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Search Results: 1 - 10 of 5729 matches for " Alonso-Larraga "
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Self-expanding metal stents versus antrectomy for the palliative treatment of obstructive adenocarcinoma of the gastric antrum Prótesis metálicas autoexpandibles versus antrectomía en el tratamiento paliativo del adenocarcinoma obstructivo del antro gástrico
Juan Octavio Alonso-Larraga,Julio César álvaro-Villegas,Sergio Sobrino-Cossio,Angélica Hernández-Guerrero
Revista Espa?ola de Enfermedades Digestivas , 2012,
Abstract: Background: gastric cancer patients are first diagnosed with an unresectable tumor in up to 40% of cases. Gastric outlet obstruction causes nausea, vomiting, dehydration and malnutrition. The aim of the study was to compare self-expanding metal stents to antrectomy and Roux-en Y gastrojejunostomy for palliation of obstructive adenocarcinoma of the gastric antrum. Methods: retrospective study in patients with obstructing cancer of the gastric antrum. Patients were divided into two groups: group A, underwent endoscopic placement of self-expanding metal stents and group B underwent surgical treatment with antrectomy and Roux-en Y gastrojejunostomy. Collected Data included: age, gender, performance status (Karnofsky's score), body mass index, histopathology, clinical stage (TNM classification), technical and clinical success of the procedure, time to oral intake, in-hospital stay, re-intervention rate, and complications related to the treatment and survival. Results: a total of 39 patients with gastric adenocarcinoma were included, 21 male and 18 female. Nineteen patients were assigned to group A and 20 patients to group B. There were no statistically significant differences between groups in regards to age, body mass index, Karnofsky's score and clinical stage. The technical and clinical success was similar for both groups. There was a statistically significant difference between groups favoring Self-expanding metal stent in time to oral intake (1 ± 0 vs. 4.9 ± 0.6 days, p = 0.0001) and in-hospital stay (0.94 ± 1.18 vs. 7.8 ± 7.7 days, p = 0.0005). We did not find statistically significant differences with regards to long-term survival. Conclusions: in patients with malignant gastric outlet obstruction due to gastric cancer, endoscopic palliation with self-expanding metal stents provide a shorter interval to oral intake, shorter in-hospital stay and lower rate of complications. Introducción: los pacientes con cáncer gástrico tienen un tumor irresecable hasta en el 40% de los casos. La obstrucción de salida gástrica ocasiona vómito, deshidratación y desnutrición. El objetivo de este estudio fue comparar las prótesis metálicas autoexpandibles con la antrectomia en el tratamiento paliativo del adenocarcinoma obstructivo del antro gástrico. Método: estudio restrospectivo en pacientes con adenocarcinoma obstructivo del antro gástrico. Los pacientes fueron divididos en dos grupos: grupo A) sujetos que fueron tratados mediante prótesis metálica autoexpandible y grupo B) aquellos que fueron tratados mediante antrectomía y gastroyeyunoanastomosis en Y de Roux. Las v
Self-expanding metal stents versus antrectomy for the palliative treatment of obstructive adenocarcinoma of the gastric antrum
Alonso-Larraga,Juan Octavio; álvaro-Villegas,Julio César; Sobrino-Cossio,Sergio; Hernández-Guerrero,Angélica; Mora-Levy,Guillermo de la; Figueroa-Barojas,Paola;
Revista Espa?ola de Enfermedades Digestivas , 2012, DOI: 10.4321/S1130-01082012000400003
Abstract: background: gastric cancer patients are first diagnosed with an unresectable tumor in up to 40% of cases. gastric outlet obstruction causes nausea, vomiting, dehydration and malnutrition. the aim of the study was to compare self-expanding metal stents to antrectomy and roux-en y gastrojejunostomy for palliation of obstructive adenocarcinoma of the gastric antrum. methods: retrospective study in patients with obstructing cancer of the gastric antrum. patients were divided into two groups: group a, underwent endoscopic placement of self-expanding metal stents and group b underwent surgical treatment with antrectomy and roux-en y gastrojejunostomy. collected data included: age, gender, performance status (karnofsky's score), body mass index, histopathology, clinical stage (tnm classification), technical and clinical success of the procedure, time to oral intake, in-hospital stay, re-intervention rate, and complications related to the treatment and survival. results: a total of 39 patients with gastric adenocarcinoma were included, 21 male and 18 female. nineteen patients were assigned to group a and 20 patients to group b. there were no statistically significant differences between groups in regards to age, body mass index, karnofsky's score and clinical stage. the technical and clinical success was similar for both groups. there was a statistically significant difference between groups favoring self-expanding metal stent in time to oral intake (1 ± 0 vs. 4.9 ± 0.6 days, p = 0.0001) and in-hospital stay (0.94 ± 1.18 vs. 7.8 ± 7.7 days, p = 0.0005). we did not find statistically significant differences with regards to long-term survival. conclusions: in patients with malignant gastric outlet obstruction due to gastric cancer, endoscopic palliation with self-expanding metal stents provide a shorter interval to oral intake, shorter in-hospital stay and lower rate of complications.
Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum
Pedro J Alcolea, Ana Alonso, Manuel J Gómez, Alicia Sánchez-Gorostiaga, Mercedes Moreno-Paz, Eduardo González-Pastor, Alfredo Tora?o, Víctor Parro, Vicente Larraga
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-31
Abstract: Immunofluorescence analysis of promastigote-specific glycoprotein gp46 and expression modulation analysis of the amastigote-specific A2 gene have revealed that concomitant exposure to temperature increase and acidification leads to amastigote-like forms. The temperature-induced gene expression profile in the absence of pH variation resembles the profile obtained under combined exposure to both factors unlike that obtained for exposure to acidification alone. In fact, the subsequent fold change-based global iterative hierarchical clustering analysis supports these findings.The specific influence of temperature and pH on the differential regulation of genes described in this study and the evidence provided by clustering analysis is consistent with the predominant role of temperature increase over extracellular pH decrease in the amastigote differentiation process, which provides new insights into Leishmania physiology.The life cycle of the trypanosomatid parasite Leishmania is digenetic because it is developed in two distinct hosts. Promastigote is the extracellular stage and differentiates inside the gut of female phlebotominae sand-fly vectors, which then transmit the parasite to the definitive mammalian host during blood meal intakes [1]. Once inside the dermis, some promastigotes interact with phagocytes and are internalised in parasitophorous vacuoles (phagolysosomes), where they differentiate into the intracellular amastigote stage and multiply [2,3]. Amastigotes are released and infect other phagocytes when the host cell collapses. Remarkable features of the new harsh environment are acidic pH (4.5-5.5) and the physiological temperature of the mammalian host (32-37°C).Phagolysosomal conditions can be mimicked in vitro to grow axenic cultures of the amastigote stage. However, there is not agreement about the equivalence of these forms to amastigotes obtained from their natural environment. In fact, axenic amastigotes are considered as amastigote-like forms (AL)
Pol -ticas Sociales II: El Caso Chileno Pol -ticas Sociales II: El Caso Chileno
Cristi??n Aedo,Osvaldo Larraga?±a
Revista de Análisis Económico (RAE) , 1993,
Abstract: Políticas Sociales II: El Caso Chileno This article characterizes the Chilean experience with the provision of social services. This is done for social programs in health care, education, monetary subsidies, and nutrition. The article provides a description of the institutional and financial aspects as well as an overall evaluation for each sector. The study of the Chilean case is important in the context of social policy reforms which is emerging in Latin American countries. The importance stems from the fact that maior issues that are being considered in the region -targeting, decentralization, private provision, cost recovery, and demand subsidies- were introduced in Chile more than a decade ago.
