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Search Results: 1 - 10 of 337568 matches for " Andrea S.; Heidel "
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Impact of an educational intervention on steroid prescribing and dosing effect on patient outcomes in COPD exacerbations
Hope,Nancy H.; Ray,Shaunta′M.; Franks,Andrea S.; Heidel,Eric;
Pharmacy Practice (Internet) , 2010, DOI: 10.4321/S1886-36552010000300002
Abstract: the increasing number of patients affected by chronic obstructive pulmonary disease (copd) and associated exacerbations has led to both rising hospital admissions and significant economic impact. evidence-based guidelines have been formulated for copd management recommending the use of low dose, oral corticosteroid therapy in the treatment of exacerbations. however, fewer than 50% of physicians′ prescribing practices appropriately reflect the published clinical guidelines on the use of systemic corticosteroids in these patients. objective: the purpose of this study was to evaluate the impact of a pharmacist-led educational intervention on prescribing practices and patient outcomes when using systemic corticosteroids in patients with copd exacerbations. methods: this retrospective case-control study included patients admitted to an inpatient family medicine service with a copd exacerbation who received systemic corticosteroids. two pharmacist-led educational interventions were delivered to prescribers to review current guidelines for managing copd exacerbations with systemic corticosteroids. patients were retrospectively identified over a three month span prior to and following the educational intervention. data was collected via chart review to evaluate prescribing practices prior to and following the educational sessions. in addition, data was collected to evaluate the effects of an educational intervention on length of stay, adverse events, and cost of treatment. results: a total of 23 pre-intervention patients and 18 post-intervention patients met inclusion criteria. after pharmacist-led interventions, guidelines were not more likely to be adhered to by prescribers when compared to guideline adherence in the pre-intervention patients. because no statistically significant change in guideline adherence was observed, there was no impact on secondary outcomes. conclusion: pharmacist-led didactic educational interventions and guideline dissemination do not improve gui
Geschlecht im Krieg Gender at War
Ulf Heidel
querelles-net , 2003,
Abstract: Der Sammelband pr sentiert ein breites Spektrum historischer Analysen zur Problematik von Geschlecht, Milit r und Gewalt vom Ersten Weltkrieg bis in die deutsch-deutsche Nachkriegszeit. Die facettenreichen und methodisch von der Oral History bis zur Diskursanalyse reichenden Beitr ge belegen die Relevanz und Omnipr senz von Geschlecht in den beharrlichsten Dom nen der M nnlichkeit. This anthology presents a broad spectrum of historical analyses dealing with issues of gender, violence, and the military, covering the period between WWI and the end of WWII. The individual contributions presented this anthology draw on a number of different methodologies, ranging from oral history to discourse analysis. Together, they substantiate the relevance and the omnipresence of gender in one of the most persistent domains of maleness.
The effects of venting and decompression on Yellow Tang (Zebrasoma flavescens) in the ornamental aquarium fish trade
Emily S Munday,Brian N Tissot,Jerry R Heidel,Tim Miller-Morgan
PeerJ , 2015, DOI: 10.7287/peerj.preprints.591v1
Abstract: Each year, over 45 countries export 30 million fish from coral reefs as part of the global marine ornamental aquarium trade. This catch volume is affected by collection methods that cause mortality. Barotrauma caused by forced ascent of collected fish from depth has been determined to be a cause of post-collection mortality. The detrimental effects of barotrauma can be prevented by decompression, or mitigated with venting (puncturing the swim bladder to release expanded internal gas). To further evaluate the effects of collection methods on fish stress and mortality, we conducted the first comprehensive study on the effects of barotrauma prevention and mitigation practices on marine ornamental fish. We examined the effects of three ascent treatments, each with decompression stops of different frequency and duration coupled with or without venting, on sublethal effects and mortality in yellow tang (Zebrasoma flavescens), using histology and serum cortisol measurements. In Z. flavescens subjected to ascent without decompression stops or venting, a mean post-collection mortality of 6.2% occurred within 24h of capture. Common collection methods in the fishery, ascent without or with one decompression stop followed by venting, resulted in no mortality. Histopathologic examination of heart, liver, head kidney, and swim bladder tissues in fish 0d and 21d post-collection revealed no significant lesions in any treatment group. Ascent without decompression stops resulted in significantly higher serum cortisol than ascent with many decompression stops, and venting alone did not affect cortisol. Future work should examine links in the supply chain following collection to determine if further handling and transport stressors affect survivorship and sublethal effects.
