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Search Results: 1 - 10 of 27334 matches for " Anish Kumar Gupta "
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ENVIRONMENTAL RESPONSIVE HYDROGELS: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM
Anish Kumar Gupta,Abdul Wadood Siddiqui
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Hydrogels are three dimensional crosslinked hydrophilic polymeric networks which has the capability to imbibe water or biological fluids. Environmentally responsive hydrogels have the ability to respond to change in their external environment. They can exhibit dramatic changes in their swelling behaviour, network structure, permeability and mechanical strength in response to change in pH or ionic strength of the surrounding fluid or temperature. Other hydrogels have the ability to respond to applied electric or magnetic field or to change in concentration of glucose. Environmental responsive hydrogels for drug delivery application also requires biocompatibility. The chemical structure of the polymer may also affect the swelling ratio of hydrogels. Hydrogels containing hydrophilic groups swell to a higher degree compared to those containing hydrophobic groups. Swelling of environmentally responsive hydrogels can be affected by changes in the temperature of the swelling media, ionic strength and pH
Material Removal Rate, Electrode Wear Rate, and Surface Roughness Evaluation in Die Sinking EDM with Hollow Tool through Response Surface Methodology
Teepu Sultan,Anish Kumar,Rahul Dev Gupta
International Journal of Manufacturing Engineering , 2014, DOI: 10.1155/2014/259129
Abstract: Electrical discharge machining is one of the earliest nontraditional machining, extensively used in industry for processing of parts having unusual profiles with reasonable precision. In the present work, an attempt has been made to model material removal rate, electrode wear rate, and surface roughness through response surface methodology in a die sinking EDM process. The optimization was performed in two steps using one factor at a time for preliminary evaluation and a Box-Behnken design involving three variables with three levels for determination of the critical experimental conditions. Pulse on time, pulse off time, and peak current were changed during the tests, while a copper electrode having tubular cross section was employed to machine through holes on EN 353 steel alloy workpiece. The results of analysis of variance indicated that the proposed mathematical models obtained can adequately describe the performances within the limits of factors being studied. The experimental and predicted values were in a good agreement. Surface topography is revealed with the help of scanning electron microscope micrographs. 1. Introduction Electrodischarge machining is a nonconventional machining process extensively used in industry for processing of parts having unusual profiles with reasonable precision [1]. Steel is a widely used engineering material. There are a variety of steels used for numerous applications. The steel is being divided into low carbon, medium carbon, and high carbon steel on the basis of carbon content. Low carbon steel contains a carbon content from 0.15% to 0.45%. It is the most common form of steel as it provides material properties that are acceptable for many applications [2]. EN 353 steel is cheaply available and widely used alloy. EN 353 is low alloy case carburized steel, predominantly used for manufacturing heavy-duty gears, shafts, pinions, and especially crown wheel [3]. Discharge current was the most significant controlling parameter in machining Al-15% SiC MMC using multihole electrode by grey relational analysis, while Taguchi method was employed to determine the relations between the machining parameters and process characteristics like MRR (material removal rate), EWR (electrode wear rate), and SR (surface roughness) [4]. The combination of maximum pulse on time and minimum pulse off time gives maximum MRR on Al-7075 alloy with brass electrode using Taguchi approach [5]. Amorim and Weingaertner concluded that the best results of MRR and surface texture for duty factor of 0.5 were obtained with tungsten-copper electrodes,
SUPPLIER ISSUES FOR LEAN IMPLEMENTATION
SATISH KUMAR SHARMA,,RAHUL DEV GUPTA,,ANISH KUMAR,,BHIM SINGH
International Journal of Engineering Science and Technology , 2011,
Abstract: Applying lean manufacturing philosophy is one of the most important concepts that help enterprises to gain competitive advantage in the world market. Suppliers are an important factor contributing to thesuccess of going lean. Major businesses in India as well as in other world, have been trying to integrate its suppliers to give better performance. In Indian small & medium scale enterprises (SME),application of lean manufacturing strategies especially in terms of supplier integration, have been far fewer. Indian SMEs are still resisting accepting the role of their suppliers to make them leaner. The aim of this study was to identify the supplier issues and their weightage in implementing the lean philosophy in Indian SMEs. The research hypothesizes that there are big opportunities for improvement in the Indian SMEs if it is made leaner by integrating its suppliers in its manufacturing system. Author identified total 21 supplier issues and divided these 21 supplier issues in four categories on conceptual basis named as Supplier Management strategy, Information Sharing with supplier, Supplier Integration, Capability to deal with uncertainty. Mean scores of all four categorized groups of supplier issues are ranked.
