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Search Results: 1 - 10 of 2736 matches for " Amparo Macías "
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Safety and Efficacy of Racotumomab-Alum Vaccine as Second-Line Therapy for Advanced Non-Small Cell Lung Cancer  [PDF]
Eduardo Santiesteban, Leslie Perez, Sailyn Alfonso, Elia Neninger, Soraida Acosta, Yoana Flores, Maurenis Hernandez, Carmen Viada, Robin García, Meylán Cepeda, Daymys Estevez, Yoisbel Moreno, Amparo Macías
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.514113
Abstract:

Despite extensive clinical research in non-small cell lung cancer (NSCLC), overall survival is still poor. Racotumomab-alum is an anti-idiotypic cancer vaccine that targets NeuGcGM3 tumor associated ganglioside. The aim of this study was to evaluate safety and efficacy of racotumomab-alum in advanced NSCLC patients with progressive disease. This expanded access program included 86 histologically confirmed NSCLC patients, 18 years or older age, with advanced disease and without therapeutic option, with ECOG performance status ≤3, adequate organ functions and signed informed consent. The primary endpoint was overall survival and toxicity was measure assessed treatment-related toxicity according CTCAEv3. The study was approved by ethical review boards of participant institutions. Racotumomab-alum treatment consisted in 5 biweekly intradermal doses (1 mg/mL) during the induction phase of treatment (2 months). The maintenance phase consisted in monthly re-immunizations until unacceptable toxicity or PS worsening. The median overall survival time of all patients treated with racotumomab-alum was 8.96 months. The survival rates at 12 and 24 months were 42.8% and 28.0%, respectively. Patients that completed the induction phase of treatment (five doses or more) reached a median OS of 12.1 months. The most common adverse events were injection site reaction, bone pain, cough and asthenia. Racotumomab-alum cancer vaccine could be considered an effective and safe treatment option as second-line therapy for advanced NSCLC. Further clinical studies should be conducted to confirm this result.

Obstáculos que pueden estar impidiendo la implicación de la ciudadanía y, en particular, de los educadores, en la construcción de un futuro sostenible: Formas de superarlos
Vilches,Amparo; Gil Pérez,Daniel; Toscano,Juan Carlos; Macías,óscar;
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2008,
Abstract: despite numerous warnings and repeated calls from experts and institutions worldwide regarding the serious problems that humanity must confront, the majority of people who receive these messages fail to react and continue with their normal activity and style of life, adapting to apparently small changes, but which in few decades are dramatically modifying living conditions on earth and already affecting billions of human beings. this lack of response is one of the main reasons why the united nations organisation introduced the decade of education for sustainable development (2005-2014). it is aimed at involving educators of all levels and in all fields from all over the world in the training of citizens in order to build a sustainable future. this article intends to analyse some of the obstacles that are impeding the involvement of society as a whole, including most educators, political leaders and even many scientists, in the building of a sustainable future and to suggest how such barriers should be tackled.
Seguridad del Racotumomab en el tratamiento de pacientes con cáncer de pulmón de células no peque as
Leslie Pérez,Daymys Estévez,Yoisbel Gastón,Amparo Macías
Vaccimonitor , 2013,
Abstract: En Cuba, el cáncer de pulmón es el segundo en incidencia y el primero en mortalidad. Por tanto, se necesita identificar nuevas opciones terapéuticas. Los enfoques inmunológicos son interesantes debido al potencial de actividad sin las toxicidades de la quimioterapia convencional. El Centro de Inmunología Molecular generó una vacuna denominada Racotumomab, la cual actúa sobre el carcinoma pulmonar, aumentando la apoptosis tumoral y disminuyendo la cantidad de vasos tumorales. Para evaluar su seguridad se realizó un estudio de acceso expandido, multicéntrico y abierto en 86 pacientes con cáncer de pulmón de células no peque as. La dosis administrada fue de 1 mg/mL por vía intradérmica. Las cinco primeras dosis se administraron cada 14 días y las restantes 10 cada 28 días, hasta completar el a o de tratamiento. Las reinmunizaciones durante el seguimiento fueron cada 28 días. Se analizó la aparición de los eventos adversos y se clasificaron acorde con los criterios de la CTC v4.02. Estos se reportaron en 58 pacientes (67,4%), para un total de 215 eventos; el más frecuente fue el ardor en el sitio de la inyección, 32 (14,9%). El uso de la vacuna en los pacientes estudiados evidenció buen nivel de seguridad y tolerancia.
