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Search Results: 1 - 10 of 323 matches for " Amen Hamdy Zaky "
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Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib  [PDF]
Amen Hamdy Zaky Aly, Ahmed EL Sayed Mohammed Khalifa, Esraa Abdallah Abdelkariem Gadallah
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911073
Abstract: Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.
Feasibility of Upfront Debulking Surgery versus Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Advanced Ovarian Cancer  [PDF]
Amen Hamdy Zaky, Adel Gabr, Doaa Wadie Maximous, Ahmed A. S. Salem, Amr Farouk Mourad, Haisam Atta, Marwa Ismail
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.92015
Abstract: Background: Inappropriately ovarian cancer cannot be detected until an advanced stage. Radical debulking surgery is considered the cornerstone in the management of advanced ovarian cancer pointing to complete tumor resolution. Unless optimal debulking cannot be achieved, these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been recommended as a novel therapeutic modality to a diversity of malignant tumors when the disease is not willing to optimal surgical resection at the time of diagnosis or the patient who unfit for aggressive debulking surgery. The purpose of this study is to compare survival in the patient with advanced ovarian cancer (stage III/IV) underwent primary debulking surgery followed by adjuvant chemotherapy (PDS-ACTR) to those who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Results: Neoadjuvant chemotherapy (NACT-IDS) showed significant complete cytoreduction and decreased in surgical morbidity in comparison to primary debulking surgery (PDS-ACTR). NACT-IDS showed significant improvement in progression-free survival (P-value 0.002) and overall survival (P-value 0.03) in comparison to PDS-ACTR. Response to NACT and residual volume were the two independent prognostic factors for overall survival. Conclusion: NACT-IDS for advanced ovarian cancer (III/IV) resulted in higher frequency of
Cutaneous Metastases from DifferentInternal Malignancies in Egypt
Amen Hamdy Zaky,Mostafa Elsayed Abd El-Wanis,Hisham Hamza,Hisham Zayan Abdel-Hafez
Middle East Journal of Cancer , 2010,
Abstract: Background:Cutaneous metastasis is defined as the spread of malignant cells froma primary malignancy to the skin. Generally, cutaneous involvement from internal malignancies is uncommon. No reports have focused on the cutaneous metastasis profiles in Egypt or the Middle Eastern population. In this study, we seek to determine the rates at which different internal malignancies give rise to cutaneous metastases upon first diagnosis of the primary tumor.Methods:Patients with internal malignancies who attended the South Egypt Cancer Institute from January 2004 through May 2010 were examined and followed to identify cutaneous metastases, which were confirmed by biopsy and histological evaluation.Results:Among 2208 cases of internal malignancies, 48 cases of cutaneous metastases were detected. The clinical profiles were similar to those from western and Asian countries, although the frequencies of primary tumors differed. Most commonly in Egypt breast cancer and urinary bladder cancers were seen.Conclusion:The risk of skin metastases depends largely on the characteristics of tumor cells, which are similar among different groups.
Preoperative Versus Postoperative Radiation Therapy in Patients with Soft Tissue Sarcomas
Mohamed Ibrahim El-sayed,Doaa Wadie Maximos,Mostafa El-sayed Abdel-wanis,Amen Hamdy Zaky
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v1n2p36
Abstract: Purpose: To evaluate treatment outcome and to determine whether or not the timing of radiotherapy (RT) was associated with any difference in disease relapse, survival, or incidence of complications in patients with soft tissue sarcomas (STS). Methods: The medical files of 63 patients with a primary, nonmetastatic, STS, treated with surgery and irradiation were evaluated. Data regarding tumor stage, grade, site, dosage and timing of radiotherapy, treatment complications, disease relapse, and disease-free (DFS) and overall survival (OAS) rates were analyzed. Results: The median follow up was 47 months (range; 5-66 months). Four-year OAS and DFS rates were 82.6% and 78.8% respectively. There were significant higher 4-year OAS (p = 0.024) and DFS (p = 0.011) rates in patients with stage I and II diseases than those in patients with stage III disease. On the other hand, there were no significant differences in 4-year OAS (p = 0.83, HR: 0.743, 95% CI: 0.165 to 3.345) and DFS (p = 0.64, HR: 0.74, 95% CI: 0.21 to 2.61) rates between preoperative and postoperative RT patients. Disease relapse for preoperative versus postoperative RT patients was not statistically different (p = 0.41). Wound complications were more frequent in preoperative RT patients (25%) compared to postoperative RT patients (8%) (p = 0.0566 chi-square). Conclusions: Preoperative irradiation has not a positive impact on survival or disease relapse rates, but is associated with high wound complication rate.
