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Search Results: 1 - 10 of 6051 matches for " Angel Aneiros-Guerrero "
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Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder
Angel Aneiros-Guerrero, Ana M Lendinez, Arturo R Palomares, Beatriz Perez-Nevot, Lidia Aguado, Alvaro Mayor-Olea, Maximiliano Ruiz-Galdon, Armando Reyes-Engel
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-75
Abstract: A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. A total of 229 individuals (69% women) were included at the study; 86 were patients with TMD and 143 were healthy control subjects. Subjects underwent to a clinical examination following the guidelines by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Genotyping of 20 Single Nucleotide Polymorphisms (SNPs), divided in two groups, was performed by multiplex minisequencing preceded by multiplex PCR. Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. A chi-square test was performed to determine the differences in genotype and allelic frequencies between TMD patients and healthy subjects. To estimate TMD risk, in those polymorphisms that shown significant differences, odds ratio (OR) with a 95% of confidence interval were calculated.Six of the polymorphisms showed statistical associations with TMD. Four of them are related to enzymes of folates metabolism: Allele G of Serine Hydoxymethyltransferase 1 (SHMT1) rs1979277 (OR = 3.99; 95%CI 1.72, 9.25; p = 0.002), allele G of SHMT1 rs638416 (OR = 2.80; 95%CI 1.51, 5.21; p = 0.013), allele T of Methylentetrahydrofolate Dehydrogenase (MTHFD) rs2236225 (OR = 3.09; 95%CI 1.27, 7.50; p = 0.016) and allele A of Methionine Synthase Reductase (MTRR) rs1801394 (OR = 2.35; 95CI 1.10, 5.00; p = 0.037). An inflammatory oxidative stress enzyme, Gluthatione S-Tranferase Mu-1(GSTM1), null allele (OR = 2.21; 95%CI 1.24, 4.36; p = 0.030) and a neurotransmission receptor, Dopamine Receptor D4 (DRD4), long allele of 48 bp-repeat (OR = 3.62; 95%CI 0.76, 17.26; p = 0.161).Some genetic polymorphisms related to folates metabolism, inflammatory oxidative stress, and neurotransmission responses to pain, has been significantly associated to TMD syndromeTemporomandibular joint disorder (TMD) is characterized by a set of symptoms
Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
Minero,Miguel Angel; Chinchilla,Misael; Marta Guerrero,Olga; Castro,Alfredo;
Revista de Biología Tropical , 2004,
Abstract: infection and multiplication of leishmania infantum and l. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. this process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. in addition multiplication rate differences in the cells from these rodent species were determined, for l. infantum as well as for l. mexicana. parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to leishmania infection. these results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. on the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals
Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
Miguel Angel Minero,Misael Chinchilla,Olga Marta Guerrero,Alfredo Castro
Revista de Biología Tropical , 2004,
Abstract: En este estudio se presenta un modelo in vitro de cultivo de fibroblastos de piel de hámster, ratón y rata hecho con el propósito de determinar diferencias en cuanto a la susceptibilidad a la infección por dos especies del género Leishmania (Kinetoplastida: Trypanosomatidae). Se realizó además un estudio ultraestructural por microscopía electrónica de transmisión con el fin de establecer si las formas intracelulares observadas correspondían a multiplicación interna o a fagocitosis múltiple. Se estudió la multiplicación de los parásitos en los fibroblastos de las tres especies de roedores infectados tanto por Leishmania infantum como por L. mexicana (cepa OCR) y las diferencias entre las tres fueron estadísticamente significativas (p< 0.05). Se observó la reproducción del parásito en las células de hámster y ratón no así en las de rata, razón por la cual a este último animal se le consideró refractario a la infección. Con base en lo anterior se sugiere que la afinidad de un protozoario por las células de un individuo así como la resistencia al ambiente intracelular pueden depender de la constitución genética de este. El análisis ultraestructural demostró la reproducción de los amastigotos dentro de vacuolas parasitóforas por lo que se descarta que la presencia de estos se deba a su transformación luego de la entrada al fibroblasto. Se sugiere entonces que dichas células podrían servir para la supervivencia del parásito y la permanencia de este parásito en los animales infectados Infection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals
Where are my followers? Understanding the Locality Effect in Twitter
Roberto Gonzalez,Ruben Cuevas,Angel Cuevas,Carmen Guerrero
Computer Science , 2011,
Abstract: Twitter is one of the most used applications in the current Internet with more than 200M accounts created so far. As other large-scale systems Twitter can obtain enefit by exploiting the Locality effect existing among its users. In this paper we perform the first comprehensive study of the Locality effect of Twitter. For this purpose we have collected the geographical location of around 1M Twitter users and 16M of their followers. Our results demonstrate that language and cultural characteristics determine the level of Locality expected for different countries. Those countries with a different language than English such as Brazil typically show a high intra-country Locality whereas those others where English is official or co-official language suffer from an external Locality effect. This is, their users have a larger number of followers in US than within their same country. This is produced by two reasons: first, US is the dominant country in Twitter counting with around half of the users, and second, these countries share a common language and cultural characteristics with US.