Obstáculos que pueden estar impidiendo la implicación de la ciudadanía y, en particular, de los educadores, en la construcción de un futuro sostenible: Formas de superarlos
Amparo Vilches,Daniel Gil Pérez,Juan Carlos Toscano,óscar Macías
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2008,
Abstract: Pese a las numerosas advertencias y reiterados llamamientos de expertos e instituciones mundiales acerca de los graves problemas a los que la humanidad ha de hacer frente, la mayoría de quienes recibimos estos mensajes continuamos sin reaccionar ante ellos y proseguimos nuestras actividades y formas de vida habituales, adaptándonos a cambios aparentemente peque os, pero que en pocas décadas están modificando dramáticamente las condiciones de vida en el planeta, afectando ya a miles de millones de seres humanos. Esta falta de respuesta es una de las razones fundamentales de la institución por Naciones Unidas de la Década de la Educación para un Desarrollo Sostenible (2005-2014), con el fin de lograr una implicación generalizada de los educadores de todos los niveles y de todas las áreas, tanto de la educación formal como de la no reglada, en la formación de la ciudadanía para la construcción de un futuro sostenible. Este artículo pretende analizar algunos de los obstáculos que impiden la implicación del conjunto de la ciudadanía, incluida la mayoría de los educadores, responsables políticos e incluso muchos científicos, en la construcción de un futuro sostenible y sugerir cómo hacerles frente. Despite numerous warnings and repeated calls from experts and institutions worldwide regarding the serious problems that humanity must confront, the majority of people who receive these messages fail to react and continue with their normal activity and style of life, adapting to apparently small changes, but which in few decades are dramatically modifying living conditions on Earth and already affecting billions of human beings. This lack of response is one of the main reasons why the United Nations Organisation introduced the Decade of Education for Sustainable Development (2005-2014). It is aimed at involving educators of all levels and in all fields from all over the world in the training of citizens in order to build a sustainable future. This article intends to analyse some of the obstacles that are impeding the involvement of society as a whole, including most educators, political leaders and even many scientists, in the building of a sustainable future and to suggest how such barriers should be tackled.
Anti-idiotype antibodies in cancer treatment
Daniel E. Gomez,Ana M. Vázquez,Daniel F. Alonso,Amparo Macías
Frontiers in Oncology , 2013, DOI: 10.3389/fonc.2013.00037
Abstract:
Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides – preclinical and clinical data
Ana M. Vázquez,Ana M. Hernández,Amparo Macías,Enrique Montero,Daniel E. Gómez,Daniel F. Alonso,Mariano R. Gabri,Roberto E. Gómez
Frontiers in Oncology , 2012, DOI: 10.3389/fonc.2012.00150
Abstract: Neu-glycolyl (NeuGc)-containing gangliosides are attractive targets for immunotherapy with anti-idiotype mAbs, because these glycolipids are not normal components of the cytoplasmic membrane in humans, but their expression has been demonstrated in several human malignant tumors. Racotumomab is an anti-idiotype mAb specific to P3 mAb, an antibody which reacts to NeuGc-containing gangliosides, sulfatides, and other antigens expressed in tumors. Preparations containing racotumomab were able to induce a strong anti-metastatic effect in tumor-bearing mice. Different Phase I clinical trials have been conducted in patients with advanced melanoma, breast cancer, and lung cancer. The results of these clinical trials demonstrated the low toxicity and the high immunogenicity of this vaccine. The induced antibodies recognized and directly killed tumor cells expressing NeuGcGM3. A Phase II/III multicenter, controlled, randomized, double blind clinical trial was conducted to evaluate the effect of aluminum hydroxide-precipitated racotumomab vaccine in overall survival in patients with advanced non-small cell lung cancer. The clinical results of this study showed a significant clinical benefit in the patients who were treated with the anti-idiotype vaccine.
