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Search Results: 1 - 10 of 417421 matches for " Ana Belén Hernández López "
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Statins and Sepsis Literature Review  [PDF]
Alicia Hernández Torres, Ana Belén Hernández Cascales, Pedro Pujante Alarcón, Alfonso López Ruiz, María Dolores Hellín Gil, María ángeles Ibá?ez Gil
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.48082
Abstract: Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infection-related complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outcomes of patients admitted to the hospital and having an infection and/or sepsis, principally in terms of intensive care unit admissions and related death.
Review: Surgical Treatment of Type 2 Diabetes  [PDF]
María Dolores Hellín Gil, Pedro Pujante Alarcón, Alfonso López Ruiz, María ángeles Iba?ez, Alicia Hernández Torres, Ana Belén Hernández Cascales
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.51005
Abstract:

In the last decades we have witnessed a significant increase in the incidence of type 2 diabetes mellitus, and obesity in parallel. So 90% of patients with Diabetes Mellitus type 2 (DM2) are obese. Changes in lifestyle (diet and exercise), behavioral therapies or the use of certain anti-obesity drugs have shown a limited effect and are not maintained over time. Currently, bariatric surgery is the most effective anti-obesity treatment, which is durable and resolves associated comorbidities. The surgical treatment of obesity for the modification of the anatomy of the digestive system is to produce gastric capacity constraints alone or associate with varying degrees of intestinal malabsorption and reduce body weight, improve and maintain the comorbidities associated weight loss by reduced food intake alone or in combination with malabsorption of this. The development of these surgical techniques has occurred in stages. With these techniques, setting to bariatric surgery is an effective, safe and proven procedure for the treatment of obesity and its complications especially DM2, as their post surgery referral mechanisms provide us with information for potential therapeutic treatment aimed at optimizing the control DM2 patients metabolic obese. In this review, we expose the evidence in treatment of DM2 with bariatric surgery and the actual hypothesis

Hypertension Unusual Cause  [PDF]
Ana Belén Hernández Cascales, Alicia Hernández Torres, María ángeles Ibá?ez Gil, Pedro Pujante Alarcón, Alfonso López Ruiz, María Dolores Hellín Gil, Juan Mayor Barrancos
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.51001
Abstract:


We expose a case of a woman with hypertension and hypokalemia. The differential diagnosis should include primary hyperaldosteronism, diuretics or lazantes intake, secondary hyperaldosteronism. In this patient, additional tests performed show no cause of hormonal disruption and the whole picture is due to a high intake of licorice. Glycyrrhetinic acid, the active component of licorice, inhibits renal IIbeta-hydroxisteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors. Licorice ingestion should be considered in the differential diagnosis of hypertension with hypokalemia.


Pleiotropic Effects of GLP-1. Cardiovascular Evidence of Effectiveness  [PDF]
Pedro Pujante Alarcón, Ana Belén Hernández Cascales, Alfonso López Ruiz, María ángeles Iba?ez Gil, Alicia Hernández Torres, María Dolores Hellín Gil
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.49091
Abstract:

Patients with diabetes are characterized by the development of cardiovascular complications: nephropathy, retinopathy, neuropathy, ischemia or hypertensive etc. Therefore, the cardiovascular involvement is the leading cause of death in patients with Diabetes Mellitus type 2 (DM2). Despite intensive treatment on classical factors of cardiovascular disease (blood pressure levels, LDL cholesterol, etc.), patients with diabetes have a high number of cardiovascular events and the onset and prognosis of these are related to glycemic control parameters, glycosylated hemoglobin (HbA1c). On the other hand, the question of the cardiovascular protective effect of some hypoglycemic treatments has been raised, asking what he has done to know more accurately about the safety and cardiovascular effects of the treatments we have today. The two most important incretin hormones are GIP (gastric inhibitory polypeptide) and GLP-1 (glucagon-like peptide-1). Treatment based on GLP-1 is a novel weapon in T2DM that achieves a reduction in HbA1c with other metabolic effects: weight loss and extra effect in dyslipidemia and blood pressure. In the last years other beneficial actions such a protector effect against myocardium ischemia and other actions in basals were reported. In this article we will try to explain the evidence of

Morbid Obesity in Diabetes Mellitus Type 2 and Exenatide  [PDF]
María Angeles Iba?ez Gil, Alfonso López Ruiz, Alicia Hernández Torres, Ana Belén Hernández Cascales, Pedro Pujante Alarcon, María Dolores Hellín Gil
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.52020
Abstract:

Worldwide, the prevalence of diabetes and obesity is increasing in recent years in developed countries. The first step of treatment is changes in lifestyle and in case of failure to initiate drug treatment. In our case, the patient with morbid obesity and glucose intolerance to metformin therapy was initiated without achieving weight loss and loss of glycemic control after 6 months of treatment. It was decided to add exenatide as an alternative to bariatric surgery. At the end of the study (12 months), it showed a weight reduction of 20.8% (Table 1), 20.83% BMI, glycosylated hemoglobin decrease of 2 points, and improved the lipid profile. So exenatide may be an acceptable option in the use of patient profile. It would be necessary to seek a new alternative treatment with minimal side effects and less healthcare costs.

