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In vivo hair growth activity of Prunus dulcis seeds in rats
R Suraj,G Rejitha,J Anbu Jeba Sunilson,K Anandarajagopal
Biology and Medicine , 2009,
Abstract: Seeds of Prunus dulcis were traditionally known for its hair growth activity. The study was aimed to investigate theefficacy of various extracts of P. dulcis as a potential hair growth promoter. Petroleum ether, methanol, chloroformand water extracts of P. dulcis seeds incorporated in oleaginous ointment base were applied topically on shaveddenuded skin of albino rats and screened for hair growth activity. Petroleum ether extract showed consistent andsignificant increase in the length of hair (p<0.001) and also showed a good percentage of hair follicles in the anagenphase after histological studies. The total number of days taken to complete hair growth for petroleum ether was 24where as for methanol, water and chloroform extracts were 28, 29 and 30 respectively. From this study it can beconcluded that the seed extracts of P. dulcis exhibits a significant potency in promoting hair growth.
In vitro Antimicrobial Evaluation of Zingiber officinale, Curcuma longa and Alpinia galanga Extracts as Natural Food Preservatives
J. Anbu Jeba Sunilson,R. Suraj,G. Rejitha,K. Anandarajagopal
American Journal of Food Technology , 2009,
Abstract: In the present study, antimicrobial activity of various extracts of Zingiber officinale, Curcuma longa and Alpinia galanga were screened against the common food borne bacteria such as Escherichia coli, Salmonella enteriditis, Clostridium perfringens, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus and fungi such as Saccharomyces cerevisiae, Hansenula anomala, Mucor mucedo, Candida albicans using disc diffusion method. All the extracts showed significant antibacterial and antifungal properties. The methanol extracts (100 μg mL-1) revealed maximum zone of inhibition (p<0.001). Zingiber officinale and Curcuma longa possessed considerably greater activity than Alpinia galanga. These findings established the potential of the selected rhizomes of Zingiberaceae family as effective natural food preservatives.
Antidiarrhoeal activity of leaves of Melastoma malabathricum linn
Sunilson JAJ,Anandarajagopal K,Kumari AVAG,Mohan S
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.
Preliminary phytochemical and antiulcer studies of Hibiscus rosa sinensis Linn. root extracts
Anita Gnana Kumari A,Palavesam A,Anbu Jeba Sunilson J,Anandarajagopal K
International Journal of Green Pharmacy , 2010,
Abstract: The antiulcer activity of various extracts of Hibiscus rosa sinensis roots was evaluated in pyloric ligation induced gastric ulcer in albino rats. The root extracts were prepared by cold maceration process with petroleum ether, alcohol and water separately. The preliminary phytochemical screening of H. rosa sinensis revealed the presence of sterols, glycosides, proteins, mucilage and flavonoids. Oral administration of aqueous and alcohol extracts (250 and 500 mg/kg) of H. rosa sinensis roots were evaluated for antiulcer activity and compared with the standard drug, lansoperazole (8 mg/kg). From the results, it can be concluded that the aqueous extract of H. rosa sinensis roots (500 mg/kg) showed highly significant (P< 0.001) dose-dependent antiulcer activity. These results lend scientific support for the plant as folk medicine.
PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF CELOSIA CRISTATA LEAF EXTRACTS
Danabalan Rubini,Dharmalingam Sudhahar,Kalusalingam Anandarajagopal
International Research Journal of Pharmacy , 2012,
Abstract: Development of anthelmintics from medicinal plants might be served as an alternative source for the conventional anthelmintic drugs. The present study was attempted to assess the possible anthelmintic activity for chloroform, methanol and aqueous extract of Celosia cristata leaves. Two different concentrations (100 mg/ml and 200 mg/ml) of these extracts were used to determine the paralysis and mortality of earthworms, Pheretima posthuma and the results were compared with standard anthelmintic drug, albendazole (100 mg/ml and 200 mg/ml). Worms placed in both aqueous and methanol extracts of C. cristata showed significant paralysis and leads mortality in dose dependent manner. Chloroform extract showed no significant activity against the worms. The results revealed that the aqueous extract had higher significant anthelmintic activity than methanol extract. The preliminary phytochemical analysis on the extracts showed the presence of alkaloids, flavanoids, triterpenoids, phenolic compounds and tannins, which might be responsible for the anthelmintic activity.
SYNTHESIS, CHARACTERIZATION AND ANTICONVULSANT ACTIVITY OF SOME PYRAZOLE DERIVATIVES
Anandarajagopal Kalusalingam,Illavarasu Arumugamb,Rajamanickam Velayutham,Umarani Natarajan
Journal of Global Pharma Technology , 2011, DOI: 10.1234/jgpt.v3i3.357
Abstract: A several number of novel 4-(aryl/substituted aryl)-1-(unsubstituted/aryl/substituted aryl)-3-phenyl-1H-pyrazoles have been synthesized by the reaction of 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones and appropriate unsubstituted and substituted hydrazine in ethanol. 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones were synthesized by the bromination of 1-substituted phenyl-3-phenyl-prop-2-en-1-ones which were synthesized by the reaction of acetophenone with appropriate unsubstituted and substituted aromatic aldehyde. The synthesized compounds were confirmed by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The anticonvulsant activity of the synthesized compounds has indicated that all the compounds significantly reduce the electro shock induced convulsions, compared to phenytoin. The pharmacological evaluation may be concluded that the replacement of 1H position of pyrazole with phenyl and substituted phenyl increases the anticonvulsant activity.
Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia
Anbu Samuel, Anandarajagopal Kalusalingam, Dinesh Chellappan, Rejitha Gopinath, Suraj Radhamani, Hj Husain, Vignesh Muruganandham, Proom Promwichit
Journal of Ethnobiology and Ethnomedicine , 2010, DOI: 10.1186/1746-4269-6-5
Abstract: Sixteen informants ranging in age from 35 to 65 years were interviewed. A total of 62 species of plants used by Orang Asli are described in this study based on field surveys and direct face to face communication. These plants belonged to 36 families and are used to treat a wide range of discomforts and diseases.The results of this study showed that majority of the Orang Asli, of Kampung Bawong are still dependent on local plants as their primary source of medication. As the first ethnomedical study in this area, publishing this work is expected to open up more studies to identify and assess the pharmacological and toxicological action of the plants from this region.Preservation and recording of ethnobotanical and ethnomedical uses of traditional medicinal plants is an indispensable obligation for sustaining the medicinal and cultural resource of mankind. Extensive research on such traditional plants is of prime importance to scientifically validate their ethnomedical claims.The study of tribal knowledge of plants is an imperative facet of ethnomedical research. People healed themselves with traditional herbal medicines and ancient remedies from time immemorial [1,2]. Human beings have found remedies within their habitat, and have adopted different strategies depending upon the climatic, phyto-geographic and faunal characteristics, as well as upon the peculiar culture and socio-structural typologies [3]. Most of such information is passed on to the following generations by traditional healers through oral communication and discipleship practice [4]. Moreover, the World Health Organization (WHO) has reported that about 80% of the world population relies on traditional medicine to cure ailments [5,6]. Plants play a major role in the treatment of diseases and still remain the foremost alternative for a large majority of people [7-9]. This knowledge, if wisely utilized, could draw out promising herbal leads [10].Perak, (Fig. 1) (5.02 N latitude and 101.08 E longitude), i
The Constrained Mean-Semivariance Portfolio Optimization Problem with the Support of a Novel Multiobjective Evolutionary Algorithm  [PDF]
K. Liagkouras, K. Metaxiotis
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.67B005
Abstract:

The paper addresses the constrained mean-semivariance portfolio optimization problem with the support of a novel multi-objective evolutionary algorithm (n-MOEA). The use of semivariance as the risk quantification measure and the real world constraints imposed to the model make the problem difficult to be solved with exact methods. Thanks to the exploratory mechanism, n-MOEA concentrates the search effort where is needed more and provides a well formed efficient frontier with the solutions spread across the whole frontier. We also provide evidence for the robustness of the produced non-dominated solutions by carrying out, out-of-sample testing during both bull and bear market conditions on FTSE-100.

Design of a Cantilever - Type Rotating Bending Fatigue Testing Machine  [PDF]
K. K. Alaneme
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1011078
Abstract: This research is centered on the design of a low–cost cantilever loading rotating bending fatigue testing machine using locally sourced materials. The design principle was based on the adaptation of the technical theory of bending of elastic beams. Design drawings were produced and components/materials selections were based on functionality, durability, cost and local availability. The major parts of the machine: the machine main frame, the rotating shaft, the bearing and the bearing housing, the specimen clamping system, pulleys, speed counter, electric motor, and dead weights; were fabricated and then assembled following the design specifications. The machine performance was evaluated using test specimens which were machined in conformity with standard procedures. It was observed that the machine has the potentials of generating reliable bending stress – number of cycles data; and the cost of design (171,000 Naira) was lower in comparison to that of rotating bending machines from abroad. Also the machine has the advantages of ease of operation and maintenance, and is safe for use.
FROM THE BOLOGNA DECLARATION IDEAS TO THE CREATION OF COL-LECTIVE INTELLIGENCE В Д ДЕЙ БОЛОНСЬКОЙ ДЕКЛАРАЦ ДО РЕАЛ Й СТВОРЕННЯ КОЛЕКТИВНОГО НТЕЛЕКТУ
K. Метешк?н,Х. Раковський
Information Technologies and Learning Tools , 2010,
Abstract: The results of Bologna process are investigated. It is underlined that theoretical – methodological bases of the Bologna process have been poorly developed. A scheme for master’s education both on requirements of separate states, and on requirements of EU is offered. Досл джуються п дсумки Болонського процесу. П дкреслю ться, що слабко розроблен теоретико-методолог чн основи Болонського процесу. Пропону ться схема навчання маг стр в, як для потреб окремих держав, так для потреб С.
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