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Search Results: 1 - 10 of 160291 matches for " Andrew B. Cutler "
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Endovascular and Surgical Treatment of Unruptured MCA Aneurysms: Meta-Analysis and Review of the Literature
Spiros L. Blackburn,Abdelrahman M. Abdelazim,Andrew B. Cutler,Kevin T. Brookins,Kyle M. Fargen,Brian L. Hoh,Yasha Kadkhodayan
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/348147
Abstract: Introduction. The best treatment for unruptured middle cerebral artery (MCA) aneurysms is unclear. We perform a meta-analysis of recent publications to evaluate the results of unruptured MCA aneurysms treated with surgical clipping and endovascular coiling. Methods. A PubMed search for articles published between January 2004 and November 2013 was performed. The R statistical software package was used to create a random effects model for each desired incidence rate. Cochran’s Q test was used to evaluate possible heterogeneity among the rates observed in each study. Results. A total of 1891 unruptured MCA aneurysms, 1052 clipped and 839 coiled, were included for analysis. The complete occlusion rate at 6–9 months mean follow-up was 95.5% in the clipped group and 67.8% in the coiled group ( ). The periprocedural thromboembolism rate in the clipping group was 1.8% compared with 10.7% in the aneurysms treated by coiling ( ). The recanalization rate was 0% for clipping and 14.3% for coiling ( ). Modified Rankin scores of 0–2 were obtained in 98.9% of clipped patients compared to 95.5% of coiled (NS). Conclusions. This review weakly supports clipping as the preferred treatment of unruptured MCA aneurysms. Clinical outcomes did not differ significantly between the two groups. 1. Introduction Endovascular coiling has emerged as an option in the management of intracranial aneurysms that traditionally have been treated through open surgical clipping [1]. In the United States, the endovascular management of intracranial aneurysms continues to increase [2, 3]. To support this trend, growing literature is demonstrating low complication rates, durable treatment, and outcomes competitive with surgical results [1, 2, 4–7]. Unlike aneurysms in other locations, the unruptured middle cerebral artery (MCA) aneurysm has several characteristics favoring surgical treatment. This includes superficial location, a familiar surgical approach, easy proximal control at the supraclinoid carotid, and minimal perforator vessels. In contrast, endovascular therapy can be somewhat more difficult in this location due to the small parent vessels, difficulty with obtaining adequate working projection views, and incorporation of branch vessels in the aneurysm. However, the endovascular management of aneurysms has evolved, and coiling of unruptured MCA aneurysms is considered an appropriate alternative to clipping for some aneurysms [8]. As the trend for endovascular management of aneurysms has grown to incorporate MCA aneurysms, recent literature has emerged to promote the surgical option as
Sipuncula from southern Brazil
Cutler, Edward B.;Cutler, Norma J.;
Boletim do Instituto Oceanográfico , 1980, DOI: 10.1590/S0373-55241980000100001
Abstract: a collection of 291 sipunculans from the continental shelf off southern brazil is described. ten species are included, two new to science (phascolion medusae and aspidosiphon longirhyncus). the latter comprises 74% of the specimens collected. four are recorded for the first time in the southwestern atlantic oceccn (golfingia eremita, g. pellucida, a. albus, and a. exhaustus). the remaining two (g. misakiana and p. hedraeum) have been recorded from brazilian waters before. while most of the material represents a warm, shallow water community (the southern end of the south brazilian province), another group of species found south of 34os in deepercooler water points to the possibility of a zoogeographical barrier on the continental slope in these latitudes.
Sipuncula from southern Brazil
Cutler, Edward B;Cutler, Norma J;
Brazilian Journal of Oceanography , 1980, DOI: 10.1590/S1679-87591980000100001
Abstract: a collection of 291 sipunculans from the continental shelf off southern brazil is described. ten species are included, two new to science (phascolion medusae and aspidosiphon longirhyncus). the latter comprises 74% of the specimens collected. four are recorded for the first time in the southwestern atlantic oceccn (golfingia eremita, g. pellucida, a. albus, and a. exhaustus). the remaining two (g. miskiana and p. hedraeum) have been recorded from brazilian waters before. while most of the material represents a warm, shallow water community (the southern end of the south brazilian province), another group of species found south of 34os in deepercooler water points to the possibility of a zoogeogrccphical barrier on the continental slope in these latitudes.
