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Search Results: 1 - 10 of 21 matches for " Allgayer "
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Profile changes in premolar extraction =Altera es no perfil em extra es de pré-molares
Allgayer, Susiane et al.
Revista Odonto Ciência , 2011,
Abstract: Objetivo: Este estudo retrospectivo avaliou pacientes tratados com exodontias de pré-molares através da análise de telerradiografias, comparando o efeito de diferentes protocolos de exodontias no perfil. Metodologia: 87 pacientes foram selecionados da clínica particular de três ortodontistas diplomados pelo Board Brasileiro de Ortodontia e Ortopedia Facial. Estes pacientes foram tratados com aparelho fixo Edgewise e foram divididos em três grupos, de acordo com a sequência de pré-molares extraídos: “Grupo 40”, primeiros pré-molares superiores (22 pacientes); “Grupo 44”, quatro primeiros pré-molares (43 pacientes); e “Grupo 45”, pri- meiros pré-molares superiores e segundos inferiores (22 pacientes). O ngulo Z e a Linha de Burstone foram utilizados para quantificar e comparar os perfis antes e após o tratamento. Resultados: O teste t-student mostrou melhora no perfil em todos os grupos, visto que o valor do angulo Z apresentou-se maior ao final do tratamento e as medidas dos lábios vieram ao encontro dos valores preconizados por Burstone. A análise das mudan as proporcionadas pelo tratamento pela ANOVA n o revelou diferen as significativas entre os grupos Conclus o: Os protocolos produzem aparências faciais semelhantes ao final do trata- mento. Purpose: This retrospective study assessed patients treated with extraction of premolars by analysis of lateral cephalograms, comparing the effect of different tooth extraction protocols on the profile. Methods: Eighty-seven patients were selected from the private practices of three orthodontists certified by the Brazilian Board of Orthodontics and Facial Orthopedics. These patients were treated with fixed edgewise appliances and divided into three groups according to the sequence in which premolars were extracted: “Group 40”, maxillary first premolars (22 patients); “Group 44”, both maxillary and mandibular first premolars (43 patients); and “Group 45”, maxillary first and mandibular second premolars (22 patients). The Z angle and the Burstone line were used to quantify and compare the profiles before and after treatment. Results: Student’s t-test showed profile improvement in all groups, as the Z angle value was higher at treatment completion and the lip measurements were in agreement with the values recommended by Burstone. Analysis of treatment changes by the ANOVA did not reveal significant differences between groups. Conclusion: The protocols produced similar facial appearance at treatment completion.
Intraradicular post and core removal followed by endodontic retreatment: thirteen-year follow-up
Susiane Allgayer,José Roberto Vanni
RSBO , 2011,
Abstract: Introduction: Endodontic retreatment, when properly indicated, allows the maintenance of dental elements. The evolution of endodontic techniques and materials has reduced the indication of surgical procedures even for teeth with intracanal posts. Case study: A 31 year-old patient related pain in tooth #12. After radiographic examination, the presence of a periapical lesion in teeth #12, #11, and #21 was found, which had already undergone to paraendodontic surgery and placement of intraradicular post and core. Treatment comprises the removal of the intracanal post and core, and the respective root canals were endodontically treated. Conclusion: The technique here exemplified, intracanal post removal and retreatment, proved to be well indicated and effective, since, at the 13-year follow-up appointment, the teeth remained without clinical and radiographic findings.