Pol -ticas Sociales I: Un Marco Conceptual para el An lisis Pol -ticas Sociales I: Un Marco Conceptual para el An lisis
Cristi??n Aedo,Osvaldo Larraga?±a
Revista de Análisis Económico (RAE) , 1993,
Abstract: This article presents an analytical review of the main aspects that need to be considered in the design and evaluation of social programs. Seven topics are presented and discussed; funding of the Social Policy, costs and benefits of a decentralization process and its impact on the effectiveness of social programs; efficiency in public spending; the targetting of the Social Policy; public provision of public services; cost recovery in social programs; and finally, an analysis of the complementarities among different social programs. Políticas Sociales I: Un Marco Conceptual para el Análisis
Laser Induced Refractive Index Change in Nematic Liquid Crystals
Crispulo Larraga,Darwin Palima,Zenaida Domingo
Science Diliman , 1999,
Abstract: We report the observation of laser induced refractive index change for a homeotropically aligned nematic liquid crystal (BDH-E7) film of 10 mm thickness. Diffraction rings were observed when an intense Ar+ ion laser hits a homeotropically aligned nematic liquid crystal at normal incidence above a threshold of 110 KW/cm2, which correspond to the threshold of the Optical Freedericksz Transition (OFT). Above the threshold, as the laser intensity was increased, the number of observed diffraction rings likewise increased. The mechanism for optical molecular reorientation has a great dependence on elastic restoring forces. By exploring the dependence of bend elastic constant, K33 with Freedericksz transition, the value of the K33 was calculated at 2.6 x 10-12 N. To investigate the behavior of Dn as a function of intensity, an experiment was performed for oblique laser incidence. It was shown that the refractive index change increased linearly from values of 0.00 1 to 0.18 at laser intensities ranging from 50 KW /cm2 to 200 KW /cm2. The Kerr coefficient n2 was calculated for various laser incidence angles.
Cellular Automata for One-Lane Traffic Flow Modelling: Safety and Automation
M. E. Larraga,J. A. del Rio
Physics , 2001,
Abstract: In recent years the modelling of traffic flow using methods from statistical physics, especially cellular automata models have allowed simulations of large traffic networks faster than real time. In this paper, we study a probabilistic cellular automaton model for microsimulations of traffic flow of automated vehicles in highways. This model describes single-lane traffic flow on a ring. We study the equilibrium properties by including a parameter of safe distance in the model and calculate the so-called fundamental diagrams (flow vs. density graph) considering parallel dynamics. This is done numerically by computer simulations of the model and by means of an analysis of speed variance.
Cellular automata for traffic flow simulation with safety embedded notions
M. E. Larraga,L. Alvarez-Icaza
Physics , 2007,
Abstract: In this paper a cellular automata model for one-lane traffic flow is presented. A new set of rules is proposed to better capture driver reactions to traffic that are intended to preserve safety on the highway. As a result, drivers behavior is derived from an analysis that determines the most appropriate action for a vehicle based on the distance from the vehicle ahead of it and the velocities of the two neighbor vehicles. The model preserves simplicity of CA rules and at the same time makes the results closer to real highway behavior. Simulation results exhibit the three states observed in real traffic flow: Free-flow states, synchronized states, and stop-and-go states.
Transient situations in traffic flow: Modelling the Mexico City Cuernavaca Highway
J. A. del Rio,M. E. Larraga
Physics , 2005, DOI: 10.1063/1.1900500
Abstract: In this paper a recent variable anticipation cellular automata model for single-lane traffic flow is extended to analyze the situation of free and congested flow in the Highway from Mexico City to Cuernavaca. This highway presents free flow in standard days; but in the returning day of long weekends or holidays it exhibits congested flow and in rush hours jamming appears. We illustrate how our CA model for traffic flow can deal appropriately with transient situations and can be used to search new alternatives that allow to improve the traffic flow in Mexican highways.
Possible Self-Organised Criticality and Dynamical Clustering of Traffic flow in Open Systems
M. E. Larraga,J. A. del Rio,Anita Mehta
Physics , 1999,
Abstract: We focus in this work on the study of traffic in open systems using a modified version of an existing cellular automaton model. We demonstrate that the open system is rather different from the closed system in its 'choice' of a unique steady-state density and velocity distribution, independently of the initial conditions, reminiscent of self-organised criticality. Quantities of interest such as average densities and velocities of cars, exhibit phase transitions between free flow and the jammed state, as a function of the braking probability R in a way that is very different from closed systems. Velocity correlation functions show that the concept of a dynamical cluster, introduced earlier in the context of granular flow is also relevant for traffic flow models.
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