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Adjunctive Therapies to Cerclage for the Prevention of Preterm Birth: A Systematic Review
Emily A. DeFranco,Amy Miyoshi Valent,Tondra Newman,Jodi Regan
Obstetrics and Gynecology International , 2013, DOI: 10.1155/2013/528158
The Spallation Neutron Source (SNS) Linac RF System
Michael Lynch,William Reass,Daniel Rees,Amy Regan,Paul Tallerico
Physics , 2000,
Abstract: The SNS linac accelerates an average beam current of 2 mA to an energy of 968 MeV. The linac is pulsed at 60 Hz with an H- beam pulse of 1 ms. The first 185 Mev of the linac uses normal conducting cavities, and the remaining length of the linac uses superconducting cavities. The linac operates at 402.5 MHz up to 87 MeV and then changes to 805 MHz for the remainder. This paper gives an overview of the Linac RF system. The overview includes a description and configuration of the high power RF components, the HV converter/modulator, and the RF controls. Issues and tradeoffs in the RF system will be discussed, especially with regards to the use of pulsed superconducting cavities.
Adjunctive Therapies to Cerclage for the Prevention of Preterm Birth: A Systematic Review
Emily A. DeFranco,Amy Miyoshi Valent,Tondra Newman,Jodi Regan,Jessica Smith,Louis J. Muglia
Obstetrics and Gynecology International , 2013, DOI: 10.1155/2013/528158
Abstract: The aim of this paper is to provide a thorough summary of published studies that have assessed the efficacy of adjunctive therapies used in addition to cervical cerclage as a preventive measure for preterm birth. We limited our paper to patients treated with cerclage plus an additional prophylactic therapy compared to a reference group of women with cerclage alone. The specific adjunctive therapies included in this systematic review are progesterone, reinforcing or second cerclage placement, tocolytics, antibiotics, bedrest, and pessary. We searched PubMed and Cochrane databases without date criteria with restriction to English language and human studies and performed additional bibliographic review of selected articles and identified 305 total studies for review. Of those, only 12 studies compared the use of an adjunctive therapy with cerclage to a reference group of cerclage alone. None of the 12 were prospective randomized clinical trials. No comparative studies were identified addressing the issues of antibiotics, bedrest, or pessary as adjunctive treatments to cerclage. None of the 12 studies included in this paper demonstrated a clear benefit of any adjunctive therapy used in addition to cerclage over and above cerclage used alone; however, few studies with small numbers limited the strength of the conclusions. 1. Introduction Cervical cerclage has been demonstrated to be an effective intervention in some subgroups of women who are at particularly high risk of spontaneous preterm birth or previable pregnancy loss. Because of the devastating outcomes associated with extreme preterm birth and previable pregnancy loss, obstetric care providers sometimes offer additional therapies in combination with cerclage that have shown benefit when used individually in other clinical scenarios for treatment of preterm labor and/or prevention of spontaneous onset of parturition. The purpose of this paper is to provide a summary of the existing medical evidence to support the use of adjunctive therapies or therapies used in addition to, cervical cerclage for the prevention of preterm birth by a systematic review of the currently available medical literature. 2. Data Sources and Study Selection For the purpose of this systematic review, we aimed to identify published studies that have assessed the efficacy of adjunctive therapies used in addition to standard prophylactic vaginal cervical cerclage as a preventive measure for preterm birth. We focused our paper to these specific adjunctive therapies that have been reported as used in addition to cerclage:
SNS Superconducting Cavity Modeling -Iterative Learning Control
Sung-il Kwon,Yi-Ming Wang,Amy Regan,Tony Rohlev,Mark Prokop,Dave Thomson
Physics , 2000,
Abstract: The SNS SRF system is operated with a pulsed beam. For the SRF system to track the repetitive reference trajectory, a feedback and a feedforward controllers has been proposed. The feedback controller is to guarantee the closed loop system stability and the feedforward controller is to improve the tracking performance for the repetitive reference trajectory and to suppress the repetitive disturbance. As the iteration number increases, the error decreases.
Design of the SNS Normal Conducting Linac RF Control System
Amy Regan,Sung-il Kwon,Tony S. Rohlev,Yi-Ming Wang,Mark S. Prokop,David W. Thomson
Physics , 2000,
Abstract: The Spallation Neutron Source (SNS) is being designed for operation in 2004. The SNS is a 1 GeV machine consisting of a combination normal-conducting and super-conducting linac as well as a ring and target area. The linac front end is a 402.5 MHz RFQ being developed by Lawrence Berkeley Lab. The DTL (at 402.5 MHz) and the CCL (at 805 MHz) stages are being developed by Los Alamos National Laboratory. The expected output energy of the DTL is 87 MeV and that of the CCL is 185 MeV. The RF control system under development for the linac is based on the Low Energy Demonstration Accelerator (LEDA) control system with some new features. This paper will discuss the new design approach and its benefits. Block diagrams and circuit specifics will be addressed. The normal conducting RF control system will be described in detail with references to the super-conducting control system where appropriate.
The effects of incivility on nursing education  [PDF]
Amy Schaeffer
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.32023

Incivility in the population has become of great interest within the past decade, particularly in the wake of the school massacre in Columbine and the recent movie theatre mass murder in Aurora, Colorado. While citizens struggle to make sense of these violent behaviors, higher education officials are perhaps most vested in exploring the causes, displays, and solutions to uncivil behavior among both faculty and students. The effects of incivility, whether classified as minor disruptions or major violence, may affect the student nurse and impede his or her progress and ability to become an empathic nurse, which is a goal of nursing education. Academic incivility may contribute to bullying in the workplace, which has been identified as a cause of attrition and contributes to the national nursing shortage. This article describes the effects of uncivil behavior on nursing faculty and students and the effect this may have on the nursing workforce.

Pigs in Space
Tom Regan
Philosophica , 1987,
Hans-Georg Gadamer’s philosophical hermeneutics: Concepts of reading, understanding and interpretation
Paul Regan
Meta : Research in Hermeneutics, Phenomenology and Practical Philosophy , 2012,
Abstract: Hans-Georg Gadamer’s philosophical hermeneutics is a popular qualitative research interpretive method aiming to explore the meaning of individual experiences in relation to understanding human interpretation. Gadamer identifies that authentic engagement with reading requires awareness of the inter-subjective nature of understanding in order to promote a reflective engagement with the text. The main concepts of Gadamer’s view of reading and understanding are explored in this paper in relation to interpreting text. Concepts such as; inter-subjectivity, Being, authenticity, fore-structure, pre-suppositions, prejudice, temporality and history are all help to enhance health and social science researchers’ understanding of his theory and its application.
Making Sense of Uncertainty: An Examination of Environmental Interpretation
Padraic Regan
International Journal of Business and Management , 2012, DOI: 10.5539/ijbm.v7n6p18
Abstract: Uncertainty in the environment has implications for an organisation’s structures, strategies and processes. By extending an existing uncertainty framework and measuring how it is influenced by strategic decision-making,entrepreneurial orientation and organisation structure, this paper explores the process of environmental interpretation. Hypotheses are formulated for testing on the European airport industry. The results show that a fourth type of uncertainty can be meaningfully added to the existing three-part framework; that the four types should be treated as separate constructs; and that rational strategic decision-making, entrepreneurial orientation and organic organisation structures are positively related to environmental uncertainty. Moreover, these variables exert different levels of influence at different stages of the interpretation process. Implications for management are considered along with study limitations and recommendations for future research.
Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity  [PDF]
Amy L. Adamson
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.31001

Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world’s adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication.

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