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Search Results: 1 - 10 of 195431 matches for " Amit D. Joshi "
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Comparative Study of Indentation Size Effects in As-Sintered Alumina and Alumina Shock Deformed at 6.5 and 12 GPa
Riya Chakraborty,Anoop K. Mukhopadhyay,Keshaw D. Joshi,Amit Rav
ISRN Ceramics , 2012, DOI: 10.5402/2012/595172
Abstract:
An Automation Tool for Single-node and Multi-node Hadoop Cluster
Vaibhav N. Keskar,Amit A. Kathade,Gopal S. Sarda,Amit D. Joshi
Journal of Artificial Intelligence , 2013,
Abstract: Many organisations are required to deal with large data sets. To handle the large data sets these organisations use hadoop cluster. But they need to set up hadoop cluster with different number of nodes several times. This is very common case for many organisations that have just started with hadoop cluster. Setting up hadoop cluster is not a difficult job but requires large human efforts and time. As the number of nodes increases, human efforts and time required also increase. An automation tool which will automate the hadoop cluster set up procedure will be the possible solution to reduce human efforts and time requirement. This study talks about the tool which will automate the hadoop cluster set up procedure. No tool had proved a single operator to install single-node and multi-node cluster.
Riots After Medical Mishaps. How can we Improve?
Amit Joshi
Nepal Orthopaedic Association Journal , 2013, DOI: 10.3126/noaj.v3i1.9317
Abstract: DOI: http://dx.doi.org/10.3126/noaj.v3i1.9317 Nepal Orthopedic Association Journal 2013 Vol.3(1): 3-4
Get Your Articles Published in MJSBH: learning from our own mistakes.
Amit Joshi
Medical Journal of Shree Birendra Hospital , 2013, DOI: 10.3126/mjsbh.v12i1.8886
Abstract: We are in the era of “publish or perish”. As a medical professional, if we do not have publication under our belt, the career will be stagnant. The publication has become mandatory for academic appointment and ladder. Because of conversion of many clinical centers to an academic institution, academic requirement has increased and this has mounted pressure on clinicians. In recent years the pressure has extended to MJSBH (Medical Journal of Shree Birendra Hospital) also, as there is exponential increase in number of articles submitted. In recent months, the visibility of our journal has increased because of inclusion of our journal into an open access system. This has raised the responsibility of editors and publishers to produce a high quality article1. On the other hand the demand on authors has also raised as they have to submit a quality and well prepared manuscript otherwise it will be rejected. The rejection rate of our journal for year 2012 was 30%, and will increase in coming years.
Medical Journal of Shree Birendra Hospital: Journey Continues.
Amit Joshi
Medical Journal of Shree Birendra Hospital , 2012, DOI: 10.3126/mjsbh.v11i1.7757
Abstract: Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/1-3 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7757
Investigating Effect of Machining Parameters of CNC Milling on Surface Finish by Taguchi Method
Amit Joshi,Pradeep Kothiyal
International Journal on Theoretical and Applied Research in Mechanical Engineering , 2013,
Abstract: CNC End milling is a unique adaption of the conventional milling process which uses an end mill tool for the machining process. CNC Vertical End Milling Machining is a widely accepted material removal process used to manufacture components with complicated shapes and profiles. During the End milling process, the material is removed by the end mill cutter. The effects of various parameters of end milling process like spindle speed, depth of cut, feed rate have been investigated to reveal their Impact on surface finish using Taguchi Methodology. Experimental plan is performed by a Standard Orthogonal Array. The results of analysis of variance (ANOVA) indicate that the feed Rate is most influencing factor for modelling surface finish. The graph of S-N Ratio indicates the optimal setting of the machining parameter which gives the optimum value of surface finish. The optimal set of process parameters has also been predicted to maximize the surface finish.
Investigating effects of process variables on MRR in EDM by using Taguchi parameter design approach
Amit Joshi,Pradeep Kothiyal
International Journal on Theoretical and Applied Research in Mechanical Engineering , 2012,
Abstract: The correct selection of manufacturing conditions is one of the most important aspects to take into consideration in the majority of manufacturing processes and, particularly, in processes related to Electrical Discharge Machining (EDM). It is a capable of machining geometrically complex or hard material components, that are precise and difficult-to-machine such as heat treated tool steels, composites, super alloys, ceramics, carbides, heat resistant steels etc. being widely used in die and mold making industries, aerospace, aeronautics and nuclear industries. OHNS-EN-31 is a high car bon alloy steel which achieves high degree of hardness with compressive strength and abrasive resistance. OHNS-EN-31 steel, which is popularly used in automotive type applications, like axle, bearings, spindle and molding dies etc. In this paper we have tried to investigate effect of machining parameter such as discharge current, pulse on time, and pulse of time on MRR in EDM while machining OHNS-EN-31 STEEL using Cu tool . A well-designed experimental scheme was used to reduce the total number of experiments. Parts of the experiment were conducted with the L18 orthogonal array based on the Taguchi method. The results of analysis of variance (ANOVA) indicate that the proposed mathematical model can be adequately describe the performance within the limit of factors being studied. The optimal set of process parameters has also been predicted to maximize the MRR.
