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Search Results: 1 - 10 of 416137 matches for " Andrew M. Ellis "
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Success Rate of Dental Implants Placed in the Atrophic Posterior Maxilla with Intentional Sinus Floor Perforation in Lieu of Indirect Sinus Augmentation: A Retrospective Report of 26 Consecutive Patients and Literature Review  [PDF]
Khurram M. Shahzad, Andrew Q. Madson, Evan M. Shipp, Andrew W. Ellis
Open Journal of Stomatology (OJST) , 2017, DOI: 10.4236/ojst.2017.72007
Abstract: Purpose: To assess surgical success rate of placing dental implants in the atrophic posterior maxilla engaging the maxillary sinus floor in patients with inadequate posterior maxillary alveolar bone height (PMABH). Methods: 26 patients with PMABH of 7 - 10 mm had 39 implants placed between July 2012 and June 2014. These implants were placed protruding apically 1 - 3 mm into the maxillary sinus engaging the sinus floor. At stage one, implants and cover screws were placed, followed by stage two, 5 - 6 months later. The implants were considered osseo-integrated in the absence of symptoms, mobility and inflammation. Periapical radiographs were taken to rule out peri-implant radiolucency. Restorative treatment was completed 2 months thereafter. Patients were scheduled to have a dental exam (6 - 12 months after delivery of prosthesis) and the implants were evaluated clinically and radiographically. A retrospective review was conducted to assess the surgical success rate of this treatment modality. Clinic charts, radiographs and digital implant log were reviewed for all patients with PMABH of 7 - 10 mm who received dental implants in the posterior maxilla to determine the success rate of this treatment modality. Results: 26 patients who had 39 implants placed were included in the study. All implants (100%) were osseo-integrated at the time of uncovering (stage 2). None of the implants (0%) had mobility or inflammation around them. Stage 2 was successfully performed on all 39 implants (100%). All implants (100%) in these patients had been restored, and were in good condition without mobility or inflammation, and had been functioning well 6 - 12 months after restoration. Conclusion: This study suggests that a high success rate can be attained placing dental implants in the posterior maxilla while perforating and engaging the cortical maxillary sinus floor. A future prospective study that compares this technique with the internal sinus lift would likely help elucidate this suggestion.
Effects of L-Dopa and Dopamine D2 Agonists on Recollection and Familiarity in Idiopathic Nondementing Parkinson’s Disease  [PDF]
Nicola M. J. Edelstyn, Thomas A. Shepherd, Andrew R. Mayes, Susan M. Sherman, Simon J. Ellis
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.24042
Abstract: Idiopathic nondementing Parkinson’s disease (PD) is marked by progressive loss of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Recent brain imaging work implicates these structures in dopamine modulated networks subserving episodic memory. These findings are of relevance to PD because they suggest that dopamine depletion contributes to the disease-dependent decline in episodic memory, and therefore, this decline should, at least partially, be remediated by dopaminergic medication. Recognition memory (RM), recollection and familiarity during recognition was examined in 17 PD patients, 12 of whom were medicated with a D2 dopamine agonist (pramipexole or ropinirole) and l-dopa, with a further 5 PD control patients on l-dopa but no D2 agonist. Memory was tested “ON” and, following a period of medication withdrawal, “OFF” and compared to a group of 14 matched healthy volunteers (HV). The HVs were also tested twice in the absence of medication. The patients on the agonists PD showed significant impairments in recollection ON- and OFF-medication, whereas the l-dopa control patients exhibited a decline in OFF-recollection only. RM and familiarity were spared in both groups ON- and OFF-medication. These findings suggest that D2 dopamine agonists (combined with l-dopa) contribute to disease-dependent episodic memory impairment.
Identity, gender, and the role of age of acquisition in face processing
Rachel M. Richards,Andrew W. Ellis
Psicológica , 2009,
Abstract: Two experiments examined the effects of age of acquisition (AoA) and the gender of stimulus faces on familiarity decisions (Experiment 1) and gender decisions (Experiment 2) to the same set of famous and unfamiliar faces presented as whole faces, internal features or external features. In Experiment 1, familiarity decisions were faster to whole faces than to internal or external features. Famous faces with early AoA were recognised faster than later acquired faces, though the effect was only reliable for famous male faces, and for whole faces and internal features rather than for external features. In Experiment 2, gender decisions were made more rapidly to whole faces than to internal or external features. Classification was faster to famous than to unfamiliar faces when the faces were presented as internal features or external features, but not when they were presented as whole faces. More gender classification errors were made to famous than to unfamiliar male faces, but there was no effect of familiarity on the accuracy of responses to female faces. AoA had no effect on gender classification of whole faces or external features. Classification from internal features was faster for early than for late acquired male faces, but faster for late than for early female faces. In the light of the anomalous results for female faces, responses to male faces were analysed separately. The results for the male faces form the focus of the discussion.
