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Search Results: 1 - 10 of 462011 matches for " Amruta A. Bakshi "
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Antioxidants deficiency: a sensitive indicator of cardiometabolic risk in chronic renal failure?
Pooja S.K. Rai,Sangita Kamath,Amruta A. Bakshi,Smita A. Deokar
International Journal of Research in Medical Sciences , 2013, DOI: 10.5455/2320-6012.ijrms20130510
Abstract: Background: Antioxidant depletion occurring in chronic renal failure patients is an important cause of associated morbidity & mortality, which in turn imposes a great socioeconomic burden of health care. Early diagnosis & targeted management of this preventable deficiency may have a positive impact on the management of co morbidities associated with chronic renal failure. Aims & Objectives: To evaluate the status of antioxidants as an early indicator of cardiometabolic risk in chronic renal failure patients. Settings & Design: This was a randomised case Control study including 10 controls of either sex with normal renal function between age group 20-60 years and 15 patients of chronic renal failure on dialysis between the age group of 16 - 60 years. Methods: 12 hour fasting venous blood samples were collected from all the participants and were assayed for various antioxidants. Statistical analysis: Results were analyzed by unpaired t test, p value was determined & Correlation coefficient was calculated amongst various parameters. Results: In the present study, significantly low levels of vitamin C ( Cases: 0.367 ± 0.13 mg/dl controls: 1.324 ± 0.61 mg/dl; p < 0.01) & vitamin E (cases: 0.235 ± 0.102 mg/dl, controls (0.854 ± 0.28 mg/dl; p < 0.01) were observed in chronic renal failure patients as compared to controls. Conclusion: Diminished levels of Vitamin C & E in our study may be an indicator of increased oxidative stress which can be a responsible factor for increased incidence of cardiovascular complications. Supplementing these patients with recommended dosage of these vitamins may provide an essential tool to reduce the burden of suffering. [Int J Res Med Sci 2013; 1(2.000): 87-92]
Click Chemical Reactions:An Emerging Approach and Its Pharmaceutical Applications
Dr. Rakesh R. Somani,Amruta A. Sabnis,Amruta V. Vaidya
International Journal of Pharmaceutical and Phytopharmacological Research , 2012,
Abstract: Click chemistry provides reactions which are simple, fast, stereospecific, give product in high yields and show many other desirable characteristics. These reactions involve linking of the reactant blocks by formation of carbon heteroatom bond between them. Out of the reactions which satisfy click reaction criteria, copper catalysed 1,3-dipolar cycloaddition of alkyne and azide (HDC reaction) has emerged as a perfect click reaction. Some click reactions which can proceed in absence of metal catalyst (metal free click chemistry) are also being developed. Click chemical reactions have wide applications in many areas of pharmaceutical sciences such as synthesis of lead discovery libraries, polymer therapeutics, drug delivery systems and bioconjugation etc.
Instability of Shear Waves in an Inhomogeneous Strongly Coupled Dusty Plasma
Amruta Mishra,P. K. Kaw,A. Sen
Physics , 2001, DOI: 10.1063/1.874183
Abstract: It is demonstrated that low frequency shear modes in a strongly coupled, inhomogeneous, dusty plasma can grow on account of an instability involving the dynamical charge fluctuations of the dust grains. The instability is driven by the gradient of the equilibrium dust charge density and is associated with the finite charging time of the dust grains. The present calculations, carried out in the generalized hydrodynamic viscoelastic formalism, also bring out important modifications in the threshold and growth rate of the instability due to collective effects associated with coupling to the compressional mode.
Ewing′s sarcoma with cutaneous metastasis - a rare entity: Report of three cases
Biswas G,Khadwal A,Kulkarni P,Bakshi A
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract: Ewing′s sarcoma (ES) is a small round cell tumor, usually arising from flat bones and diaphyseal region of long bones. It is commonly found in the first two decades of life. It is curable when diagnosed in the localized stage and requires multimodality treatment. ES is a chemosensitive tumor. It metastasizes commonly to lung, pleura and other bones. Less common sites of metastasis are lymph nodes, CNS and liver. Skin metastasis is extremely uncommon. It occurs in up to 9% of all patients with cancer. Growth pattern of cutaneous metastasis is unpredictable and may not reflect that of primary tumor. We hereby report three cases of Ewing′s sarcoma that developed skin metastasis.