Cetuximab and biomarkers in non-small-cell lung carcinoma
Patil N, Abba M, Allgayer H
Biologics: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/BTT.S24217
Abstract: uximab and biomarkers in non-small-cell lung carcinoma Review (2398) Total Article Views Authors: Patil N, Abba M, Allgayer H Published Date July 2012 Volume 2012:6 Pages 221 - 231 DOI: http://dx.doi.org/10.2147/BTT.S24217 Received: 09 May 2012 Accepted: 08 June 2012 Published: 13 July 2012 Nitin Patil, Mohammed Abba, Heike Allgayer Department of Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg and Molecular Oncology of Solid Tumors Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany Abstract: Cancer progression is a highly complex process that is driven by a constellation of deregulated signaling pathways and key molecular events. In non-small-cell lung cancer (NSCLC), as in several other cancer types, the epidermal growth factor receptor (EGFR) and its downstream signaling components represent a key axis that has been found not only to trigger cancer progression but also to support advanced disease leading to metastasis. Two major therapeutic approaches comprising monoclonal antibodies and small molecule tyrosine kinase inhibitors have so far been used to target this pathway, with a combination of positive, negative, and inconsequential results, as judged by patient survival indices. Since these drugs are expensive and not all patients derive benefits from taking them, it has become both pertinent and paramount to identify biomarkers that can predict not only beneficial response but also resistance. This review focuses on the chimeric monoclonal antibody, cetuximab, its application in the treatment of NSCLC, and the biomarkers that may guide its use in the clinical setting. A special emphasis is placed on the EGFR, including its structural and mechanistic attributes.
Cetuximab and biomarkers in non-small-cell lung carcinoma
Patil N,Abba M,Allgayer H
Biologics: Targets and Therapy , 2012,
Abstract: Nitin Patil, Mohammed Abba, Heike AllgayerDepartment of Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg and Molecular Oncology of Solid Tumors Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyAbstract: Cancer progression is a highly complex process that is driven by a constellation of deregulated signaling pathways and key molecular events. In non-small-cell lung cancer (NSCLC), as in several other cancer types, the epidermal growth factor receptor (EGFR) and its downstream signaling components represent a key axis that has been found not only to trigger cancer progression but also to support advanced disease leading to metastasis. Two major therapeutic approaches comprising monoclonal antibodies and small molecule tyrosine kinase inhibitors have so far been used to target this pathway, with a combination of positive, negative, and inconsequential results, as judged by patient survival indices. Since these drugs are expensive and not all patients derive benefits from taking them, it has become both pertinent and paramount to identify biomarkers that can predict not only beneficial response but also resistance. This review focuses on the chimeric monoclonal antibody, cetuximab, its application in the treatment of NSCLC, and the biomarkers that may guide its use in the clinical setting. A special emphasis is placed on the EGFR, including its structural and mechanistic attributes.Keywords: NSCLC, cetuximab, biomarker, cancer progression
Molecular targeted therapies for breast cancer treatment
Claus M Schlotter, Ulf Vogt, Heike Allgayer, Burkhard Brandt
Breast Cancer Research , 2008, DOI: 10.1186/bcr2112
Abstract: Treatment of early-stage breast cancer requires a multimodality approach to eradicate residual cancer and prevent recurrent disease. Targeting the pathways that promote or sustain growth and invasion of carcinoma cells is critical to effective treatment of breast cancer [1,2].Targeting the oestrogen receptor (ER) is the oldest molecular targeted therapy approach, and widespread use of the selective ER modulator tamoxifen in breast cancer is responsible for major improvements in cure rates, quality of life and disease prevention during the past 25 years. Targeting both HER2 (human epidermal growth factor receptor 2) with trastuzumab and the vascular endothelial growth factor (VEGF) with bevacizumab in combination with chemotherapy has become a further milestone of molecular targeted therapy [3-5]. However, intrinsic and acquired resistance to endocrine and/or cytostatic treatments is still a common feature that limits the benefits of these novel therapeutic strategies. Therefore, clinical trials of endocrine or cytotoxic therapies combined with growth factor pathway inhibitors or their downstream signalling elements are warranted; such approaches may allow us to improve upon the current standard of care for breast cancer patients [6]. Unfortunately, despite encouraging preclinical data, some of these combinations have yielded disappointing results in the clinical setting [7].This review describes and critically discusses targeted therapies for induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis (Fig. 1). Table 1 summarizes both finished and ongoing studies in this area.Apoptosis is a precisely regulated and evolutionarily conserved programme of cell suicide, which plays important roles during embryogenesis and immunology. Disturbances in the physiological programme of apoptosis prolong the life of cells and thereby promote carcinogenesis. Consequently, apoptosis is frequently diminished in cancer cells,