Isospin Asymmetry in Nuclei and Neutron Stars
Andrew W. Steiner,Madappa Prakash,James M. Lattimer,Paul J. Ellis
Physics , 2004, DOI: 10.1016/j.physrep.2005.02.004
Abstract: The roles of isospin asymmetry in nuclei and neutron stars are investigated using a range of potential and field-theoretical models of nucleonic matter. The parameters of these models are fixed by fitting the properties of homogeneous bulk matter and closed-shell nuclei. We discuss and unravel the causes of correlations among the neutron skin thickness in heavy nuclei, the pressure of beta-equilibrated matter at a density of 0.1 fm$^{-3}$, the derivative of the nuclear symmetry energy at the same density and the radii of moderate mass neutron stars. Constraints on the symmetry properties of nuclear matter from the binding energies of nuclei are examined. The extent to which forthcoming neutron skin measurements will further delimit the symmetry properties is investigated. The impact of symmetry energy constraints for the mass and moment of inertia contained within neutron star crusts and the threshold density for the nucleon direct Urca process, all of which are potentially measurable, is explored. We also comment on the minimum neutron star radius, assuming that only nucleonic matter exists within the star.
Isospin Asymmetry in Nuclei, Neutron Stars, and Heavy-Ion Collisions
Andrew W. Steiner,Madappa Prakash,James M. Lattimer,Paul J. Ellis
Physics , 2005, DOI: 10.1556/APH.25.2006.2-4.8
Abstract: The roles of isospin asymmetry in nuclei and neutron stars are investigated using a range of potential and field-theoretical models of nucleonic matter. The parameters of these models are fixed by fitting the properties of homogeneous bulk matter and closed-shell nuclei. We discuss and unravel the causes of correlations among the neutron skin thickness in heavy nuclei, the pressure of beta-equilibrated matter at a density of 0.1 fm$^{-3}$, and the radii of moderate mass neutron stars. The influence of symmetry energy on observables in heavy-ion collisions is summarized.
Avian Species Richness in Relation to Intensive Forest Management Practices in Early Seral Tree Plantations
Jay E. Jones,Andrew J. Kroll,Jack Giovanini,Steven D. Duke,Tana M. Ellis,Matthew G. Betts
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043290
Abstract: Managers of landscapes dedicated to forest commodity production require information about how practices influence biological diversity. Individual species and communities may be threatened if management practices truncate or simplify forest age classes that are essential for reproduction and survival. For instance, the degradation and loss of complex diverse forest in young age classes have been associated with declines in forest-associated Neotropical migrant bird populations in the Pacific Northwest, USA. These declines may be exacerbated by intensive forest management practices that reduce hardwood and broadleaf shrub cover in order to promote growth of economically valuable tree species in plantations.
Biological Characteristics and Clinical Outcome of Triple Negative Primary Breast Cancer in Older Women – Comparison with Their Younger Counterparts
Binafsha M. Syed, Andrew R. Green, Christopher C. Nolan, David A. L. Morgan, Ian O. Ellis, Kwok-Leung Cheung
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100573
Abstract: Triple negative (ER, PgR and HER2 negative) breast cancers (TNBCs) are often considered as a poor prognostic phenotype. There is dearth of evidence showing the prevalence and biological behaviour of TNBCs in older women. This study aimed to analyse their biological characteristics in comparison with a well characterised younger series from a single centre with long term clinical follow-up. Over 37 years (1973–2010), 1,758 older (≥70 years) women with early operable (<5 cm) primary breast cancer were managed in a dedicated clinic and have complete clinical information available. Of these 813 patients underwent primary surgery and 575 had good quality tumour samples available for tissue microarray analysis using indirect immunohistochemistry. A total of 127 patients (22.1%) had TNBCs and full biological analysis of 15 biomarkers was performed. The results were compared with those of their younger (<70 years) counterparts 342 (18.9%) from a previously characterised, consecutive series of primary breast cancer treated in the same unit (1986–1998). The 127 older patients with TNBCs showed lower rates of Ki67 and CK 7/8 positivity and high rates of bcl2 and CK18 positivity when compared with their younger counterparts (p<0.05). There was no significant difference in the long term clinical outcome between the two age groups, despite the fact that 47% of the younger patients had adjuvant chemotherapy, while none in the older cohort received such treatment. EGFR, axillary stage and pathological size showed prognostic significance in older women with TNBCs on univariate analysis. Despite not having received adjuvant chemotherapy, the older series had clinical outcome similar to the younger patients almost half of whom had chemotherapy. This appears to be related to other biomarkers (in addition to ER/PgR/HER2) eg Ki67, bcl2 and cytokeratins which have different expression patterns influencing prognosis.
