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Search Results: 1 - 10 of 178070 matches for " Angie E Garcia "
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Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
Benoit Melchior,Angie E Garcia,Bor?Kai Hsiung,Katherine M Lo
ASN Neuro , 2010, DOI: 10.1042/an20100010
Abstract: Vaccine-based autoimmune (anti-amyloid) treatments are currently being examined for their therapeutic potential in Alzheimer's disease. In the present study we examined, in a transgenic model of amyloid pathology, the expression of two molecules previously implicated in decreasing the severity of autoimmune responses: TREM2 (triggering receptor expressed on myeloid cells 2) and the intracellular tolerance-associated transcript, Tmem176b (transmembrane domain protein 176b). In situ hybridization analysis revealed that both molecules were highly expressed in plaque-associated microglia, but their expression defined two different zones of plaque-associated activation. Tmem176b expression was highest in the inner zone of amyloid plaques, whereas TREM2 expression was highest in the outer zone. Induced expression of TREM2 occurred co-incident with detection of thioflavine-S-positive amyloid deposits. Transfection studies revealed that expression of TREM2 correlated negatively with motility, but correlated positively with the ability of microglia to stimulate CD4+ T-cell proliferation, TNF (tumour necrosis factor) and CCL2 (chemokine ligand 2) production, but not IFNγ (interferon γ) production. TREM2 expression also showed a positive correlation with amyloid phagocytosis in unactivated cells. However, activating cells with LPS (lipopolysaccharide), but not IFNγ, reduced the correlation between TREM2 expression and phagocytosis. Transfection of Tmem176b into both microglial and macrophage cell lines increased apoptosis. Taken together, these data suggest that, in vivo, Tmem176b+ cells in closest apposition to amyloid may be the least able to clear amyloid. Conversely, the phagocytic TREM2+ microglia on the plaque outer zones are positioned to capture and present self-antigens to CNS (central nervous system)-infiltrating lymphocytes without promoting pro-inflammatory lymphocyte responses. Instead, plaque-associated TREM2+ microglia have the potential to evoke neuroprotective immune responses that may serve to support CNS function during pro-inflammatory anti-amyloid immune therapies.
Long-acting nifedipine in the management of the hypertensive patient
Morgan E Snider,Donald S Nuzum,Angie Veverka
Vascular Health and Risk Management , 2008,
Abstract: Morgan E Snider1, Donald S Nuzum2, Angie Veverka21Virginia Commonwealth University Health Systems Richmond, VA USA; 2Wingate University School of Pharmacy Wingate, NC USAAbstract: Hypertension is a global condition affecting billions worldwide. It is a significant contributor to cardiovascular events, cardiac death and kidney disease. A number of medication classes exist to aid healthcare providers and their patients in controlling hypertension. Nifedipine, a dihydropyridine calcium channel blocker, was once one of the most widely used medications for hypertension, but safety and tolerability concerns along with the introduction of new classes of antihypertensive medications and an increasing pool of data showing mortality benefit of other classes caused nifedipine to fall out of favor. More recently, long-acting formulations were developed and made available to clinicians. These newer formulations were designed to address many of the concerns raised by earlier formulations of nifedipine. Numerous clinical trials have been conducted comparing long-acting nifedipine to many of the more commonly prescribed antihypertensive medications. This review will address the pharmacology, pharmacokinetics and the available clinical trial data on long-acting nifedipine and summarize its role in the management of hypertension.Keywords: nifedipine, calcium channel blockers, hypertension
O SOFREDOR COMO EXEMPLO NO FOTOJORNALISMO: notas sobre os limites de uma identidade
Angie Biondi
Brazilian Journalism Research , 2011,
Abstract: O sofrimento é trazido por fotografias de imprensa desde o período moderno. Galerias de sofredores exibem as marcas de seus infortúnios como registro legítimo das guerras, atentados, doen as. Ancoradas em um caráter indicial acentuado, estas imagens também constituem e intensificam um campo complexo de visibilidade no qual atuam disputas e pactos de acessos e lugares. O propósito deste texto é discutir os modos de tornar o sofrimento uma classifica o quando associa o sofredor à condi o de um pertencimento. Assim, atados a uma identidade, corpo e express o serviriam apenas à conforma o de um ethos, como um modelo exemplar de personagem. Para além da descri o destas estratégias, buscamos refletir a experiência afetiva com este universo de imagens sob a perspectiva de um encontro possível com o singular, o sujeito qualquer, trazido pela imagem.
THE SUFFERER AS MODEL IN PHOTOJOURNALISM: notes on the limit of identity
Angie Biondi
Brazilian Journalism Research , 2011,
Abstract: Suffering has been caused by press photographs ever since the start of Modern times. Sufferers in galleries exhibit the marks of their misfortunes as a legitimate record of wars, attempts, diseases. Anchored on an acute indicial character, such images also constitute and intensify a complex field of visibility in which disputes and access or placement pacts come into action. The purpose of this text is to discuss the means for turning suffering into a classificationin which it associates the sufferer with a condition of belonging. Thus, tied to an identity, body and expression would serve solelythe conformation of an ethos, as an exemplary model of personage. In order to describe these strategies, we seek to reflect on affective experiences in this universe of images from the perspective of apossible encounter with what is singular, with any one subject, which is brought about by image.
