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Isolated hepatic tuberculosis
Bangroo A,Malhotra Amit
Journal of Indian Association of Pediatric Surgeons , 2005,
Abstract: Hepatic tuberculosis is usually associated with an active pulmonary or miliary tuberculosis, but rarely localizes as a liver tumor mass. The clinical presentation of isolated liver tuberculosis is so rare and atypical that it challenges the clinical acumen of the treating physician. Diagnostic modalities like ultrasound and computed tomography can miss the diagnosis. Ultimately, the diagnosis is confirmed by demonstrating an acid fast Mycobacterium in aspirated pus or necrotic material.
Network Security Threats and Protection Models
Amit Kumar,Santosh Malhotra
Computer Science , 2015,
Abstract: In a brave new age of global connectivity and e-commerce, interconnections via networks have heightened, creating for both individuals and organizations, a state of complete dependence upon vulnerable systems for storage and transfer of information. Never before, have so many people had power in their own hands. The power to deface websites, access personal mail accounts, and worse more the potential to bring down entire governments, and financial corporations through openly documented software codes. This paper discusses the possible exploits on typical network components, it will cite real life scenarios, and propose practical measures that can be taken as safeguard. Then, it describes some of the key efforts done by the research community to prevent such attacks, mainly by using Firewall and Intrusion Detection Systems.
MEDICAL MANAGEMENT OF DENTAL CARIES: A CHANGE IN THERAPEUTIC APPROACH
Amit Malhotra,Mithra N. Hegde
International Research Journal of Pharmacy , 2013,
Abstract: Dental caries is an infectious, communicable disease, which causes destruction of teeth by acid-forming bacteria found in dental plaque. Caries progression or reversal is determined by the balance between protective and pathological factors in the mouth. There have been revolutions in every field and dentistry is no exception to it, these changes have led to a change in concept from the conventional surgical approach of removing dental decay and cutting of tooth structure to the medical model which deals with interception of disease at different stages and possible reversal of the disease process. The key to medical paradigm is determination of caries risk in an individual and effective early detection of initial carious lesions. There are various equipments available in market which uses different principles for diagnosing caries susceptibility in an individual. In the years of thorough research different agents have been investigated for their role in caries prevention and reversal. There is a separate treatment plan for managing patients falling in different risk category. This article outlines the need for the medical management of dental caries and how it can be a viable option in dental decay management.
Effect of Gas Phase Heat Sink on Suppression of Opposed Flow Flame Spread over Thin Solid Fuels in Microgravity Environment
Vinayak Malhotra,Chenthil Kumar,Amit Kumar
Journal of Combustion , 2012, DOI: 10.1155/2012/837019
Abstract: A two-dimensional numerical model of opposed flow flame spread over thin solid fuel is formulated and modeled to study the effect of gas phase heat sink (a wire mesh placed parallel to the fuel surface) on the flame-spread rate and flame extinction. The work focuses on the performance of the wire mesh in microgravity environment at an oxygen concentration 21%. The simulations were carried out for various mesh parameters (wire diameter, “ ” and number of wires per unit length, “ ”) and mesh distance perpendicular to fuel surface “ ”. Simulations show that wire mesh is effective in reducing flame-spread rate when placed at distance less than flame width (which is about 1?cm). Mesh wire diameter is determined not to have major influence on heat transfer. However, smaller wire diameter is preferred for better aerodynamics and for increasing heat transfer surface area (here prescribed by parameter “ ”). Flame suppression exhibits stronger dependence on number of wires per unit length; however, it is relatively insensitive to number of wires per unit length beyond certain value (here 20?cm?1). 1. Introduction Diffusion flames formed over condensed fuels are well known to spread along the surface of the fuel by heat transfer from flame to fuel surface ahead of the flame. The heat transferred from the flame to the fuel pyrolyzes it to vapors which upon mixing with surrounding air form a combustible mixture. This combustible mixture is ignited by the flame behind and hence advances forward over the surface of the fuel. The study of flame spread phenomena is primarily driven by the need to have better fire safety, by means of enhanced understanding of the mechanisms that control the spread rates and extinction. Traditionally, the flame spread phenomena over solid fuels are studied under two basic categories: opposed flow flame spread and concurrent flow flame spread. This classification is based on the relative direction of flame spread with respect to the ambient gas velocity vector. In opposed flow flame spread, the flame spreads against the flow direction and in concurrent flow flame spread, the flame spreads in the direction of flow. Present work relates to the study of opposed flow spreading flame on thin solid fuel (cellulose sheets with area density 57?g/cm2) in zero gravity. Following the classical work of De Ris [1] on opposed flow spreading flames in 1969, over the last four decades research works have contributed significantly to the improvement in the understanding of the flame spread phenomena. The works [2–7] provide an excellent review on the
Alopecia universalis in Down syndrome: Response to therapy
Sethuraman Gomathy,Malhotra Amit,Sharma Vinod
Indian Journal of Dermatology, Venereology and Leprology , 2006,
Abstract:
Lichen sclerosus: Role of occlusion of the genital skin in the pathogenesis
Gupta Somesh,Malhotra Amit,Ajith C
Indian Journal of Dermatology, Venereology and Leprology , 2010,
Abstract: Lichen sclerosus (LS) is a chronic inflammatory skin disease, which most commonly involves the anogenital region. The etiology of LS is obscure, but genetic susceptibility, autoimmune mechanisms, infective agents like human papillomavirus and spirochaetes, and Koebner phenomenon has been postulated as causative factors. We report our observation in 6 patients (3 males and 3 females) with histologically proven lichen sclerosus that showed relative sparing of the uncovered areas of the genitals, thereby suggesting that the occlusion of the genital skin may be playing a greater role in the causation of LS than is currently thought, in both sexes.
