Abstract:
Introduction: According to the most recent AUA/SUFU guidelines, intradetrusor
onabotulinumtoxinA (BTN/A) is a standard, evidence strength grade B, third line
treatment option for refractory non-neurogenic overactive bladder (OAB).
Urinary retention is the most common clinically significant reported side effect ranging from 5.4% to 43% in previous
studies. The aim of this study was to
investigate the real-time rate of urinary retention in patients treated with BTN/A for refractory
non-neurogenic OAB in a multi-institutional study.Methods: Retrospective chart review identified 71 patients who were treated with 100U
BTN/A for refractory non-neurogenic OAB from August 2011 to July 2015 at two
institutions. Using a flexible cystoscope, 100U Botox® reconstituted with 10 ml normal saline was administered. Injections of 1ml (10units/mL)
were administered in 10 evenly distributed sites sparing the trigone. Pre and
post BTN/A post-void residuals (PVR) were reviewed. Urinary retention was defined as PVR >200mL requiring clean intermittent catheterization (CIC). Results: After exclusion, the study group consisted of 66
patients with a mean age

Abstract:
Objectives. To evaluate whether there are any demographic or urodynamic differences in patients with idiopathic overactive bladder (I-OAB) that respond and do not respond to intradetrusor injections of botulinum toxin-A (BTX-A). Methods. This represents a secondary analysis of data collected from an investigator initiated randomized trial designed to evaluate clinical differences in outcomes for 100 versus 150 U BTX-A in patients with I-OAB. Preinjection demographic and urodynamic data were collected. Patients were evaluated 12 weeks after injection and were determined to be responders or nonresponders as defined by our criteria. Statistical comparisons were made between groups. Results. In patients with overactive bladder without incontinence (OAB-Dry), there were no variables that could be used to predict response to BTX-A. On univariate analysis, younger patients with overactive bladder with incontinence (OAB-Wet) were more likely to respond to BTX-A than older patients. However, this relationship was no longer statistically significant on multivariate analysis. Conclusions. We were unable to identify any preinjection demographic or urodynamic parameters that could aid in predicting which patients will achieve clinical response to BTX-A. Future studies are necessary to further evaluate this question.

Abstract:
The teratogenicity of thalidomide has been known since the early 1960s [1]. Thalidomide is currently used world wide, including the United States, to treat erythema nodosum leprosum, multiple myeloma, refractory Crohn’s disease, aphthous stomatitis and HIV wasting syndrome. New cases of thalidomide phocomelia are being reported as well. We report a case of the anesthetic challenges of a 23 year-old parturient with thalidomide phocomelia and review the important anesthetic challenges it presents. Spontaneous vaginal delivery under continuous lumbar epidural was achieved in this challenging patient. However, it required careful planning for reliable intravenous access and the use of magnetic resonance imaging (MRI) of her pelvis and lumbar spine.

Abstract:
This article shows the asymptotics of distributions of various functionals of the Beta$(2-\alpha,\alpha)$ $n$-coalescent process with $1<\alpha<2$ when $n$ goes to infinity. This process is a Markov process taking {values} in the set of partitions of $\{1, \dots, n\}$, evolving from the intial value $\{1\},\cdots, \{n\}$ by merging (coalescing) blocks together into one and finally reaching the absorbing state $\{1, \dots, n\}$. The minimal clade of $1$ is the block which contains $1$ at the time of coalescence of the singleton $\{1\}$. The limit size of the minimal clade of $1$ is provided. To this, we express it as a function of the coalescence time of $\{1\}$ and sizes of blocks at that time. Another quantity concerning the size of the largest block (at deterministic small time and at the coalescence time of $\{1\}$) is also studied.