Self-Expandable Metal Stents in Palliation of Inoperable Esophageal & Gastro-Oesophageal Carcinoma
Ahmed A. S. Salem,Ashraf Al-yamany,Esam Abd-el Mohsen,Amen H. Zaky
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v1n1p159
Abstract: Background: Most of patients with carcinoma of the esophagus are inoperable at the time of presentation. The aim of this study was to evaluate the results of self expandable metal stents for the treatment of malignant dysphagia. Material & Methods: This study was conducted at Assiut University, Egypt from July 2009 to Dec 2011. Twenty Enrolled patients with grade 3 or 4 dysphagia due to inoperable carcinoma of the esophagus and gastro-oesophageal junction underwent Self Expandable Metal Stenting under endoscopic guidance. They were followed during all the study period. Dysphagia score will be calculated at baseline and at follow up according to Atkinson’s scale. Data were analyzed using SPSS version 16. Results: Mean age of patients was 55.5±15 years with male to female ratio of 3:2. Mean dysphagia score improved from 3.4 (pre-stent) to 1.07 (post-stent) (p <0.05). Improvement in dysphagia (conversion of grade 3 or 4 dysphagia into grade 1 or 0) was seen in 90% of patients. Eight patients required re-intervention after initial improvement for their stent blockage (40%) and two patients followed conservatively for stent migration (10%). Other minor complications like cough and regurgitation occurred in 10% and 40% patients respectively. Most patients experienced severe chest pain necessitating narcotic analgesics. One patient with pulmonary metastasis died within one week, three patients died within 3months, ten patients died within 1.5 years and six patients under flow-up until now. Conclusion: Self expandable metal stents are an effective method for palliation of dysphagia but not without complications.
The Prognostic Significance of Pre and Post Treatment Neutrophil to Lymphocyte Ratio in Breast Cancer Patients  [PDF]
Nehal A. Rayan, Amen H. Zaky, Hanan A. Eltyb, Ashraf Zeidan, Asmaa M. Zahran
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.107044
Abstract: Background: The neutrophil/lymphocyte ratio (NLR) has been reported to reflect systemic inflammation and independent prognostic significance in different types of cancer. In present study, we analyzed the association between NLR and clinicopathologic features and verified the significance of NLR as a prognostic factor for patients with breast cancer. Patients and Methods: A total of 388 patients with stage I - III breast cancer were retrospectively recruited into this study. Associations with clinicopathologic factors and NLR were assessed; disease-free survival and overall survival were estimated. Results: There was no significant association between NLR and clinicopathologic factors. Patients with low pre/post-treatment NLR had longer OS. Conclusion: A high pre/postoperative NLR may be considered an important factor for predicting poor prognosis in non-metastatic breast cancer patients.
Mothers’ Knowledge Regarding Preventive Measures of Food Poisoning in Yemen  [PDF]
Waled Amen Mohammed Ahmed
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.61006
Abstract: Background: The WHO considers food poisoning the main cause of morbidity and mortality in developing countries, and the responsible for high levels of loss of productivity in developed countries. Objective: The study aims to assess the mothers’ knowledge about preventive measures of food poisoning in Sharaab, Taiz, Yemen. Method: This is a descriptive study. It was conducted in Sharaab, Yemen during period extended from April to November 2014. It involved 180 mothers selected by simple random sampling. Data were collected by using designed structured and pre-tested questionnaire and then were analyzed by (SPSS) Version 20. Result: The findings showed that 60% of mothers have heard about food poisoning. The mothers’ knowledge about transmission of diseases by food was acceptable; 68.9% knew. When they were asked to detail the diseases, cholera was the most reported by about 84.4%, diarrhea 50%, and food poisoning 22.2% only. Regarding the mothers’ knowledge about causes of food poisoning, about 65.5% of them mentioned contaminated food, and 49.4% mentioned contaminated hands while 37.2% of them mentioned contaminated utensils. The total knowledge was calculated; it was about 40.72%. Conclusion: It was found that, mothers’ knowledge about preventive measures of food poisoning is not satisfactory concerning most items including: food related diseases, causes of food poisoning and preventive measures for food poisoning such as hand washing, washing vegetables and cooking appropriately. The mothers in Yemen, Taiz, Sharaab have low level of knowledge about food poisoning prevention. There is a need for strengthening the situation through educational sessions.
Acquired Complete Heart Block with Long QT Interval and Recurrent Polymorphic Ventricular Tachycardia: A Case Report  [PDF]
Hosam Zaky, Jassem Al Hashmi
Open Journal of Internal Medicine (OJIM) , 2016, DOI: 10.4236/ojim.2016.62008
Abstract: We are reporting a case of acquired complete heart block and long QT interval (a dispersion of repolarization that leads to polymorphic ventricular tachycardia) that has presented with loss of conscious and proved to be due to torsade de pointes. The patient responded well to cardiac pacing and beta blocker therapy. The association of complete acquired heart block and long QT interval is quite rare.
Foremost of Noble Ladies " "
Mohamed Zaky
Historical Kan Periodical , 2009,
Abstract: Hatshepsut (or Hatchepsut) meaning, Foremost of Noble Ladies, was the fifth pharaoh of the eighteenth dynasty of Ancient Egypt. She is generally regarded by Egyptologists as one of the most successful pharaohs, reigning longer than any other woman of an indigenous Egyptian dynasty.
Overview Of Life And Civilization In Ancient Egypt
Mohamed Zaky
Historical Kan Periodical , 2008,
Abstract: - Sources of ancient Egyptian history.- Introduction to ancient Egyptian civilization.- Part of Daily Life. .
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