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Search Results: 1 - 10 of 335983 matches for " Andrés Machicote "
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IL28B SNPs rs12979860 and rs8099917 Are Associated with Inflammatory Response in Argentine Chronic HCV Patients  [PDF]
Andrés Machicote, Diego Flichmann, Eloisa Arana, Silvia Paz, Hugo Fainboim, Leonardo Fainboim, Pablo M. Fernández
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.92009
Abstract: Background: Hepatitis C virus (HCV) is a major cause of chronic liver disease, including cirrhosis and liver cancer. The aim of our study was to determine whether IL28B single nucleotide polymorphisms (SNPs) rs12979860 and rs8099917 can be considered a prognostic host factor in untreated chronic HCV patients. Methods: We set up a real-time Allele Specific PCR amplification to determine the allele present in each polymorphic site, and statistically grouped and compared this result with clinical data. Results: We determined rs12979860 and rs8099917 genotype and allele frequencies in a single cohort of untreated chronically HCV-infected patients. We found significant associations between higher inflammatory activity, measured as ALT levels or METAVIR scores and rs12979860 CC (P = 0.0013 and P = 0.0033, respectively) and rs8099917 TT (P = 0.0005 and P = 0.0264, respectively) genotypes. Interestingly, considering both genotypes together, we also found association with ALT levels (P = 0.0003; OR = 5.125) or METAVIR scores (P = 0.0038; OR = 5.179), suggesting and additive effect on liver inflammation in these patients. Conclusion: we show association between hepatic inflammatory activity in a single Argentinean untreated chronically HCV cohort and SNPs located in the interferon lambda gene region. The studied polymorphisms, together with further innate and adaptive immune responses, clearly play a role in modulating the HCV infected patients outcome, contributing to hepatic inflammation and possible fibrosis/cirrhosis.
The Higher Education System in Argentina. Networks, Genealogies and Conflicts  [PDF]
Santos Sharpe Andrés
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.618200
Abstract: The present manuscript aims to identify the genealogies, understood in a Foucaultian perspective, which leads to the actual Higher Education System in Argentina, by distinguishing how series of events are organized, distributed, organized in terms of institutional relations, signifying chains in the social amalgam and educational networks. This analysis will allow understanding the hierarchical relationships between higher education institutions and how the differences on cultural and curricular traditions and history also motivate (though not impose) the differences on the students and on policies. Finally, it is as well an accurate description of the Higher Education System in Argentina with a strong emphasis on universities.
On the Origin of the Common Bean (Phaseolus vulgaris L.)  [PDF]
Andrés J. Cortés
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.410248
Abstract:

Phylogeographic methods provide the tools to accurately access the geographic origin and diversification of crop species. In the present commentary, I urge the common bean community to face those methods and a tree-thinking mentality with regards to the long standing debate of the origin of common bean. Such efforts will ultimately bring back interest into wild bean studies and reinforce the uniqueness of this species as a system to study diversification, domestication and adaptive processes across the two most diverse hotspots in the world.

The Role of R&D in Shaping Public Sector Typologies: An European Perspective  [PDF]
Andrés Maroto, Luis Rubalcaba
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.37110
Abstract: One of functions of the modern public states for improving dynamism in the economic system is the use of their support to cope with the market and systemic failures created in the innovation area: the R&D promoted by public administrations can be considered a dimension, among others, of their performance in society. This paper explores the relationships between the R&D promoted by public administrations and the different typologies of states from a European perspective. The results show some similarities between the public sectors in terms of general characteristics such as performance or stability and the most R&D-oriented promoters. However, differences are found depending on indicators and types analyzed. The existence of large differences within each type of public sector is also confirmed. Results suggest the influence that pro-innovation profiles of public sectors might exert on general innovation system and performance patterns in EU countries.
A Global Public Good: The Linkage between Veterinary Medicine and the Sanitary Management of Food Hygiene  [PDF]
Andrés Cartín Rojas
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.35058
Abstract:

Ensuring food safety is a key and crucial factor for those agro-exporting nations seeking to improve their competitiveness, opening new options for global markets and positioning their products at a better price. A number of international guidelines serve a reference framework for defining national public policies aimed to provide safe food to the population. Veterinary services act as guarantors in this process along all the manufacture and value chain. The public and private veterinary services are nurtured and amalgamate together to ensure the attainment of common goals; strengthen and foment a robust and efficient alimentary legislation by using the World Animal Health Organization’s normative as a standard reference. In this conceptual paper, an appraisal about the interrelationship and the interconnection between veterinary professionals and the sanitary management of food hygiene is widely developed by reviewing relevant literature, and discussing current trends. The author adopts an inductive approach, designed to generate understanding and propositions about this relevant topic.

