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Search Results: 1 - 10 of 489427 matches for " Ana María; Hevia "
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Síndrome de Lynch: Caracterización genético clínica. Caso clínico Hereditary non-polyposis colorectal cancer: Report of four siblings
Alejandro Zárate,Karin álvarez,Ana María Wielandt,Montserrat Hevia
Revista médica de Chile , 2008,
Abstract: Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch Syndrome is an autosomic dominant syndrome involving 596-1096 of colorectal cancer patients. Mutations in MLH1 and MSH2 genes account for most cases. These two genes particípate in the DNA mismatch repair pathway. Therefore mutation carriers show microsatellite instability (MSI) in tumors. This syndrome is characterized by the early development of colorectal cancer (before 50 years) and an increased incidence of cancer in other organs. We report four siblings from a family diagnosed with HNPCC. All of them were subjected to colonic surgery for colorectal cancer Moreover, one patient developed an ampulloma after her colon surgery. The molecular-genetic analysis revealed three brothers with microsatellite instability in the tumor tissue, the absence of the MLH1 protein, and the presence of a germ Une mutation localized in introm 15 ofthe MLH1 gene
Síndrome de Lynch: Caracterización genético clínica. Caso clínico
Zárate,Alejandro; álvarez,Karin; Wielandt,Ana María; Hevia,Montserrat; De la Fuente,Marjorie; Carvallo,Pilar; López-K?stner,Francisco;
Revista médica de Chile , 2008, DOI: 10.4067/S0034-98872008000600011
Abstract: hereditary non-polyposis colorectal cancer (hnpcc) or lynch syndrome is an autosomic dominant syndrome involving 596-1096 of colorectal cancer patients. mutations in mlh1 and msh2 genes account for most cases. these two genes particípate in the dna mismatch repair pathway. therefore mutation carriers show microsatellite instability (msi) in tumors. this syndrome is characterized by the early development of colorectal cancer (before 50 years) and an increased incidence of cancer in other organs. we report four siblings from a family diagnosed with hnpcc. all of them were subjected to colonic surgery for colorectal cancer moreover, one patient developed an ampulloma after her colon surgery. the molecular-genetic analysis revealed three brothers with microsatellite instability in the tumor tissue, the absence of the mlh1 protein, and the presence of a germ une mutation localized in introm 15 ofthe mlh1 gene
Trasplante renal en pediatría: una década de experiencia multicéntrica
Cano Sch.,Francisco; Rosati M.,a; Pinto S.,Viola; Quiero,Ximena; Lagos R.,Elizabeth; Delucchi B.,Angela; Hevia A.,Pilar; Salas del C.,Paulina; Rodríguez S.,Eugenio; Ramírez P.,Katica; María Lillo,Ana;
Revista chilena de pediatría , 2001, DOI: 10.4067/S0370-41062001000600004
Abstract: paedriatric renal transplant is the treatment of choice in chronic renal failure (crf), in that it permits the recuperation to differing degrees the severe consequences of uraemia, especially in terms of growth retardation. objective: to evaluate the results of renal transplantation in 3 hospital centers during a 10 year period (1989-99). patients and methods: a retrospective study using a standard protocol carried out in the hospitals exequiel gonzález cortés, luis calvo mackenna and san juan de dios between july 1989 and july 1999. 3 types of variables were analyzed; 1) demographic description, 2) growth between birth and the last year of follow-up, and 3) transplant related factors, especially immunosuppression, transplant complications and graft function during annual periods. continuous variables were expressed as mean + sd, growth as z score, renal function as 1/plasma creatinine, and together with the analysis of acute rejection in relation to live or cadaveric donor, were analyzed using pearson′s chi-squared. renal function with regards to warm or cold ischaemia was evaluated using student′s t-test, while kaplan-meier curves were used in the analysis of survival at 1,3, and 5 years both for patients and grafts. in all the tests a p value < 0.05 was considered significant. results: 98 transplants were carried out on 92 patients, aged 10.9 + 3.2 years, range 2-17, the 3 most important causes of crf were reflux nephropathy, renal dis- or hypoplasia and chronic glomerulonephritis. growth showed a fall from a z of -0.6 at birth, to -2.14 at the beginning of dialysis (p < 0.05) to -2.57 at the moment of transplant (p < 0.05). at 3 and 5yrs post transplant the z values were -2.38 and -2.93 respectively. actuarial patient survival rates at 1, 3 and 5yrs were 97.8, 95.2 and 92.6 for live donors and 92.6, 92.6, and 92.6 for cadaveric donors respectively. graft survival for live donors was 89, 78 and 71% and cadaveric donors 84, 76 and 70% during the same time interval
Actualización en el diagnóstico y manejo de la Infección Urinaria en pediatría
Salas del C,Paulina; Barrera B,Patricia; González C,Claudia; Zambrano O,Pedro; Salgado D,Ignacio; Quiroz,Lily; Lillo D,Ana María; Hevia J,Pilar; Cavagnaro SM,Felipe;
Revista chilena de pediatría , 2012, DOI: 10.4067/S0370-41062012000300009
Abstract: urinary tract infection (uti) is a common infectious disease in children. traditionally uti has been considered as a marker of underlying anatomical or functional urological abnormalities. in the last decades all children with febrile uti were recommended to undergo imagenological studies looking for renal scarring or urinary tract abnormalities. the goal of this article it is to update the concepts of febrile uti studies, treatments and follow-up. the imagenological studies are unpleasant for children and distressing for their parents. current data do not provide enough evidence about the effectiveness of broad studies in uti, therefore physicians should be more selective in order to find out patients who requiere surgical or medical intervention. these recommendations are based on nice guidelines and support the concept that one of the most important issues to avoid renal damage is a prompt diagnosis and effective treatment.