Age of acquisition effects in word recognition and production in first and second languages
Cristina Izura,Andrew W. Ellis
Psicológica , 2002,
Abstract: Four experiments explored the age of acquisition effects in the first and second languages of dominant Spanish-English bilinguals. In Experiment 1 (picture naming task) and Experiment 2 (lexical decision task), an age of acquisition effect was observed in a second language acquired after childhood as well as in the first language. The results suggest that age of acquisition effects reflect the order of word acquisition, which may in turn reflect the state of the lexical network when new words are learnt. The results do not support the idea that age of acquisition effects reflect differences between words learned during some critical period in childhood and words learned later in life. In Experiments 3 and 4, the age/order of second language acquisition affected lexical decision latencies regardless of the age at which translation equivalents were acquired in the first language, suggesting that the age of acquisition effect is linked to the acquisition of word forms rather than meanings.
Probing $\sim L_{*}$ Lyman-break Galaxies at $z\approx 7$ in GOODS-South with WFC3 on HST
Stephen M. Wilkins,Andrew J. Bunker,Richard S. Ellis,Daniel Stark,Elizabeth R. Stanway,Kuenley Chiu,Silvio Lorenzoni,Matt J. Jarvis
Physics , 2009, DOI: 10.1111/j.1365-2966.2009.16175.x
Abstract: We analyse recently acquired near-infrared Hubble Space Telescope imaging of the GOODS-South field to search for star forming galaxies at z~7.0. By comparing WFC 3 0.98 micron Y-band images with ACS z-band (0.85 micron) images, we identify objects with colours consistent with Lyman break galaxies at z~6.4-7.4. This new data covers an area five times larger than that previously reported in the WFC3 imaging of the Hubble Ultra Deep Field, and affords a valuable constraint on the bright end of the luminosity function. Using additional imaging of the region in the ACS B, V and i-bands from GOODS v2.0 and the WFC3 J-band we attempt to remove any low-redshift interlopers. Our selection criteria yields 6 candidates brighter than Y_AB = 27.0, of which all except one are detected in the ACS z-band imaging and are thus unlikely to be transients. Assuming all 6 candidates are at z~7 this implies a surface density of objects brighter than Y_AB = 27.0 of 0.30\pm0.12 arcmin-2, a value significantly smaller than the prediction from the z ~ 6 luminosity function. This suggests continued evolution of the bright end of the luminosity function between z = 6 to 7, with number densities lower at higher redshift.
IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines
XingWu Zhu, Lori A Mulcahy, Rabab AA Mohammed, Andrew HS Lee, Hester A Franks, Laura Kilpatrick, Acelya Yilmazer, E Claire Paish, Ian O Ellis, Poulam M Patel, Andrew M Jackson
Breast Cancer Research , 2008, DOI: 10.1186/bcr2195
Abstract: Immunohistochemistry was used to determine IL-17 expression in breast cancers. Matrigel invasion assays were employed to examine the effect of IL-17 on cancer cell invasion by a panel of breast cancer cell lines. The role of matrix metalloproteinases (MMPs) was investigated with selective antagonists and immunoassays for MMP-2, MMP-3, MMP-9 and tissue inhibitor of MMP.IL-17-expressing cells with macrophage morphology were identified in the peritumoural area of a proportion of patients (8/19 patients). Macrophages were confirmed by CD68 staining on serial sections. With the exception of occasional lymphocytes, one patient with rare multinucleate giant cells and one patient with occasional expression of IL-17 in tumour cells, no other IL-17-positive cells were detected. Addition of IL-17 to cell lines in vitro stimulated marked invasion of Matrigel. In contrast, IL-17 did not promote the invasion of MCF7 or T47D cell lines. Invasion was initially thought to be dependent on MMPs, as evidenced by the broad-spectrum MMP inhibitor GM6001 and selective antagonists of MMP-2/MMP-9 and MMP-3. Measurement of MMP-2, MMP-3 and MMP-9, and tissue inhibitor of MMP 1 secretion, failed to reveal any changes in expression following IL-17 exposure. In contrast, TNF promoted secretion of MMPs but IL-17 did not augment TNF, indicating that IL-17 acts via an independent mechanism.The present study is the first to describe in situ expression of IL-17 protein in human breast tumours and to propose a direct association between IL-17 and breast cancer invasion. The precise effectors of IL-17-dependent invasion remain to be characterised but could include a range of proteases such as a disintegrin and metalloproteinase protein or astacins. Nevertheless, this work identifies a novel potential mechanism for breast cancer invasion and tumour progression, the prognostic implication of which is currently under investigation.In recent years IL-17 has become regarded as a key mediator at the interfac
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