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The Impact of Social Factors on Economic Growth: Empirical Evidence for Romania and European Union Countries
Ana-Maria Popa
Romanian Journal of Fiscal Policy , 2012,
Abstract: This study analyzes the relationship between the social factors and the economic growth. A summary of social and economic environment is presented for Romania. As such, the paper analyzes the global evolution of social and economic environment over time and establishes a direct correlation between human development and economic welfare. An econometric model and a clustering model are tested for European Union countries. The results of the paper reveal the social factors that are positively correlated with the economic growth (i.e. the expected years of schooling and the life expectancy) and, respectively, the factors that are negatively correlated with the economic growth (i.e. the population at risk of poverty and the unemployment rate).
Evaluation of the Controlled Release Ability of Theophylline from Xanthan/Chondroitin Sulfate Hydrogels  [PDF]
Ana-Maria Oprea, Manuela-Tatiana Nistor, Lenuta Profire, Marcel Ionel Popa, Catalina Elena Lupusoru, Cornelia Vasile
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.42017
Abstract:

The xanthan/chondroitin sulfate (X/CS) hydrogels, obtained by a crosslinking technique, were evaluated in vitro and in vivo as matrices for theophylline release. The influence of pH of simulated physiological media on the X/CS swelling behaviour at 37°C was investigated. The hydrogels theophylline loading degree was evaluated by near infrared chemical imaging (NIR-CI) technique and confirmed also by FT-IR spectroscopy; the drug loading was about 77.5% based on PLS-DA prediction (Partial least squares-Discriminate Analysis). The release profiles of theophylline from X/CS hydrogels in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) depend on CS content. The release mechanisms were controlled by the drug solubility and ionic properties of the polymers. In vivo theophylline delivery was done by oral administration. Pharmacokinetic analysis revealed sustained-release characteristics for 50/50 X/CS theophylline-loaded formulation compared with raw theophylline which was rapidly absorbed, distributed and eliminated. A good in vitro-in vivo correlation was found.

Xenodiversity of decapod species (Crustaceea: Decapoda: Reptantia) from the Romanian waters
Ana-Maria Petrescu , Ana-Maria Krapal , Oana Paula Popa , Elena Iulia Iorgu , Luis Ovidiu Popa
Travaux du Muséum National d'Histoire Naturelle "Grigore Antipa" , 2010, DOI: 10.2478/v10191-010-0006-7
Abstract: This paper is a synthesis of the faunistic data present in the specialized literature on the alien decapod species identified in the Romanian fauna between 1951 and 2010: Orconectes limosus (Rafinesque, 1817), Callinectes sapidus Rathbun, 1896, Rhithropanopeus harrisii (Gould, 1841), Eriocheir sinensis H. Milne Edwards, 1853, Hemigrapsus sanguineus (de Haan, 1835), Palaemon macrodactylus Rathbun, 1902, Dyspanopeus sayi (Smith, 1869).
Isolation and Characterization of New Microsatellite Markers for the Invasive Softshell Clam, Mya arenaria (L.) (Bivalvia: Myidae)
Ana-Maria Krapal,Oana Paula Popa,Elena Iulia Iorgu,Marieta Costache,Luis Ovidiu Popa
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13022515
Abstract: The invasive softshell clam ( Mya arenaria Linnaeus, 1758) is native to the northwestern region of the Atlantic Ocean. This species has been introduced in the northeast Pacific and along the European coasts, due to intense naval transports and aquaculture, and it is now present in all the European seas. In this paper we describe seven new microsatellite loci for Mya arenaria. The isolated loci are polymorphic with a number of alleles per locus between 6 and 14. The observed and expected heterozygosities ranged from 0.417 to 0.951, and from 0.643 to 0.895, with an average of 0.716 and 0.775, respectively. These microsatellite markers should be useful in analyzing this species’ genetic diversity, which could explain various processes of its invasion history.