Diante da Dor, Dentro da Cena: outros pactos do olhar no fotojornalismo contemporaneo
Contemporanea : Revista de Comunica??o e Cultura , 2010,
Abstract: This paper purpose to reflect about how some exemples from the photojournalism today treat the suffering situations to construct a reading using aspects from melodrama. Sharing the conception “melodramatic imagination” from Peter Brooks (1995) that it understands its concepts stops beyond the delimitation of a sort or of the simple setting of a systematic model of narrative, but as a “way to see and to try the world”, this text indicates aspects of the relation between photojournalism and melodrama, in wich the figures of the personages and its emphasis in their private histories in such a way assume how much special and especific treatment in these vehicles. This approach, however, beyond requesting an affective engagement of the look considers, to the spectator, a moral landmark in the way as it tries these images.
Antimicrobial Susceptibility Testing of Mycobacterium bovis Isolates from Michigan White-Tailed Deer during the 2009 Hunting Season
Scott D. Fitzgerald,Angie M. Schooley,Dale E. Berry,John B. Kaneene
Veterinary Medicine International , 2011, DOI: 10.4061/2011/903683
Abstract: Michigan has had an ongoing outbreak of endemic Mycobacterium bovis which has been recognized within and sustained by its free-ranging white-tailed deer population since 1994. Worldwide, organisms within the Mycobacterium tuberculosis complex have exhibited the ability to develop resistance to antimicrobial agents, resulting in both the multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of human tuberculosis. Michigan's Bovine Tuberculosis Working Group has conducted active antimicrobial susceptibility testing on wildlife isolates of the endemic M. bovis organism at five-year intervals to detect any emerging drug resistance patterns. The results of 33 white-tailed deer origin isolates collected from the 2009 hunting season are reported here. There continues to be no evidence of any drug resistance except for pyrazinamide resistance. These results are likely due to the lack of antibacterial treatment applied to either wildlife or domestic animals which would provide selection pressure for the development of drug resistance. 1. Introduction The state of Michigan has had an ongoing free-ranging white-tailed deer tuberculosis surveillance and control program since 1994 [1, 2]. It appears that deer serve as the primary reservoir host in the state of Michigan, with elk and a variety of wild carnivores and omnivores serving as spill-over hosts, and to date there have been 50 cattle herds infected by M. bovis [3], While some progress has been made on controlling the spread of M. bovis outside of the endemic 12 county area and the overall incidence rate of infection in deer has dropped from around 4.9% to approximately 1.7%, there remain ongoing programs for surveillance, and the ultimate goal is to eradicate the disease from both domestic cattle and wild deer [4]. Since M. bovis is also infectious to humans, a multiagency task force consisting of personnel from state departments (Michigan Department of Natural Resources and Environment, Michigan Department of Agriculture, and Michigan Department of Community Health), from a public university (Michigan State University), and from a federal agency (United States Department of Agriculture) have formed a bovine tuberculosis task force to deal with issues concerning wildlife, domestic animals, and human health [1, 2]. Bovine tuberculosis threatens human health through direct acquisition of the disease from field dressing infected deer, from airborne transmission of the disease from infected cattle or captive deer, and from ingestion of unpasteurized milk or undercooked meat products including
Obesity prevention in child care: A review of U.S. state regulations
Sara E Benjamin, Angie Cradock, Elizabeth M Walker, Meghan Slining, Matthew W Gillman
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-188
Abstract: We conducted a review of regulations for child care facilities for all 50 states and the District of Columbia. We examined state regulations and recorded key nutrition and physical activity items that may contribute to childhood obesity. Items included in this review were: 1) Water is freely available; 2) Sugar-sweetened beverages are limited; 3) Foods of low nutritional value are limited; 4) Children are not forced to eat; 5) Food is not used as a reward; 6) Support is provided for breastfeeding and provision of breast milk; 7) Screen time is limited; and 8) Physical activity is required daily.Considerable variation exists among state nutrition and physical activity regulations related to obesity. Tennessee had six of the eight regulations for child care centers, and Delaware, Georgia, Indiana, and Nevada had five of the eight regulations. Conversely, the District of Columbia, Idaho, Nebraska and Washington had none of the eight regulations. For family child care homes, Georgia and Nevada had five of the eight regulations; Arizona, Mississippi, North Carolina, Oregon, Tennessee, Texas, Vermont, and West Virginia had four of the eight regulations. California, the District of Columbia, Idaho, Iowa, Kansas, and Nebraska did not have any of the regulations related to obesity for family child care homes.Many states lack specific nutrition and physical activity regulations related to childhood obesity for child care facilities. If widely implemented, enhancing state regulations could help address the obesity epidemic in young children in the United States.Rates of obesity in children continue to rise in the United States and abroad [1-4]. Even among preschool-aged children the prevalence of obesity is alarmingly high, with 26.2% of children aged 2 through 5 years in the United States classified as either overweight or obese [2]. Even in childhood, obesity is associated with a variety of adverse health consequences that can include Type II diabetes mellitus [5,6], hyperte