A novel metered dose transdermal spray formulation for oxybutynin
Bakshi A,Bajaj A,Malhotra G,Madan M
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: The objective of the present work was to develop a metered dose spray formulation for transdermal delivery of oxybutynin and to carry out the in vitro characterization of the optimized formulation. Oxybutynin release from a series of ethanol/acetone/methylal based formulations was assessed in vitro and the developed formulation was used for delivery from a metered dose spray. Various qualitative and quantitative parameters like spray pattern, particle size distribution, pH, evaporation time, pump seal efficiency test, average weight per metered dose, content per spray and content uniformity were evaluated. The different film forming agents were assessed and carbopol (0.5%) and lutrol (0.1%) were found to give good clarity of solution, evaporation rate, spray pattern and tackiness of the film. Diffusion studies of the optimized formulations through the semipermeable membrane showed the release of drug to the extent of almost 50% over a period of 24 h. Stability studies were conducted as per ICH guidelines and indicated that formulations were stable. Skin irritation studies were performed using rabbit as an animal model. The results obtained show that the metered dose transdermal spray formulation can be a promising and innovative therapeutic system for the transdermal administration of oxybutynin.
Pairing in spin polarized two-species fermionic mixtures with mass asymmetry
S. A. Silotri,D. Angom,H. Mishra,Amruta Mishra
Physics , 2008, DOI: 10.1140/epjd/e2008-00169-0
Abstract: We discuss on the pairing mechanism of fermions with mismatch in their fermi momenta due to a mass asymmetry. Using a variational ansatz for the ground state we also discuss the BCS -BEC crossover of this system. It is shown that the breached pairing solution with a single fermi surface is stable in the BEC regime. We also include the temperatures effect on the fermion pairing within an approximation that is valid for temperatures much below the critical temperature.
Rotating compact objects with magnetic fields
Anshu Gupta,Amruta Mishra,Hiranmaya Mishra,A. R. Prasanna
Physics , 1998, DOI: 10.1088/0264-9381/15/10/016
Abstract: We consider here the structure of rotating compact objects endowed with a magnetic field in general relativity as models of pulsars. We discuss first the structure of rotating stars in the framework of Hartle taking different realistic equations of state and study their effects on bulk properties of the star. We consider the possibilty of rotating stars with a quark matter core. We further analyse the structure of the magnetic field in the interior of the star as affected by different equations of state as well as due to rotation.
Foreign Direct Investment and Wage Inequality: The Case of China
A.S.M. Rejaul Hassan Karim Bakshi
Pakistan Journal of Social Sciences , 2012,
Abstract: China is the second largest recipient of FDI inflows nowadays, a preferred destiny for the global investors after USA. In study, FDI is said to be creating a favored local group depending on skill intensities, it requires and if the investment is technologically advanced than the host country s state, then this can lead to greater income disparity. China is evidenced with a spectacularly huge FDI inflow in the past decade along with increasing income inequality. This study attempts to analyze, whether FDI inflows in China has any role in increasing inequality over time. Finding of this study is quite clear: foreign funded industries in China are enjoying persistently higher wages than the national averages and the higher the skilled intensive foreign investment is the higher is the wages.
Cytomegalovirus oesophagitis in a patient with non-hodgkin′s lymphoma
Hingmire S,Biswas G,Bakshi A,Desai S
Indian Journal of Medical Microbiology , 2008,
Abstract: Cytomegalovirus (CMV) infection is frequent in immunocompromised patients, especially in AIDS, organ transplantation and rarely in Hodgkin′s disease and Non-Hodgkin′s lymphoma (NHL). We present a case of NHL with CMV oesophagitis, which has rarely been documented in literature. Apart from fungal and herpes simplex infections, as the common differential diagnosis for oesophagitis in patients of lymphoma, CMV should be considered an important etiologic agent. Early diagnosis and prompt treatment of CMV oesophagitis with gancyclovir can avert significant morbidity and avoid unacceptable treatment delays.
Influence of Season and Phytohormones on Rooting Behaviour of Green Bamboo by Cuttings
Sajad RAZVI,Subhash NAUTIYAL,Meena BAKSHI,Jahangeer A. BHAT
International Journal of Conservation Science , 2011,
Abstract: Bamboos are important sources of income for rural households in India and elsewhere. Bamboo is increasingly identified as potential species for poverty reduction programs in many countries including India. The present study was carried out to develop the farmer’s friendly protocol for mass multiplication of Bambusa vulgaris through ex vitro methods. During the present study rooting was obtained in three seasons except winter season and the variation in all the physiological characters with seasons & treatments were significant at P<0.001. Maximum average (62.00) rooting percentage and (24.41 cm) root length was found in rainy season followed by summer season with average (50.33) rooting percentage and (15.31 cm) root length. However, (47.33) rooting percentage and (16.80 cm) root length was achieved in spring season. Among the three auxins used for pretreatment, IBA showed more positive response on rooting as compared to IAA and NAA. In winter season no rooting and sprout were observed in any treated cuttings.
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