Cerebrovascular Disorders: Role of Aging
Aurel Popa-Wagner,Ana-Maria Buga,Ryan C. Turner,Charles L. Rosen
Journal of Aging Research , 2012, DOI: 10.1155/2012/128146
Abstract:
ROS and Brain Diseases: The Good, the Bad, and the Ugly
Aurel Popa-Wagner,Smaranda Mitran,Senthilkumar Sivanesan,Edwin Chang,Ana-Maria Buga
Oxidative Medicine and Cellular Longevity , 2013, DOI: 10.1155/2013/963520
Abstract: The brain is a major metabolizer of oxygen and yet has relatively feeble protective antioxidant mechanisms. This paper reviews the Janus-faced properties of reactive oxygen species. It will describe the positive aspects of moderately induced ROS but it will also outline recent research findings concerning the impact of oxidative and nitrooxidative stress on neuronal structure and function in neuropsychiatric diseases, including major depression. A common denominator of all neuropsychiatric diseases including schizophrenia and ADHD is an increased inflammatory response of the brain caused either by an exposure to proinflammatory agents during development or an accumulation of degenerated neurons, oxidized proteins, glycated products, or lipid peroxidation in the adult brain. Therefore, modulation of the prooxidant-antioxidant balance provides a therapeutic option which can be used to improve neuroprotection in response to oxidative stress. We also discuss the neuroprotective role of the nuclear factor erythroid 2-related factor (Nrf2) in the aged brain in response to oxidative stressors and nanoparticle-mediated delivery of ROS-scavenging drugs. The antioxidant therapy is a novel therapeutic strategy. However, the available drugs have pleiotropic actions and are not fully characterized in the clinic. Additional clinical trials are needed to assess the risks and benefits of antioxidant therapies for neuropsychiatric disorders. 1. Introduction The earth began its life without free oxygen in its atmosphere [1]. Oxygen accumulation is a consequence of the establishment and propagation of photosynthesizing archea and bacteria on this planet [2]. With the arrival of the world’s first de facto pollutant (i.e., oxygen), approximately 3 billion years ago there evolved organisms that reductively metabolized oxygen to produce ATP in mitochondria [3] (i.e., aerobic respiration). Mitochondrial energy metabolism yields several reactive oxygen species (ROS) including oxygen ions ( , the primary ROS), free radicals, and peroxides (inorganic and organic). The presence of ROS produced profound consequences for life on earth, both beneficial and deleterious. For example, a wealth of evidence suggests that high levels of ROS are intimately linked to the appearance of neuronal death in various neurological disorders. These include chronic diseases (Parkinson’s disease or Alzheimer’s disease) [4], acute injury of the brain (brain trauma and cerebral ischemia) [5, 6], or psychiatric disorders (autism, attention deficit hyperactivity disorder, depression, and schizophrenia)
Cerebrovascular Disorders: Role of Aging
Aurel Popa-Wagner,Ana-Maria Buga,Ryan C. Turner,Charles L. Rosen,Emil Toescu
Journal of Aging Research , 2012, DOI: 10.1155/2012/128146
Abstract:
Sinanodonta woodiana (Mollusca: Bivalvia: Unionidae): Isolation and Characterization of the First Microsatellite Markers
Oana Paula Popa,Luis Ovidiu Popa,Ana-Maria Krapal,Dumitru Murariu,Elena Iulia Iorgu,Marieta Costache
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12085255
Abstract: Sinanodonta woodiana (Lea, 1834) is a large Unionid species with a real invasion success. It colonized Europe, Central America, the Indonesian Islands and recently North America. The species life cycle involves a larval parasitic stage on freshwater fish species which contributes to the spread of the mussel. In this paper we describe, for the first time, eight polymorphic microsatellite loci for the species Sinanodonta woodiana. The genetic screening of individuals confirmed that all loci were highly polymorphic. The number of alleles per locus ranged from 7 to 14 and the observed heterozygosity ranged from 0.650 to 0.950. These loci should prove useful to study the species population genetics which could help to infer important aspects of the invasion process.
Repeated PTZ Treatment at 25-Day Intervals Leads to a Highly Efficient Accumulation of Doublecortin in the Dorsal Hippocampus of Rats
Ana-Maria Buga, Raluca Vintilescu, Adrian Tudor Balseanu, Oltin Tiberiu Pop, Costin Streba, Emil Toescu, Aurel Popa-Wagner
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039302
Abstract: Background Neurogenesis persists throughout life in the adult mammalian brain. Because neurogenesis can only be assessed in postmortem tissue, its functional significance remains undetermined, and identifying an in vivo correlate of neurogenesis has become an important goal. By studying pentylenetetrazole-induced brain stimulation in a rat model of kindling we accidentally discovered that 25±1 days periodic stimulation of Sprague-Dawley rats led to a highly efficient increase in seizure susceptibility. Methodology/Principal Findings By EEG, RT-PCR, western blotting and immunohistochemistry, we show that repeated convulsive seizures with a periodicity of 25±1 days led to an enrichment of newly generated neurons, that were BrdU-positive in the dentate gyrus at day 25±1 post-seizure. At the same time, there was a massive increase in the number of neurons expressing the migratory marker, doublecortin, at the boundary between the granule cell layer and the polymorphic layer in the dorsal hippocampus. Some of these migrating neurons were also positive for NeuN, a marker for adult neurons. Conclusion/Significance Our results suggest that the increased susceptibility to seizure at day 25±1 post-treatment is coincident with a critical time required for newborn neurons to differentiate and integrate into the existing hippocampal network, and outlines the importance of the dorsal hippocampus for seizure-related neurogenesis. This model can be used as an in vivo correlate of neurogenesis to study basic questions related to neurogenesis and to the neurogenic mechanisms that contribute to the development of epilepsy.
La construction discursive de la signification : le point de vue argumentatif
Ana-Maria Cozma
Synergies Roumanie , 2010,
Abstract: Résumé : Le discours joue un r le central dans les théories sémantiques de l’argumentation, la signification lexicale étant fonction des discours argumentatifs auxquels elle impose des contraintes. En nous appuyant sur deux théories issues de l’argumentation dans la langue, la Théorie des Blocs Sémantiques et la Théorie des Possibles Argumentatifs, nous confronterons la manière dont le discours est intégré dans la théorie sémantique. Nous montrerons que les variations en la matière sont inséparables des objectifs que se donnent les deux théories : pour l’une, rendre compte des contraintes sémantiques imposées par la langue même au discours et, pour l’autre, rendre compte de la manière dont les significations de la langue permettent de construire des représentations à travers les discours.Abstract : Discourse plays a central role in the semantic theories of argumentation, as lexical meaning is determined according to the argumentative discourses it constrains. Based on Semantic Blocs Theory and Argumentative Probabilities Semantics, both closely related to the argumentation within language theory, I examine the way discourse is integrated into semantic theory. I show that variations on this matter must be considered with respect to the aims these theories express, and that the first one is concerned with the semantic constraints that language imposes on discourse, while the second one aims to explain the way linguistic meaning allows to construct representations through discourse.
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