Tratamento ortod?ntico-cirúrgico da assimetria facial esquelética: relato de caso
Allgayer, Susiane;Mezzomo, Fernanda Santos;Polido, Waldemar Daudt;Rosenbach, Gabriella;Tavares, Carlos Alberto Estevanell;
Dental Press Journal of Orthodontics , 2011, DOI: 10.1590/S2176-94512011000600016
Abstract: introduction: facial asymmetries consist of an imbalance between the homologous skeletal structures of the face. most people present some degree of facial asymmetry, since a state of perfect symmetry is rare. this common asymmetry only becomes relevant when it is perceivable by the patient. in this situation, either orthodontic surgical correction or orthodontic treatment is normally chosen. objective: this study, based on literature review, has been illustrated by a case report comprising le fort i orthognathic surgery for maxillary advancement and rotation, with conservative treatment for the mandible. conclusion: knowledge of the patient's chief complaint and expectations, as well as proper diagnostic exams, are important factors to decide the treatment plan and for the final treatment outcome.
Traumatic injuries during the postoperative period after orthognathic surgery in patient with complete bilateral cleft lip and palate
Menezes, Luciane Macedo de;Rizzatto, Susana Maria Deon;Allgayer, Susiane;Heitz, Cláiton;
Revista Odonto Ciência , 2011, DOI: 10.1590/S1980-65232011000400015
Abstract: purpose: cleft lip and palate are the most common congenital deformities affecting the face and oral cavity. the procedure to be adopted when facing cleft lip and palate depends on their complexity, comprising treatment by an interdisciplinary team aiming at rehabilitation. esthetic, functional and emotional implications occur in different manners and intensities, depending on the type of cleft. the aim of this paper is to guide professionals in this field, especially oral surgeons, for the treatment of patients with these congenital deformities and cases of postoperative complications. case description: the present case illustrates the treatment of a patient with complete bilateral cleft lip and palate, who suffered facial trauma in the postoperative period after orthognathic surgery. the clinical and radiographic success could be observed two years after the trauma by fall. conclusion: patients submitted to orthognathic surgery are subject to postoperative complications. infection, vehicle accidents, firearm accidents and domestic violence are among the most common causes of complications in the postoperative period. knowledge on these problems allows the adoption of preventive measures to avoid serious complications mainly in patients with clefts who require an interdisciplinary team approach comprising multiple health care professionals.
Influence of premolar extractions on the facial profile evaluated by the Holdaway analysis
Allgayer, Susiane;Lima, Eduardo M. Santayana de;Mezomo, Maurício Barbieri;
Revista Odonto Ciência , 2011, DOI: 10.1590/S1980-65232011000100007
Abstract: purpose: this retrospective study aimed at assessing patients treated with extraction of premolars through cephalometry in lateral teleradiography, comparing the effect of different tooth extraction protocols on the facial profile. methods: for this study, 87 patients (31 boys and 56 girls) were selected from the private practices of three dentists certified by the brazilian board of orthodontics and facial orthopedics. these patients were treated with fixed edgewise appliance and divided into three groups, according to the sequence in which premolars were extracted "group 40" comprised 22 patients treated with extractions of the first two superior premolars, adopted as the control group; "group 44" comprised 43 patients treated with extractions of the four first premolars; and "group 45" comprised 22 patients treated with extractions of first superior premolars and second inferior premolars. the holdaway analysis was used to quantify and compare the group profiles before and after treatment. results: student's t-tests showed a profile improvement in all groups. when groups were compared, anova showed that only the inferior sulcus to the h line showed differences in incremental changes resulting from the treatment. group 44 showed a significantly higher difference than group 40. conclusion: we conclude that the protocols produce similar facial appearances.