Relación entre el género y las experiencias de cortejo y actitudes hacia las relaciones románticas en adolescentes bogotanos
Claudia Caycedo E.,Ingri Cubides,Angie Martín,Omar Fernando Cortés
Psicología desde el Caribe , 2007,
Abstract: El propósito de este estudio fue encontrar las relaciones que existen entre el género, las experiencias de cortejo románticas y las actitudes hacia el amor, en un grupo de 223 adolescentes con edades entre 15 y 18 a os, de dos colegios mixtos de la ciudad de Bogotá. Este estudio forma parte de un trabajo más amplio acerca de las relaciones románticas en adolescentes bogotanos. Los datos fueron analizados por medio de ANOVA de una vía y análisis correlacional. No se encontraron diferencias significativas en ninguna de las escalas aplicadas, lo cual no es consistente con estudios similares. Se observaron tendencias no significativas en relación con el involucramiento en las relaciones, las salidas con la pareja en grupo y creencias asociadas al amor a primera vista y a la perfección del amor. Los resultados encontrados pueden ser explicados por variables culturales asociadas a los roles de género y las contingencias y metacontingencias propias del grupo social en relación con las relaciones románticas. Los resultados permiten ampliar la comprensión acerca de las relaciones afectivas y plantean interrogantes acerca de los procesos de socialización en este campo que pueden servir como base para futuras investigaciones.
Assessment of Genetic Associations between Common Single Nucleotide Polymorphisms in RIG-I-Like Receptor and IL-4 Signaling Genes and Severe Respiratory Syncytial Virus Infection in Children: A Candidate Gene Case-Control Study
Nico Marr, Aaron F. Hirschfeld, Angie Lam, Shirley Wang, Pascal M. Lavoie, Stuart E. Turvey
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100269
Abstract: The majority of cases of severe pediatric respiratory syncytial virus (RSV) infection occur in otherwise healthy infants who have no identifiable risk factors, suggesting that additional subclinical factors, such as population genetic variation, influence the course of RSV infection. The objective of this study was to test if common single nucleotide polymorphisms (SNPs) in genes encoding for immune signalling components of the RIG-I-like receptor (RLR) and IL-4-signalling pathways affect the outcome of RSV infection in early life. We genotyped 8 SNPs using allele-specific probes combined with real-time PCR. Each of the SNPs tested had previously been established to have a functional impact on immune responsiveness and two of the SNPs in the IL4 and IL4R genes had previously been associated with severe RSV bronchiolitis. Association with susceptibility to severe RSV infection was tested by statistically comparing genotype and allele frequencies in infants and young children hospitalized with severe RSV bronchiolitis (n = 140) with two control groups—children who tested positive for RSV but did not require hospitalization (n = 100), and a general population control group (n = 285). Our study was designed with sufficient power (>80%) to detect clinically-relevant associations with effect sizes ≥1.5. However, we detected no statistically significant differences in allele and genotype frequencies of the investigated SNPs between the inpatient and control groups. To conclude, we could not replicate the previously reported association with SNPs in the IL4 and IL4R genes in our independent cohort, nor did we find that common SNPs in genes encoding for RLRs and the downstream adapter MAVS were associated with susceptibility to severe RSV infections. Despite the existing evidence demonstrating a functional immunological impact of these SNPs, our data suggest that the biological effect of each individual SNP is unlikely to affect clinical outcomes of RSV infection.
Mixed Species Flock, Nest Height, and Elevation Partially Explain Avian Haemoparasite Prevalence in Colombia
Angie D. González, Nubia E. Matta, Vincenzo A. Ellis, Eliot T. Miller, Robert E. Ricklefs, H. Rafael Gutiérrez
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100695
Abstract: The high avian biodiversity present in the Neotropical region offers a great opportunity to explore the ecology of host-parasite relationships. We present a survey of avian haemoparasites in a megadiverse country and explore how parasite prevalences are related to physical and ecological host characteristics. Using light microscopy, we documented the presence of haemoparasites in over 2000 individuals belonging to 246 species of wild birds, from nine localities and several ecosystems of Colombia. We analysed the prevalence of six avian haemoparasite taxa in relation to elevation and the following host traits: nest height, nest type, foraging strata, primary diet, sociality, migratory behaviour, and participation in mixed species flocks. Our analyses indicate significant associations between both mixed species flocks and nest height and Haemoproteus and Leucocytozoon prevalence. The prevalence of Leucocytozoon increased with elevation, whereas the prevalence of Trypanosoma and microfilariae decreased. Plasmodium and Haemoproteus prevalence did not vary significantly with elevation; in fact, both parasites were found up to 3300m above sea level. The distribution of parasite prevalence across the phylogeny of bird species included in this study showed little host phylogenetic signal indicating that infection rates in this system are evolutionarily labile. Vector distribution as well as the biology of transmission and the maintenance of populations of avian haemoparasites deserve more detailed study in this system.
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