Nuclear Odontogenic Ameloblast-Associated Protein (ODAM) Correlates with Melanoma Sentinel Lymph Node Metastasis  [PDF]
Sagar S. Gandhi, Daniel P. Kestler, Charles T. Bruker, James M. McLaughlin, Robert E. Heidel, Sabina Siddiqui, James S. Foster, Keith D. Gray, John Bell, Alan Solomon, James Lewis
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48151
Abstract:

We have examined primary tumor sections from melanoma patients by immunohistochmistry (IHC) for the presence of the odontogenic ameloblast-associated protein (ODAM). Within these patient tissues we have observed a correlation of nuclear ODAM staining in the primary tumors with sentinel lymph node (SLN) metastasis. Surgically, SLN invasion in melanoma is considered an important indicator of more aggressive, invasive melanoma and to date there are limited biomarkers which strongly correlate with metastatic disease. The observation that ODAM staining in melanoma associates with SLN invasion may have important prognostic implications which could assist in the management of melanoma. Notably, ODAM expression may correlate with pathway-signaling we have previously reported to be affected by ectopic ODAM expression in cultured melanoma and breast cancer cell lines.

Warrantless GPS Tracking: Who Cares About Vehicle Transponders – What About Your Cell Phone?
Eric Samuel Heidel
Journal of International Commercial Law and Technology , 2013,
Abstract: The government now regularly gathers information from individuals’ smartphones. Cellular providers are allowing the government to access the GPS data that users’ smartphones exchange with the provider. While there are legitimate purposes for this disclosure without the consent of the smartphone user, there are many instances were no emergency situation exists and no search warrant is even sought. The law currently views sharing GPA data with a cellular provider as a voluntarily disclosure, creating a lesser expectation of privacy. Although posting locations on social networking sites is a clear public disclosure, using modern technology for directions or other conveniences should not cause an individual to forfeit privacy.
Preconditioning for boundary control problems in incompressible fluid dynamics
Gennadij Heidel,Andy Wathen
Mathematics , 2015,
Abstract: PDE-constrained optimization is a field of numerical analysis that combines the theory of PDEs, nonlinear optimization and numerical linear algebra. Optimization problems of this kind arise in many physical applications, prominently in incompressible fluid dynamics. In recent research, efficient solvers for optimization problems governed by the Stokes and Navier--Stokes equations have been developed which are mostly designed for distributed control. Our work closes a gap by showing the effectiveness of an appropriately modified preconditioner to the case of Stokes boundary control. We also discuss the applicability of an analogous preconditioner for Navier--Stokes boundary control and provide some numerical results.