Vortex Unpinning in Precessing Neutron Stars
B. Link,C. Cutler
Physics , 2001, DOI: 10.1046/j.1365-8711.2002.05726.x
Abstract: The neutron vortices thought to exist in the inner crust of a neutron star interact with nuclei and are expected to pin to the nuclear lattice. Evidence for long-period precession in pulsars, however, requires that pinning be negligible. We estimate the strength of vortex pinning and show that hydrodynamic forces present in a precessing star are likely sufficient to unpin all of the vortices of the inner crust. In the absence of precession, however, vortices could pin to the lattice with sufficient strength to explain the giant glitches observed in many radio pulsars.
Are alcoholism treatments effective? The Project MATCH data
Robert B Cutler, David A Fishbain
BMC Public Health , 2005, DOI: 10.1186/1471-2458-5-75
Abstract: This was a secondary analysis of data from a multisite clinical trial of alcohol dependent volunteers (N = 1726) who received outpatient psychosocial therapy. Analyses were confined to the primary outcome variables, percent days abstinent (PDA) and drinks per drinking day (DDD). Overall tests between treatment outcome and treatment quantity were conducted. Next, three specific groups were highlighted. One group consisted of those who dropped out immediately; the second were those who dropped out after receiving only one therapy session, and the third were those who attended 12 therapy sessions.Overall, a median of only 3% of the drinking outcome at follow-up could be attributed to treatment. However this effect appeared to be present at week one before most of the treatment had been delivered. The zero treatment dropout group showed great improvement, achieving a mean of 72 percent days abstinent at follow-up. Effect size estimates showed that two-thirds to three-fourths of the improvement in the full treatment group was duplicated in the zero treatment group. Outcomes for the one session treatment group were worse than for the zero treatment group, suggesting a patient self selection effect. Nearly all the improvement in all groups had occurred by week one. The full treatment group had improved in PDA by 62% at week one, and the additional 11 therapy sessions added only another 4% improvement.The results suggest that current psychosocial treatments for alcoholism are not particularly effective. Untreated alcoholics in clinical trials show significant improvement. Most of the improvement which is interpreted as treatment effect is not due to treatment. Part of the remainder appears to be due to selection effects.A fundamental belief of addiction treatment is that therapy is effective. Addiction counselors are encouraged to use methods that have been shown to be effective in high quality clinical trials [1]. Three of the best of those methods were selected for Projec
Oceanography of Accreting Neutron Stars: Non-Radial Oscillations and Periodic X-Ray Variability
Lars Bildsten,Andrew Cumming,Greg Ushomirsky,Curt Cutler
Physics , 1997,
Abstract: Observations of quasi-periodic oscillations (QPOs) in the luminosity from many accreting neutron stars (NS) have led us to investigate a source of periodicity prevalent in other stars: non-radial oscillations. After summarizing the structure of the atmosphere and ocean of an accreting NS, we discuss the various low l g-modes with frequencies in the 1-100 Hz range. Successful identification of a non-radial mode with an observed frequency would yield new information about the thermal and compositional makeup of the NS, as well as its radius. We close by discussing how rapid rotation changes the g-mode frequencies.
The City-Level Effects of Offshoring  [PDF]
Perry Burnett, Harvey Cutler
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.510094
Abstract: This paper uses a city-level computable general equilibrium (CGE) model to examine the impacts of offshoring for three different periods in the US economy for cities that did not lose jobs to firms relocating overseas. We examine offshoring of final retail and merchandising goods in the 1950- 1980 period, manufactured goods (intermediate goods) in the 1970-2000 period, and current service sector and high-skilled jobs. The impacts of offshoring vary considerably over these time periods. Most notably, when offshoring occurs in high-skilled industries such as computer software and bioengineering, the contributions to economic growth will be smaller compared to the retail and manufacturing experiences over the last 60 years. The results also show wage and per household income effects.