Identification of Nonlinear Systems From the Knowledge Around Different Operating Conditions: A Feed-Forward Multi-Layer ANN Based Approach
Sayan Saha,Saptarshi Das,Anish Acharya,Abhishek Kumar,Sumit Mukherjee,Indranil Pan,Amitava Gupta
Computer Science , 2012,
Abstract: The paper investigates nonlinear system identification using system output data at various linearized operating points. A feed-forward multi-layer Artificial Neural Network (ANN) based approach is used for this purpose and tested for two target applications i.e. nuclear reactor power level monitoring and an AC servo position control system. Various configurations of ANN using different activation functions, number of hidden layers and neurons in each layer are trained and tested to find out the best configuration. The training is carried out multiple times to check for consistency and the mean and standard deviation of the root mean square errors (RMSE) are reported for each configuration.
AN OVERVIEW ON STEM CELL AS A GENETIC MEDICINE
Anish K Gupta
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Stem cell treatments are a type of genetic medicine that introduces new cells into damaged tissue in order to treat a disease or injury. A number of stem cell treatments exist, although most are still experimental and/or costly, with the notable exception of bone marrow transplantation. Stem cells are a unique and important set of cells that are not specialized. Stem cells retain the ability to become many or all of the different cell types in the body and thereby play a critical role in repairing organs and body tissues throughout life. Stem cells provide the opportunity to study the growth and differentiation of individual cells into tissues. For over 30 years, bone marrow, and more recently, umbilical cord blood stem cells have been used to treat cancer patients with conditions such as leukemia and lymphoma. Understanding these processes could provide insights into the causes of birth defects, genetic abnormalities, and other disease states.
Experimental Investigation on Material Transfer Mechanism in WEDM of Pure Titanium (Grade-2)
Anish Kumar,Vinod Kumar,Jatinder Kumar
Advances in Materials Science and Engineering , 2013, DOI: 10.1155/2013/847876
Abstract: This research work mainly focused on experimental investigation on material transfer mechanism in WEDM of pure titanium. The effects of machining parameters such as pulse on time, pulse off time, peak current, spark gap voltage, wire feed, and wire tension on the material removal rate (MRR), overcut, and surface roughness for pure titanium in WEDM process were explored. The selected machined samples were analyzed using energy dispersive X-ray analysis, scanning electron microscope, and X-ray diffraction techniques. It was observed from the results that a significant material transfer occurred from the dielectric, as well as tool, electrode on the work surface either in free form and/or in compound form. Also the multiresponse optimization of process parameters was done using desirability approach. The predictions from this model were validated by conducting experiments. 1. Introduction The use of light, thin, and compact mechanical elements has recently become a global trend. The search for new, lightweight material with greater strength and toughness has led to the development of new generation of materials such as titanium. Having greater hardness and reinforcement strength, these materials are difficult to machine by the traditional methods. Although these materials can be machined conventionally, subsurface damages such as metallurgical alterations, work hardening, and microcracks can occur. Since the cost of using conventional machining is generally prohibitive, nonconventional machining such as wire electric discharge machining (WEDM) is the ideal technique in dealing with these materials [1]. Wire electrical discharge machining (WEDM) is a specialized thermal machining process capable of accurately machining parts with varying hardness or complex shapes, which have sharp edges that are very difficult to be machined by the main stream machining processes. This practical technology of the WEDM process is based on the conventional EDM sparking phenomenon utilizing the widely accepted noncontact technique of material removal. Since the introduction of the process, WEDM has evolved from a simple means of making tools and dies to the best alternative of producing microscale parts with the highest degree of dimensional accuracy and surface finish quality. Some of the common applications of WEDM are including the fabrication of the stamping and extrusion tools and dies, fixtures and gauges, prototypes, aircraft and medical parts, and grinding wheel form tools [2]. The material removal mechanism of WEDM is very similar to the conventional EDM process
