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Search Results: 1 - 10 of 5126 matches for " Angela Vasaturo "
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A Novel Chemotaxis Assay in 3-D Collagen Gels by Time-Lapse Microscopy
Angela Vasaturo, Sergio Caserta, Ilaria Russo, Valentina Preziosi, Carolina Ciacci, Stefano Guido
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052251
Abstract: The directional cell response to chemical gradients, referred to as chemotaxis, plays an important role in physiological and pathological processes including development, immune response and tumor cell invasion. Despite such implications, chemotaxis remains a challenging process to study under physiologically-relevant conditions in-vitro, mainly due to difficulties in generating a well characterized and sustained gradient in substrata mimicking the in-vivo environment while allowing dynamic cell imaging. Here, we describe a novel chemotaxis assay in 3D collagen gels, based on a reusable direct-viewing chamber in which a chemoattractant gradient is generated by diffusion through a porous membrane. The diffusion process has been analysed by monitoring the concentration of FITC-labelled dextran through epifluorescence microscopy and by comparing experimental data with theoretical and numerical predictions based on Fick's law. Cell migration towards chemoattractant gradients has been followed by time-lapse microscopy and quantified by cell tracking based on image analysis techniques. The results are expressed in terms of chemotactic index (I) and average cell velocity. The assay has been tested by comparing the migration of human neutrophils in isotropic conditions and in the presence of an Interleukin-8 (IL-8) gradient. In the absence of IL-8 stimulation, 80% of the cells showed a velocity ranging from 0 to 1 μm/min. However, in the presence of an IL-8 gradient, 60% of the cells showed an increase in velocity reaching values between 2 and 7 μm/min. Furthermore, after IL-8 addition, I increased from 0 to 0.25 and 0.25 to 0.5, respectively, for the two donors examined. These data indicate a pronounced directional migration of neutrophils towards the IL-8 gradient in 3D collagen matrix. The chemotaxis assay described here can be adapted to other cell types and may serve as a physiologically relevant method to study the directed locomotion of cells in a 3D environment in response to different chemoattractants.
Le proposte di riforma normativa a sostegno delle vittime di reato
Giulio Vasaturo
Rivista di Criminologia, Vittimologia e Sicurezza , 2007,
Abstract: La frammentarietà e la lacunosità della normativa vigente in materia di sostegno alle vittime di reato rende obiettivamente approssimativo il sistema di tutela di quanti, nel nostro Paese, subiscono gli effetti - spesso devastanti sotto il profilo personale, economico, psicologico, familiare, relazionale – di un’azione criminosa. Con questa consapevolezza, già da diversi anni numerose componenti dell’associazionismo spontaneo ed alcune importanti realtà accademiche hanno avviato un vivace dibattito che ha finito col coinvolgere le varie forze parlamentari e vasti strati della società civile. Al di là delle divergenze di sensibilità e di opinioni, è unanimemente avvertita l’esigenza di pervenire, in maniera oramai improcrastinabile, all’adozione di una piattaforma normativa omogenea, con lo scopo di fornire alla vittima (diretta ed indiretta) di una fattispecie delittuosa gli strumenti più efficaci per vedersi riconosciuto il diritto al risarcimento del danno materiale, biologico e morale che è stato patito; il diritto all’assistenza istituzionale; il diritto all’inclusione sociale; il diritto all’accesso a forme di mediazione in grado di condurre realmente all’attuazione di un modello diffuso di restorative justice. Il presupposto di un simile progetto di riforma, tanto ambizioso quanto necessario, va senz’altro rinvenuto nella modifica/integrazione dell’art. 111 della Costituzione che, nel delineare i princìpi del c.d. giusto processo, inspiegabilmente omette ogni riferimento al soggetto passivo del reato. Agli atti del Parlamento sono depositate diverse proposte con cui si intende definire la cornice di quella legge quadro per l’assistenza, il sostegno, la tutela delle vittime di reati sulla base della quale dovrà elevarsi, conformemente a quanto disposto dalla decisione europea 2001/220/GAI del 15.3.2001, il nostro ordinamento di tutela delle persone lese da azioni criminose. All’esame critico delle varie ipotesi di riforma legislativa è dedicato questo primo contributo dell’Osservatorio normativo e giurisprudenziale sulla vittima.