Derivation of Injury-Responsive Dendritic Cells for Acute Brain Targeting and Therapeutic Protein Delivery in the Stroke-Injured Rat
Nathan C. Manley, Javier R. Caso, Melissa G. Works, Andrew B. Cutler, Ilona Zemlyak, Guohua Sun, Carolina D. Munhoz, Sydney Chang, Shawn F. Sorrells, Florian V. Ermini, Johannes H. Decker, Anthony A. Bertrand, Klaus M. Dinkel, Gary K. Steinberg, Robert M. Sapolsky
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061789
Abstract: Research with experimental stroke models has identified a wide range of therapeutic proteins that can prevent the brain damage caused by this form of acute neurological injury. Despite this, we do not yet have safe and effective ways to deliver therapeutic proteins to the injured brain, and this remains a major obstacle for clinical translation. Current targeted strategies typically involve invasive neurosurgery, whereas systemic approaches produce the undesirable outcome of non-specific protein delivery to the entire brain, rather than solely to the injury site. As a potential way to address this, we developed a protein delivery system modeled after the endogenous immune cell response to brain injury. Using ex-vivo-engineered dendritic cells (DCs), we find that these cells can transiently home to brain injury in a rat model of stroke with both temporal and spatial selectivity. We present a standardized method to derive injury-responsive DCs from bone marrow and show that injury targeting is dependent on culture conditions that maintain an immature DC phenotype. Further, we find evidence that when loaded with therapeutic cargo, cultured DCs can suppress initial neuron death caused by an ischemic injury. These results demonstrate a non-invasive method to target ischemic brain injury and may ultimately provide a way to selectively deliver therapeutic compounds to the injured brain.
A large-scale field study examining effects of exposure to clothianidin seed-treated canola on honey bee colony health, development, and overwintering success
G. Christopher Cutler,Cynthia D. Scott-Dupree,Maryam Sultan,Andrew D. McFarlane,Larry Brewer
PeerJ , 2015, DOI: 10.7717/peerj.652
Abstract: In summer 2012, we initiated a large-scale field experiment in southern Ontario, Canada, to determine whether exposure to clothianidin seed-treated canola (oil seed rape) has any adverse impacts on honey bees. Colonies were placed in clothianidin seed-treated or control canola fields during bloom, and thereafter were moved to an apiary with no surrounding crops grown from seeds treated with neonicotinoids. Colony weight gain, honey production, pest incidence, bee mortality, number of adults, and amount of sealed brood were assessed in each colony throughout summer and autumn. Samples of honey, beeswax, pollen, and nectar were regularly collected, and samples were analyzed for clothianidin residues. Several of these endpoints were also measured in spring 2013. Overall, colonies were vigorous during and after the exposure period, and we found no effects of exposure to clothianidin seed-treated canola on any endpoint measures. Bees foraged heavily on the test fields during peak bloom and residue analysis indicated that honey bees were exposed to low levels (0.5–2 ppb) of clothianidin in pollen. Low levels of clothianidin were detected in a few pollen samples collected toward the end of the bloom from control hives, illustrating the difficulty of conducting a perfectly controlled field study with free-ranging honey bees in agricultural landscapes. Overwintering success did not differ significantly between treatment and control hives, and was similar to overwintering colony loss rates reported for the winter of 2012–2013 for beekeepers in Ontario and Canada. Our results suggest that exposure to canola grown from seed treated with clothianidin poses low risk to honey bees.
Valuing Carbon Recycling through Ethanol: Zero Prices for Environmental Goods  [PDF]
Charles B. Moss, Andrew Schmitz
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.43032
Abstract:

The Energy Independence and Security Act of 2007 imposes a Renewable Fuel Standard met through a combination of corn and cellulosic ethanol. A variety of rationales support this policy including the recycling of atmospheric carbon. This study examines the economic dimensions of this problem focusing on the role of zero prices for environmental goods and the use of an environmental equivalent. When environmental goods are taken into account, the optimal price policy cannot be defined with certainty.

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