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Search Results: 1 - 10 of 623 matches for " Amal Rayan "
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Multiple Primary Malignancies: Metastatic Renal with Early Breast and Endometrial Cancers: A Case Report  [PDF]
Amal Rayan, Abbas Ahmed M. Ashraf, Hebat Allah M. Bakri
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911075
Abstract: Double primary malignancies could be divided into two categories, depending on the interval between tumor diagnoses. A secondary malignancy could be defined as a new cancer that has occurred as a result of previous treatment with radiation or chemotherapy. Second primary malignancy can occur at any age but its commonly at old age. A 46 premenopausal female patient presented to our outpatient clinic complaining from a mass in her right breast, routine metastatic work-up for distant metastasis declared multiple hepatic metastases, RT renal mass, and bone metastases. Palliative radiotherapy to tender and weight bearing sites followed by 4 cycles of systemic chemotherapy FEC regimen were received. Tru-cut needle biopsy from renal mass detected renal cell carcinoma of clear cell type, the patient started sunitinib and tamoxifen with bisphosphonate (Zoledronic acid), assessment of the response revealed reduction of the size and number of HFLs, and the size of renal mass, so the patient was decided to do cytoreductive nephrectomy and then continued on TAM and sunitinib. Collectively, due to the rising incidence of multiple primary malignancies, further studies should be done not only for better clinical evaluation and treatments but also for accurate determination of possible causes, pathogenesis, effective managements and screening programs.
Capecitabine and Oxaliplatin versus 5-Fluorouracil in the Neoadjuvant Chemoradiation for Patients with Locally Advanced Rectal Carcinoma: A Comparative Study  [PDF]
Amal Rayan, Hosam A. Hasan, Asmaa M. Zahran, Ahmed Soliman, Khalid Rezk
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.910063
Abstract: Aim of work: This study aimed to evaluate the resectability rate, rate of conservative surgery, toxicity, local control, and disease free survival for oxaliplatin and capecitabine based chemoradiation compared to standard 5-FU based chemoradiation in locally advanced cancer rectum. Patients and methods: 65 patients were eligible; 33 patients received oxaliplatin and capecitabine based chemoradiation (arm I) and 32 patients received 5-FU based chemoradiation (arm II). Results: The overall response rate in arms I and II were 78.7% and 87.5% respectively. Conservative surgery was done in 81.81% and 53.13% of patients with arms I and II, pathologic complete response (pCR) rate was significantly better in arm I than arm II (30.3% vs. 21.9%, P < 0.01). 3-year recurrence rates were 54.5% and 56.2% in arms I, II respectively; the median disease free survival (DFS) were 30 months and 15 months in arms I and II respectively. Grade III anemia, grade IV diarrhea and severe proctitis were developed in a significantly large number of patients with arm I; in addition deep venous thrombosis (DVT) was developed in 15.15% of patients with arm I but none in arm II. Conclusion: The addition of oxaliplatin to the preoperative chemo radiation increased the response rate mainly pCR rate which was considered a target goal in the neoadjuvant treatment, but it was not recommended because of higher toxicity and no significant effect on DFS in different response groups of arm I when compared to arm II, but longer follow up may be needed to evaluate the overall survival.
Accelerated Hyper Fractionated Radiotherapy in Localized Ewing’s Sarcoma with or without Surgery: What’s New? A Phase II Study  [PDF]
Amal Rayan, Ahmed Soliman, Khalid F. Riad, Asmaa M. Zahran, Hosam A. Hasan
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.910067
Abstract: Background and aim of work: We aimed from this study to determine the response and local relapse free survival (RFS) of pediatric patients with localized Ewing’s sarcoma treated with accelerated hyper-fractionated RT. Patient and methods: This study was a nonrandomized uncontrolled phase II study and was conducted at clinical oncology department and south Egypt cancer institute; it involved 28 patients with histologically confirmed Ewing’s sarcoma; all of them were subjected to PET/CT whenever possible or MRI with contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the protocol of accelerated hyper fractionated RT. Results: The overall response rate (ORR) was 92.9% by MRI
The Impact of Neutrophil to Lymphocytic Ratio (NLR) as a Predictor of Treatment Outcomes in Rectal Carcinomas: A Retrospective Cohort Study  [PDF]
Samir Eid, Hoda Hasan, Doaa Abdel-Aleem, Amal Rayan
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.109064
Abstract: Background and aim: The prognostic role of neutrophil to lymphocyte ratio (NLR) has been shown in many solid tumors included in a recent meta-analysis of one hundred studies. We aimed to evaluate the prognostic value of neutrophil to lymphocyte ratio in treatment outcomes; response and survival of patients with different stages of rectal cancers. Patients and methods: All patients with pathologically confirmed cancer rectum presented to our department during the period from January 2012 to the end of 2014 were included in this retrospective study, these recruited patients were evaluated through their files to determine different objectives of our study. Results: The median overall survival was 31 ± 4.676 months while disease free survival was 40 ± 2.346 for the whole study group; neutrophil to lymphocyte ratio was negatively correlated with overall survival with r = 0.743, P < 0.001, also with disease free survival with r = 0.717, P < 0.0001. Neutrophil to lymphocyte ratio was positively correlated with the number of positive lymph nodes dissected to total number of lymph nodes dissected ratio with r = +0.254, P =
On the Maximum Likelihood and Least Squares Estimation for the Inverse Weibull Parameters with Progressively First-Failure Censoring  [PDF]
Amal Helu
Open Journal of Statistics (OJS) , 2015, DOI: 10.4236/ojs.2015.51010
Abstract: In this article, we consider a new life test scheme called a progressively first-failure censoring scheme introduced by Wu and Kus [1]. Based on this type of censoring, the maximum likelihood, approximate maximum likelihood and the least squares method estimators for the unknown parameters of the inverse Weibull distribution are derived. A comparison between these estimators is provided by using extensive simulation and two criteria, namely, absolute bias and mean squared error. It is concluded that the estimators based on the least squares method are superior compared to the maximum likelihood and the approximate maximum likelihood estimators. Real life data example is provided to illustrate our proposed estimators.
