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Search Results: 1 - 10 of 1231 matches for " Amitava Chakrabarti "
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Evaluation of Lercanidipine in Paclitaxel-Induced Neuropathic Pain Model in Rat: A Preliminary Study
Lekha Saha,Debasish Hota,Amitava Chakrabarti
Pain Research and Treatment , 2012, DOI: 10.1155/2012/143579
Abstract: Objective. To demonstrate the antinociceptive effect of lercanidipine in paclitaxel-induced neuropathy model in rat. Materials and Methods. A total of 30 rats were divided into five groups of six rats in each group as follows: Gr I: 0.9% NaCl, Gr II: paclitaxel?+?0.9% NaCl, Gr III: paclitaxel?+?lercanidipine 0.5?μg/kg, Gr IV: paclitaxel?+?lercanidipine 1?μg/kg, and Gr V: paclitaxel?+?lercanidipine 2.5?μg/kg. Paclitaxel-induced neuropathic pain in rat was produced by single intraperitoneal (i.p.) injection of 1?mg/kg of paclitaxel on four alternate days (0, 2, 4, and 6). The tail flick and cold allodynia methods were used for assessing the pain threshold, and the assessments were done on days 0 (before first dose of paclitaxel) and on days 7, 14, 21, and 28. Results. There was a significant decrease ( ) in the tail flick and cold allodynia latency in the paclitaxel-alone group from day 14 onward when compared with day 0. In the lercanidipine groups, the decrease in the tail flick and cold allodynia latency was not observed in 1.0 and 2.5?μg/kg groups and it was statistically significant ( ) when compared with paclitaxel-alone group. 1. Introduction Neuropathic pain is a type of pain which is caused by damage to or dysfunction of the nervous system. [1] Neuropathic pain cannot be explained by a single disease process or a single specific location of damage. It is a disorder in the structure and function of peripheral, motor, sensory, and/or autonomic neurons either partially or completely [2]. Neuropathic pain may be divided into peripheral, central, or mixed (peripheral and central) neuropathic pain. As much as 7% to 8% of the population is affected and in 5%, it may be severe [3]. In order to evaluate the mechanisms of neuropathic pain and to find new therapeutic approaches, different experimental neuropathic pain models have been developed which include chronic constriction injury of sciatic nerve, partial sciatic nerve ligation, and partial transaction of sciatic nerve. Current knowledge regarding the mechanisms of neuropathic pain is incomplete and is biased by a focus on animal models of peripheral nerve injury, and the treatment is often unsatisfactory. It is an area of largely unmet therapeutic need. The current pharmacological mainstays of clinical management are tricyclic antidepressants and certain anticonvulsants, but these only achieve clinically significant (>50%) pain relief in 40–60% of patients and are associated with several side effects. Opioids are generally considered to be less effective in neuropathic pain than in inflammatory pain
Research methodological issues in evaluating herbal interventions
Dipika Bansal, Debasish Hota, Amitava Chakrabarti
Open Access Journal of Clinical Trials , 2010, DOI: http://dx.doi.org/10.2147/OAJCT.S9029
Abstract: earch methodological issues in evaluating herbal interventions Review (4136) Total Article Views Authors: Dipika Bansal, Debasish Hota, Amitava Chakrabarti Published Date February 2010 Volume 2010:2 Pages 15 - 21 DOI: http://dx.doi.org/10.2147/OAJCT.S9029 Dipika Bansal, Debasish Hota, Amitava Chakrabarti Postgraduate Institute of Medical Education and Research, Chandigarh, India Abstract: Randomized controlled trials provide the best evidence, and is seen as the gold standard for allopathic research. Herbal therapies are not an integral part of conventional care although they are still used by patients in their health care management. These medicines need to be subjected to rigorous research to establish their effectiveness and safety. Clearly defined treatments are required and should be recorded in a manner that enables other suitably trained researchers to reproduce them reliably. Quality control of herbal products is also a prerequisite of credible clinical trials. Methodological strategies for investigating the herbal interventions and the issues regarding appropriate patient selection, randomization and blinding, placebo effects and choice of comparator, occupational standardization and the selection of appropriate study endpoints to prove efficacy are being discussed. This paper will review research options and propose some suggestions for future research design.
