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Search Results: 1 - 10 of 11476 matches for " Amy Tan Bee Choo "
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Leadership for healthcare
Amy Tan Bee Choo,Jason Cheah
International Journal of Integrated Care , 2011,
A New Unmanned Aerial Vehicle Synthetic Aperture Radar for Environmental Monitoring
Voon Chet Koo;Yee Kit Chan;Gobi Vetharatnam;Ming Yam Chua;Chot Hun Lim;Chee-Siong Lim;C. C. Thum;Tien Sze Lim;Zahid bin Ahmad;Khairul Annuar Mahmood;Mohd Hamadi Bin Shahid;Chin Yang Ang;W. Q. Tan;Poi Ngee Tan;Kuo Shen Yee;W. G. Cheaw;Huey Shen Boey;A. L. Choo;Bee Cheng Sew
PIER , 2012, DOI: 10.2528/PIER11092604
Abstract: A new Unmanned Aerial Vehicle (UAV) Synthetic Aperture Radar (SAR) has been developed at Multimedia University, in collaboration with Agency of Remote Sensing Malaysia. The SAR operates at C-band, single $VV$-polarization, with 5 m x 5 m spatial resolution. Its unique features include compact in size, light weight, low power and capable of performing real-time imaging. A series of field measurements and flight tests has been conducted and good quality SAR images have been obtained. The system will be used for monitoring and management of earth resources such as paddy fields, oil palm plantation and soil surface. This paper reports the system design and development, as well as some preliminary results of the UAVSAR.
Juida WAN,Bee Hoon TAN
The Turkish Online Journal of Distance Education , 2011,
Abstract: The digital explosion of information on the Internet has resulted in a need for a new and up-to-date way for Digital Natives to learn English. Educators have reported numerous benefits of using weblogs in English language learning. This article presents a small scale study on the use of weblogs for English language learning at tertiary level in Malaysia. Twenty six students kept weblogs for a duration of a semester. This study investigated how students perceived the use of weblogs for English language learning. A questionnaire which was made up of both close-ended and open-ended questions was administered at the end of the study. A mixture of quantitative and qualitative methods was used to analyse the students’ responses to the questionnaire. The study found that students were aware of their audience when they blogged and that they geared their writing towards their audience. In addition, they also interacted with others through the use of the comment feature on their weblogs. Furthermore, the majority of the students enjoyed blogging and found weblogs useful for English language learning. This study found that weblogs are promising interactive tools for English language learning.
The Turkish Online Journal of Distance Education , 2012,
Abstract: The rapid growth of using Web 2.0 tools such as blogs has increased online courses in education. Questioners are the most commonly used instruments to assess students’ attitudes toward the online courses. This study provides a set of specific guidelines that the researchers used to develop a questionnaire to measure students’ attitudes toward the course blog. It focuses on test construction and instrument validation as two primary stages in developing the questionnaire and details a series of steps nested within two stages. Participants were 30 undergraduate students enrolled in a course blog. To analyze the data, qualitative findings of interview were complemented by statistical results from quantitative data. To improve content adequacy and internal validity of the instrument items, 25 students who took part in piloting the instrument were interviewed. We carried out Statistical analysis to evaluate inter-item correlations, and reliability alpha coefficient of the instrument items. The guidelines applied in this study can be used in other studies to develop a valid instrument to measure other constructs, particularly when a researcher does not have access to a large sample.