Spatio-Temporal Prediction of Root Zone Soil Moisture Using Multivariate Relevance Vector Machines  [PDF]
Bushra Zaman, Mac McKee
Open Journal of Modern Hydrology (OJMH) , 2014, DOI: 10.4236/ojmh.2014.43007
Abstract:
Root zone soil moisture at one and two meter depths are forecasted four days into the future. In this article, we propose a new multivariate output prediction approach to root zone soil moisture assessment using learning machine models. These models are known for their robustness, efficiency, and sparseness; they provide a statistically sound approach to solving the inverse problem and thus to building statistical models. The multivariate relevance vector machine (MVRVM) is used to build a model that forecasts soil moisture states based upon current soil moisture and soil temperature conditions. The methodology combines the data at different depths from 5 cm to 50 cm, the largest of which corresponds to the depth at which the soil moisture sensors are generally operational, to produce soil moisture predictions at larger depths. The MVRVM test results for soil moisture predictions at 1 m and 2 m depth on the 4th day are excellent with RMSE = 0.0131 m3/m3 for 1 m; and RMSE = 0.0015 m3/m3 for 2 m forecasted values. The statistics of predictions for 4th day (CoE = 0.87 for 1 m and CoE = 0.96 for 2 m) indicate good model generalization capability and computations show good agreement with actual measurements with R2 = 0.88 and R2 = 0.97 for 1 m and 2 m depths, respectively. The MVRVM produces good results for all four days. Bootstrapping is used to check over/under-fitting and uncertainty in model estimates.
Psychosis and Silent Celiac Disease in a Down Syndrome Adolescent: A Case Report
Amparo Morant
Case Reports in Pediatrics , 2011, DOI: 10.1155/2011/970143
Abstract: Celiac disease is an autoimmune systemic disorder. It presents gastrointestinal and nongastrointestinal manifestations as well as associated conditions. We report a 16-year-old Down syndrome girl who presented psychosis symptomatology, and she was diagnosed as having silent celiac disease. Olanzapine treatment and gluten-free diet were satisfactory. It is necessary to consider celiac disease in Down syndrome patients with psychiatric symptoms, mainly psychotic symptomatology.
Perspectivas de la estética y la política en J. F. Lyotard
Vega,Amparo;
Revista de Estudios Sociales , 2010,
Abstract: the central perspectives and concepts of the aesthetics and politics of the philosophy of jean-fran?oise lyotard are presented in this text. the emergence from the war leads lyotard, starting with his first texts in 1948, to question politics, ask for a critical philosophy (phenomenology, 1954), and a later distance himself from philosophy during the years in which he became a militant with the marxist group which published the magazine socialism or barbarism, with which he remains until 1966. why philosophyze (1964) captures the aforementioned experience and defines the orientation and research themes of later investigations of critical philosophy from which aesthetics, politics, and the concepts that relate these two areas are given thought. a first critical perspective of aesthetics focuses on the relationship between desire and arts, and between desire and the critical discourse, starting with discourse, figure (1971) and ending with libidinal economy (1974). this study ends with a nietzsche-like aesthetic and politic described as paths adrift with the strongest of libidinal intensities. the evaluation of these practices in libidinal economy and the devices of capitalism, in particular, lead lyotard to change his perspective. from pragmatic analyses of the games of language in discourses, knowledge and tales, as well as the practices and institutions of advanced societies, the postmodern condition (1982-1985) integrates the aesthetic manner of reflexive judgement (kant) to the proposal of a postmodern "critical knowledge". the enthusiasm (1986) proposes a analogy of aesthetic and critical judgment applied to the political. due to the multiplication of languages and their heterogeneity, unsolvable conflicts arise which are analyzed by lyotard, mostly under the concept of diferend (the difference, 1983), the sublime in the postmodern explained to children, and the inhuman. in covering these issues, this text defines steps and analogous elements between critique, a
SEA Presidential address: Group connectivity and cooperation
Amparo Urbano
SERIEs , 2011, DOI: 10.1007/s13209-011-0066-3
Abstract: This lecture provides a modeling of “group connectivity” by proposing a generalization of the concept of a graph. This new approach not only captures binary relations between agents but also high-order relations among subsets of them. The model allows us to characterize the minimal structures of cooperation survival in a spatial Prisoners’ Dilemma game in a Moore neighborhood and helps explain the existence of persistent “islands of cooperation” in hostile environments. The dynamic behavior shows an increase in the fraction of cooperators relative to the standard spatial Prisoners’ Dilemma game.
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