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Search Results: 1 - 10 of 13925 matches for " Andresa Borges Soares "
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Granular cell tumor: case report in an uncommon location
Vera Cavalcanti de Araújo,Andresa Borges Soares,Luciano Roberto Dipe,Cristiane Furuse
RGO : Revista Gaúcha de Odontologia , 2008,
Abstract: Granular cell tumor is a relatively rare, benign neoplasia that can occur in any part of the body, and in the oral cavity, the tongue is the location most commonly affected. They are generally nodular, single, well delimited, asymptomatic, slow growing, and most frequent in women during the fourth and sixth decades of life. Histologically it is characterized by a proliferation of polygonal cells with a granular appearance, which group themselves in nests, cords or sheets and present a strong immunohistochemical marker for S-100 protein,and a pseudoepitheliomatous hyperplasia can also be present. The treatment of choice is its complete surgical removal and in general,the prognosis is good, with rare recurrences, however cases of local aggressiveness and malign transformation have been related in theliterature. The aim of this article was to relate a clinical case of granular cell tumor located in an uncommon site, showing its clinical,histopathologic and immunohistochemical aspects and forms of treatment.
Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists
Vera Cavalcanti de Araujo, Fabricio Passador-Santos, Cecilia Turssi, Andresa Borges Soares, Ney Soares de Araujo
Diagnostic Pathology , 2013, DOI: 10.1186/1746-1596-8-6
Abstract: These surveys included studies from different researchers, countries and continents. The 57 surveys for which it was possible to calculate the percentage of PLGAs among all malignant minor salivary gland tumors (MMSGT) were included in this review.The statistical analyses show significant differences in the PLGA percentage by time period, country and continent in the studies included in this review. The percentage of PLGAs among MMSGTs varied among the studies, ranging from 0.0% to 46.8%. PLGA rates have varied over the period studied and have most recently increased. The frequency of reported PLGA cases also varied from 0.0% to 24.8% by the country in which the MMSGT studies were performed. The PLGA percentages also varied significantly by continent, with frequencies ranging from 3.9% in Asia to 20.0% in OceaniaBased on these results, we concluded that although the accuracy of PLGA diagnoses has improved, they remain a challenge for pathologists. To facilitate PLGA diagnoses, we have therefore made some suggestions for pathologists regarding tumors composed of single-layer strands of cells that form all of the histological patterns present in the tumor, consistency of the cytological appearance and uniformly positive CK7, vimentin and S100 immunohistochemistry, which indicate a single PLGA phenotype.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1059098656858324 webcitePolymorphous low-grade adenocarcinoma (PLGA) is a malignant epithelial tumor characterized by cytological uniformity, morphological diversity, an infiltrative growth pattern and low metastatic potential [1]. This tumor was recognized as a distinct entity in 1983 by Freedman and Lumerman and Batsakis et al., and it was named polymorphous low-grade adenocarcinoma by Evans and Batsakis in 1984 [2-4].Clinically PLGA presents as an indolent asymptomatic swelling but occasionally can be painful and even ulcerate. The most common location of PLGA is th
Fibrosarcoma originating in the mandible
Soares,Andresa Borges; Lins,Lauro Henrique Sousa; Mazedo,Adriana Parizzoto; Pereira Neto,Joao Sarmento; Vargas,Pablo Agustin;
Medicina Oral, Patología Oral y Cirugía Bucal (Internet) , 2006,
Abstract: fibrosarcoma is a malignant mesenchymal neoplasm of fibroblasts that rarely affects the oral cavity and can cause local recurrences or metastasis. in this article we describe a case of primary fibrosarcoma in the mandible in a 16-year-old girl. microscopically the tumor showed an intense proliferation of spindle-shaped cells, varying little in size and shape and arranged in parallel bands, partly crossing each other, the mitotic activity was increased and there was nuclear pleomorphism. immunohistochemically the cells only showed immunoreactivity for vimentin and negativity for s-100 protein, cd 68, cytokeratin cocktail, hmb-45, cd34, pan actin hhf 35, desmin, smooth muscle actin and epithelial membrane antigen (ema). based on clinical, radiological, histological and immunohistochemical findings the final diagnosis was high-grade intra-osseous fibrosarcoma. the treatment choice was radical surgery with mandibular reconstruction. after one year and nine months of the treatment the patient displayed multiple metastases. radiation therapy and chemotherapy were used as adjuvant treatment. unfortunately, the girl died two years after initial diagnosis.
