Background: Wheat is a potent allergen source and is one of
the causes of baker’s asthma and food allergy. The best strategy for managing
food hypersensitivity involves strict avoidance of the trigger. However, wheat
is quite difficult to avoid. Several alternative strategies for the treatment
of food allergy are under study. Spelt is a possible hypoallergenic crop that
may be tried in patients with wheat allergy. Methods: We have evaluated the allergenic IgE hypersensitivity mediated by spelt in wheat allergic patients.
Overall, 66 patients who suffered from baker’s asthma or food allergy (45 males
and 21 females, mean age 28.6 ± 12.9 years) were included. We have also compared its reactivity with standard- ized extracts from wheat and with purified non-specific
lipid transfer proteins from wheat (Tri a 14) and from peach (Pru p 3).
Immunodetection with spelt and common bread wheat extracts (Triticum aestivum,
cultivar Astral) was per- formed. Fresh wheat and spelt grain extracts were used
both for oral and bronchial challenge and skin tests. Specific IgE detection to
different cereals was performed using the Immuno CAP System (Phadia, Uppsala, Sweden). The bronchial challenge was positive with wheat Astral in 44 (67%)
patients, all of them suffered from asthma. Thirteen (29.54%) of these 44
patients had negative the challenge with spelt. The
oral challenge with wheat Astral was positive in 22 (33%) patients
with wheat food allergy, and the same test was positive in only in 6 of them
with spelt (27.3%). The diagnostic
yield (sensitivity, specificity and predictive values) of routine tests
There are several reports on the prevalence and importance of milk allergens in the induction of allergic diseases, whereas its role in the induction of autoimmune disease was rarely studied. So, the present work aimed to study the diagnosis and the efficacy of oral antigen specific immunotherapy (OAIT) on two groups of autoimmune disease patients namely, rheumatic arthritis (RA), group II, and systemic lupus erythematosus (SLE), group III, who has allergens for milk as an effective treatment option. From the assessment of the data obtained and the clinical outcome of RA and SLE patients after food elimination strategy and milk immunotherapy, it was evident that there were significant reductions (P < 0.001) in the levels of total IgE, specific IgE, Rheumatic factor (R.F), C-reactive protein (C.R.P), Anti-nuclear antibodies (ANA) and anti-double stranded DNA antibodies (Anti-ds DNA) compared to pretreated levels. Moreover, the immunotherapy induced “blocking antibodies” by remarkable highly significant increasing in IgG, phagocytic inhibition test (PIT %), Complement component 3(C3), and Complement component 4 (C4) levels. More improvement was noticed in the SLE as a result of the immunotherapy. Conclusion: milk desensitization is a gained interest and a safe valuable effective treatment of autoimmune conditions in Egypt.
The present study examined the effects of air pollutants on people’s health, focusing on dust produced from automobile tires while cars drive on roads. The annual volume of dust resulting from tire wear, calculated based on the number of automobiles registered in Japan, was 1747245.4 m3. To put it simply, this translates to approximately 1.4 times the volume of the Tokyo Dome, a famous Japanese baseball stadium. Particulate substances are categorized into three groups depending on their size, and dust resulting from tire wear is classified into the coarse particle mode along with mold spores, pollen, and dust produced from brake pads. This study examined whether or not tire dust causes health damage similarly to pollen, a particulate substance in the same group. There were 38/cm2 dust particles resulting from tire wear on a busy road in Osaka Prefecture, and this number was larger than that of cedar pollen/cm2 (35), a cause of hay fever, identified in Hokkaido. The results suggest that tire dust may also adversely affect the health of people if any of its constituents has a toxicity or causes allergies.