Conclusions: The Micro RPM can relia-bly and accurately measure maximal respiratory mouth pressures and its use could be applied both in the clinical and the research setting.
The Cross-Sectional Risk Premium of Decomposed Market Volatility in UK Stock Market  [PDF]
Yan Yang, Laurence Copeland
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.27006
Abstract:

We decompose UK market volatility into short- and long-run components using EGARCH component model and examine the cross-sectional prices of the two components. Our empirical results suggest that these two components are significantly priced in the cross-section and the negative risk premia are consistent with the existing literature. The Fama-French three-factor model is improved by the inclusion of the two volatility components. However, our ICAPM model using market excess return and the decomposed volatility components as state variables compares inferiorly to the traditional three-factor model.

Hexadecapolar Kondo effect in URu$_2$Si$_2$?
Anna I. Toth,Gabriel Kotliar
Physics , 2011, DOI: 10.1103/PhysRevLett.107.266405
Abstract: We derive the coupling of a localized hexadecapolar mode to conduction electrons in tetragonal symmetry. The derivation can be easily adapted to arbitrary multipoles in arbitrary environment. We relate our model to the two-channel Kondo (2CK) model and show that for an $f^2$-configuration, a relevant crystal field splitting in addition to the 2CK interaction is intrinsic to tetragonal symmetry. We discuss possible realizations of a hexadecapolar Kondo effect in URu$_2$Si$_2$. Solving our model we find good agreement with susceptibility and specific heat measurements in Th$_{1-x}$U$_x$Ru$_2$Si$_2$ ($x\ll1$).
Endothelial Cell Permeability during Hantavirus Infection Involves Factor XII-Dependent Increased Activation of the Kallikrein-Kinin System
Shannon L. Taylor,Victoria Wahl-Jensen,Anna Maria Copeland,Peter B. Jahrling,Connie S. Schmaljohn
PLOS Pathogens , 2013, DOI: 10.1371/journal.ppat.1003470
Abstract: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) are diseases caused by hantavirus infections and are characterized by vascular leakage due to alterations of the endothelial barrier. Hantavirus-infected endothelial cells (EC) display no overt cytopathology; consequently, pathogenesis models have focused either on the influx of immune cells and release of cytokines or on increased degradation of the adherens junction protein, vascular endothelial (VE)-cadherin, due to hantavirus-mediated hypersensitization of EC to vascular endothelial growth factor (VEGF). To examine endothelial leakage in a relevant in vitro system, we co-cultured endothelial and vascular smooth muscle cells (vSMC) to generate capillary blood vessel-like structures. In contrast to results obtained in monolayers of cultured EC, we found that despite viral replication in both cell types as well as the presence of VEGF, infected in vitro vessels neither lost integrity nor displayed evidence of VE-cadherin degradation. Here, we present evidence for a novel mechanism of hantavirus-induced vascular leakage involving activation of the plasma kallikrein-kinin system (KKS). We show that incubation of factor XII (FXII), prekallikrein (PK), and high molecular weight kininogen (HK) plasma proteins with hantavirus-infected EC results in increased cleavage of HK, higher enzymatic activities of FXIIa/kallikrein (KAL) and increased liberation of bradykinin (BK). Measuring cell permeability in real-time using electric cell-substrate impedance sensing (ECIS), we identified dramatic increases in endothelial cell permeability after KKS activation and liberation of BK. Furthermore, the alterations in permeability could be prevented using inhibitors that directly block BK binding, the activity of FXIIa, or the activity of KAL. Lastly, FXII binding and autoactivation is increased on the surface of hantavirus-infected EC. These data are the first to demonstrate KKS activation during hantavirus infection and could have profound implications for treatment of hantavirus infections.
