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Search Results: 1 - 10 of 326001 matches for " Amr S Soliman "
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Differences in Molecular Pathologic Characteristics of PancreaticAdenocarcinoma between Egyptian andMoroccan Patients
Sara Robinson,Amr S. Soliman,Mehdi Karkouri,Hoda Gad Omer
Middle East Journal of Cancer , 2010,
Abstract: Introduction:Pancreatic cancer has not been well studied, especially in developingcountries. Materials and Methods:We studied the variations in genetic mutations inpancreatic adenocarcinoma between Moroccan and Egyptian populations. Themolecular pathology of 30 tumors from a large hospital in Casablanca, Morocco wereexamined and compared with the findings of 44 tumors from the Gharbiah Governatein Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons5-8 were evaluated. Results:Overall, differences in the rates of K-ras mutations were not statisticallysignificant (48.00 and 34.09%, respectively); however differences in rates of p53mutations were statistically significant with p53 mutations more common in Moroccantumors than in Egyptian tumors (46.67 and 16.28%, respectively). G?Tmutations ofthe K-ras gene were most commonly seen Egyptian tumors, whereas G?Amutationswere the most common type of mutations in Moroccan tumors. Logistic regressionanalysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5predicted the country of residence and those mutations occurred more frequently inMoroccan patients. Conclusion:Our study shows that differences exist within the Arab population inthe molecular pathology of both the K-ras and p53 genes. Further studies are necessaryto clarify the differences in molecular pathways of pancreatic cancer in the Middle Eastand to investigate the role of environmental and/or genetic factors related to thosepathways.
Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry
Darlene Veruttipong,Amr S Soliman,Samuel F Gilbert,Taylor S Blachley
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i30.3997
Abstract: AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population’s statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55%) than rural (45%) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.
Healthcare access and mammography screening in Michigan: a multilevel cross-sectional study
Tomi F Akinyemiju, Amr S Soliman, May Yassine, Mousumi Banerjee, Kendra Schwartz, Sofia D Merajver
International Journal for Equity in Health , 2012, DOI: 10.1186/1475-9276-11-16
Abstract: To assess determinants of breast cancer screening among women in Michigan USA, focusing on individual and neighborhood socio-economic status and healthcare access.Data from 1163 women ages 50-74 years who participated in the 2008 Michigan Special Cancer Behavioral Risk Factor Survey were analyzed. County-level SES and healthcare access were obtained from the Area Resource File. Multilevel logistic regression models were fit using SAS Proc Glimmix to account for clustering of individual observations by county. Separate models were fit for each of the two outcomes of interest; mammography screening and clinical breast examination. For each outcome, two sequential models were fit; a model including individual level covariates and a model including county level covariates.After adjusting for misclassification bias, overall cancer screening rates were lower than reported by survey respondents; black women had lower mammography screening rates but higher clinical breast examination rates than white women. However, after adjusting for other individual level variables, race was not a significant predictor of screening. Having health insurance or a usual healthcare provider were the most important predictors of cancer screening.Access to healthcare is important to ensuring appropriate cancer screening among women in Michigan.
Individual and Neighborhood Socioeconomic Status and Healthcare Resources in Relation to Black-White Breast Cancer Survival Disparities
Tomi F. Akinyemiju,Amr S. Soliman,Norman J. Johnson,Sean F. Altekruse
Journal of Cancer Epidemiology , 2013, DOI: 10.1155/2013/490472
Trends in Breast Cancer Stage and Mortality in Michigan (1992–2009) by Race, Socioeconomic Status, and Area Healthcare Resources
Tomi F. Akinyemiju, Amr S. Soliman, Glenn Copeland, Mousumi Banerjee, Kendra Schwartz, Sofia D. Merajver
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061879
Abstract: The long-term effect of socioeconomic status (SES) and healthcare resources availability (HCA) on breast cancer stage of presentation and mortality rates among patients in Michigan is unclear. Using data from the Michigan Department of Community Health (MDCH) between 1992 and 2009, we calculated annual proportions of late-stage diagnosis and age-adjusted breast cancer mortality rates by race and zip code in Michigan. SES and HCA were defined at the zip-code level. Joinpoint regression was used to compare the Average Annual Percent Change (AAPC) in the median zip-code level percent late stage diagnosis and mortality rate for blacks and whites and for each level of SES and HCA. Between 1992 and 2009, the proportion of late stage diagnosis increased among white women [AAPC = 1.0 (0.4, 1.6)], but was statistically unchanged among black women [AAPC = ?0.5 (?1.9, 0.8)]. The breast cancer mortality rate declined among whites [AAPC = ?1.3% (?1.8,?0.8)], but remained statistically unchanged among blacks [AAPC = ?0.3% (?0.3, 1.0)]. In all SES and HCA area types, disparities in percent late stage between blacks and whites appeared to narrow over time, while the differences in breast cancer mortality rates between blacks and whites appeared to increase over time.