Research methodological issues in evaluating herbal interventions
Dipika Bansal,Debasish Hota,Amitava Chakrabarti
Open Access Journal of Clinical Trials , 2010,
Abstract: Dipika Bansal, Debasish Hota, Amitava ChakrabartiPostgraduate Institute of Medical Education and Research, Chandigarh, IndiaAbstract: Randomized controlled trials provide the best evidence, and is seen as the gold standard for allopathic research. Herbal therapies are not an integral part of conventional care although they are still used by patients in their health care management. These medicines need to be subjected to rigorous research to establish their effectiveness and safety. Clearly defined treatments are required and should be recorded in a manner that enables other suitably trained researchers to reproduce them reliably. Quality control of herbal products is also a prerequisite of credible clinical trials. Methodological strategies for investigating the herbal interventions and the issues regarding appropriate patient selection, randomization and blinding, placebo effects and choice of comparator, occupational standardization and the selection of appropriate study endpoints to prove efficacy are being discussed. This paper will review research options and propose some suggestions for future research design.Keywords: CAM research, herbal therapies, methodology, clinical trial
Singlet-Higgs-Boson Signals at Hadron Colliders
Anindya Datta,Amitava Raychaudhuri,Sreerup Raychaudhuri,Surajit Chakrabarti
Physics , 1995, DOI: 10.1007/BF02909173
Abstract: Many extensions of the Standard Model include $SU(2)_L \times U(1)_Y$ singlet higgs bosons, $h^0$, and also vectorlike fermions which couple to it. The production and detection possibilities of such singlet neutral scalars at hadron colliders are considered for different scenarios of vectorlike fermions. We find that for some values of masses and couplings, detection at the CERN Large Hadron Collider (LHC) appears to be a distinct possibility, while at the Fermilab Tevatron upgrade the $h^0$ might be observed only in very favourable circumstances.
Adsorptive Mass Transport of Dye on Rice Husk Ash  [PDF]
Debasish Sarkar, Amitava Bandyopadhyay
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.25049
Abstract: Experimentations have been carried out to characterize the adsorption of Methylene Blue (MB) and Congo Red (CR) dyes in the aqueous phase onto Rice Husk Ash (RHA). Theoretically analyses are also made for describing the sorption and diffusion processes. The effective pore diffusivities of the dye molecules studied in RHA are determined by a suitable global optimization technique. The depth of penetration, on the other hand, has been estimated for various initial concentrations of dyes. Theoretically predicted concentration pro-files are compared with the experimental values at different initial concentrations of these dyes. Such com-parative studies indicate that the predicted values are in excellent agreement with the experimental values.
Bt cotton influencing enzymatic activities under varied soils  [PDF]
Kasturikasen Beura, Amitava Rakshit
Open Journal of Ecology (OJE) , 2013, DOI: 10.4236/oje.2013.38059
Abstract:

The enzymatic activity was evaluated under both Bt and non-Bt systems in varied soil type. The study was conducted during the 2010 wet season (July to December) in a net-house at the Institute of Agricultural Sciences of Banaras Hindu University. It was carried out on three different soil ordersi.e.entisol, inceptisol and alfisol. Bt cotton (cvNCS-138) and its non-transgenic isoline (cvNCS-138) were grown until maturity. A no crop pot was maintained with three replications for all the three soil orders. Study design was a factorial experiment under a completely randomized block design with three replications. The study concludes that soil under Bt cotton cultivar produced significantly higher amount of phosphatase activity than both nonBt and no crop treatments at three growth stages. And the value decreased as the crop growth period advanced. The interaction effect between soil type and Bt-crop was found to be significant in different growth stages throughout the growing season. Results from the study revealed that a significant reduction (9.4%) of the dehydrogenase activity and soil respiration (5%) in the rhizosphere of Bt cotton over non-Bt isoline.

Bifurcation and Chaos in Delayed Cellular Neural Network Model  [PDF]
Pritha Das, Amitava Kundu
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.25027
Abstract: This paper deals with control of chaotic behavior of a delayed Cellular Neural Network (DCNN) model which is a one-dimensional regular array of four cells with continuous activation function. We investigate different dynamical behaviors including limit cycle, torus, and chaos for different range of weight parameters of the system. Regarding synaptic weight as parameter, Hopf bifurcations are obtained in the system without delay. In the delayed model condition for the Global asymptotic stability of the equilibrium point is presented. Numerical simulation and results are given to show the role of delay in chaos control of the CNNs.