New tips for structure prediction by comparative modeling
Anwar Rayan
Bioinformation , 2009,
Abstract: Comparative modelling is utilized to predict the 3-dimensional conformation of a given protein (target) based on its sequence alignment to experimentally determined protein structure (template). The use of such technique is already rewarding and increasingly widespread in biological research and drug development. The accuracy of the predictions as commonly accepted depends on the score of sequence identity of the target protein to the template. To assess the relationship between sequence identity and model quality, we carried out an analysis of a set of 4753 sequence and structure alignments. Throughout this research, the model accuracy was measured by root mean square deviations of Cα atoms of the target-template structures. Surprisingly, the results show that sequence identity of the target protein to the template is not a good descriptor to predict the accuracy of the 3-D structure model. However, in a large number of cases, comparative modelling with lower sequence identity of target to template proteins led to more accurate 3-D structure model. As a consequence of this study, we suggest new tips for improving the quality of comparative models, particularly for models whose target-template sequence identity is below 50%.
Co-Higgs bundles on P^1
Steven Rayan
Mathematics , 2010,
Abstract: Co-Higgs bundles are Higgs bundles in the sense of Simpson, but with Higgs fields that take values in the tangent bundle instead of the cotangent bundle. Given a vector bundle on P^1, we find necessary and sufficient conditions on its Grothendieck splitting for it to admit a stable Higgs field. We characterize the rank-2, odd-degree moduli space as a universal elliptic curve with a globally-defined equation. For ranks r=2,3,4, we explicitly verify the conjectural Betti numbers emerging from the recent work of Chuang, Diaconescu, Pan, and Mozgovoy on the ADHM formula. We state the result for r=5.
Constructing co-Higgs bundles on CP^2
Steven Rayan
Mathematics , 2013, DOI: 10.1093/qmath/hau017
Abstract: On a complex manifold, a co-Higgs bundle is a holomorphic vector bundle with an endomorphism twisted by the tangent bundle. The notion of generalized holomorphic bundle in Hitchin's generalized geometry coincides with that of co-Higgs bundle when the generalized complex manifold is ordinary complex. Schwarzenberger's rank-2 vector bundle on the projective plane, constructed from a line bundle on the double cover CP^1 \times CP^1 \to CP^2, is naturally a co-Higgs bundle, with the twisted endomorphism, or "Higgs field", also descending from the double cover. Allowing the branch conic to vary, we find that Schwarzenberger bundles give rise to an 8-dimensional moduli space of co-Higgs bundles. After studying the deformation theory for co-Higgs bundles on complex manifolds, we conclude that a co-Higgs bundle arising from a Schwarzenberger bundle with nonzero Higgs field is rigid, in the sense that a nearby deformation is again Schwarzenberger.
Genomic analysis of a heterogeneous Mendelian phenotype: multiple novel alleles for inherited hearing loss in the Palestinian population
Tom Walsh, Amal Rayan, Judeh Sa'ed, Hashem Shahin, Jeanne Shepshelovich, Ming K Lee, Koret Hirschberg, Mustafa Tekin, Wa'el Salhab, Karen B Avraham, Mary-Claire King, Moien Kanaan
Human Genomics , 2006, DOI: 10.1186/1479-7364-2-4-203
Acne Flares among University Female Students: The Role of Perceived Factors  [PDF]
Amal A. Kokandi
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33A2006

Objectives: Acne is a common skin disease especially in adolescents and young adults. Several pathogenetic factors are implicated in causing the disease. Typically acne flares and remits in its course. Several factors can cause flares. The aim of this study was to assess the perceived factors of acne flares and the idea of sun creams causing skin darkening. Methods: A questionnaire study of the perceived factors in causing acne flares was studied in university female students. These included food, stress, hygiene and menstrual periods. In addition, the effect of sun creams on causing skin darkening was asked. Results: Food was implicated by 43.2% of patients. Stress and menstrual periods were thought to exacerbate acne by more than 70% of patients while 80% of patients did not think bad hygiene worsened acne. 40% of patients thought the use of sun creams cause skin darkening. Conclusion: More controlled studies are needed to explore the effect of food on acne. Dermatologists need to explain the benefit of using sun creams especially to acne patients while using standard treatments.

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