Individual and Neighborhood Socioeconomic Status and Healthcare Resources in Relation to Black-White Breast Cancer Survival Disparities
Tomi F. Akinyemiju,Amr S. Soliman,Norman J. Johnson,Sean F. Altekruse,Kathy Welch,Mousumi Banerjee,Kendra Schwartz,Sofia Merajver
Journal of Cancer Epidemiology , 2013, DOI: 10.1155/2013/490472
Abstract: Background. Breast cancer survival has improved significantly in the US in the past 10–15 years. However, disparities exist in breast cancer survival between black and white women. Purpose. To investigate the effect of county healthcare resources and SES as well as individual SES status on breast cancer survival disparities between black and white women. Methods. Data from 1,796 breast cancer cases were obtained from the Surveillance Epidemiology and End Results and the National Longitudinal Mortality Study dataset. Cox Proportional Hazards models were constructed accounting for clustering within counties. Three sequential Cox models were fit for each outcome including demographic variables; demographic and clinical variables; and finally demographic, clinical, and county-level variables. Results. In unadjusted analysis, black women had a 53% higher likelihood of dying of breast cancer and 32% higher likelihood of dying of any cause ( ) compared with white women. Adjusting for demographic variables explained away the effect of race on breast cancer survival (HR, 1.40; 95% CI, 0.99–1.97), but not on all-cause mortality. The racial difference in all-cause survival disappeared only after adjusting for county-level variables (HR, 1.27; CI, 0.95–1.71). Conclusions. Improving equitable access to healthcare for all women in the US may help eliminate survival disparities between racial and socioeconomic groups. 1. Introduction Breast cancer incidence and mortality rates have declined steadily in the US for the past 10–15 years [1–7]. The relative 5-year survival rate for breast cancer overall has also increased in the past decade to 89% [8]. Unfortunately, disparities exist in breast cancer outcomes between racial groups in the US. Although survival has increased for both white and black women over time, the survival increase in black women has been smaller [2]. Five-year relative survival for breast cancer was 90% for white women and 77% for black women between 2001 and 2007 [8, 9]. Several reasons have been suggested for the survival disparity between black and white women, including racial differences in access to and utilization of screening and treatment [10–12], risk factors that are differentially distributed by race [10, 13–15] and socioeconomic status (SES) [14, 16–20], and biological differences such as tumor aggressiveness [21, 22]. The results of research studies assessing the role of SES in racial disparities in breast cancer survival are mixed; some studies reported that racial differences in survival disappear after adjusting for SES [17, 19, 20,
Urinary bisphenol A concentrations in girls from rural and urban Egypt: a pilot study
Muna S Nahar, Amr S Soliman, Justin A Colacino, Antonia M Calafat, Kristen Battige, Ahmed Hablas, Ibrahim A Seifeldin, Dana C Dolinoy, Laura S Rozek
Environmental Health , 2012, DOI: 10.1186/1476-069x-11-20
Abstract: We measured urinary concentrations of total (free plus conjugated) species of BPA in spot samples in urban (N = 30) and rural (N = 30) Egyptian girls, and compared these concentrations to preexisting data from age-matched American girls (N = 47) from the U.S. National Health and Nutrition Examination Survey (NHANES). We also collected anthropometric and questionnaire data regarding food storage behaviors to assess potential routes of exposure.Urban and rural Egyptian girls exhibited similar concentrations of urinary total BPA, with median unadjusted values of 1.00 and 0.60 ng/mL, respectively. Concentrations of urinary BPA in this group of Egyptian girls (median unadjusted: 0.70 ng/mL) were significantly lower compared to age-matched American girls (median unadjusted: 2.60 ng/mL) according to NHANES 2009-2010 data. Reported storage of food in plastic containers was