Integrin Alpha-V Beta-3-Matrix Metalloproteinase-2 (MMP-2), Cross-Talk  [PDF]
Hrishikesh Sil, Amitava Chatterjee
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.69087
Abstract: The present study aimed to detect comparative expression of integrin αVβ3 and its involvement in expression and activation of matrix metalloproteinase-2 (MMP-2) in 25 malignant human breast tumor and adjacent normal breast tissues from different clinical TNM stages (DCIS to T4) of the disease and possible involvement of known regulating parameters of MMP-2 like TIMP-2, MT1-MMP and EMPRIN. Integrin αVβ3 was highly expressed in tumors than adjacent normal breast tissues. Pro-MMP-2(72-KD) was mainly expressed in adjacent normal tissues compared to tumors. The mature forms of MMP-2 (68 KD and 64 KD) were found only in tumors. Appreciable expression of TIMP-2 and induction of MT1-MMP and EMPRIN in T2-T4 stages suggested their possible role in MMP-2 activation. Over expression Integrin αVβ3 in tumors than adjacent normal breast tissues was an indication of cancer progression with involvement of integrin signaling. We conclude that, the co-precipitation of MMP-2 with αvβ3 by anti-αv antibody is a strong indication that integrin α
Screening for Aphid Incidence on Some Potato Germplasm in Plains of West Bengal  [PDF]
Biplab Kahar, Amitava Konar
Agricultural Sciences (AS) , 2016, DOI: 10.4236/as.2016.76036
Abstract: A field trial was conducted to study the impact of various potato germplasm against aphids, Myzus persicae (Sulzer) and Aphis gossypii Glover (Aphididae: Hemiptera) during rabi season from November to March in 2012-2013 and 2013-2014, respectively at Adisaptagram Block Seed Farm, Hooghly, West Bengal. The population of aphids was started on potato crop in between third week of December and first week of January irrespective of various germplasms, except K. Chipsona-2, where its infestation was initiated during second and third week of January. Then, their population was gradually increased to reach its critical level (ETL) during first and second week of January in most of the potato germplasm, except in K. Anand, K. Chipsona-1, K. Chipsona-2 and Sailaja, where it was crossed in between fourth week of January and first week of February. The peak population of aphids was observed during third and fourth week of February in most of the potato germplasm. It was observed that K. Ashoka, K. Badshah, K. Chandramukhi, K. Jawahar, K. Jyoti and K. Pukhraj were highly susceptible to the pests, while K. Anand and K. Sutlez were moderately susceptible but K. Chipsona-1 , K. Chipsona-2 and K. Sailaja were less susceptible or tolerant to the pests. Maximum tuber yield (t/ha) of potato was recorded in K. Badshah (36.58 - 43.92) while it was lowest in K. Chandramukhi (22.08 - 22.12).
Relationship among Different Soil Biochemical Methods to Determine Soil Health  [PDF]
Amitava Chatterjee, Umesh Acharya
Open Journal of Soil Science (OJSS) , 2018, DOI: 10.4236/ojss.2018.811022
Abstract: Numerous soil biochemical methods are used to determine the soil health status, but the relationships among these methods are not well understood. Relationships among soil biochemical tests, 1) chloroform fumigated microbial biomass C (CFMBC), 2) permanganate oxidizable C (POXC), 3) Solvita CO2-burst (Solvita), 4) Solvita labile amino nitrogen (SLAN), and short-term soil CO2 efflux during laboratory incubation using (v) Alkali-base trap (Alkali) and (vi) infrared gas analyzer (IRGA), were evaluated for nine agricultural soils collected across the Red River Valley of North Dakota and Minnesota, USA. Not a single test is comprehensive to relate with all soil biochemical tests. Coefficient of variation percentage for particular method varied with soil type. Among six tests, CFMBC is significantly (p < 0.05) related with Alkali (r = 0.37), Solvita (r = 0.57), SLAN (r = 0.52), and POXC (r = 0.68). Soil CFMBC correlates with most of soil biochemical tests and can be potential to determine soil biochemical condition.
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