Analysis and design of randomised clinical trials involving competing risks endpoints
Bee-Choo Tai, Joseph Wee, David Machin
Trials , 2011, DOI: 10.1186/1745-6215-12-127
Abstract: We describe how competing events may be summarised in such trials using cumulative incidence functions and Gray's test. The statistical modelling of competing events using proportional cause-specific and subdistribution hazard functions, and the corresponding procedures for sample size estimation are outlined. These are illustrated using data from a randomised clinical trial (SQNP01) of patients with advanced (non-metastatic) nasopharyngeal cancer.In this trial, treatment has no effect on the competing event of loco-regional recurrence. Thus the effects of treatment on the hazard of distant metastasis were similar via both the cause-specific (unadjusted csHR = 0.43, 95% CI 0.25 - 0.72) and subdistribution (unadjusted subHR 0.43; 95% CI 0.25 - 0.76) hazard analyses, in favour of concurrent chemo-radiotherapy followed by adjuvant chemotherapy. Adjusting for nodal status and tumour size did not alter the results. The results of the logrank test (p = 0.002) comparing the cause-specific hazards and the Gray's test (p = 0.003) comparing the cumulative incidences also led to the same conclusion. However, the subdistribution hazard analysis requires many more subjects than the cause-specific hazard analysis to detect the same magnitude of effect.The cause-specific hazard analysis is appropriate for analysing competing risks outcomes when treatment has no effect on the cause-specific hazard of the competing event. It requires fewer subjects than the subdistribution hazard analysis for a similar effect size. However, if the main and competing events are influenced in opposing directions by an intervention, a subdistribution hazard analysis may be warranted.In a randomised, double-blind, three-period clinical trial of lisinopril in patients with chronic heart failure [1], factors associated with different modes of cardiovascular death were investigated to guide physicians in their treatment decisions. In this trial, sudden death was considered as a competing risk for chronic h
Podcast Applications in Language Learning: A Review of Recent Studies
Md. Masudul Hasan,Tan Bee Hoon
English Language Teaching , 2013, DOI: 10.5539/elt.v6n2p128
Abstract: Many dynamic approaches have emerged due to computer technology in facilitating language learning skills. Podcasting is one such novel tool being exploited by teachers to deliver educational content and to encourage learning outside the classroom. Research on podcasting pedagogy suggests that podcasting greatly helps learners develop various skills of English language. The study reviewed twenty journal articles to determine the effects of podcast on ESL students’ language skills and attitude levels. It was found that podcasts greatly support learning not just in speaking and listening but also in other language skills and areas such as grammar, pronunciation and vocabulary.
Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but Are Transcriptionally and Biologically Different  [PDF]
Candida Vaz, Betty Tan Bee Tee, Delicia Yong, Qian Yi Lee, Vivek Tanavde
Stem Cell Discovery (SCD) , 2017, DOI: 10.4236/scd.2017.71001
Abstract: Mesenchymal stromal cells (MSCs) can be obtained from several sources and the significant differences in their properties make it crucial to investigate the differentiation potential of MSCs from different sources to determine the optimal source of MSCs. We investigated if this biological heterogeneity in MSCs from different sources results in different mechanisms for their differentiation. In this study, we compared the gene expression patterns of phenotypically defined MSCs derived from three ontogenically different sources: Embryonic stem cells (hES-MSCs), Fetal limb (Flb-MSCs) and Bone Marrow (BM-MSCs). Differentially expressed genes between differentiated cells and undifferentiated controls were compared across the three MSC sources. We found minimal overlap (5% - 16%) in differentially expressed gene sets among the three sources. Flb-MSCs were similar to BM-MSCs based on differential gene expression patterns. Pathway analysis of the differentially expressed genes using Ingenuity Pathway Analysis (IPA) revealed a large variation in the canonical pathways leading to MSC differentiation. The similar canonical pathways among the three sources were lineage specific. The Flb-MSCs showed maximum overlap of canonical pathways with the BM-MSCs, indicating that the Flb-MSCs are an intermediate source between the less specialised hES-MSC source and the more specialised BM-MSC source. The source specific pathways prove that MSCs from the three ontogenically different sources use different biological pathways to obtain similar differentiation outcomes. Thus our study advocates the understanding of biological pathways to obtain optimal sources of MSCs for various clinical applications.
