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Search Results: 1 - 10 of 14763 matches for " Andrea Kerényi "
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Dichloridobis(2-methoxydibenzo[c,e][1,2]oxaphosphorine-κP)platinum(II) trichloromethane solvate
Tamás Holczbauer,György Keglevich,Andrea Kerényi,Mátyás Czugler
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809006643
Abstract: The title compound, [PtCl2(C13H11O2P)2]·CHCl3, has a rare PtCl2 bridging of two dibenzooxaphosphorine ligands through the metal atom. The PtII ion is in a slightly distorted square-planar environment. The trichloromethane solvent molecule shows rotational disorder (major occupancy is 0.75) and is placed near to the inversion centre at (1/2, 1/2, 0) in channels parallel to the a axis. The solvent molecule is linked to the complex molecule via intermolecular bifurcated C—H...Cl and C—H...O hydrogen bonds. The crystal structure is further stabilized by π–π interactions involving the benzene rings, with a centroid–centroid distance of 3.658 (8) .
On the Theory of Human Decisions in the Age of “beneficial globalization”
Katalin Martinás,ádám Kerényi
Interdisciplinary Description of Complex Systems , 2010,
Abstract: The globalisation is a complex phenomenon with many advantageous and disadvantageous consequences. In this paper we investigate the linkage between globalised market economy and the happiness through the ethical implications of the greatest happiness principle in a system approach. We also investigate the terms of the beneficial globalisation. Our proposition is that: the main condition of the good globalisation should be Bentham’s principle: the greatest happiness for the greatest number and the United States Declaration of Independence’s famous phrase pursuit of happiness.We face the following problem: the globalization assures – due to its Nature – the growth of Z, which is the marketed part of the globalization, but not the total happiness.The main question in political philosophy is: What do we need to do in order to live together well? In complex approach, based on the wealth increase law we take into account the parameters, which will be changed by the human decisions (i) as well as the long-term expectations, which are motivating the decisions themselves (ii). Factors (i) are the followings: material goods, money, parameters of human physiology (e.g. health), psychology (knowledge), sociology (e.g. friends, power). These quantities are measurable in principle, i.e. they can be mapped into the set of real numbers. The changes are exchanges between two agents or with the nature, and there is production/consumption inside the agent.
Co-Swarming and Local Collapse: Quorum Sensing Conveys Resilience to Bacterial Communities by Localizing Cheater Mutants in Pseudomonas aeruginosa
Vittorio Venturi,Iris Bertani,ádám Kerényi,Sergiu Netotea,Sándor Pongor
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009998
Abstract: Members of swarming bacterial consortia compete for nutrients but also use a co-operation mechanism called quorum sensing (QS) that relies on chemical signals as well as other secreted products (“public goods”) necessary for swarming. Deleting various genes of this machinery leads to cheater mutants impaired in various aspects of swarming cooperation.
A simple model for the early events of quorum sensing in Pseudomonas aeruginosa: modeling bacterial swarming as the movement of an "activation zone"
Sergiu Netotea, Iris Bertani, Laura Steindler, ádám Kerényi, Vittorio Venturi, Sándor Pongor
Biology Direct , 2009, DOI: 10.1186/1745-6150-4-6
Abstract: The onset of swarming in environmental P. aeruginosa PUPa3 was described with a simplified computational model in which cells in random motion communicate via a diffusible signal (representing N-acyl homoserine lactones, AHL) as well as diffusible, secreted factors (enzymes, biosurfactans, i.e. "public goods") that regulate the intensity of movement and metabolism in a threshold-dependent manner. As a result, an "activation zone" emerges in which nutrients and other public goods are present in sufficient quantities, and swarming is the spontaneous displacement of this high cell-density zone towards nutrients and/or exogenous signals. The model correctly predicts the behaviour of genomic knockout mutants in which the QS genes responsible either for the synthesis (lasI, rhlI) or the sensing (lasR, rhlR) of AHL signals were inactivated. For wild type cells the model predicts sustained colony growth that can however be collapsed by the overconsumption of nutrients.While in more complex models include self-orienting abilities that allow cells to follow concentration gradients of nutrients and chemotactic agents, in this model, displacement towards nutrients or environmental signals is an emergent property of the community that results from the action of a few, well-defined QS genes and their products. Still the model qualitatively describes the salient properties of QS bacteria, i.e. the density-dependent onset of swarming as well as the response to exogenous signals or cues.This paper was reviewed by Gáspár Jékely, L. Aravind, Eugene V. Koonin and Artem Novozhilov (nominated by Eugene V. Koonin).Quorum sensing (QS) is a form of gene regulation based on cell-density, which depends on inter-cellular communication involving the production of and response to signaling molecules [1] (Figure 1A). QS is advantageous to a community of bacteria by facilitating adaptation to changing environmental conditions and enhancing their defense capabilities against other microorganisms or
Locality versus globality in bacterial signalling: can local communication stabilize bacterial communities?