Recensione / Recension / Book Review
Vasaturo Giulio
Rivista di Criminologia, Vittimologia e Sicurezza , 2011,
Abstract: Book review of: Bravo F., Criminalità economica e controllo sociale. Impresa etica e responsabilità ex d.lgs. 231/01, Clueb, Bologna, 2010
Verità è giustizia per le vittime del terrorismo italiano. Un’ipotesi di mediazione sociale
Giulio Vasaturo
Rivista di Criminologia, Vittimologia e Sicurezza , 2007,
Abstract: At a time in which new forms of extremism and old conspiracies emerge, which threaten and exasperate social, historical, and political life, one strongly feels the necessity of embarking on a communal mission to awaken public opinion, the scientific community, and institutions, to issues concerning the victims of Italian terrorist crimes of the ’70s and ’80s. This would help to raise those issues within a process of social mediation that does not, nor can legitimate such horrendous crimes. The aim is not to put the men who encouraged armed agression and those who suffered from it on the same level, nor to impose a canonical “repentance”, or any easy inclination towards indulgence. Actually, the need is for some form of dialogue to become a tool of preference through which the desire of justice and truth frustrated so far, could be met. Such desire unites the victims of terrorism, and weighs heavily on the past, present and future of our country. By listening to the pleas from the victims’ families, the author of this paper proposes that a Commission for truth on the history of Italian terrorism be set up. Such commission, referring to past successful experiences in different international contexts, and particularly post-apartheid South Africa, could yield for the first time concrete methods to help us reconstruct the scenes and the responsibilities hidden behind the long trail of blood, which has stained our recent history. At a time when many jail sentences for “diehard” convicts for acts of terrorism committed between 1969 and 1988 are coming to an end, this seems to be our only realistic chance of giving a long awaited answer – in the silence and bitterness of everyday life – to the living and the dead, to all the innocent victims of “armed agression”, and finally to the civic consciousness of our country. à cette époque où de nouveaux extrémismes et de vieilles trames reviennent à polluer et à exaspérer la vie sociale, historique et politique, on per oit de plus en plus la nécessité de se diriger vers un itinéraire partagé de sensibilisation et de mobilisation de l'opinion publique, de la communauté scientifique, des Institutions, pour que les instances qui viennent de la part des victimes du terrorisme italien des années 70 et 80 trouvent écoute et réponse. Cela aiderait à commencer un processus de médiation sociale qui ne devrait ni donner légitimité à ces crimes affreux ni égaliser ceux qui ont voulu la lutte armée et ceux qui l'ont subie. Tout en écoutant les sollicitations provenant des parents des victimes des "années de plomb", l'auteur de cet
Women entrepreneurship in Romania
Angela ON
Revista Romana de Economie , 2011,
Abstract: Considering entrepreneurship the domain with the greatest potential for creativity and innovation, any investigation on this field is recommended, in order to reveal new aspects that can influence the small enterprises development. From this point of view, female entrepreneurship represents an important source of innovation, only partially exploited or even forgotten.
Impact of Simulated Airborne Soot on Maize Growth and Development  [PDF]
Angela Anda, Berndett Illes
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.38092
Abstract: Various effects of the dry deposition of soot on maize were investigated in Keszthely (Hungary) in two consecutive years. In order to be able to study a wider range of weather conditions, some of the plants were placed in a Thornthwaite-Matter type evapotranspirometer and given ad libitum water supplies. Pollution with airborne black carbon was simulated throughout the season by distributing rates of 3 g?m–2 a week using a motorised dust sprayer. Among the plant growth parameters, the leaf area index was increased by 3% - 14%, depending on the year, suggesting that the plants were able to absorb the carbon settling on the leaves. The black carbon reduced the albedo of the canopy by 17.5% - 21.8%, depending on the year, forcing the polluted maize to absorb more energy. Part of this surplus energy was utilised for increased evapotranspiration (3.9% and 11% in the two years) and to raise the surface temperature of the canopy by 1℃ - 2℃ during the mid-day hours. The effect of the contamination on maize was more intense in the hot, dry year. The unfavourable effect of soot on maize fertilisation could be observed as a significant increase in the number of deformed ears, leading to a reduction in grain dry matter. The reduction in dry matter yield for polluted maize grown with irrigation in the evapotranspirometer was far less severe than that on non-irrigated plots, suggesting that irrigation was the most obvious solution for mitigating the negative effects of contamination with airborne soot.