Ciudad: espacios y flujos
Antonio Elizalde Hevia,María Emilia Tijoux
Polis : Revista de la Universidad Bolivariana , 2008,
Abstract:
El UNICEF en Cuba: necesidades de información y política de servicios
Nú?ez Paula,Israel; Alcalde Hevia,María Eugenia;
ACIMED , 1999,
Abstract: this papers is a synthesis of a research conducted to determine and register with precision the universe of potential users from the documentation center of the unicef?s office in cuba with an adequate segmentation of its real groups and service priorities (differential services policy), and to methodologically design the investigation of the specific information nedds of each priority segment, according to the resources available to this purspose. every variable, source, technique or instrument, every segmentation or priority criterion is carefully based on research so that the methodology may be applied, step by step, to another information entity, and to take it as a basis together with the "metodological guide for the study of needs" by israel nu?ez. the paper is included, as a particular case, in a series of investigations made within the communication management area among the users and customers of the information entities and systems. the conclusions may be applied to the case of the information entities of the national offices of international bodies or organizations. this specific case of the unicef is considered of great importance. its present projection is also described in this analysis.
Valor nutricional de las harinas de clitoria ternatea y brachiaria humidicola en la alimentación de pollos de engorde
Monforte,Juana; Carías,Diamela; Cioccia,Anna María; Hevia,Patricio;
Interciencia , 2002,
Abstract: considering the possibility of partial replacement of imported soybean and maize flours in chicken feed, clitoria ternatea and brachiaria humidicola were nutritionally evaluated. sun-dried leaves were chemically analyzed and a biological assay was performed on chickens that consumed, from day 1 after birth, isocaloric and isoproteic diets with 15% clitoria or brachiaria added to a comercial chicken starter. protein content and metabolizable energy of clitoria were higher and its fiber content lower than brachiaria. although clitoria showed better nutritional potential, results showed that 15% brachiaria can be substituted in the control diet without affecting feed consumption and efficiency, growth, protein utilization and metabolizable energy, while 15% clitoria substitution reduced consumption and growth, affecting the studied parameters. additionally, the incorporation of either leafage was associated to an increaed yellow pigmentation in chicken legs, peaks and grease. the results indicate that brachiaria can be incorporated as partial substitute in raw materials for comercial chicken feed. in the case of clitoria lower substitution percentages are recommended.
Efecto de un incremento en la diuresis sobre la absorción y retención de algunos nutrientes en ratas
Monsalve,Cecilia; Carías,Diamela; Cioccia,Anna María; Hevia,Patricio;
Acta bioqu?-mica cl?-nica latinoamericana , 2007,
Abstract: previous studies have shown that, in rats, the administration of the diuretic furosemide increases diuresis as well as urinary loss of electrolytes and essential nutrients. this loss has a negative effect on electrolytes and nutrient reserves. since one alternative to help protect these reserves is to increase intestinal absorption, the purpose of this study was to evaluate the absorption, urinary loss and tissue reserves of nitrogen, calcium, magnesium, sodium, potassium and zinc in rats offered 0, 0.5, 1.0 and 1.5 mg furosemide per g diet, daily during 23 days. the diuretic caused a dose dependent polyuria, a reduction in food intake, growth and feed efficiency. in addition, those rats had increased urinary loss of nitrogen and minerals. nitrogen, calcium and zinc absorption were not affected, but magnesium, sodium and potassium increased slightly. intestinal absorption could not compensate for urinary loss. in general, this study showed that in rats, this diuretic had a negative effect on nutritional status caused by a reduction in food intake and also in the utilization of the nutrients consumed. the reduction in nutrient utilization associated with this diuretic may be partly explained by a poor nutrient retention by the kidney which was not compensated by an increase in intestinal absorption.