Theoretical Deduction of the Hubble Law Beginning with a MoND Theory in Context of the ΛFRW-Cosmology  [PDF]
Nelson Falcon, Andrés Aguirre
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.44051
Abstract: We deduced the Hubble law and the age of the Universe, through the introduction of the Inverse Yukawa Field (IYF), as a non-local additive complement of the Newtonian gravitation (Modified Newtonian Dynamics). As a result, we connected the dynamics of astronomical objects at great scale with the Friedmann-Robertson-Walker ΛFRW) model. From the corresponding formalism, the Hubble law can be expressed as = (4π[G]/c)r, which was derived by evaluating the IYF force at distances much greater than 50 Mpc, giving a maximum value for the expansion rate of the universe of H0(max≈ 86.31 km·s-1Mpc-1, consistent with the observational data of 392 astronomical objects from NASA/IPAC Extragalactic Database (NED). This additional field (IYF) provides a simple interpretation of dark energy as the action of baryonic matter at large scales. Additionally, we calculated the age of the universe as 11 Gyr, in agreement with recent measurements of the age of the white dwarfs in the solar neighborhood.
Simulación numérica de la interconexión de corte de vigas mixtas de acero de alta resistencia y hormigón UHPC
Panés,Andrés;
Obras y proyectos , 2011, DOI: 10.4067/S0718-28132011000200002
Abstract: this article presents numerical analyses on composite beams made of high strength steel and ultra high performance concrete (uhpc). due to the high compressive strength of uhpc very slender structures with thin concrete elements are feasible. however, local stresses in the composite joints increase significantly due to the higher load capacity. for that, continuous shear connectors have been developed. numerical simulations are explained to the study of composite beams related to the shear connection (springs). details of uhpc are also presented. a composite beam with non-linear material properties was modelled. beam-bending tests were simulated with abaqus to calibrate the numerical model. the numerical results agree relatively well with the test results, even after first crack initiation. in addition, a three dimensional model with volume elements for the steel and the concrete parts and non-linear spring elements for the shear connection were implemented. the results from performed push-out tests were used in the nonlinear model of the springs elements. the punctual application of the forces in the model due to the springs were the reason for tension peaks and on this account there was an earlier loss of stiffness compared to the beam test result. the ultimate load and the occurring slip were satisfactorily calculated.
Bar Restaurant Barlovento
Andrés Garcés
ARQ , 2001,
Abstract:
Simulación numérica de la interconexión de corte de vigas mixtas de acero de alta resistencia y hormigón UHPC Numerical simulation of the interconnection of high strength steel composite beams and UHPC concrete
Andrés Panés
Obras y Proyectos , 2011,
Abstract: Este artículo presenta análisis numéricos de vigas mixtas de acero de alta resistencia y hormigón de ultra alto desempe o UHPC. Debido a la alta resistencia a la compresión del hormigón UHPC, son posibles estructuras muy esbeltas con elementos de hormigón delgados. Sin embargo, tensiones locales aumentan considerablemente en las uniones entre estos dos materiales debido a la mayor capacidad de carga. Para ello, han sido desarrollados conectores de corte continuos. Simulaciones numéricas son explicadas para estudiar vigas mixtas con conectores de corte (resortes). También se presentan detalles de los hormigones UHPC. Se modela una viga mixta con propiedades no lineales de los materiales. Ensayos de flexión de vigas son simulados con ABAQUS para calibrar el modelo numérico. Los resultados numéricos concuerdan relativamente bien con los resultados experimentales incluso después de iniciada la primera grieta. Además se implementó un modelo tridimensional con elementos de volumen para las partes de acero y hormigón y elementos de resorte no lineales para la conexión de corte. Los resultados de ensayos push-out fueron usados en el modelo no lineal de los elementos de resorte. La aplicación de cargas puntuales en el modelo debido a los resortes explican las tensiones máximas y debido a esto la pérdida de rigidez más temprana comparada con los ensayos de la viga. La carga última y la ocurrencia de deslizamiento fueron estimadas satisfactoriamente. This article presents numerical analyses on composite beams made of high strength steel and Ultra High Performance Concrete (UHPC). Due to the high compressive strength of UHPC very slender structures with thin concrete elements are feasible. However, local stresses in the composite joints increase significantly due to the higher load capacity. For that, continuous shear connectors have been developed. Numerical simulations are explained to the study of composite beams related to the shear connection (springs). Details of UHPC are also presented. A composite beam with non-linear material properties was modelled. Beam-bending tests were simulated with ABAQUS to calibrate the numerical model. The numerical results agree relatively well with the test results, even after first crack initiation. In addition, a three dimensional model with volume elements for the steel and the concrete parts and non-linear spring elements for the shear connection were implemented. The results from performed push-out tests were used in the nonlinear model of the springs elements. The punctual application of the forces in the model due to the
Effect of Sludge Amendment on Remediation of Metal Contaminated Soils
Andrés Navarro
Minerals , 2012, DOI: 10.3390/min2040473
Abstract: Column-leaching and pilot-scale experiments were conducted to evaluate the use of biosolids (sewage sludges) to control the mobilization of metals from contaminated soils with smelting slags. The pilot-scale experiments using amended soils showed that Cu, Pb and Sb were retained, decreasing their concentrations from 250 mg/L, 80 mg/L and 6?mg/L, respectively in the leachates of contaminated soils, to <20 mg/L, 40 mg/L and 4?mg/L, respectively, in the amended material. Hydrogeochemical modeling of the leachates using Minteq revealed that the degree of complexation of Cu rose 56.3% and 57.6% in leachates of amended soils. Moreover, Cu may be immobilized by biosolids, possibly via adsorption by oxyhydroxides of Fe or sorption by organic matter. The partial retention of Pb coincides with the possible precipitation of chloropyromorphite, which is the most stable mineral phase in the pH-Eh conditions of the leachates from the amended material. The retention of Sb may be associated with the precipitation of Sb 2O 3, which is the most stable mineral phase in the experimental conditions. The organic amendments used in this study increased some metal and metalloid concentrations in the leachates (Fe, Mn, Ni, As and Se), which suggests that the organic amendments could be used with caution to remediate metal contaminated areas.
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