oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

4 ( 1 )

2019 ( 169 )

2018 ( 329 )

2017 ( 320 )

Custom range...

Search Results: 1 - 10 of 248704 matches for " Ana C.; Salcedo-Cifuentes "
All listed articles are free for downloading (OA Articles)
Page 1 /248704
Display every page Item
Violencia sexual en jóvenes de 10 a 19 a?os. Cali, 2001-2006
Restrepo-Gutiérrez,Ana C.; Salcedo-Cifuentes,Mercedes; Bermúdez-Escobar,Amparo;
Revista de Salud Pública , 2009, DOI: 10.1590/S0124-00642009000600005
Abstract: objective characterising sexual violence reported by youngsters aged 10 to 19 in cali between 2001 and 2006. components and methods young people aged 10 to 19 who had been referred to a forensic clinic by a competent authority between 2001 and 2006 were defined as being presumed victims of sexual crimes. variables of time, place and personsubjected to sexual crime committed by a family member (intrafamily), an acquaintance or unknown public individual (extrafamily) were compared. there were 661 cases of presumed victims of sexual abuse from both sexes in the age-range being studied. the information was taken from the forensic clinic's patient records. chi square and relative risk were used in the statistical analysis of the data so collected concerning frequency for presumed sexual victims aged 10 to 19 and analysing the relationships between variables. results 83 % of the cases in the study were female, 78 % were students and more than 50 % were 15 year-old minors. the aggressors were known in 78 % of the cases. a significant association was found between involvement with the aggressor and the place where the incident occurred with a victim's age. conclusions the characteristics of sexual violence occurring in adolescents were constant and comparable with historical studies where family dynamics and organisation made such scene opportune for this type of violent act to be perpetrated.
Epidemiología genómica y paraparesia espástica tropical asociada a la infección por el virus linfotrópico humano de células T tipo 1
Salcedo-Cifuentes,Mercedes; Domínguez,Martha C; García-Vallejo,Felipe;
Revista Panamericana de Salud Pública , 2011, DOI: 10.1590/S1020-49892011001100004
Abstract: objective: characterize the genomic environment of the sequences adjacent to human t-cell lymphotropic virus type 1 (htlv-1) in patients with htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp) in different regions of colombia and japan. methods: a total of 71 recombinant clones with human genome sequences adjacent to 5' ltr in patients with ham/tsp were compared to the genome browser and genbank databases. sixteen structural and compositional genome variables were identified, and statistical analysis was conducted in the r computer program, version 2.8.1, in a 0.5 mb window. results: a total of 43.0% of the proviruses were located in the group c chromosomes; 74% of the sequences were located in the telomeric and subtelomeric regions (p < 0.05). a cluster analysis was used to establish the hierarchical relations between the genome characteristics included in the study. the analysis of principal components identified the components that defined the preferred genome environments for proviral integration in cases of ham/tsp. conclusions: htlv-1 was integrated more often in chromatin regions rich in cpg islands with a high density of genes and line type repetitions, and dna transposons which, overall, would form the genomic environments targeted for integration. this new scenario will promote substantial changes in the field of public health and in epidemiological management of infectious diseases. it will also foster the development of powerful tools for increasing the efficiency of epidemiological surveillance
Expansión clónica y caracterización genómica del proceso de integración del virus linfotrópico humano tipo I en la leucemia/linfoma de células T en adultos
Salcedo-Cifuentes,Mercedes; Cabrera,Jesús; Cuesta-Astroz,Yesid; Carrascal,Edwin; Eizuru,Yoshito; Domínguez,Martha C; Sánchez,Adalberto; García-Vallejo,Felipe;
Biomédica , 2009,
Abstract: introduction. although the integration of human t-cell lymphotropic virus type i into the t-cells is not a random process, the mechanistic details are not understood. objectives. the characteristics of the flanking host chromatin were evaluated at the integration sites in adult t-cell leukaemia/lymphoma (atll) patients infected with the virus. materials and methods. from seven leukemic colombian patients positive for the human t-cell lymphotropic virus type i (htlv-i), lymphocyte dna samples were extracted and amplified by inverse polymerase chain reaction (ipcr). clonal expansion and human genome nucleotide composition in an extension of 50 bp was determined. to establish the characteristics of the human genome flanking provirus, 61 ipcr sequences from colombian and japanese atll patients, were analyzed in silico to obtain insights about the genomic structure, functions and nature of associated chromatin. results. the clonal expansion of cell clones was predominantly oligoclonal. from 61 ipcr sequences, 155 alignments with homology higher than 95% (e-value <0.05) were screened. seventy-five percent of those sequences corresponded to non coding elements that include repetitive and non-repetitive dna. fifty percent of the proviral integrations were associated with chromosomes of a and b groups. viral dna integration tended to favor exons of genes that replicated early, controlled the cell cycle, or were involved in signal transduction. conclusions. the results indicated that htlv-i integration was preferentially directed towards genomic environments with high c:g content, and toward genes that replicate early, regulate cell cycle or involved with signal transduction.