Effecto de la diarrea inducida con lactosa sobre la disponibilida de los macronutrientes y la función inmune en ratas nutridas y desnutridas
Arciniegas,Esther Linda; Cioccia,Anna María; Hevia,Patricio;
Archivos Latinoamericanos de Nutrición , 2000,
Abstract: effect oflactose induced diarrhea on macronutrients digestibility and immune function in well-nourished a undernourished rats. in this study we compared the availability nutrients in a balanced diet offered to young well-nourished and undemourished sprague dawley rats, with and without diarrhea. malnutrition was induced by restricting food intake (50%) in on half of the rats for 2 weeks and diarrhea was induced by including 45% lactose in the diet after malnutrition had been established. during the experiment which lasted 8 d the animals were kept on the same feeding protocol but one half of the nourished and one half of undernourished received lactose to induce diarrhea. the results showed that the inclusion of lactose at 45% in the diet caused a severe diarrhea both in the nourished and undernourished rats. this diarrhea however, resulted in a reduction in food intake and growth only in well-nourished rats. in the rats with diarrhea the apparent digestibility of the diet and of its macronutrients decreased compared with the animals without diarrhea but this reduction was less apparent in undemourished rats. similar results were obtained in relation to the retention of nitrogen and energy. in this case, diarrhea was associated with retentions which were lower than those seen in the rats without diarrhea but the undemourished rats with diarrhea retained more energy than the well-nourished rats with diarrhea. malnutrition resulted in lower packed cell volume, leukocyte count and thyms weight but diarrhea in the malnourished rats did not cause a further reduction in these variables as it did in the well-nourished animals. in general, these results indicate that in well-nourished rats, diarrhea had a negative effect whereas in the undemourished group it did not. it appears that the undemourished rats compensated their nutrient utilization so that diarrhea did not worsen their undernourished condition.
Efecto de un incremento en la diuresis sobre la absorción y retención de algunos nutrientes en ratas Effect of an increase in diuresis on absorption and retention of some nutrients in rats
Cecilia Monsalve,Diamela Carías,Anna María Cioccia,Patricio Hevia
Acta bioqu?-mica cl?-nica latinoamericana , 2007,
Abstract: Estudios previos en ratas han demostrado que la administración del diurético furosemida aumenta la pérdida urinaria de electrolitos y nutrientes, causando un efecto negativo sobre las reservas de los mismos. Una alternativa para proteger esas reservas es incrementar la absorción intestinal. Así, se evaluó la absorción, pérdidas urinarias y reservas corporales de nitrógeno, calcio, magnesio, sodio, potasio y cinc, en cuatro grupos de ratas: control, y tres grupos experimentales que consumieron furosemida en concentraciones de 0,5; 1,0 y 1,5 mg/g de dieta, durante 23 días. El diurético causó poliuria dosis dependiente, disminución en el consumo de alimento, la eficiencia y el crecimiento. También, provocó un aumento en las pérdidas urinarias del nitrógeno y minerales. La absorción de nitrógeno, calcio y cinc no se modificó, mientras que la del magnesio, sodio y potasio aumentó ligeramente. Se determinó que la absorción no compensó las pérdidas urinarias. Así, la furosemida afectó negativamente la retención de nutrientes y electrolitos, provocando una reducción en las reservas corporales de los mismos. Este diurético tiene un efecto negativo sobre el estado nutricional en ratas, causado por la reducción en el consumo de alimento, así como en la utilización de los nutrientes consumidos. La reducción en la utilización de los nutrientes asociada con este diurético, puede ser explicada en parte, por una pobre retención de nutrientes por el ri ón, que no puede ser compensada por un incremento en la absorción intestinal. Previous studies have shown that, in rats, the administration of the diuretic furosemide increases diuresis as well as urinary loss of electrolytes and essential nutrients. This loss has a negative effect on electrolytes and nutrient reserves. Since one alternative to help protect these reserves is to increase intestinal absorption, the purpose of this study was to evaluate the absorption, urinary loss and tissue reserves of nitrogen, calcium, magnesium, sodium, potassium and zinc in rats offered 0, 0.5, 1.0 and 1.5 mg furosemide per g diet, daily during 23 days. The diuretic caused a dose dependent polyuria, a reduction in food intake, growth and feed efficiency. In addition, those rats had increased urinary loss of nitrogen and minerals. Nitrogen, calcium and zinc absorption were not affected, but magnesium, sodium and potassium increased slightly. Intestinal absorption could not compensate for urinary loss. In general, this study showed that in rats, this diuretic had a negative effect on nutritional status caused by a reduction in food intak
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