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Search Results: 1 - 10 of 404840 matches for " Alma M. Perez "
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Genetic Modifiers of MeCP2 Function in Drosophila
Holly N. Cukier,Alma M. Perez,Ann L. Collins,Zhaolan Zhou,Huda Y. Zoghbi,Juan Botas
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000179
Abstract: The levels of methyl-CpG–binding protein 2 (MeCP2) are critical for normal post-natal development and function of the nervous system. Loss of function of MeCP2, a transcriptional regulator involved in chromatin remodeling, causes classic Rett syndrome (RTT) as well as other related conditions characterized by autism, learning disabilities, or mental retardation. Increased dosage of MeCP2 also leads to clinically similar neurological disorders and mental retardation. To identify molecular mechanisms capable of compensating for altered MeCP2 levels, we generated transgenic Drosophila overexpressing human MeCP2. We find that MeCP2 associates with chromatin and is phosphorylated at serine 423 in Drosophila, as is found in mammals. MeCP2 overexpression leads to anatomical (i.e., disorganized eyes, ectopic wing veins) and behavioral (i.e., motor dysfunction) abnormalities. We used a candidate gene approach to identify genes that are able to compensate for abnormal phenotypes caused by MeCP2 increased activity. These genetic modifiers include other chromatin remodeling genes (Additional sex combs, corto, osa, Sex combs on midleg, and trithorax), the kinase tricornered, the UBE3A target pebble, and Drosophila homologues of the MeCP2 physical interactors Sin3a, REST, and N-CoR. These findings demonstrate that anatomical and behavioral phenotypes caused by MeCP2 activity can be ameliorated by altering other factors that might be more amenable to manipulation than MeCP2 itself.
Unilateral Impact of Altered Loading by Changing Teeth Height on the TMJ Fibrocartilage: Disc and Condyle of Wistar Rats  [PDF]
Roxanne M. Olvera-Farias, Jose Raymundo Cruz-Perez, Rogelio Salinas-Gutierrez, Jose Antonio Guerrero-Diaz de Leon, Juan B. Kouri-Flores, Raul Rosales-Iba?ez, David Masuoka Ito, Alma Lilian Guerrero Barrera
Microscopy Research (MR) , 2016, DOI: 10.4236/mr.2016.42003
Abstract: Temporomandibular joint (TMJ) is sensitive to loading and mechanical stress that provokes morphological changes produced by the impact in the occlusal plane. Here, this impact is evaluated in TMJ articular disc and articular cartilage using an in vivo model of unilateral occlusal plane impact and by analysis of serial tissue sections stained with Hematoxylin-Eosin (H-E) or with Masson trichrome technique. Thus, six groups of 5 Wistar rats (200 - 250 g) are subjected to biomechanical dental stimulation by placing unilateral resin occlusal interference, or unilateral tooth wear made by upper left molars artificial mechanical devastation (1 control and 2 experimental groups for each treatment). Each treatment is evaluated two times at 1 and 15 days post-treatment. By H-E staining, control groups show chondrocytes arrangement as several cord cell groups in comparison with the experimental groups, which show an arrangement in one cord cell along of articular disc. However, this yields no significant difference (p < 0.05) in cell number between control and experimental groups. In contrast, in articular cartilage chondrocytes are random distributed along the superficial zone in control groups, while in experimental groups cell-free regions are observed in superficial zone. An image Blue hue analysis for trichrome stain is performed to quantify collagen; this shows a significant collagen decrease (p < 0.05) in almost all experimental groups compared with the controls. A degenerative process biomechanically induced by unilateral occlusal plane modification, causes cell and tissue changes on the TMJ structures that remain the degenerative changes observed in early osteoarthritis.