Recurrent Giant Cell Tumor of the Distal End Radius: A Case Report and Surgical Treatment with Wide Resection and Reconstruction with Non-Vascularised Autologous Proximal Fibular Graft  [PDF]
Venkatesh Gupta, Vijaya Kumar
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.411045
Abstract: Giant cell tumour of the distal radius is the 3rd most common site after proximal tibia and distal femur. It is locally aggressive and is associated with a high rate of recurrence. Although it is usually treated with various modalities of treatment, wide resection and reconstruction with proximal fibular autograft is most commonly accepted in recurrent cases. The following is a case report of such a case with surgical management.
Color Image Enhancement Techniques: A Critical Review
Anish Kumar Vishwakarma,Agya Mishra
Indian Journal of Computer Science and Engineering , 2012,
Abstract: Image enhancement is one of the key issues in high quality pictures such as digital camera and HDTV. Since Image clarity is very easily affected by lighting, weather, or equipment that has been used to capture the image. These conditions lead to image may suffer from loss of information. As a result, many techniques have developed known as image Enhancement techniques to recover the information in an image. This paper presents a literature review on some of the image Enhancement techniques for color image enhancement like, Contrast Stretching, Histogram Equalization and its improvement versions, Homomorphic Filtering, Retinex, and Wavelet Multiscale Transform. Comparison of all the techniques concludes the better approach for its future research.
Assessment of the Impact of Risk Aggregation on S/w Development Cost Using Soft Computing Techniques
Shweta,Sanjay Kumar,Anish Mittal
International Journal of Computer Science and Management Studies , 2012,
Abstract: Risk is one of the major factors to decide the software cost,reliability and the software dead lines. As the software proposal is presented along with this risk analysis also begin. With each step of software development some risk factor is added with software cost. Other then this some other factors like availability of resources, software duration also effect the software risk. In this proposed work we will evaluate the software aggregative risk based onsome of these factors. The proposed work is about to evaluate the software risk aggregation based on some weight-age. The work will be carried out using soft computing techniques. Here the risk is divided in different categorize based on the risk impact and then an risk aggregation based computation is implemented to find actual risk in the software system.
Vibration of Visco-Elastic Parallelogram Plate with Parabolic Thickness Variation  [PDF]
Arun Kumar Gupta, Anuj Kumar, Yogesh Kumar Gupta
Applied Mathematics (AM) , 2010, DOI: 10.4236/am.2010.12017
Abstract: The main objective of the present investigation is to study the vibration of visco-elastic parallelogram plate whose thickness varies parabolically. It is assumed that the plate is clamped on all the four edges and that the thickness varies parabolically in one direction i.e. along length of the plate. Rayleigh-Ritz technique has been used to determine the frequency equation. A two terms deflection function has been used as a solution. For visco-elastic, the basic elastic and viscous elements are combined. We have taken Kelvin model for visco-elasticity that is the combination of the elastic and viscous elements in parallel. Here the elastic element means the spring and the viscous element means the dashpot. The assumption of small deflection and linear visco-elastic properties of “Kelvin” type are taken. We have calculated time period and deflection at various points for different values of skew angles, aspect ratio and taper constant, for the first two modes of vibration. Results are supported by tables. Alloy “Duralumin” is considered for all the material constants used in numerical calculations
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