O lugar dos sujeitos e a quest?o da hipossuficiência na promo??o da saúde
Fernandez, Juan Carlos Aneiros;Westphal, Marcia Faria;
Interface - Comunica??o, Saúde, Educa??o , 2012, DOI: 10.1590/S1414-32832012005000037
Abstract: this article discusses the notion of subject hypo-sufficiency that is present in texts focusing on health promotion. it presents the results from a doctoral study in which five doctoral theses and four master's dissertations on health promotion were reviewed. the analytical framework was built around the notions of social dynamics, the rationales used and visions relating to the project of modernity present in the material researched. from this, the etiologies for producing the concept of subject hypo-sufficiency and therefore the place that this production reserves for it can be interpreted. significant occurrences of this notion of hypo-sufficiency were observed and it was seen to approach scientism.
Caracterización morfológica, física, química, mineralógica y génesis de un pedón sódico alcalino ubicado en Papelón, estado Portuguesa
Guerrero-Alves,Jose P; Pla-Sentis,Ildefonso; Valera,Angel;
Agronomía Tropical , 2009,
Abstract: salt-affected soils are a major factor limiting plant growth and productivity of crop plants. out of the 831 million hectares that the fao/unesco reports worldwide as salt affected soils more than 50 % (434 million hectares) are alkaline-sodic soils. this study was conduced in order to identify factors and processes in the genesis of an alkalinesodic soil from the alluvial plains of portuguesa river. morphological, physical, chemical and mineralogical attributes were determined. results indicated exchangeable sodium percentage (esp) up to 43 %, nahco3 accumulation, high phs (>8.5), very high bulk densities (up to 2.03 mg m-3), both low hydraulic conductivity (< 0.5 mm h-1) and macroporosity values (<3.4%) in btn and cn horizons, caco3 precipitation, mixed mineralogy characterized by clorite, interstratified 10/14m, quartz and micas. it was inferred that the soil was produced, first, from materials grounded by glacial ice action in venezuelan andes during the arid phase of pleistocene. later, during the holocene humid and warmer climate, sediments were transported and deposited in plains of portuguesa river and then interacted with nahco3 rich waters in micro-depressions. alkaline sodium salts could be formed by weathering of sodic silicates in rocks from venezuelan andes or from accumulation of organic matter in a reduction environment with elimination of sulfates as h2s. the soil evolved to promote clay migration, substitution of ca-mg by sodium in soil exchange complex, caco3 precipitation, natric horizon formation, elimination of salts in deep drainage, and finally, when total salt quantities diminished to critic levels the degradation of soil structure was produced
Cinética de crecimiento in vitro de dos cepas de Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) en células miocárdicas de roedores con diferente susceptibilidad
Angel B,Rafael-Oswaldo; Chinchilla C,Misael; Guerrero B,Olga Marta; Castro C,Alfredo;
Revista de Biología Tropical , 2007,
Abstract: in vitro growth kinetics of two trypanosoma cruzi (kinetoplastida: trypanosomatidae) clones in myocardial cells from rodents of different susceptibility. two trypanosoma cruzi isolates, tcr-4 from costa rica and ues-1 from el salvador, were studied in vitro to compare their infectivity or resistance and intracellular replication in myocardial cells in three strains of mice and rats: ngp white mice, c3 h mice and sprague dowley rats. myocardial cells were cultured on coverslips at 37 o c in a humid 10 % co2 atmosphere and then infected at a ratio of one tripomastigote per cell. samples were studied after 24, 72, 96 and 120 h of infection to determine parasite infection capacity and intracellular multiplication. both parasites had the highest infection capacity in c3 h mice, followed by ngp mice cells with a very low infection rate. lastly, almost no trypanosoma cruzi multiplication was observed in sprague dowley rats, suggesting a strong natural resistance in this animal to both strains of the parasite. the ues-1 isolate presented higher multiplication and greater invasion than the tcr-4 strain, showing greater virulence of ues-1 in heart cells, at least in vitro. rev. biol. trop. 55 (1): 121-126. epub 2007 march. 31.