Investigating Effect of Machining Parameters of CNC Milling on Surface Finish by Taguchi Method
Amit Joshi,Pradeep Kothiyal
International Journal on Theoretical and Applied Research in Mechanical Engineering , 2012,
Abstract: CNC End milling is a unique adaption of the conventional milling process which uses an end mill tool for the machining process. CNC Vertical End Milling Machining is a widely accepted material removal process used to manufacture components with complicated shapes and profiles. During the End milling process, the material is removed by the end mill cutter. The effects of various parameters of end milling process like spindle speed, depth of cut, feed rate have been investigated to reveal their Impact on surface finish using Taguchi Methodology. Experimental plan is performed by a Standard Orthogonal Array. The results of analysis of variance (ANOVA) indicate that the feed Rate is most influencing factor for modeling surface finish. The graph of S-N Ratio indicates the optimal setting of the machining parameter which gives the optimum value of surface finish. The optimal set of process parameters has also been predicted to maximize the surface finish.
Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia
Amit K. Mittal, Nagendra K. Chaturvedi, Rae A. Rohlfsen, Payal Gupta, Avadhut D. Joshi, Ganapati V. Hegde, R. Gregory Bociek, Shantaram S. Joshi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070352
Abstract: Earlier, we reported that CTLA4 expression is inversely correlated with CD38 expression in chronic lymphocytic leukemia (CLL) cells. However, the specific role of CTLA4 in CLL pathogenesis remains unknown. Therefore, to elucidate the possible role of CTLA4 in CLL pathogenesis, CTLA4 was down-regulated in primary CLL cells. We then evaluated proliferation/survival in these cells using MTT, 3H-thymidine uptake and Annexin-V apoptosis assays. We also measured expression levels of downstream molecules involved in B-cell proliferation/survival signaling including STAT1, NFATC2, c-Fos, c-Myc, and Bcl-2 using microarray, PCR, western blotting analyses, and a stromal cell culture system. CLL cells with CTLA4 down-regulation demonstrated a significant increase in proliferation and survival along with an increased expression of STAT1, STAT1 phosphorylation, NFATC2, c-Fos phosphorylation, c-Myc, Ki-67 and Bcl-2 molecules. In addition, compared to controls, the CTLA4-downregulated CLL cells showed a decreased frequency of apoptosis, which also correlated with increased expression of Bcl-2. Interestingly, CLL cells from lymph node and CLL cells co-cultured on stroma expressed lower levels of CTLA4 and higher levels of c-Fos, c-Myc, and Bcl-2 compared to CLL control cells. These results indicate that microenvironment-controlled-CTLA4 expression mediates proliferation/survival of CLL cells by regulating the expression/activation of STAT1, NFATC2, c-Fos, c-Myc, and/or Bcl-2.
Genetic Variation in the Base Excision Repair Pathway, Environmental Risk Factors, and Colorectal Adenoma Risk
Roman Corral, Juan Pablo Lewinger, Amit D. Joshi, A. Joan Levine, David J. Vandenberg, Robert W. Haile, Mariana C. Stern
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071211
Abstract: Cigarette smoking, high alcohol intake, and low dietary folate levels are risk factors for colorectal adenomas. Oxidative damage caused by these three factors can be repaired through the base excision repair pathway (BER). We hypothesized that genetic variation in BER might modify colorectal adenoma risk. In a sigmoidoscopy-based study, we examined associations between 182 haplotype tagging SNPs in 14 BER genes, and colorectal adenoma risk, and examined their potential role as modifiers of the effect cigarette smoking, alcohol intake, and dietary folate levels. Among all individuals, no statistically significant associations between BER SNPs and adenoma risk persisted after correction for multiple comparisons. However, among Asian-Pacific Islanders we observed two SNPs in FEN1 and one in NTHL1, and among African-Americans one SNP in APEX1 that were associated with colorectal adenoma risk. Significant associations were also observed between SNPs in the NEIL2 gene and rectal adenoma risk. Three SNPS modified the effect of smoking (MUTYH interaction p = 0.002; OGG1 interaction p = 0.013); FEN1 interaction p = 0.013)), one SNP in LIG3 modified the effect of alcohol consumption (interaction p = 0.024) and two SNPs in LIG3 modified the effect of dietary folate (interaction p = 0.001 and p = 0.08) on colorectal adenoma risk. These findings support a role for genetic variants in the BER pathway as potential modifiers of colorectal adenoma risk. Our findings strengthen the role of oxidative damage induced by key lifestyle and dietary risk factors in colorectal adenoma formation.
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