Role of Plasmodium falciparum thrombospondin-related anonymous protein in host-cell interactions
Reetesh Akhouri, Ashwani Sharma, Pawan Malhotra, Amit Sharma
Malaria Journal , 2008, DOI: 10.1186/1475-2875-7-63
Abstract: Plasmodium falciparum TRAP (PfTRAP) and its subdomains were expressed in a mammalian expression system, and eleven different mutants generated to study interaction of PfTRAP with liver cells. Binding studies between HepG2 cell extracts and PfTRAP were performed using co-immunoprecipitation protocols.Five different amino acid residues of PfTRAP that are involved in liver cell binding have been identified. These PfTRAP mutants bound to heparin like the wild type PfTRAP thereby suggesting a non-heparin mediated binding of PfTRAP to liver cells. Three Src family proteins -Lyn, Lck and CrkL which interact with PfTRAP are also identified. Liver cell extracts and immunoprecipitated Src family kinases phosphorylated PfTRAP at multiple sites. An analysis of multiple TRAP sequences revealed Src homology 3 domain (SH3) binding motifs.Binding of PfTRAP to SH3-domain containing proteins like Src-family kinases and their ability to phosphorylate PfTRAP suggests a novel role for PfTRAP in cell signaling during sporozoite invasion and homing inside the liver cells. These data shed new light on TRAP-liver cell interactions.Malaria is a major parasitic disease that claims more than two million lives and causes more than 500 million clinical cases every year [1]. Despite continuous efforts to control malaria, it remains a major health problem in the tropical world, mainly due to Plasmodium falciparum. Since the search for a malaria vaccine remains elusive, there is a constant and pressing need to identify new drug and vaccine targets. Malaria infection in humans starts when infected female Anopheles mosquitoes take their blood meal and inject sporozoites into the host (human) skin. Although, it remains unclear how sporozoites reach hepatocytes, experimental evidence suggests role of various molecules for successful infection that includes components both from the host and the parasite. Apicomplexans lack a classical locomotory organelles like flagellum or cilium but show an actin base
CIRCUIT MINIMIZATION IN VLSI USING PSO & GA ALGORITHMS
RAJDEEP SINGH, AMIT ARORA, GURJIT SINGH, JAGJIT MALHOTRA
International Journal of Engineering Trends and Technology , 2012,
Abstract: Circuit partitioning is the more critical step in the physical design of various circuit in VLSI. In this partitioning main objective is to minimize the number of cuts. For this PSO algorithm is proposed for the optimization of VLSI inter connection (net list) bipartition. Meanwhile, the corresponding evaluation function and the operators of crossover and mutation are designed. The algorithm is implemented to test various benchmark circuits. Compared with the traditional genetic algorithm (GA) with the same evaluation function and the same genetic operators concerned the hybrid PSO and GA algorithm will give better results.
Superficial basal cell carcinoma on face treated with 5% imiquimod cream
Malhotra Amit,Bansal Arika,Mridha Asit,Khaitan Binod
Indian Journal of Dermatology, Venereology and Leprology , 2006,
Abstract: Imiquimod, an immune response modifier, is known to possess both anti-viral and anti-tumor effect. We report our experience of treating a large superficial spreading basal cell carcinoma with 5% imiquimod cream. A 65-year-old male had an asymptomatic, hyperpigmented, slowly progressive, indurated, 3 x 4 cm plaque on the left cheek for two months. Biopsy from the lesion showed features of basal cell carcinoma. The patient was treated with imiquimod 5% cream, topically three times a week for six months with complete resolution of the lesion and without any side-effects. There was no clinical or histological recurrence after three months of stopping the treatment.
Energy Efficient Path Determination in Wireless Sensor Network Using BFS Approach  [PDF]
Shilpa Mahajan, Jyoteesh Malhotra
Wireless Sensor Network (WSN) , 2011, DOI: 10.4236/wsn.2011.311040
Abstract: The wireless sensor networks (WSN) are formed by a large number of sensor nodes working together to provide a specific duty. However, the low energy capacity assigned to each node prompts users to look at an important design challenge such as lifetime maximization. Therefore, designing effective routing techniques that conserve scarce energy resources is a critical issue in WSN. Though, the chain-based routing is one of significant routing mechanisms but several common flaws, such as data propagation delay and redundant transmission, are associated with it. In this paper, we will be proposing an energy efficient technique based on graph theory that can be used to find out minimum path based on some defined conditions from a source node to the destination node. Initially, a sensor area is divided into number of levels by a base station based on signal strength. It is important to note that this technique will always found out minimum path and even alternate path are also saved in case of node failure.
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