Intraoral Adult Rhabdomyoma: A Case Report
Ana Amelia Souza,Vera Cavalcanti de Araújo,Fabricio Passador Santos,Elizabeth Ferreira Martinez,Jose Ferreira de Menezes Filho,Ney Soares de Araujo,Andresa Borges Soares
Case Reports in Dentistry , 2013, DOI: 10.1155/2013/741548
Abstract: A case of adult rhabdomyoma is reported. The lesion is a rare benign tumor of skeletal muscle origin which occurs predominantly in the head and neck region. In the present case, the clinical diagnosis favored a benign salivary gland tumor. Histologically, the tumor was composed of large round, oval, and polygonal cells of varying size with abundant pale, eosinophilic, fine, granular cytoplasm with peripherally located nuclei. Immunohistochemically, the lesion was positive for muscle-specific actin, smooth muscle actin, desmin, S100 protein, and Masson’s trichrome. Electron microscopic examination confirmed the presence of numerous myofibrils. The lesion was treated by surgical resection. The clinical, histological, immunohistochemical, and ultrastructural features are discussed in this study. 1. Introduction Rhabdomyomas are rare benign tumors derived from striated muscle, and can be classified generally into two types: cardiac type and extracardiac type. Cardiac rhabdomyoma occurs almost exclusively in the pediatric age group and may be associated with tuberous sclerosis, neurofibromatosis, and sebaceous adenomas. Current opinion is that the cardiac type represents a hamartomatous growth [1]. Extracardiac rhabdomyoma can be divided into three groups (adult, fetal, and genital types) with regards to clinical and morphological differences. The adult type is characterized by a slowly growing mass typically seen in the head and neck of elderly patients. In the fetal type, the lesion also typically involves the head and neck region and tends to occur at younger ages. The genital type is almost always found in the vulvovaginal region of middle-aged women [2]. The fetal and vaginal types are morphologically similar [3]. Seventy-seven percent of all extracardiac rhabdomyomas occur in the head and neck and 14% in the genital region [4]. The adult rhabdomyoma is the most common form of extracardiac rhabdomyoma. The tumor arises mainly within the head and neck region where it is believed to originate from the skeletal musculature of the third and fourth branchial arches. It is so called because of the histological resemblance to mature skeletal muscle cells [5]. These tumors are usually solitary; however, several authors have reported cases of adult multifocal extracardiac rhabdomyomas [6, 7]. In this paper we report a rare case of an adult rhabdomyoma originating in the floor of the mouth. 2. Case Report The patient, a 40-year-old white woman, came to dentistry complaining of a painless swelling in the left floor of mouth that had been present for 6 months. The
Neutrophils in Oral Paracoccidioidomycosis and the Involvement of Nrf2
Vera Cavalcanti Araújo, Ana Paula Dias Demasi, Andresa Borges Soares, Fabrício Passador-Santos, Marcelo Henrique Napimoga, Elizabeth Ferreira Martinez, Nadir Severina Freitas, Ney Soares Araújo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076976
Abstract: Neutrophils have been implicated in granuloma formation in several infectious diseases, in addition to their main phagocytic and pathogen destruction role. It has been demonstrated that Nrf2 regulates antioxidant protection in neutrophils, attenuating inflammation without compromising the hosts bacterial defense. In this study, we analyzed the presence of neutrophils in Paracoccidioides brasiliensis mycosis (PCM), as well as the immunoexpression of Nrf2. Thirty-nine cases of oral PCM were classified according to quantity of fungi and to the presence of loose or well-organized granulomas and microabscesses. An Nrf2 antibody was used for immunohistochemical analysis. The results showed that neutrophils are present in microabscesses and loose granulomas, but were absent in structured granulomas. A greater quantity of fungi was shown in cases with only loose granulomas when compared to loose and well organized granulomas. Nrf2 was observed in the nuclei of neutrophils of loose granulomas and abscesses, with its expression in loose granulomas maintained despite the additional presence of well organized granulomas in the same specimen. This study suggests that neutrophils participate in P. brasiliensis granuloma formation and that Nrf2 has a possible role in neutrophil survival, via modulation of the inflammatory response.
Impact of the Objective Function on the Construction of Internal Grids of Wind Farms Using Genetic Algorithm  [PDF]
Paulo R. Monteiro Duailibe, Thiago T. Borges, André F. Schiochet, Carlos Alberto P. Soares
Open Journal of Civil Engineering (OJCE) , 2016, DOI: 10.4236/ojce.2016.65057
Abstract: The macro complex of the construction industry is energy intensive. Solutions that enable the supply of this demand while meeting the principles of sustainability are needed. The construction of wind farms has been a strategy employed by many countries to produce clean energy. An increase in the construction of wind farms has also been witnessed in Brazil. This calls for different activities, such as the design and construction of infrastructure. This article focuses on the design of internal medium voltage distribution grids for wind farms. The purpose is to find a radial configuration that connects a set of wind generators to the substation, in an optimum way, minimizing operational and construction costs, reducing loss and therefore contributing to sustainability. In large farms, the project design consists of a large combinatorial optimization problem, given the large number of possible configurations to be deployed. Finding the best solution for the internal grid depends on the criterion adopted for the objectives pursued. This article analyzes the different criteria that can be adopted in the design of the wind farm’s internal grid using a methodology based on genetic algorithm (GA). Its aim is to identify their influence on the solution of the problem and help decision-making by finding the most adequate criterion for the objectives pursued. The results show that the design of the internal grid is sensitive to the criteria adopted for the objective function. In addition, the degree of sensitivity is analyzed, showing that, in some cases, the solutions are not economically attractive and do not contribute to the reduction of losses.