Epidemiología y bioinformática en el estudio de la Leucemia Linfoma de Células T del Adulto asociada a la infección con VLHT-1
Salcedo-Cifuentes,Mercedes; Restrepo,Oscar; García-Vallejo,Felipe;
Revista de Salud Pública , 2011, DOI: 10.1590/S0124-00642011000100011
Abstract: objectives establishing a correlation between the number of htlv-1 provirus and the characteristics of the genomic environment in atl cases. methodology a systematic search was made of publications as well as a meta-analysis of the pertinent literature considering proviruses per chromosome and structural and functional characteristics of flanking chromatin regions as variables. the concordance of experts' study was evaluated by spearman rho correlation. publication bias was analysed by funnel plot and the egger statisgrapher. a fixed effects model was applied according to heterogeneity evaluation to combine the results of integration occurring in coding sequences as well as coding sequences according to their molecular function. results the expert concepts' kappa index was 0.7 and no publication bias was observed. the meta-analysis result was homogeneous (p>0.05). htlv-1 integration was directed towards several chromosomes' telomeric and subtelomeric regions. the combination of published results in the articles which were analysed supported the hypothesis of integration events being site-directed towards coding regions of the human genome (p<0.05). moreover, the groups of genes having enzymatic and receptor functions was statistically significant. conclusion the results led to concluding that htlv-i integration in the atll cases analysed here was not random but was directed towards regulatory regions. such results could help to explain the role of some processes involved in leukemogenesis.
Expansión clónica y caracterización genómica del proceso de integración del virus linfotrópico humano tipo I en la leucemia/linfoma de células T en adultos Clonal expansion and genomic characterization of the human T-cell lymphotropic virus type I during the integration process in adult T-cell leukemia/lymphoma
Mercedes Salcedo-Cifuentes,Jesús Cabrera,Yesid Cuesta-Astroz,Edwin Carrascal
Biomédica , 2009,
Abstract: Introducción. Aunque la integración del virus linfotrópico humano tipo I no es al azar, se desconocen muchos de los detalles de este proceso. Objetivo. Evaluar las características de la cromatina celular adyacente a secuencias provirales en pacientes con leucemia/linfoma de células T en adultos asociada al virus. Materiales y métodos. Se extrajo el ADN de biopsias de siete pacientes colombianos con leucemia/linfoma de células T en adultos y positivos para el virus linfotrópico humano tipo I. éste se amplificó mediante reacción inversa en cadena de la polimerasa, para determinar el grado de expansión clónica y su composición de nucleótidos. A partir de 61 secuencias de ADN humano adyacentes a provirus, provenientes de pacientes leucémicos colombianos y japoneses, se efectuó un análisis in silico para obtener datos sobre su integración, las características de la cromatina y sus funciones asociadas. Resultados. La expansión de clones celulares fue predominantemente oligoclónica. De las 61 secuencias de ADN adyacente a provirus, se seleccionaron 155 alineamientos que cumplieron con los criterios de inclusión (homologías≥95%, e-value≤0,05). De éstos, 74,84% fueron secuencias no codificantes repetidas y no repetidas. El 45,95% de las integraciones provirales se localizó en los cromosomas de los grupos A y B. Se observaron tendencias de integración hacia exones de genes que se replican tempranamente, regulan el ciclo celular y participan en la transducción de se ales. Conclusiones. Los resultados permiten postular que la integración del virus linfotrópico humano tipo I se dirigiría hacia un ambiente genómico caracterizado por elevado contenido de C:G, genes de replicación temprana que regularían el ciclo celular y la transducción de se ales. Introduction. Although the integration of human T-cell lymphotropic virus type I into the T-cells is not a random process, the mechanistic details are not understood. Objectives. The characteristics of the flanking host chromatin were evaluated at the integration sites in adult T-cell leukaemia/lymphoma (ATLL) patients infected with the virus. Materials and methods. From seven leukemic Colombian patients positive for the human T-cell lymphotropic virus type I (HTLV-I), lymphocyte DNA samples were extracted and amplified by inverse polymerase chain reaction (IPCR). Clonal expansion and human genome nucleotide composition in an extension of 50 bp was determined. To establish the characteristics of the human genome flanking provirus, 61 IPCR sequences from Colombian and Japanese ATLL patients, were analyzed in silico to obtain