The Institutionalization of Life Cycle Assessment in Mexico  [PDF]
Nora Munguia, Clara Rosalia Alvarez, Rafael Perez, Alma Flores, Francisco Martinez, Luis Velazquez
Journal of Environmental Protection (JEP) , 2015, DOI: 10.4236/jep.2015.68073
Abstract: This article presents a study of Life Cycle Assessment (LCA) at a slaughterhouse located in north-western Mexico with the purpose of testing the premise of a low degree of institutionalization of Industrial Ecology in Mexico. The article aims at analyzing the current role played by the Mexican academia in increasing the degree of institutionalization of the concept of LCA in northwestern Mexico. There was conducted a life cycle analysis study according to the standards ISO 14040: 2006, NMX-SAA-14040-IMNC-2008NOM in a Federally Inspected Type (TIF by Spanish acronym) Slaughterhouse in the state of Sonora in Northwest Mexico. The slaughter process was characterized by observing the production tasks during several walkthroughs the production lines and by having short interviews with workers, supervisors, and the manager. The CH4 emissions were calculated using the guidelines suggested by the Intergovernmental Panel on Climate Change (IPCC 2006). The present LCA case study revealed opportunities for improving the environmental performance of the slaughterhouse by taking measures such as the reduction of CH4 from enteric fermentation since methane was one of the main greenhouse gases responsible for climate change. Although, the LCA generated reliable information in terms of climate change or water eutrophication, the chances of implementing sustainable initiatives were unlikely because the benefits to reduce the impacts to climate change or to reduce the water crisis would be unnoticeable and unaffordable for companies. Findings in this study also confirmed the importance of Mexican universities for promoting and conducting more LCA studies among private and public organizations in order to guide firms towards this tool. The case study here presented gives insights to LCA stakeholders in Mexico to implement or improve the effectiveness of their potential LCA initiatives through the identification of strategies, opportunities, and barriers.
Historia y narrativa en procesos de auto reconocimiento étnico
Tozzini,M. Alma;
Av?? , 2008,
Abstract: processes of ethnic self aknowledgement in peoples that until recent defined themselves by a "national" identity, are not new as a social phenomena any more. nevertheless, those processes continue to be a controversial issue, and the academic environment is usually summoned to analize them. based on the ethnografhic study of a specific case in lago puelo, northwestern chubut, the present article intends to be a contribution to the debate over the possibilities that the anthropological approach of the analysis of the "native" narratives can provide to the understanding of these processes as well as to the formulation of new and better questions which could not be satisfied with "normative" academic responses.
Phylogenetic studies and modern classification of the Pyraloidea (Lepidoptera )
Solis,M. Alma;
Revista Colombiana de Entomología , 2007,
Abstract: pyraloidea, the third largest superfamily of the lepidoptera, is comprised of two families - pyralidae and crambidae. the history of families previously placed in the pyraloidea is discussed. the group now includes about 16,000 species worldwide. morphologically, the superfamily is defined by a basally scaled proboscis and the presence of abdominal tympanal organs. the larvae of many species are economically important pests of crops (e. g.: sugarcane, corn, rice), and stored products such as seeds and grains. currently 22 subfamilies comprise the pyraloidea; only the 19 subfamilies that occur in the western hemisphere are discussed. there is a paucity of recent research using cladistic methods and phylogenetic analyses across all taxa.