Vittorio Venturi, ádám Kerényi, Beáta Reiz, Dóra Bihary, Sándor Pongor
Biology Direct , 2010, DOI: 10.1186/1745-6150-5-30
Abstract: We propose that a large microbial community can be pictured as a theatre of spontaneously emerging, partially overlapping, locally recruited microcommunities whose members interact primarily among themselves, via secreted (signalling) molecules or cell-cell contacts. We hypothesize that stability in an open environment relies on a predominantly local steady state of intercellular communication which ensures that i) deleterious mutants or strains can be excluded by a localized collapse, while ii) microcommunities harbouring useful traits can persist and/or spread even in the absence of specific protection mechanisms.Some elements of this model can be tested experimentally by analyzing the behaviour of synthetic consortia composed of strains having well-defined communication systems and devoid of specific defence mechanisms. Supporting evidence can be obtained by in silico simulations.The hypothesis provides a framework for a systematic comparison of bacterial community behavior in open and closed environments. The model predicts that local signalling may enable multispecies communities to colonize open, structured environments. On the other hand, a confined niche or a host may be more likely to be colonized by a bacterial mono-species community, and local communication here provides a control against spontaneously arising cheaters, provided that survival depends on cooperation.This article was reviewed by G. Jékely, L. Aravind and E. Szathmáry (nominated by F. Eisenhaber)Many bacteria and other unicellular organisms live in large, multispecies communities in which the participants jointly exploit the resources. Multispecies consortia are a major form of bacterial life and often contain hundreds of different species that share secreted materials in a densely packed environment. Social behaviour must be an essential trait throughout bacterial evolution [1], however there is no sufficient experimental evidence to explain why such consortia can be stable against environm
Stability of Multispecies Bacterial Communities: Signaling Networks May Stabilize Microbiomes
ádám Kerényi, Dóra Bihary, Vittorio Venturi, Sándor Pongor
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057947
Abstract: Multispecies bacterial communities can be remarkably stable and resilient even though they consist of cells and species that compete for environmental resources. In silico models suggest that common signals released into the environment may help selected bacterial species cluster at common locations and that sharing of public goods (i.e. molecules produced and released for mutual benefit) can stabilize this coexistence. In contrast, unilateral eavesdropping on signals produced by a potentially invading species may protect a community by keeping invaders away from limited resources. Shared bacterial signals, such as those found in quorum sensing systems, may thus play a key role in fine tuning competition and cooperation within multi-bacterial communities. We suggest that in addition to metabolic complementarity, signaling dynamics may be important in further understanding complex bacterial communities such as the human, animal as well as plant microbiomes.
Effect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes
Attila Gergely Végh,Krisztina Nagy,Zoltán Bálint,ádám Kerényi,Gábor Rákhely,Gy rgy Váró,Zsolt Szegletes
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/670589
Abstract: Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues. Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet. We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC) and on purple membrane of Halobacterium salinarum. Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane. Purple membrane was much more resistant against indolicidin, probably due to its high protein content. Indolicidin preferred the border of membrane disks, where the lipids are more accessible. These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction.