Phylogenetic relatedness and host plant growth form influence gene expression of the polyphagous comma butterfly (Polygonia c-album)
Hanna M Heidel-Fischer, Dalial Freitak, Niklas Janz, Lina S?derlind, Heiko Vogel, S?ren Nylin
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-506
Abstract: In total 120 genes were identified to be differentially expressed in P. c-album after feeding on different host plants, 55 of them in the midgut and 65 in the restbody of the caterpillars. Expression patterns could be confirmed with an independent method for 14 of 27 tested genes. Pairwise similarities in upregulation in the midgut of the caterpillars were higher between plants that shared either growth form or were phylogenetically related. No known detoxifying enzymes were found to be differently regulated in the midgut after feeding on different host plants.Our data suggest a complex picture of gene expression in response to host plant feeding. While each plant requires a unique gene regulation in the caterpillar, both phylogenetic relatedness and host plant growth form appear to influence the expression profile of the polyphagous comma butterfly, in agreement with phylogenetic studies of host plant utilization in butterflies.Chemical defenses of plants influence the host range of herbivorous insects [1-4]. Although by no means the only factor involved in shaping insect-host associations [5], few researchers would argue against its general importance. However, there is an ongoing argument over the reasons for similarities among plant defense chemicals. There are two ways for evolution to achieve similarity: either through shared ancestry or through evolutionary convergence (or parallelism). Ehrlich and Raven [2] suggested that related insects tend to feed on related plants, and several other studies have continued to demonstrate a role of host plant phylogeny (shared ancestry) on patterns of host plant use [6-14]. Hence, there is strong support for a historical component in patterns of host plant use.On the other hand, several authors have also pointed out that plant chemistry does not always follow phylogeny [10,15,16]. Feeny [17] suggested that plant defense strategies should differ depending on their "apparency"; plants that are long-lived and/or physically la
Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials
Jeremy D. Heidel,Thomas Schluep
Journal of Drug Delivery , 2012, DOI: 10.1155/2012/262731
Abstract: Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drugs. One leading class of nanoparticles involves the use of linear, cyclodextrin-containing polymers (CDPs). As is discussed in this paper, CDPs can incorporate therapeutic payloads into nanoparticles via covalent attachment of prodrug/drug molecules to the polymer (the basis of the Cyclosert platform) or by noncovalent inclusion of cationic CDPs to anionic, nucleic acid payloads (the basis of the RONDEL platform). For each of these two approaches, we review the relevant molecular architecture and its rationale, discuss the physicochemical and biological properties of these nanoparticles, and detail the progress of leading drug candidates for each that have achieved clinical evaluation. Finally, we look ahead to potential future directions of investigation and product candidates based upon this technology.
Recursive simulation of quantum annealing
A. P. Sowa,M. J. Everitt,J. H. Samson,S. E. Savel'ev,A. M. Zagoskin,S. Heidel,J. C. Zú?iga-Anaya
Physics , 2015, DOI: 10.1088/1751-8113/48/41/415301
Abstract: The evaluation of the performance of adiabatic annealers is hindered by lack of efficient algorithms for simulating their behaviour. We exploit the analyticity of the standard model for the adiabatic quantum process to develop an efficient recursive method for its numerical simulation in case of both unitary and non-unitary evolution. Numerical simulations show distinctly different distributions for the most important figure of merit of adiabatic quantum computing --- the success probability --- in these two cases.
Impact of an educational intervention on steroid prescribing and dosing effect on patient outcomes in COPD exacerbations
Hope NH,Ray SM,Franks AS,Heidel E
Pharmacy Practice (Granada) , 2010,
Abstract: The increasing number of patients affected by chronic obstructive pulmonary disease (COPD) and associated exacerbations has led to both rising hospital admissions and significant economic impact. Evidence-based guidelines have been formulated for COPD management recommending the use of low dose, oral corticosteroid therapy in the treatment of exacerbations. However, fewer than 50% of physicians’ prescribing practices appropriately reflect the published clinical guidelines on the use of systemic corticosteroids in these patients. Objective. The purpose of this study was to evaluate the impact of a pharmacist-led educational intervention on prescribing practices and patient outcomes when using systemic corticosteroids in patients with COPD exacerbations. Methods. This retrospective case-control study included patients admitted to an inpatient family medicine service with a COPD exacerbation who received systemic corticosteroids. Two pharmacist-led educational interventions were delivered to prescribers to review current guidelines for managing COPD exacerbations with systemic corticosteroids. Patients were retrospectively identified over a three month span prior to and following the educational intervention. Data was collected via chart review to evaluate prescribing practices prior to and following the educational sessions. In addition, data was collected to evaluate the effects of an educational intervention on length of stay, adverse events, and cost of treatment.Results. A total of 23 pre-intervention patients and 18 post-intervention patients met inclusion criteria. After pharmacist-led interventions, guidelines were not more likely to be adhered to by prescribers when compared to guideline adherence in the pre-intervention patients. Because no statistically significant change in guideline adherence was observed, there was no impact on secondary outcomes.Conclusion. Pharmacist-led didactic educational interventions and guideline dissemination do not improve guideline adherence and prescribing practices with respect to systemic corticosteroids in COPD exacerbations.
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