Cinética de crecimiento in vitro de dos cepas de Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) en células miocárdicas de roedores con diferente susceptibilidad
Rafael-Oswaldo Angel B,Misael Chinchilla C,Olga Marta Guerrero B,Alfredo Castro C
Revista de Biología Tropical , 2007,
Abstract: Dos cepas de Trypanosoma cruzi, una originaria de Costa Rica (TCR-4) y otra de El Salvador (UES-1) fueron comparadas in vitro en cuanto a su infectividad y multiplicación en células miocárdicas de ratón blanco NGP, ratón C3H y rata Sprague Dowley con el fin de determinar la resistencia natural de las células de estos animales. Las células miocárdicas fueron cultivadas en cubreobjetos y posteriormente infectadas con tripomastigotos sanguíneos de la cepa respectiva en una relación de un parásito por célula miocárdica y posteriormente incubados a 37 oC con 10 % de CO2 en atmósfera húmeda. Para determinar la capacidad infectante y multiplicación intracelular se analizaron muestras a las 24, 72, 96 y 120 h de infección, determinándose la curva de crecimiento y la tasa de multiplicación intracelular. Se encontró que las dos cepas fueron capaces de multiplicarse en las células miocárdicas de ratón C3H, muy poco en ratón NGP y prácticamente nada en rata, lo que sugiere una resistencia natural de las células de estos últimos dos animales. La cepa UES-1 tuvo una tasa de multiplicación e invasión mayor (p=0.001) sugiriendo por lo tanto una virulencia, al menos in vitro superior a la cepa TCR-4. In vitro growth kinetics of two Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) clones in myocardial cells from rodents of different susceptibility. Two Trypanosoma cruzi isolates, TCR-4 from Costa Rica and UES-1 from El Salvador, were studied in vitro to compare their infectivity or resistance and intracellular replication in myocardial cells in three strains of mice and rats: NGP white mice, C3 H mice and Sprague Dowley rats. Myocardial cells were cultured on coverslips at 37 o C in a humid 10 % CO2 atmosphere and then infected at a ratio of one tripomastigote per cell. Samples were studied after 24, 72, 96 and 120 h of infection to determine parasite infection capacity and intracellular multiplication. Both parasites had the highest infection capacity in C3 H mice, followed by NGP mice cells with a very low infection rate. Lastly, almost no Trypanosoma cruzi multiplication was observed in Sprague Dowley rats, suggesting a strong natural resistance in this animal to both strains of the parasite. The UES-1 isolate presented higher multiplication and greater invasion than the TCR-4 strain, showing greater virulence of UES-1 in heart cells, at least in vitro. Rev. Biol. Trop. 55 (1): 121-126. Epub 2007 March. 31.
Is Content Publishing in BitTorrent Altruistic or Profit-Driven
Ruben Cuevas,Michal Kryczka,Angel Cuevas,Sebastian Kaune,Carmen Guerrero,Reza Rejaie
Computer Science , 2010,
Abstract: BitTorrent is the most popular P2P content delivery application where individual users share various type of content with tens of thousands of other users. The growing popularity of BitTorrent is primarily due to the availability of valuable content without any cost for the consumers. However, apart from required resources, publishing (sharing) valuable (and often copyrighted) content has serious legal implications for user who publish the material (or publishers). This raises a question that whether (at least major) content publishers behave in an altruistic fashion or have other incentives such as financial. In this study, we identify the content publishers of more than 55k torrents in 2 major BitTorrent portals and examine their behavior. We demonstrate that a small fraction of publishers are responsible for 66% of published content and 75% of the downloads. Our investigations reveal that these major publishers respond to two different profiles. On one hand, antipiracy agencies and malicious publishers publish a large amount of fake files to protect copyrighted content and spread malware respectively. On the other hand, content publishing in BitTorrent is largely driven by companies with financial incentive. Therefore, if these companies lose their interest or are unable to publish content, BitTorrent traffic/portals may disappear or at least their associated traffic will significantly reduce.
In No-Man’s Land. Community, Identities and Moral Lives in Depopulated Settings in the North of Spain  [PDF]
Angel Paniagua
Advances in Applied Sociology (AASoci) , 2011, DOI: 10.4236/aasoci.2011.11002
Abstract: The purpose of this article is to study the different ways depopulation is reflected from moral or ethical perspectives of geographical thinking. The objective here is to determine how moral lives (that reflect different opinions about the situational justice, spatial-environmental identity, affective morality and individual trajectory) are maintained in depopulated regions. It has been acknowledged that socio-cultural traditions in each space orientate the moral construction of depopulation, both in relation to socio-ecological repercussions, and also to construction of the community, or in processes of intra or extra-area socio-political negotiation. Some case studies are presented which have been analysed from a qualitative methodological approach, which considers residence in the area, systematic observations and semi-structured interviews.
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