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In vivo hair growth activity of Prunus dulcis seeds in rats
R Suraj,G Rejitha,J Anbu Jeba Sunilson,K Anandarajagopal
Biology and Medicine , 2009,
Abstract: Seeds of Prunus dulcis were traditionally known for its hair growth activity. The study was aimed to investigate theefficacy of various extracts of P. dulcis as a potential hair growth promoter. Petroleum ether, methanol, chloroformand water extracts of P. dulcis seeds incorporated in oleaginous ointment base were applied topically on shaveddenuded skin of albino rats and screened for hair growth activity. Petroleum ether extract showed consistent andsignificant increase in the length of hair (p<0.001) and also showed a good percentage of hair follicles in the anagenphase after histological studies. The total number of days taken to complete hair growth for petroleum ether was 24where as for methanol, water and chloroform extracts were 28, 29 and 30 respectively. From this study it can beconcluded that the seed extracts of P. dulcis exhibits a significant potency in promoting hair growth.
In vitro Antimicrobial Evaluation of Zingiber officinale, Curcuma longa and Alpinia galanga Extracts as Natural Food Preservatives
J. Anbu Jeba Sunilson,R. Suraj,G. Rejitha,K. Anandarajagopal
American Journal of Food Technology , 2009,
Abstract: In the present study, antimicrobial activity of various extracts of Zingiber officinale, Curcuma longa and Alpinia galanga were screened against the common food borne bacteria such as Escherichia coli, Salmonella enteriditis, Clostridium perfringens, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus and fungi such as Saccharomyces cerevisiae, Hansenula anomala, Mucor mucedo, Candida albicans using disc diffusion method. All the extracts showed significant antibacterial and antifungal properties. The methanol extracts (100 μg mL-1) revealed maximum zone of inhibition (p<0.001). Zingiber officinale and Curcuma longa possessed considerably greater activity than Alpinia galanga. These findings established the potential of the selected rhizomes of Zingiberaceae family as effective natural food preservatives.
Gastroprotective and Antioxidant Activities of the Roots of Hibiscus aculeatus Roxb in Rats
J. Anbu Jeba Sunilson,R. Varatharajan,P. Jayaraj,T. John
International Journal of Pharmacology , 2008,
Abstract: Ethanol extract of Hibiscus aculeatus (HAE) was assessed in different acute and chronic gastric ulcer models in rats. HAE, 50-200 mg kg-1 administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (9.21-52.63% protection, p<0.05), aspirin (23.95-56.25% protection, p<0.05), ethanol (13.55-58.47% protection, p<0.05), cold-restraint stress (18.34-72.92% protection, p<0.05 to p<0.001) and acetic acid (p<0.05 to p<0.001) induced acute and chronic ulcers. HAE also significantly (p<0.001) reduced the ulcer incidence (40 and 10%) and severity (54.35 and 85.37% protection) of duodenal ulcer, induced by cysteamine. HAE offered protection (49.57 and 58.97%) against ethanol-induced depletion of gastric wall mucus. And also, HAE reduced the ulcer index with significant decrease in plasma corticosterone (21.15 and 33.51% protection, p<0.05), lipid peroxidation (16.66 and 38.88% protection, p<0.01 and p<0.001), superoxide dismutase (17.64 and 47.25% protection, p<0.05 and p<0.001) and an increase in catalase (25.84 and 83.14% protection, p<0.05 and p<0.001) activity respectively. Preliminary phytochemical screening of the HAE showed positive test for flavanoids, terpenoids, steroids, tannins and saponins. The results indicate that HAE possesses gastroprotective and antioxidant activity.
Hepatoprotective Activity of Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats
J. Anbu Jeba Sunilson,M. Muthappan,Amitava Das,R. Suraj
International Journal of Pharmacology , 2009,
Abstract: Coccinia grandis Linn. (Cucurbitaceae) is a perennial branched handsome tendril climber, distributed through out India. It has been used in folk medicine for the treatment of jaundice. The aim of this work was to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the leaves of C. grandis against liver damage induced by CCl4 in rats. The ethanolic extract at an oral dose of 200 mg kg -1 exhibited a significant (p<0.05) protective effect as shown by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing levels of total protein and albumin levels as compared to silymarin, the positive control. These biochemical observations were supported by histopathological examination of liver sections. The activity may be due to the presence of flavonoid compounds. The extracts showed no signs of acute toxicity up to a dose level of 2000 mg kg -1. Thus it could be concluded that ethanolic extract of C. grandis leaves possesses significant hepatoprotective activity.