Current Attitudes of Anesthesiologists towards Medically Futile Care  [PDF]
Angela Saettele,Joseph Kras
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34048
Abstract: Purpose: To explore anesthesiologists’ perceptions of the reasons underlying why physicians continue to provide care that they consider futile. Methods: A qualitative study was conducted utilizing a grounded theory approach. Four separate focus groups (2 resident physician groups and 2 attending physician groups) were conducted over a three week span. An interview guide was used consisting of a proposed definition of futility and five open-ended questions. Responses to the five open-ended questions were used to guide follow up questions. Transcribed audio recordings were then analyzed. Results: With data reduction, we were able to separate responses into definitions of futility, stories of cases where futile care was provided, and opinions as to the underlying causes of continuing to provide futile care. A variety of opinions was obtained, suggesting the possibility that different groups (surgeons, anesthesiologists, family members) view questions of futility differently. Conclusions: Complete agreement on a definition of futility does not exist. Even when some agreement exists, there is great difficulty in predicting outcomes in individual cases. Future quantitative studies may provide more evidence of trends in underlying reasons for providing futile care. Focused education efforts may then lead to more agreement between all involved.
Current Attitudes of Anesthesiologists towards Medically Futile Care  [PDF]
Angela Saettele, Joseph Kras
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34048
Abstract:

Purpose: To explore anesthesiologists’ perceptions of the reasons underlying why physicians continue to provide care that they consider futile. Methods: A qualitative study was conducted utilizing a grounded theory approach. Four separate focus groups (2 resident physician groups and 2 attending physician groups) were conducted over a three week span. An interview guide was used consisting of a proposed definition of futility and five open-ended questions. Responses to the five open-ended questions were used to guide follow up questions. Transcribed audio recordings were then analyzed. Results: With data reduction, we were able to separate responses into definitions of futility, stories of cases where futile care was provided, and opinions as to the underlying causes of continuing to provide futile care. A variety of opinions was obtained, suggesting the possibility that different groups (surgeons, anesthesiologists, family members) view questions of futility differently. Conclusions: Complete agreement on a definition of futility does not exist. Even when some agreement exists, there is great difficulty in predicting outcomes in individual cases. Future quantitative studies may provide more evidence of trends in underlying reasons for providing futile care. Focused education efforts may then lead to more agreement between all

Keeping the White Family Together: Racial Disparities in the Out-of-Home Placements of Maltreated Children  [PDF]
Angela M. Kaufman
Advances in Applied Sociology (AASoci) , 2013, DOI: 10.4236/aasoci.2013.38041
Abstract: The likelihood of being removed from the home following a case of maltreatment is much higher for black youth than for whites. Two explanations exist in the literature. The first, black children experience more serious forms of maltreatment and have fewer resources to remedy the maltreatment situation than do whites. The second, there is an underlying racial bias within the child welfare system. The present study examines 789 dependency cases from child welfare services in a large urban county in the Northwest United States. Using multiple logistic regression models, it examines whether race has an effect on child placement within the child welfare system, and whether the factors influencing placement are the same for white and black youth. Findings illustrate a racial disparity in out-of-home placements supporting both of the competing explanations in the current literature. Overall, the present study finds that two separate processes seem to be at play in the placement decisions of maltreated youth, and concludes with possible explanations for this differential treatment.
Analysing a Pricing Policy for a Home Centre: A Case Study  [PDF]
Dora Maglione, Angela Diblasi
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.31002
Abstract:

One critical aspect of retailer category management is pricing the items in order to maximize total profits. To define an appropriate pricing policy, a retailer should evaluate how changes in prices of a set of items may impact their shelves or inter demands. In this setting, elasticities play a major role. In addition, a proper policy can be defined from different points of view. In this paper, estimation of a profit function and its maximization under different scenarios is used as a tool to analyze such policy. Estimation of this function is performed through a previous selection of items within a home center category. Then, an adequate AIDS model allowing calculation of elasticities is fitted. Moreover, a profit function is defined in terms of prices and demands. This functionis linearized for the following two purposes, to express it in terms of elasticities, and to maximize it more easily under the consideration of different sets of item prices defined in a convex set. Then, confidence intervals for the total and marginal profits were built to gather the randomness of demands. The results are applied to the selected items in a home center that behaves as a monopoly in the area.

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