Nursing care plan standardized breastfeeding
Susana de la Flor Picado,Ana Belén Hernández López
NURE Investigación , 2013,
Abstract: The superiority of human milk in feeding the human infant is incontestable. Breastmilk is a living food can′t be copied and is supported by numerous arguments in support of excellence, both biological and anthropometric or economic. Despite it, has been a significant decline in this practice. Scientific advances, sociological changes and the lack f health personnel have contributed to this expense. Currently, both the WHO and UNICEF cone try relaunching excusive breastfeeding as feeding the infant until 6 months of life. Initiatives whit the Baby Friendly Hospital or the Strategic Plan for the Protection, Promotion and Support of Breastfeeding trying to promote the recognition of breastfeeding as irrefutable cornerstone for optimal growth and development of our children.Goal: Unify care criteria and actions to promote breastfeeding initiation and maintenance of the same, improving communication between professionals and between them and patients.Methodology: Care Development Plan following the NANDA taxonomies, NOC, NIC.Conclusions: Standardized work promotes decision making and performance of nursing staff to develop a happy breastfeeding.
Focalidad neurológica en paciente anticoagulado
López Martínez,Lorena; Hernández Fernández,Francisco; Juliá Mollá,Enrique; Perona Moratalla,Ana Belén;
Revista Clínica de Medicina de Familia , 2011, DOI: 10.4321/S1699-695X2011000300011
Abstract: we report the case of a 63 year old woman who came to the emergency department due to difficulty in expressing herself linguistically and right limb weakness of sudden onset. she had a history of chronic atrial fibrillation (af) and being insufficiently anticoagulated. the first diagnosis to consider is acute ischemic stroke of cardioembolic origin. cerebrovascular disease is the second cause of death worldwide
Evolution of Biochemical Effects of Byetta® in Type 2 Diabetics with Cardiovascular Risk  [PDF]
Alfonso López Ruiz, María ángeles Ibá?ez Gil, Pedro Pujante Alarcón, Alicia Hernández Torres, Ana Belen Hernández Cascales, María Dolores Hellín Gil
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.49094
Abstract:

The objective of this study was to examine longitudinally the effects of exenatide on different physical and biochemical markers, evaluated in adult type 2 diabetic patients with cardiovascular risk. Data were recorded from 10 patients who attended the outpatient primary care health center Mariano Iago Yecla, Murcia province, Spain in the period of December 2009 to October 2011 and who were treated with Byetta®. Differences were statistically significant (p < 0.05) in HbA1c from the third month of treatment, and trends of decrease in body weight from the third week of treatment. There was a significant and better glycemic control. Overall effect was interpreted as a sensitizer drug of the parameters evaluated. Randomized studies are recommended with a minimum follow-up of 2 years, to see if the results are maintained over time.

Basic and instrumented life support intervention protocol in an adult patient in accordance to new ERC 2005 recommendations
Guillermo Arturo Ca?adas de la Fuente,Ana Belén López Bueno,Carolina Fernández Lao,Elena María Martín López
NURE Investigación , 2009,
Abstract: In this study we make a brief account of the last valid recommendations related to basic life support in 2005. They are the result of the study and the analysis by International Liaison Committee On Resuscitation (ILCOR) and the American Hearth Association (AHA).Like the European Resuscitation Council (ERC) did before, they adopted new rules published on international framework with his inherent changes. On the whole, they has not developed so much, nearly all of them were aimed to improve the efficiency on several skill that take part of the process. In this way, some changes has been justified as a result of obtained data on the study and previous normative test, therefore their modification had scientific evidence.Both, adopted modifications and protocol, are described in order to exemplify all health personnel and other professionals. Like a common aim these changes try to unify criteria to make a universal protocol, independent from professional category and people who applies basic or instrumented CPR.So, new guides try to simplify different techniques and to improve those improvable aspects, at the same time that support better multidisciplinary teams integration in a new algorithm just as we describe on the study.
A Loop-Mediated Isothermal Amplification (LAMP) Assay for Early Detection of Schistosoma mansoni in Stool Samples: A Diagnostic Approach in a Murine Model
Pedro Fernández-Soto ,Javier Gandasegui Arahuetes,Alicia Sánchez Hernández,Julio López Abán,Belén Vicente Santiago,Antonio Muro
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0003126
Abstract: Background Human schistosomiasis, mainly due to Schistosoma mansoni species, is one of the most prevalent parasitic diseases worldwide. To overcome the drawbacks of classical parasitological and serological methods in detecting S. mansoni infections, especially in acute stage of the disease, development of cost-effective, simple and rapid molecular methods is still needed for the diagnosis of schistosomiasis. A promising approach is the loop-mediated isothermal amplification (LAMP) technology. Compared to PCR-based assays, LAMP has the advantages of reaction simplicity, rapidity, specificity, cost-effectiveness and higher amplification efficiency. Additionally, as results can be inspected by the naked eye, the technique has great potential for use in low-income countries. Methodology/Principal findings A sequence corresponding to a mitochondrial S. mansoni minisatellite DNA region was selected as a target for designing a LAMP-based method to detect S. mansoni DNA in stool samples. We used a S. mansoni murine model to obtain well defined stool and sera samples from infected mice with S. mansoni cercariae. Samples were taken weekly from week 0 to 8 post-infection and the Kato-Katz and ELISA techniques were used for monitoring the infection. Primer set designed were tested using a commercial reaction mixture for LAMP assay and an in house mixture to compare results. Specificity of LAMP was tested using 16 DNA samples from different parasites, including several Schistosoma species, and no cross-reactions were found. The detection limit of our LAMP assay (SmMIT-LAMP) was 1 fg of S. mansoni DNA. When testing stool samples from infected mice the SmMIT-LAMP detected S. mansoni DNA as soon as 1 week post-infection. Conclusions/Significance We have developed, for the first time, a cost-effective, easy to perform, specific and sensitive LAMP assay for early detection of S. mansoni in stool samples. The method is potentially and readily adaptable for field diagnosis and disease surveillance in schistosomiasis-endemic areas.
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