SPdb – a signal peptide database
Khar Choo, Tin Tan, Shoba Ranganathan
BMC Bioinformatics , 2005, DOI: 10.1186/1471-2105-6-249
Abstract: SPdb integrates information from two sources (a) Swiss-Prot protein sequence database which is now part of UniProt and (b) EMBL nucleotide sequence database. The database update is semi-automated with human checking and verification of the data to ensure the correctness of the data stored. The latest release SPdb release 3.2 contains 18,146 entries of which 2,584 entries are experimentally verified signal sequences; the remaining 15,562 entries are either signal sequences that fail to meet our filtering criteria or entries that contain unverified signal sequences.SPdb is a manually curated database constructed to support the understanding and analysis of signal peptides. SPdb tracks the major updates of the two underlying primary databases thereby ensuring that its information remains up-to-date.Günter Blobel discovered that "proteins have intrinsic signals that govern their transport and localization in the cell" [1]. Proteins synthesised at the ribosome (cytoplasm or rough endoplasmic reticulum), mitochondria or chloroplast are transported to their site of function. This process is known as protein targeting and it depends on targeting signals to direct the proteins to their specific locations.There are many different classes of targeting signals. One of the commonly occurring signals is formed by short, transient peptides known as signal peptides or leader sequences, which are usually found at the amino terminus of secreted proteins. Signal peptides are present in both prokaryotic and eukaryotic cells, indicating its ancient universal origins. They function like a postal address label on an envelope by targeting the proteins for secretion or to specific organelle for further processing. The signal peptides are cleaved off and degraded upon reaching their targeted locations. Interestingly, not all proteins possess signal peptides [2,3], suggesting that other mechanisms for protein targeting exist.Over the years, several prediction tools [4-10] have been developed
The Turkish Online Journal of Distance Education , 2010,
Abstract: Due to the wide application of advanced technology in education, many attitude scales have been developed to evaluate learners’ attitudes toward educational tools. However, with the rapid development of emerging technologies, using blogs as one of the Web 2.0 tools is still in its infancy and few blog attitude scales have been developed yet. In view of this need, a lot of researchers like to design a new scale based on their conceptual and theoretical framework of their own study rather than using available scales. The present study reports the design and development of a blog attitude scale (BAS). The researchers developed a pool of items to capture the complexity of the blog attitude trait, selected 29 items in the content analysis, and assigned the scale comprising 29 items to 216 undergraduate students to explore the underlying structure of the BAS. In exploratory factor analysis, three factors were discovered: blog anxiety, blog desirability, and blog self-efficacy; 14 items were excluded. The extracted items were subjected to a confirmatory factor analysis which lent further support to the BAS underpinning structure.
Finding common ground to achieve a “good death”: family physicians working with substitute decision-makers of dying patients. A qualitative grounded theory study
Tan Amy,Manca Donna
BMC Family Practice , 2013, DOI: 10.1186/1471-2296-14-14
Abstract: Background Substitute decision-makers are integral to the care of dying patients and make many healthcare decisions for patients. Unfortunately, conflict between physicians and surrogate decision-makers is not uncommon in end-of-life care and this could contribute to a “bad death” experience for the patient and family. We aim to describe Canadian family physicians’ experiences of conflict with substitute decision-makers of dying patients to identify factors that may facilitate or hinder the end-of-life decision-making process. This insight will help determine how to best manage these complex situations, ultimately improving the overall care of dying patients. Methods Grounded Theory methodology was used with semi-structured interviews of family physicians in Edmonton, Canada, who experienced conflict with substitute decision-makers of dying patients. Purposeful sampling included maximum variation and theoretical sampling strategies. Interviews were audio-taped, and transcribed verbatim. Transcripts, field notes and memos were coded using the constant-comparative method to identify key concepts until saturation was achieved and a theoretical framework emerged. Results Eleven family physicians with a range of 3 to 40 years in clinical practice participated. The family physicians expressed a desire to achieve a “good death” and described their role in positively influencing the experience of death. Finding Common Ground to Achieve a “Good Death” for the Patient emerged as an important process which includes 1) Building Mutual Trust and Rapport through identifying key players and delivering manageable amounts of information, 2) Understanding One Another through active listening and ultimately, and 3) Making Informed, Shared Decisions. Facilitators and barriers to achieving Common Ground were identified. Barriers were linked to conflict. The inability to resolve an overt conflict may lead to an impasse at any point. A process for Resolving an Impasse is described. Conclusions A novel framework for developing Common Ground to manage conflicts during end-of-life decision-making discussions may assist in achieving a “good death”. These results could aid in educating physicians, learners, and the public on how to achieve productive collaborative relationships during end-of-life decision-making for dying patients, and ultimately improve their deaths.
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