The Ambivalent Role of Idiosyncratic Risk in Asymmetric Tournaments  [PDF]
Kerstin Pull, Hendrik B?ker, Agnes B?ker
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33A004
Abstract:

In our paper, we analyze the interplay of contestant heterogeneity and idiosyncratic risk in rank-order tournaments: While in symmetric tournaments an increase in idiosyncratic risk reduces incentives, in asymmetric tournaments this is not necessarily the case: Rather, we show that increasing the level of idiosyncratic risk in asymmetric tournaments will at first increase and—only after a critical risk level has been reachedreduce incentives. We find this critical risk level to be higher, the larger the degree of contestant heterogeneity. Concerning practical implications, it is more important to reduce idiosyncratic risk in the tournament when contestants are similar and less beneficial when contestants are heterogeneous. In light of the fact that equilibrium effort levels in tournaments with a low level of contestant heterogeneity are by far higher than those in tournaments with high levels of contestant heterogeneity, the advice would be to simultaneously reduce contestant heterogeneity (e.g., by league-building or handicapping) and idiosyncratic risk.

The serpentine mitral valve and cerebral embolism
James Ker
Cardiovascular Ultrasound , 2011, DOI: 10.1186/1476-7120-9-7
Abstract: In this case report a valvular strand, giving a peculiar serpentine appearance to the mitral valve is described. This mitral valvular strand was the only explanation for an episode of cerebral embolism, presenting with a transient right sided hemiparesis.It is proposed that a randomized study involving combined treatment with aspirin and clopidogrel is warranted in young patients with valvular strands, presenting with a first episode of cerebral embolism.Valvular strands have been described as small, well-delineated masses with a predilection for the valvular endocardium [1]. Clinically these strands present as filiform material attached to cardiac valve edges and is detected by transesophageal echocardiography [2].These strands, as visualized by transesophageal echocardiography are associated with systemic embolization, especially stroke and notably these strokes tend to occur among younger persons [3,4].A 32 year old man presented with an acute onset of right sided hemiparesis. This occurred within the matter of minutes without any preceding warning symptoms. He had no known illnesses or allergies. He was a non smoker who never had any previous surgery and did not use illicit drugs. He works in the pharmaceutical industry and never experienced any similar symptoms before.The right sided hemiparesis resolved spontaneously over the next three hours and at the time of clinical examination no objective neurological signs were present. An MRI and MRA scan of the brain and cerebral vasculature were normal. His electrocardiogram and biochemical analysis, including electrolytes, glucose, thyroid function and full blood count were within normal limits. Carotid-IMT and Doppler studies of both carotid arteries were normal. Holter electrocardiography excluded the occurrence of intermittent arrhythmias as a possible cause for embolism. Paradoxical embolism was excluded by the absence of both a patent foramen ovale and deep venous thrombosis. Infective endocarditis was excluded
The subaortic tendon as a mimic of hypertrophic cardiomyopathy
James Ker
Cardiovascular Ultrasound , 2009, DOI: 10.1186/1476-7120-7-31
Abstract: Also appreciated today is the enormous genotypic and phenotypic heterogeneity of this disease with more than 300 mutations over more than 24 genes, encoding various sarcomeric, mitochondrial and calcium-handling proteins, all as genetic causes for hypertrophic cardiomyopathy.Phenotypically, the disease can vary from negligible to extreme hypertrophy, affecting either the left and/or right ventricle in an apical, midventricular or subaortic location.Left ventricular false tendons are thin, fibrous or fibromuscular structures that traverse the left ventricular cavity. Recently, a case report was presented where it was shown that such a false tendon, originating from a subaortic location, was responsible for striking ST-segment elevation on the surface electrocardiogram.In this case report, a case is presented where such a subaortic tendon led to the classic echocardiographic appearance of hypertrophic cardiomyopathy, thus in the assessment of hypertrophic cardiomyopathy, this entity needs to be excluded in order to prevent a false positive diagnosis of hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy (HCM) was first described in 2 publications between 1957–1959 by Brock [1-3]. During this period Teare [1,4] also described the entity of asymmetrical septal hypertrophy in 8 autopsy cases.HCM is the most prevalent genetic cardiovascular disease, as it affects one in 500 individuals and exhibits enormous genotypic and phenotypic heterogeneity [5].Phenotypically, hypertrophy can vary from negligible to extreme – similarly fibrosis and myocyte disarray can also range from negligible to extreme [5]. This phenotypic variation is the result of the vast array of mutations present in the family of HCM [5].These mutations can be inherited (familial) or can occur de novo (sporadic) [6].Currently, more than 300 mutations, which are scattered over more than 24 genes are known as causes for HCM [5]. These involved genes encode various proteins of the sarcomere, mitochondria an
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