Preliminary phytochemical and antiulcer studies of Hibiscus rosa sinensis Linn. root extracts
Anita Gnana Kumari A,Palavesam A,Anbu Jeba Sunilson J,Anandarajagopal K
International Journal of Green Pharmacy , 2010,
Abstract: The antiulcer activity of various extracts of Hibiscus rosa sinensis roots was evaluated in pyloric ligation induced gastric ulcer in albino rats. The root extracts were prepared by cold maceration process with petroleum ether, alcohol and water separately. The preliminary phytochemical screening of H. rosa sinensis revealed the presence of sterols, glycosides, proteins, mucilage and flavonoids. Oral administration of aqueous and alcohol extracts (250 and 500 mg/kg) of H. rosa sinensis roots were evaluated for antiulcer activity and compared with the standard drug, lansoperazole (8 mg/kg). From the results, it can be concluded that the aqueous extract of H. rosa sinensis roots (500 mg/kg) showed highly significant (P< 0.001) dose-dependent antiulcer activity. These results lend scientific support for the plant as folk medicine.
An Intelligent Mining Framework based on Rough Sets for Clustering Gene Expression Data
J. Jeba Emilyn,K. Ramar
Journal of Applied Sciences , 2012,
Abstract: The main aim of this study is not only to develop a biclustering algorithm that would successfully identify gene patterns but also to propose an intelligent clustering framework that would improve the cluster quality. Our framework for mining co-regulated genes from gene expression dataset is composed of three important steps: a preprocessing step to refine the data, an intelligent procedure to predict the possible number of biclusters and a procedure based on rough sets to cluster the gene datasets. Our algorithm is said to be intelligent, in the sense that it can predict the possible number of biclusters. Since, the algorithm is based on rough sets, there are high possibilities of placing a gene in more than one bicluster and thus allows overlapping of biclusters. A theoretical understanding of the proposed algorithm is analyzed and results are illustrated with different gene expression data sets. The analysis and the experiment shows that the method is more intelligent and efficient.
Electrochemical studies on inert filler incorporated poly (vinylidene fluoride - hexafluoropropylene) (PVDF - HFP) composite electrolytes
Wilson, J.;Ravi, G.;Kulandainathan, M. Anbu;
Polímeros , 2006, DOI: 10.1590/S0104-14282006000200006
Abstract: the ionic conductivity, thermal stability and lithium transference number have been investigated in composite polymer electrolytes (cpe) of poly(vinylidene fluoride - hexafluoropropylene) (pvdf-hfp) incorporating nano fillers of alo[oh]n or gal2o3, with liclo4 as salt. the compatibility of the composite polymer electrolyte with lithium metal anode has also been studied. the effect of particle size on the compatibility of li/ cpe/ li symmetric cells has also been analyzed.
Antioxidant and hepatoprotective effect of the roots of Hibiscus esculentus Linn.
Sunilson J,Jayaraj P,Mohan M,Kumari A
International Journal of Green Pharmacy , 2008,
Abstract: The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals invitro with IC 50 of 620 μg/ml, 2300 μg/ml, 870 μg/ml and 610 μg/ml. [Fe 2+ /ascobate system], 730 μg/ml, [Fe 3+ /ADP/ascorbate system], for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation respectively. The oral administration of the extract (250 and 500 mg/kg body weight), significantly reduce CCl 4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [Glutamate oxaloacetate transaminase (GOT), Glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with standard drug silymarin [20 mg/kg, P.O.)
Normalized graph-cut based Necrotic Image Segmentation of Brain Tumours
J.S. JUFIN,D. JEBA DERWIN?
International Journal of Computer Science and Mobile Computing , 2013,
Abstract: This paper aims at enhancing Necrotic regions based Normalized graph –cut segmentation ofBrain Tumour on contrast T1 Magnetic Resonance (MR) Images. Image segmentation means a process ofpartition an image into more distinct regions. The brain tumour segmentation methods rely on the intensityenhancement. A large Varity of different tumour segmentation approaches used for medical imagesegmentation. Among them, a clustering method have been investigated and used. In this paper, CA (CellularAutomata) based seeded tumour segmentation algorithm is proposed. Which determine the Volume ofInterest (VOI) and seed selection. First, establish the connection of the CA-based segmentation to the graphcutmethod to show that the iterative CA framework solves the shortest path problem. This paper describesegmentation method consist of two phases. In the first phase, the MR Image is acquired from patientdatabase and contrast enhancing the image. In the second phase, the CA algorithm run twice for backgroundseed (healthy cell) and foreground seed (tumour cell) for probability calculation. Furthermore, apply Graph-Cut (GC) method to differentiate necrotic and enhancing tumour tissue content, which gains importance fora detailed assessment of radiation therapy response.
Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice
Vijayalakshmi A,Ravichandiran V,Anbu J,Velraj Malarkodi
Indian Journal of Pharmacology , 2011,
Abstract: Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice. Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test. Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups. Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.
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