CONCESIóN DEL MONOPOLIO DE JUEGOS DE APUESTAS Y AZAR EN EL VALLE DEL CAUCA
ALONSO CIFUENTES,JULIO CéSAR; GALLEGO LONDO?O,ANA ISABEL;
Estudios Gerenciales , 2010,
Abstract: "beneficencia del valledel cauca " is a state-owned enterprise in charge of exploiting the gambling monopoly in the state. beneficencia del valledel cauca hired the consulting services of cienfi at universidad icesi to conduct a market study and prepare a marketing plan that would serve as basis for bidding for concessions for exploiting the monopoly of the smallbets game in five different zones in valle del cauca state. one of the most important results of this study is the projection of small-bets game?s sales based, among other aspects, on a central tendency measure of the investment per person in a year. this case presents decision-making problem associated with the selection of a central tendency measure and the implications of that decision
PRIMERA APROXIMACIóN A LA CARACTERIZACIóN Y MEDICIóN DE LAS INDUSTRIAS CULTURALES EN CALI
ALONSO CIFUENTES,JULIO CéSAR; GALLEGO LONDO?O,ANA ISABEL;
Estudios Gerenciales , 2011,
Abstract: this document presents a summary of the results of the characterization and measurement of cultural industries in cali. it also describes the situation of these industries in this city and proposes goals and actors necessary in order for the industry to thrive as a driver of economic development. it was found that cultural industries account for around 1,0% of the city?s gdp and generate 2,7% of all employment. it is a sector with high levels of informality, low levels of exports, and high volatility of production. until recently, this sector lacked public policies oriented towards fostering development.
PRIMERA APROXIMACIóN A LA CARACTERIZACIóN Y MEDICIóN DE LAS INDUSTRIAS CULTURALES EN CALI
JULIO CéSAR ALONSO CIFUENTES,ANA ISABEL GALLEGO LONDO?O
Estudios Gerenciales , 2011,
Abstract: En este documento se presentan los resultados de la caracterización y medición de las industrias culturales de Cali. Así mismo, se describe el panorama de estas industrias en la ciudad y se planteanlos retos y actores necesarios para el florecimiento de la industria como motor de desarrollo del municipio. Se estima que la industria cultural pesa alrededor del 1,0% en el PIB y 2,7% en el empleo de la ciudad. Se encuentra que es un sector con altos niveles de informalidad de la empresa y del empleo, con bajos niveles de exportación y alta volatilidad en la producción y, hasta hace poco, el sector carecía por completo de políticas públicas orientadas a su desarrollo.
CONCESIóN DEL MONOPOLIO DE JUEGOS DE APUESTAS Y AZAR EN EL VALLE DEL CAUCA
JULIO CéSAR ALONSO CIFUENTES,ANA ISABEL GALLEGO LONDO?O
Estudios Gerenciales , 2010,
Abstract: La Beneficencia del Valle del Cauca (Colombia) contrató con el CIENFI de la Universidad Icesi una consultoría que serviría como base para la licitación por la concesión de las apuestas permanentes en cinco zonas del Valle del Cauca. Uno de los resultados fundamentales del estudio era la proyección de las ventas brutas, que se basa, entre otras cosas, en una medida de tendencia central de la inversión en apuestas permanentes (chance de aquí en adelante) por persona en el a o. En el caso se presenta información relevante para la toma de decisión sobre la medida de tendencia central pertinente para la proyección de las ventas de chance y por lo tanto del valor de la concesión.
Modelación molecular y variación estructural de las integrasas de dos retrovirus humanos: HTLV-I y VIH-1
García Vallejo,Felipe; Cuesta Astroz,Yesid; Domínguez,Martha C; Sánchez,Adalberto; Salcedo Cifuentes,Mercedes; Díaz,Diane María; Quintana,Milton;
Revista Salud Uninorte , 2009,
Abstract: objective: to analyze the molecular characteristics and amino acid sequence variations of htlv-i and of hiv-1 integrases and their population variants. materials adn methods: data mining and analysis of integrase sequences and protein structure data bases by using appropriate software for modelling and search for polymorphic substitutions in htlv-i and hiv-1 integrase amino acid sequences previously reported. results: htlv-i and hiv-1 integrases are proteins of 288 amino acid residues. structural modeling of tertiary folding of htlv-i integrase catalytic central domain’s, showed closed structural characteristic with those of hiv-1, asv and rsv. from 103 full amino acid sequences of hiv-1 integrase, 53 substitutions located in 46 different codons were recorded. the more frequents correspond to n27g (32,1%), l101i (31,1%), a265v (30,1%) and t123a (27,0%). none of these frequent substitutions introduced changes in the folding of hiv-1 native integrase. conclusion: the tridimensional structure of central catalytic domain would influence the integrase activity and its relationship with potentially inhibitory molecules. those observed amino acid substitutions were neutral and do not alter the native protein structure. our data confirm those previously published, and enable us to propose that in is a new and promissory target for develop more effective antiviral therapies in the xxi century.
Page 1 /248704
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.