a significant predictor of increasing concentrations of urinary BPA.Despite the relatively low urinary BPA concentrations within this Egyptian cohort, the significant association between food storage behaviors and increasing urinary BPA concentration highlights the need to understand food and consumer product patterns that may be closing the gap between urban and rural lifestyles.Bisphenol A (BPA) is a monomer used in epoxy resins and polycarbonate plastic production. BPA is one of the highest volume chemicals with worldwide annual production of more than 8 billion pounds [1]. BPA continues to play a fundamental role in the plastics industry, given that BPA-based plastic materials have a variety of desirable properties including transparency, high impact strength, malleability, and superior adhesive properties [2]. BPA-based materials have a broad range of applications and are found in many commonly used products such as water bottles, dental sealants, medical equipment, epoxy resin linings in food and beverage cans, and thermal paper. Exposure is nearly ubiquitous in the general U.S. population, with ove
Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: A pilot exposure assessment study
Justin A Colacino, Amr S Soliman, Antonia M Calafat, Muna S Nahar, Adrienne Van Zomeren-Dohm, Ahmed Hablas, Ibrahim A Seifeldin, Laura S Rozek, Dana C Dolinoy
Environmental Health , 2011, DOI: 10.1186/1476-069x-10-40
Abstract: We collected one spot urine sample from 60 10-13 year old females, 30 from rural Egypt, and 30 from urban Egypt from July to October 2009. Samples were analyzed for 11 phthalate metabolites. Additionally, we collected anthropometrics as well as questionnaire data concerning food storage behaviors, cooking practices, and cosmetic use. Phthalate metabolite concentrations were compared between urban and rural Egyptians as well as to age and gender matched Americans.Monoethyl phthalate (MEP), was detected at the highest concentration in urine of Egyptian girls (median: 43.2 ng/mL in rural, 98.8 ng/mL in urban). Concentrations of urinary metabolites of di-(2-ethylhexyl) phthalate and dibutyl phthalate were comparable between Egyptians and age matched US girls. Storage of food in plastic containers was a statistically significant predictor of urinary mono-isobutyl phthalate (MiBP) concentrations when comparing covariate adjusted means.Urinary concentrations of phthalate metabolites were similar in Egyptian and US populations, suggesting that phthalate exposure also occurs in developing nations. Dietary intake is likely an important route of exposure to phthalates in both urban and rural populations.Phthalates are a family of chemicals that have a wide range of applications in consumer goods, including children's toys, building materials, food packaging, cosmetics, cleaning materials, pharmaceuticals, and medical devices [1]. The molecular weight of the phthalate typically will determine in which application the compound is utilized. Higher molecular weight phthalates, such as di-(2-ethylhexyl) phthalate (DEHP), are most often used as plasticizers in polyvinyl chloride (PVC), while lower molecular weight phthalates, such as diethyl phthalate (DEP) and dimethyl phthalate (DMP), are used in cosmetics, insecticides, and pharmaceutical applications [2]. Phthalates, when used as plasticizers, are not chemically bound to PVC, hence they can leach from consumer products into air
Preliminary Evaluation of New Quinoa Genotypes under Sandy Soil Conditions in Egypt  [PDF]
Amr S. Shams
Agricultural Sciences (AS) , 2018, DOI: 10.4236/as.2018.911100
