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Search Results: 1 - 10 of 2678 matches for " Andrey Sobolev "
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Integrated platform and API for electrophysiological data
Andrey Sobolev,Adrian Stoewer,Aljoscha Leonhardt,Philipp L. Rautenberg,Christian J. Kellner,Christian Garbers,Thomas Wachtler
Frontiers in Neuroinformatics , 2014, DOI: 10.3389/fninf.2014.00032
Abstract: Recent advancements in technology and methodology have led to growing amounts of increasingly complex neuroscience data recorded from various species, modalities, and levels of study. The rapid data growth has made efficient data access and flexible, machine-readable data annotation a crucial requisite for neuroscientists. Clear and consistent annotation and organization of data is not only an important ingredient for reproducibility of results and re-use of data, but also essential for collaborative research and data sharing. In particular, efficient data management and interoperability requires a unified approach that integrates data and metadata and provides a common way of accessing this information. In this paper we describe GNData, a data management platform for neurophysiological data. GNData provides a storage system based on a data representation that is suitable to organize data and metadata from any electrophysiological experiment, with a functionality exposed via a common application programming interface (API). Data representation and API structure are compatible with existing approaches for data and metadata representation in neurophysiology. The API implementation is based on the Representational State Transfer (REST) pattern, which enables data access integration in software applications and facilitates the development of tools that communicate with the service. Client libraries that interact with the API provide direct data access from computing environments like Matlab or Python, enabling integration of data management into the scientist's experimental or analysis routines.
Observations and modeling of the massive young star AFGL 4176: From large scales to small
Paul Boley,Roy van Boekel,Hendrik Linz,Jeroen Bouwman,Andrey Sobolev,Thomas Henning
Physics , 2011,
Abstract: We present spatially-resolved mid-infrared interferometric observations of the massive young stellar object AFGL 4176, together with literature and survey data. We model these observations using a simple, spherically-symmetric radiative transfer model, and find that the observational data are consistent with a highly luminous star surrounded by a thick envelope.
On the massive young stellar object AFGL4176: High-spatial-resolution multi-wavelength observations and modeling
Paul Boley,Hendrik Linz,Roy van Boekel,Jeroen Bouwman,Thomas Henning,Andrey Sobolev
Physics , 2012, DOI: 10.1051/0004-6361/201218905
Abstract: Deeply embedded and at distances of several kiloparsecs, massive young stellar objects (MYSOs) present numerous challenges for observation and study. In this work, we present spatially-resolved observations of one MYSO, AFGL 4176, together with survey and literature data, ranging from interferometric observations with VLTI/MIDI in the mid-infrared, to single-dish Herschel measurements in the far-infrared, and sub-millimeter data from APEX. We consider this spatially-resolved, multi-wavelength data set in terms of both radiative transfer and geometric models. We find that the observations are well described by one-dimensional models overall, but there are also substantial deviations from spherical symmetry at scales of tens to hundreds of astronomical units, which are revealed by the mid-infrared interferometric measurements. We use a multiple-component, geometric modeling approach to explain the mid-infrared emission on scales of tens to hundreds of astronomical units, and find the MIDI measurements are well described by a model consisting of a one-dimensional Gaussian halo and an inclined (\theta=60 deg) circumstellar disk extending out to several hundred astronomical units along a position angle of 160 deg. Finally, we compare our results both with previous models of this source, and with those of other MYSOs, and discuss the present situation with mid-infrared interferometric observations of massive stars.
Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I
Tatiana A Slastnikova, Eftychia Koumarianou, Andrey A Rosenkranz, Ganesan Vaidyanathan, Tatiana N Lupanova, Alexander S Sobolev, Michael R Zalutsky
EJNMMI Research , 2012, DOI: 10.1186/2191-219x-2-59
Abstract: MNTs are recombinant multifunctional polypeptides that we have developed for achieving selective delivery of short-range therapeutics into cancer cells. MNTs contain functional modules for receptor binding, internalization, endosomal escape and nuclear translocation, thereby facilitating the transport of drugs from the cell surface to the nucleus. The MNT described herein utilized EGF as the targeting ligand and was labeled with 125I using N-succinimidyl-4-guanidinomethyl-3-[125I]iodobenzoate (SGMIB). Membrane binding, intracellular and nuclear accumulation kinetics, and clonogenic survival assays were performed using the EGFR-expressing A431 epidermoid carcinoma and D247 MG glioma cell lines.[125I]SGMIB-MNT bound to A431 and D247 MG cells with an affinity comparable to that of native EGF. More than 60% of internalized [125I]SGMIB-MNT radioactivity accumulated in the cell nuclei after a 1-h incubation. The cytotoxic effectiveness of [125I]SGMIB-MNT compared with 125I-labeled bovine serum albumin control was enhanced by a factor of 60 for D247 MG cells and more than 1,000-fold for A431 cells, which express higher levels of EGFR.MNT can be utilized to deliver 125I into the nuclei of cancer cells overexpressing EGFR, significantly enhancing cytotoxicity. Further evaluation of [125I]SGMIB-MNT as a targeted radiotherapeutic for EGFR-expressing cancer cells appears warranted.Radionuclides emitting densely ionizing Auger electrons impart high cytotoxicity when they decay in close proximity to nuclear DNA due to the formation of double-strand breaks, resulting in severe DNA damage [1]. Because Auger electrons are characterized by short path lengths in the tissue and a very high linear energy transfer, their cytotoxic effects are limited to a sphere of a few nanometers in the immediate vicinity of the site of decay [2]. This property potentially makes them highly selective for killing targeted single cancer cells, provided that they can be specifically delivered to tumor cel
