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For the past thirty years, intense efforts have been made to record atomic scale movies that reveal the movement of atoms in molecules, the fast dynamical processes in biological tissues and cells, and the changes in the structure of a solid confined to nano-scale volumes. A combination of sub-nanometer spatial resolution with picosecond or even femtosecond temporal resolution is required for such atomic movies. Additional important information can be obtained when the energy of the electron beam transmitted through the sample is measured. The four dimensional (4D) spatially and temporally resolved ultrafast electron microscopy method is made possible by the extremely high detection efficiency that is reached in 4D electron microscopy. Using ultra-short electron bunches for the visualization of biological tissue can also improve the spatial resolution compared to conventional electron microscopes, thereby enabling the study of complex biological samples of relevance to the life sciences. Of particular interest to a broad audience is the possibility to create a video, and in the future, a real atomic movie, using 4D electron tomography.