Abstract: Field trial was carried out at Ismailia Research Station, Ismailia Governorate, Egypt to evaluate some quinoa genotypes under arid environment of sandy soil for identifying its agronomic potentiality, chemical composition and economic opportunity. Nine quinoa genotypes including six Peruvian varieties (Amarilla Marangani, Amarilla Sacaca, Blanca de Junin, Kancolla, Salcedo INIA and Rosada de Huancayo) and three new accessions (QS14, QS16 and QS17-2) were compared in randomized complete block design with three replications. The results revealed that quinoa proved success in sandy soil with suitable grain yield under Egyptian conditions. QS17-2 accession stays only from 115 to 120 days in the field according to environmental factors and treated as short duration accession, while growth duration of the four varieties; Blanca de Junin, Kancolla, Salcedo INIA and Rosada de Huancayo, as well as, accessions of QS14 and QS16 were moderate. Amarilla Marangani and Amarilla Sacaca varieties had the longest duration genotypes. Amarilla Sacaca and Amarilla Marangani varieties, as well as, QS17-2 accession gave the highest grain yield compared with the other genotypes. The highest protein content in quinoa grains was 13.60%, which recorded from QS17-2 accession, while the lowest value (10.75%) was recorded by Blanca de Junin variety. Moreover, Salcedo INIA variety had the lowest saponins content in quinoa grains (0.07%) while QS16 accession recorded the highest content (0.22%). The economic evaluation gave a clear indicator of the lower farm prices of quinoa grains in Egypt (US$ 1000/ton), which gives a comparative advantage to Egypt in the MENA region for quinoa exportation.
Risk Factors for Chronic Mastitis in Morocco and Egypt
Hanna N. Oltean,Amr S. Soliman,Omar S. Omar,Tamer F. Youssef,Mehdi Karkouri,Azza Abdel-Aziz,Ahmad Hablas,Taylor Blachley,Ali Tahri,Sofia D. Merajver
International Journal of Inflammation , 2013, DOI: 10.1155/2013/184921
Abstract: Chronic mastitis is a prolonged inflammatory breast disease, and little is known about its etiology. We identified 85 cases and 112 controls from 5 hospitals in Morocco and Egypt. Cases were women with chronic mastitis (including periductal, lobular, granulomatous, lymphocytic, and duct ectasia with mastitis). Controls had benign breast disease, including fibroadenoma, benign phyllodes, and adenosis. Both groups were identified from histopathologically diagnosed patients from 2008 to 2011, frequency-matched on age. Patient interviews elicited demographic, reproductive, breastfeeding, and clinical histories. Cases had higher parity than controls (OR = 1.75, 1.62–1.90) and more reported history of contraception use (OR = 2.73, 2.07–3.61). Cases were less likely to report wearing a bra (OR = 0.56, 0.47–0.67) and less often used both breasts for breastfeeding (OR = 4.40, 3.39–5.72). Chronic mastitis cases were significantly less likely to be employed outside home (OR = 0.71, 0.60–0.84) and more likely to report mice in their households (OR = 1.63, 1.36–1.97). This is the largest case-control study reported to date on risk factors for chronic mastitis. Our study highlights distinct reproductive risk factors for the disease. Future studies should further explore these factors and the possible immunological and susceptibility predisposing conditions. 1. Introduction Chronic mastitis (CM) is a group of diseases characterized by chronic inflammation of the breast, affecting mainly women of reproductive age in their fourth decade [1–3]. CM is histopathologically defined as inflammation of the breast, with the microabscess formation and/or the presence of granulomas [1]. This disease generally involves the breast unilaterally and may affect every quadrant region except for the subareolar area [2]. Cases mainly present with a breast mass, which may involve the overlying skin or penetrate the underlying pectoralis muscle with nipple retraction, sinus formation, and axillary lymphadenopathy [1]. Other symptoms may include galactorrhea, inflammation, pain, peau d’orange, tumorous indurations, nipple retraction and/or discharge, diffuse heaviness and enlargement, and ulcerations of the skin [4]. The disease may be locally aggressive with a recurrence rate between 16% and 50% [1]. Due to this variable clinical presentation and these similarities in symptoms as well as clinical and radiological findings with inflammatory breast cancer, diagnosis is difficult and must be confirmed histopathologically after surgical excision or core biopsy [1]. Diagnosis of CM should be
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