Influence of premolar extractions on the facial profile evaluated by the Holdaway analysis =Influência de exodontias de pré-molares no perfil facial avaliada pela análise de Holdaway
Allgayer, Susiane,Lima, Eduardo Martinelli Santayana de,Mezomo, Maurício Barbieri
Revista Odonto Ciência , 2011,
Abstract: Objetivo: Este trabalho retrospectivo tem como proposta avaliar pacientes tratados com exodontias de pré-molares através de cefalometria em telerradiografia de perfil, comparando o efeito de diferentes protocolos de exodontias no perfil. Metodologia: Oitenta e sete pacientes (31 meninos e 56 meninas) foram selecionados da clínica particular de três ortodontistas diplomados pelo Board Brasileiro de Ortodontia e Ortopedia Facial. Estes pacientes foram tratados com aparelho fixo Edgewise foram divididos em três grupos, compreendendo a sequência de exodontia de pré-molares empregada Grupo 40 compreendendo 22 pacientes tratados com exodontia de primeiros pré-molares superiores, Grupo 44 compreendendo 43 pacientes tratados com exodontia de quatro primeiros pré-molares e Grupo 45 compreendendo 22 pacientes tratados com exodontia de primeiros pré-molares superiores e segundos inferiores. A Análise de Holdaway foi utilizada para quantificar e comparar os perfis antes e após o tratamento dos grupos. Resultados: O teste t-Student mostrou melhora no perfil em todos os grupos. Quando comparados entre si, ANOVA revelou que apenas a medida sulco lábio inferior em rela o à linha H apresentou diferen as nas mudan as incrementais proporcionadas pelo tratamento, em que o grupo 44 apresentou uma diferen a significativamente superior ao grupo 40. Conclus o: A partir dos resultados concluiu-se que os protocolos produzem aparências faciais semelhantes.
Mini-implants: mechanical resource for molars uprighting
Susiane Allgayer,Deborah Platcheck,Ivana Ardenghi Vargas,Raphael Carlos Drumond Loro
Dental Press Journal of Orthodontics , 2013,
Abstract: INTRODUCTION: The early orthodontic treatment allows correction of skeletal discrepancies by growth control, and the elimination of deleterious habits, which are risk factors for the development of malocclusions, favoring for the correction of tooth positioning later in a second treatment stage. During development of teeth and occlusion, the mandibular second molars commonly erupt in the oral cavity after all other teeth of the anterior region. In their eruptive process there may be a condition known as tooth impaction, which precludes its complete eruption and requires proper uprighting treatment. The temporary anchorage devices allow disimpaction and movement of these teeth directly to their final position, without the need of patient compliance or reaction movements in other parts of the arch. OBJECTIVE: This paper aims at describing a case report of the treatment of a patient with Angle Class II malocclusion, performed in two phases, in which mini-implants were used for uprighting the impacted mandibular second molars. INTRODU O: o tratamento ortod ntico precoce permite a corre o das discrepancias esqueléticas por meio do controle de crescimento e a elimina o de hábitos deletérios, que s o fatores de risco para o desenvolvimento de más oclus es, que favorecem a corre o do posicionamento dentário mais tardiamente, em uma segunda fase do tratamento. Durante o desenvolvimento da denti o e da oclus o, normalmente o segundo molar inferior chega à cavidade bucal após todos os dentes posicionados anteriormente a ele. Durante seu processo eruptivo, pode ocorrer uma condi o chamada "impac o dentária", em que sua erup o completa é interrompida, exigindo tratamento apropriado para verticaliza o. Os dispositivos temporários de ancoragem permitem a desimpac o e a movimenta o desses dentes diretamente às suas posi es finais, sem a necessidade de coopera o do paciente e sem movimento de rea o nas outras unidades da arcada. OBJETIVO: descrever o tratamento de um caso de má oclus o Classe II de Angle, realizado em duas fases, durante o qual foram utilizados mini-implantes para verticaliza o dos segundos molares inferiores impactados.
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