Abstract:
This article shows the asymptotics of distribution and moments of the size $X_n$ of the minimal clade of a randomly chosen individual in a Bolthausen-Sznitman $n$-coalescent for $n\to\infty$. The Bolthausen-Sznitman $n$-coalescent is a Markov process taking states in the set of partitions of $\left\{1,\ldots,n\right\}$, where $1,\ldots,n$ are referred to as individuals. The minimal clade of an individual is the equivalence class the individual is in at the time of the first coalescence event this individual participates in.\\ The main tool used is the connection of the Bolthausen-Sznitman $n$-coalescent with random recursive trees introduced by Goldschmidt and Martin (see \cite{goldschmidtmartin}). This connection shows that $X_n-1$ is distributed as the number $M_n$ of all individuals not in the equivalence class of individual 1 shortly before the time of the last coalescence event. Both functionals are distributed like the size $RT_{n-1}$ of an uniformly chosen table in a standard Chinese restaurant process with $n-1$ customers.We give exact formulae for these distributions.\\ Using the asymptotics of $M_n$ shown by Goldschmidt and Martin in \cite{goldschmidtmartin}, we see $(\log n)^{-1}\log X_n$ converges in distribution to the uniform distribution on [0,1] for $n\to\infty$.\\ We provide the complimentary information that $\frac{\log n}{n^k}E(X_n^k)\to \frac{1}{k}$ for $n\to\infty$, which is also true for $M_n$ and $RT_n$.

Abstract:
multistage simulation is employed to help predicting the future actions of collaborating or competing agents, interacting in the mini-world covered by a temporal database. at each stage, their goals are inferred from the current situation, with the help of rules designed to model their behavioural patterns, in turn extracted from records of their past actions. besides goal-inference rules, the simulation machinery adapts and combines plan-recognition and generation algorithms. the resulting environment is highly interactive, allowing the user to interfere in various ways. a prototype tool (ipg), implemented in prolog augmented with constraint programming features, was developed and is being used to run experiments.

Abstract:
We study the coherent dynamics of a quantum many-body system subject to a time-periodic driving. We argue that in many cases, destructive interference in time makes most of the quantum averages time-periodic, after an initial transient. We discuss in detail the case of a quantum Ising chain periodically driven across the critical point, finding that, as a result of quantum coherence, the system never reaches an infinite temperature state. Floquet resonance effects are moreover observed in the frequency dependence of the various observables, which display a sequence of well-defined peaks or dips. Extensions to non-integrable systems are discussed.

Abstract:
By means of a Floquet analysis, we study the quantum dynamics of a fully connected Lipkin-Ising ferromagnet in a periodically driven transverse field showing that thermalization in the steady state is intimately connected to properties of the $N\to \infty$ classical Hamiltonian dynamics. When the dynamics is ergodic, the Floquet spectrum obeys a Wigner-Dyson statistics and the system satisfies the eigenstate thermalization hypothesis (ETH): Independently of the initial state, local observables relax to the $T=\infty$ thermal value, and Floquet states are delocalized in the Hilbert space. On the contrary, if the classical dynamics is regular no thermalization occurs. We further discuss the relationship between ergodicity and dynamical phase transitions, and the relevance of our results to other fully-connected periodically driven models (like the Bose-Hubbard), and possibilities of experimental realization in the case of two coupled BEC.

Abstract:
The ultra-high energy cosmic rays observed at the Earth are most likely accelerated in extra-galactic sources. For the typical luminosities invoked for such sources, the electric current associated to the flux of cosmic rays that leave them is large. The associated plasma instabilities create magnetic fluctuations that can efficiently scatter particles. We argue that this phenomenon forces cosmic rays to be self-confined in the source proximity for energies $E

Abstract:
Most models of the origin of ultra high energy cosmic rays rely on the existence of luminous extragalactic sources. Cosmic rays escaping the galaxy where the source is located produce a sufficiently large electric current to justify the investigation of plasma instabilities induced by such current. Most interesting is the excitation of modes that lead to production of magnetic perturbations that may scatter particles thereby hindering their escape, or at least changing the propagation mode of escaping cosmic rays. We argue that self-generation of waves may force cosmic rays to be confined in the source proximity for energies $E\lesssim 10^{7} L_{44}^{2/3}$ GeV for low background magnetic fields ($B_{0}\ll nG$). For larger values of $B_{0}$, cosmic rays are confined close to their sources for energies $E\lesssim 2\times 10^{8} \lambda_{10} L_{44}^{1/4} B_{-10}^{1/2}$ GeV, where $B_{-10}$ is the field in units of $0.1$ nG, $\lambda_{10}$ is its coherence length in units of 10 Mpc and $L_{44}$ is the source luminosity in units of $10^{44}$ erg/s.