O plano inclinado de Galileu: uma medida manual e uma medida com aquisi??o automática de dados
Soares, Reginaldo R;Borges, Paulo de F;
Revista Brasileira de Ensino de Física , 2010, DOI: 10.1590/S1806-11172010000200012
Abstract: we are going to do a discussion about the lab activities in a learning physics project. the project's first part has used history of science to introduce aristotelian and galilean concepts of movement. project's second part has used open lab activities and low cost materials to reproduce the galileo's inclined plane experiment. the experiment was developed to hands on and shows the extremely hard work to measure time manually. we have used a pvc tube with holes 20 cm separated, a small ball and a chronometer to manual measures. after this very imprecise measure it was introduced a microcomputer and ldr sensors to acquire data, make position versus time tables and draw the respective graphics. the experimental activity is open so that the students can explore, test and discuss solutions for all the process of measure, since the sensors ldr still the graphics drawing using spreadsheet. we have used logo free software to acquire data and process control. the tube was placed horizontally to investigate galilean inertial behavior and inclined to investigate the free fall acceleration. an evaluation process is made.
A History of Science classroom experience: Teaching the movement concept.
Reginaldo R. Soares,Paulo de F. Borges
Latin-American Journal of Physics Education , 2010,
Abstract: We have used the History of Science to introduce movement ideas and concepts from Aristotle to Copernicus, Brahe, Kepler and Galileo, aiming to help students to surmount their difficulties and to review misconceptions originated in the common sense. Those author’s basic texts started the discussion and a small list of questions was worked out. After getting the student’s comprehension of Aristotle, Brahe, Kepler, Copernicus and Galileo’s ideas, they have been tested, so as to guarantee their understanding of the nature of Science, its evolutional character and the full meaning of the expression Modern Science. Following this, we introduced Galileo’s inclined plane experiment, in which we are able to study linear uniform movements and free fall accelerated movements. This activity had two phases: first we repeated the procedures used in Galileo’s time, and secondly we have used a microcomputer and LOGO to acquire data and draw graphs and tables. Students were then induced to (re)negotiate the meanings, including now the experimentally observed facts. We discussed the accuracy and precision of measurement processes, and students manifested doubts about Galileo’s interpretation of the results. At this moment, the data acquisition process became an influential aspect to guarantee the confidence in the physical interpretation of the experiment. Our theoretical base was the social-interactionist constructivism to pedagogical activities allied to History of Science to introduce and negotiate the meaning of movement. We believe the student’s conceptual profiles were enriched and the evolution of the movement concepts was clarified for them.
Representa o da sobrecarga familiar e ades o aos servi os alternativos em saúde mental
Pedro Humberto Faria Campos,Carlene Borges Soares
Psicologia em Revista , 2005,
Abstract: O presente estudo teve por objetivo realizar uma investiga o acercado impacto da representa o da sobrecarga, elaborada por cuidadoresdiretos de pacientes cr nicos, na ades o aos servi os alternativospropostos em oposi o ao modelo hospitalocêntrico. A sobrecarga se refere à presen a de problemas, dificuldades ou eventos adversos que afetam significativamente a vida dos familiares ou cuidadores responsáveis pelo paciente, e corresponde ao elementodo sofrimento explicitamente atribuído ao paciente. Participaramdo estudo dez cuidadores considerados aderentes e nove considerados“n o-aderentes”, que foram submetidos a uma entrevista semi-diretiva, centrada nas diferentes dimens es da sobrecarga descritosna literatura. Os resultados nos permitem supor que a sobrecargaemocional é percebida como sendo a mais difícil de enfrentare indicam a existência de seu efeito sobre a ades o. Por outro ladoas variáveis de gênero e classe social aparecem como macro reguladoresdesta sobrecarga.
Establishing a stem cell culture laboratory for clinical trials
Sekiya, Elíseo Joji;Forte, Andresa;Kühn, Telma Ingrid Borges de Bellis;Janz, Felipe;Bydlowski, Sérgio Paulo;Alves, Adelson;
Revista Brasileira de Hematologia e Hemoterapia , 2012, DOI: 10.5581/1516-8484.20120057
Abstract: adult stem/progenitor cells are found in different human tissues. an in vitro cell culture is needed for their isolation or for their expansion when they are not available in a sufficient quantity to regenerate damaged organs and tissues. the level of complexity of these new technologies requires adequate facilities, qualified personnel with experience in cell culture techniques, assessment of quality and clear protocols for cell production. the rules for the implementation of cell therapy centers involve national and international standards of good manufacturing practices. however, such standards are not uniform, reflecting the diversity of technical and scientific development. here standards from the united states, the european union and brazil are analyzed. moreover, practical solutions encountered for the implementation of a cell therapy center appropriate for the preparation and supply of cultured cells for clinical studies are described. development stages involved the planning and preparation of the project, the construction of the facility, standardization of laboratory procedures and development of systems to prevent cross contamination. combining the theoretical knowledge of research centers involved in the study of cells with the practical experience of blood therapy services that manage structures for cell transplantation is presented as the best potential for synergy to meet the demands to implement cell therapy centers.
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