Boris Akunin and the rise of the Russian detective genre
Olga Sobolev
Australian Slavonic and East European Studies , 2005,
Sustainable Development of the Cement Industry and Blended Cements to Meet Ecological Challenges
Konstantin Sobolev
The Scientific World Journal , 2003, DOI: 10.1100/tsw.2003.23
Neo: an object model for handling electrophysiology data in multiple formats
Samuel Garcia,Domenico Guarino,Florent Jaillet,Todd Jennings,Robert Pr?pper,Philipp L. Rautenberg,Chris C. Rodgers,Andrey Sobolev,Thomas Wachtler,Pierre Yger,Andrew P. Davison
Frontiers in Neuroinformatics , 2014, DOI: 10.3389/fninf.2014.00010
Abstract: Neuroscientists use many different software tools to acquire, analyze and visualize electrophysiological signals. However, incompatible data models and file formats make it difficult to exchange data between these tools. This reduces scientific productivity, renders potentially useful analysis methods inaccessible and impedes collaboration between labs. A common representation of the core data would improve interoperability and facilitate data-sharing. To that end, we propose here a language-independent object model, named “Neo,” suitable for representing data acquired from electroencephalographic, intracellular, or extracellular recordings, or generated from simulations. As a concrete instantiation of this object model we have developed an open source implementation in the Python programming language. In addition to representing electrophysiology data in memory for the purposes of analysis and visualization, the Python implementation provides a set of input/output (IO) modules for reading/writing the data from/to a variety of commonly used file formats. Support is included for formats produced by most of the major manufacturers of electrophysiology recording equipment and also for more generic formats such as MATLAB. Data representation and data analysis are conceptually separate: it is easier to write robust analysis code if it is focused on analysis and relies on an underlying package to handle data representation. For that reason, and also to be as lightweight as possible, the Neo object model and the associated Python package are deliberately limited to representation of data, with no functions for data analysis or visualization. Software for neurophysiology data analysis and visualization built on top of Neo automatically gains the benefits of interoperability, easier data sharing and automatic format conversion; there is already a burgeoning ecosystem of such tools. We intend that Neo should become the standard basis for Python tools in neurophysiology.
Anisotropic hyperfine interactions in FeP studied by 57Fe Mossbauer spectroscopy and 31P NMR
Igor A. Presniakov,Alexey V. Sobolev,Andrey A. Gippius,Ivan V. Chernyavskii,Martina Schaedler,Norbert Buettgen,Sergey A. Ibragimov,Igor V. Morozov,Andrei V. Shevelkov
Physics , 2015,
Abstract: We report results of 57Fe Mossbauer and 31P NMR studies of a phosphide FeP powder sample performed in a wide temperature range including the point (TN ~ 120 K) of magnetic phase transitions. The 57Fe Mossbauer spectra at low temperatures T < TN consist of very diffuse Zeeman pattern with line broadenings and sizeable spectral asymmetry. It was shown that the change of the observed spectral shape is consistent with the transition into the space modulated helicoidal magnetic structure. Analysis of the experimental spectra was carried out assuming the anisotropy of the magnetic hyperfine field Hhf at the 57Fe nuclei when the Fe3+ magnetic moment rotates with respect to the principal axis of the electric field gradient (EFG) tensor. The obtained large temperature independent anharmonicity parameter m ~ 0.96 of the helicoidal spin structure results from easy-axis anisotropy in the plane of the iron spin rotation. It was assumed that the very low maximal value of Hhf(11K) ~ 36 kOe and its high anisotropy delta_Hanis(11K) ~ 30 kOe can be attributed to the stabilization of iron cations in the low-spin state (SFe = 1/2). The 31P NMR measurements demonstrate an extremely broad linewidth reflecting the spatial distribution of the transferred internal magnetic fields of the Fe3+ ions onto P sites in the magnetically ordered state.
Enrichment of nitrous oxide reducing bacteria from coastal marsh sediments  [PDF]
Khuong B. T. Nguyen, Dmitri Sobolev
Open Journal of Ecology (OJE) , 2013, DOI: 10.4236/oje.2013.34034

We attempted to recover organisms capable of respiratory nitrous oxide reduction with acetate as an electron donor from a variety of coastal marine sediments from Lavaca Bay area, Texas by use of liquid enrichment cultures. Putative positive cultures were analyzed by amplifying eubacterial and archaeal 16S rRNA gene fragments and analyzing their diversity by separating them by a denaturing gradient gel electrophoresis (DGGE). No Archaea was detected in our enrichments; however, positive enrichments from coastal salt marsh indicated the presence of putative nitrous oxide reducing bacteria. DGGE patterns of the amplified DNA were similar between enrichments, with ca. 7 obvious bands. The dominant bands were tentatively identified as members of the Gammaproteobacteria class, closely related to various denitrifying pseudomonads. Our results indicate that coastal marine environments may sustain a nitrous oxide reducing community, although nitrous oxide reduction is probably an opportunistic form of metabolism in that environment.

An Electrostatic Catastrophe Machine as an Attosecond Pulse Generator  [PDF]
Andrey Gitin
Optics and Photonics Journal (OPJ) , 2014, DOI: 10.4236/opj.2014.412034
Abstract: The generation of an attosecond pulse in the ultraviolet range is described in the terms of the catastrophe theory. A simple criterion of tunneling is proposed. The criterion allows constructing the quasiclassical model of the generator of attosecond laser pulses based on the interaction of an electric field of extremely powerful femtosecond pulse with the valence electron in the potential well of the gas atom.
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