Kolonizacja przewodu pokarmowego niemowl t grzybami dro d opodobnymi
Krystyna Stencel-Gabriel,Aldona Lukas,Anna Obuchowicz,Iwona Gabriel
Medical Mycology , 2006,
Abstract: Wprowadzenie: Kandydoza jako choroba infekcyjna wywo ywana jest przez grzyby dro d akopodobne, a w szczególno ci przez gatunek C. albicans i wyst puje na terenie ca ego globu. Najcz stsz przyczyn biegunek o pod o u grzybiczym w grupie niemowl t do 12. mies. . jest C. albicans (37,1%). Celem badania jest ocena zmienno ci wyst powania grzybów dro d akopodobnych w przewodzie pokarmowym niemowl t od 0. do 18. miesi., uwzgl dniaj c czynniki rodowiskowe mog ce mie wp yw na wilgotno rodowiska wewn trzdomowego. Materia i metody: Grup badan stanowi o 101 noworodków z 3 miast Górnego ?l ska. W badanej grupie dodatni wywiad atopowy u matki stwierdzono u 15 osób (14,8%). Okna plastikowe w mieszkaniach by y u 40 dzieci, a okna drewniane u 61. Ogrzewanie CO by o w 48 domach mieszkalnych, gazowe w 12, w glowe - 37, a elektryczne w 4 mieszkaniach. 47 niemowl t karmiono naturalnie do 3. mies. ., 31 niemowl t do 6. miesi., do 12. mies. . - 20, a do 18. mies. . 3 dzieci by o karmionych piersi . Doustne probiotyki stosowano mi dzy 0.-3. mies. . u 10,8% niemowl t, mi dzy 3.-6. mies. . u 12,87%, mi dzy 6.-12. mies. . u 16,83%, 12.-18. mies. . u 7,92%. Próbki ka u pobierano w okresie noworodkowym,3., 6., 12. i 18. mies. . Wyniki: Mediany izolowanej ilo ci grzybów w poszczególnych miesi cach wynosi y u noworodków=2,228*103 (n=7), w 3. mies. . media-na=l,200><104 (n=21), w 6. mies. . mediana=l,8><104 (n=13), 12. mies. . mediana=2,520><104 (n=42), w 18. mies. . mediana=3,25><104 (n=12). Wzrost ten nie jest znamienny statystycznie wzgl dem poszczególnych pomiarów w 0., 3., 6., 12., 18. mies. . (p=0,748). Nie wykazano zale no ci mi dzy rodzajem ogrzewania i okien zamontowanych w mieszkaniach. Wnioski: W okresie niemowl cym wyst puje sta y wzrost ilo ci grzybów izolowanych z przewodu pokarmowego niemowl t.
Meeting the Challenges for Agriculture
Les Copeland
Agriculture , 2011, DOI: 10.3390/agriculture1010001
Abstract: Ensuring food security is an ongoing global challenge. Many forecasts point to a need to increase food production by at least 70% if we are to feed the world’s projected population of nine billion in 2050. Recent volatility in commodity prices and the general upward trend in the cost of food are indicators that global food systems are now driven by demand rather than supply. There are various reasons for this: greater demand for animal protein with economic growth in developing countries; the continuing increase in world population; competition between food and bioenergy crops for land and water; low inventories of world grain stocks; reduced investment in agricultural R&D; and unfavorable weather resulting in a succession of poor harvests around the world. Increasing production of grains, which are the foundation of the human food supply, will have to be achieved through higher crop yields without boosting inputs of land, water and energy. Meeting community expectations for environmental stewardship and sustainability, and adapting food production to increasingly variable climate, add greatly to the challenge.
Spectral geometry of Riemannian Legendre foliations
Gabriel Baditoiu,Stere Ianus,Anna Maria Pastore
Mathematics , 2010,
Abstract: We obtain geometric characterizations of isospectral minimal Riemannian Legendre foliations on compact Sasakian manifolds of constant $\phi$-sectional curvature.
Quantifying the Clinical Significance of Cannabis Withdrawal
David J. Allsop, Jan Copeland, Melissa M. Norberg, Shanlin Fu, Anna Molnar, John Lewis, Alan J. Budney
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044864
Abstract: Background and Aims Questions over the clinical significance of cannabis withdrawal have hindered its inclusion as a discrete cannabis induced psychiatric condition in the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). This study aims to quantify functional impairment to normal daily activities from cannabis withdrawal, and looks at the factors predicting functional impairment. In addition the study tests the influence of functional impairment from cannabis withdrawal on cannabis use during and after an abstinence attempt. Methods and Results A volunteer sample of 49 non-treatment seeking cannabis users who met DSM-IV criteria for dependence provided daily withdrawal-related functional impairment scores during a one-week baseline phase and two weeks of monitored abstinence from cannabis with a one month follow up. Functional impairment from withdrawal symptoms was strongly associated with symptom severity (p = 0.0001). Participants with more severe cannabis dependence before the abstinence attempt reported greater functional impairment from cannabis withdrawal (p = 0.03). Relapse to cannabis use during the abstinence period was associated with greater functional impairment from a subset of withdrawal symptoms in high dependence users. Higher levels of functional impairment during the abstinence attempt predicted higher levels of cannabis use at one month follow up (p = 0.001). Conclusions Cannabis withdrawal is clinically significant because it is associated with functional impairment to normal daily activities, as well as relapse to cannabis use. Sample size in the relapse group was small and the use of a non-treatment seeking population requires findings to be replicated in clinical samples. Tailoring treatments to target withdrawal symptoms contributing to functional impairment during a quit attempt may improve treatment outcomes.
El papel del intestino superior en la patogénesis de la diabetes: se abre una interesante puerta en el área de investigación Role of the foregut in the pathogenesis of diabetes: opening an interesting perspective for research in this area
Gabriel J Echeverri,Duilio Pagano,Anna Casu,Claudia Montoya
Revista Colombiana de Cirugía , 2010,
Abstract:
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