Phylogenetic studies and modern classification of the Pyraloidea (Lepidoptera ) Estudios filogenéticos y clasificación actual de los Pyraloidea (Lepidoptera )
M. Alma Solis
Revista Colombiana de Entomología , 2007,
Abstract: Pyraloidea, the third largest superfamily of the Lepidoptera, is comprised of two families - Pyralidae and Crambidae. The history of families previously placed in the Pyraloidea is discussed. The group now includes about 16,000 species worldwide. Morphologically, the superfamily is defined by a basally scaled proboscis and the presence of abdominal tympanal organs. The larvae of many species are economically important pests of crops (e. g.: sugarcane, corn, rice), and stored products such as seeds and grains. Currently 22 subfamilies comprise the Pyraloidea; only the 19 subfamilies that occur in the Western Hemisphere are discussed. There is a paucity of recent research using cladistic methods and phylogenetic analyses across all taxa. Pyraloidea, la tercera superfamilia más grande de Lepidoptera, está compuesta por dos familias Pyralidae y Crambidae. Se discute la historia de las familias previamente ubicadas en Pyraloidea. Actualmente el grupo incluye cerca de 16.000 especies en el mundo. Morfológicamente, la superfamilia se define por una proboscis con escamas basales y por la presencia de órganos timpánicos abdominales. Las larvas de muchas especies son plagas de cultivos económicamente importantes (p. ej.: ca a de azúcar, maíz, arroz) y de productos almacenados tales como granos y semillas. Actualmente los Pyraloidea comprenden 22 subfamilias, solo se discuten las 19 subfamilias que se encuentran en el hemisferio occidental. Hay pocas investigaciones recientes que usen métodos cladísticos y análisis filogenéticos en todos los taxones.
La formación profesional del psicólogo. Líneas de trabajo para la configuración de un proyecto alternativo de profesión.
Alma Herrera Márquez
Perfiles educativos , 1993,
Abstract: Las propuestas que se desarrollan aquí tienen como objetivo el problematizar al psicólogo en el por que, para que y para quien formar profesionales de la psicología en escenarios sociales e históricos cambiantes. Para ello, el trabajo se ha dividido en tres apartados: a) los problemas derivados del escenario dominante para la formación profesional, b) los problemas de la construcción de un proyecto de profesión para la psicología y c) las lineas de trabajo que pudiera ayudar a su construcción.
Formación científico-profesional: propuesta para la universidad pública de México
Alma Herrera Márquez
Perfiles educativos , 1996,
Abstract: Hoy en día cualquier propuesta educativa debe estar inserta dentro de un proyecto de desarrollo nacional orientado a la integración nacional y la interdependencia mundial. Así, la propuesta que se presenta aquí, para la formación científico profesional en México, se inscribe dentro del nuevo orden internacional, considerando el desarrollo y la tendencia de la investigación y la tecnología, así como los problemas actuales que enfrenta.
Responsabilidad social: Eje de la transformación de la universidad en la era de la globalización
Alma Herrera M.
Universidades , 2010,
La potestad del Consejo de Seguridad para solicitar a la Corte Penal Internacional la suspensión de una investigación o de un enjuiciamiento
Alma C. Borjas M.
Revista Derecho del Estado , 2011,
Abstract: El presente artículo analiza la potestad concedida al Consejo de Seguridad por el Estatuto de Roma, establecida en su artículo 16, referida a la posibilidad de solicitar a la Corte la suspensión de una investigación o de un enjuiciamiento. En la práctica, ya se ha hecho uso de dicha facultad, pero en circunstancias que podrían considerarse cuestionables. Por ello serán objeto de análisis las resoluciones 1422 (2002) y 1487 (2003) del Consejo de Seguridad como manifestaciones del abuso de esta potestad. Para ello se tomarán como punto de referencia los requisitos que el Estatuto establece para el ejercicio de esta potestad; se advierte en estas resoluciones el incumplimiento de aquéllos. En este sentido, se constató la ausencia de la determinación de una amenaza a la paz y a la seguridad internacionales, requisito indispensable para el uso de los poderes de este órgano en el marco del capítulo VII de la Carta; la ausencia de un caso específico y el hecho de querer usar esta potestad como una forma de inmunidad general, como se advierte de la exclusión de los miembros de misiones de mantenimiento de paz de la jurisdicción de la Corte, entre otros aspectos. Por lo antes planteado, se expone la posibilidad que tendría la Corte de revisión judicial de las solicitudes de suspensión del Consejo. La Corte no está vinculada por la Carta de las Naciones Unidas y, en este sentido, no le es aplicable el contenido del artículo 25 de ésta, por lo que no existiría un límite legal para que la Corte revisara la conformidad de las peticiones del Consejo con el Estatuto e incluso con la Carta de Naciones Unidas.
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