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Search Results: 1 - 10 of 406373 matches for " Allen Alexandra M "
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CerealsDB 2.0: an integrated resource for plant breeders and scientists
Wilkinson Paul A,Winfield Mark O,Barker Gary LA,Allen Alexandra M
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-219
Abstract: Background Food security is an issue that has come under renewed scrutiny amidst concerns that substantial yield increases in cereal crops are required to feed the world’s booming population. Wheat is of fundamental importance in this regard being one of the three most important crops for both human consumption and livestock feed; however, increase in crop yields have not kept pace with the demands of a growing world population. In order to address this issue, plant breeders require new molecular tools to help them identify genes for important agronomic traits that can be introduced into elite varieties. Studies of the genome using next-generation sequencing enable the identification of molecular markers such as single nucleotide polymorphisms that may be used by breeders to identify and follow genes when breeding new varieties. The development and application of next-generation sequencing technologies has made the characterisation of SNP markers in wheat relatively cheap and straightforward. There is a growing need for the widespread dissemination of this information to plant breeders. Description CerealsDB is an online resource containing a range of genomic datasets for wheat (Triticum aestivum) that will assist plant breeders and scientists to select the most appropriate markers for marker assisted selection. CerealsDB includes a database which currently contains in excess of 100,000 putative varietal SNPs, of which several thousand have been experimentally validated. In addition, CerealsDB contains databases for DArT markers and EST sequences, and links to a draft genome sequence for the wheat variety Chinese Spring. Conclusion CerealsDB is an open access website that is rapidly becoming an invaluable resource within the wheat research and plant breeding communities.
Healthcare professionals' perceptions of pain in infants at risk for neurological impairment
Lynn M Breau, Patrick J McGrath, Bonnie Stevens, Joseph Beyene, Carol S Camfield, G Allen Finley, Linda Franck, Alexandra Howlett, Karel O'Brien, Arne Ohlsson
BMC Pediatrics , 2004, DOI: 10.1186/1471-2431-4-23
Abstract: Neonatal Intensive Care Units (NICU's) at two tertiary pediatric centers. Ninety-five healthcare professionals who practice in the NICU (50 nurses, 19 physicians, 17 respiratory therapists, 9 other) participated. They rated the pain (0–10 scale and 0–6 Faces Pain Scale), distress (0–10), effectiveness of cuddling to relieve pain (0–10) and time to calm without intervention (seconds) for nine video clips of neonates receiving a heel stick. Prior to each rating, they were provided with descriptions that suggested the infant had mild, moderate or severe risk for neurological impairment. Ratings were examined as a function of the level of risk described.Professionals' ratings of pain, distress, and time to calm did not vary significantly with level of risk, but ratings of the effectiveness of cuddling were significantly lower as risk increased [F (2,93) = 4.4, p = .02]. No differences in ratings were found due to participants' age, gender or site of study. Physicians' ratings were significantly lower than nurses' across ratings.Professionals provided with visual information regarding an infants' pain during a procedure did not display the belief that infants' level of risk for neurological impairment affected their pain experience. Professionals' estimates of the effectiveness of a nonpharmacological intervention did differ due to level of risk.Research on pain in infants has progressed considerably over the past twenty years. The nature and frequency of procedural pain in the neonatal intensive care unit (NICU) is now understood [1], many measures have been developed for assessment of acute pain in the NICU [2] and many pain interventions have now been evaluated [3].However, much less is known about the pain experienced by neonates who are at risk for neurological impairment (NI), as most studies of neonatal pain have either excluded this group or have not examined data specific to them within larger data sets. We do know that this group represents approximately 10% of
Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence
Beno?t Remenant, Bénédicte Coupat-Goutaland, Alice Guidot, Gilles Cellier, Emmanuel Wicker, Caitilyn Allen, Mark Fegan, Olivier Pruvost, Mounira Elbaz, Alexandra Calteau, Gregory Salvignol, Damien Mornico, Sophie Mangenot, Valérie Barbe, Claudine Médigue, Philippe Prior
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-379
Abstract: The genomes of three tomato bacterial wilt pathogens, CFBP2957 (phy. IIA), CMR15 (phy. III) and PSI07 (phy. IV) were sequenced and manually annotated. These genomes were compared with those of three previously sequenced R. solanacearum strains: GMI1000 (tomato, phy. I), IPO1609 (potato, phy. IIB), and Molk2 (banana, phy. IIB). The major genomic features (size, G+C content, number of genes) were conserved across all of the six sequenced strains. Despite relatively high genetic distances (calculated from average nucleotide identity) and many genomic rearrangements, more than 60% of the genes of the megaplasmid and 70% of those on the chromosome are syntenic. The three new genomic sequences revealed the presence of several previously unknown traits, probably acquired by horizontal transfers, within the genomes of R. solanacearum, including a type IV secretion system, a rhi-type anti-mitotic toxin and two small plasmids. Genes involved in virulence appear to be evolving at a faster rate than the genome as a whole.Comparative analysis of genome sequences and gene content confirmed the differentiation of R. solanacearum species complex strains into four phylotypes. Genetic distances between strains, in conjunction with CGH analysis of a larger set of strains, revealed differences great enough to consider reclassification of the R. solanacearum species complex into three species. The data are still too fragmentary to link genomic classification and phenotypes, but these new genome sequences identify a pan-genome more representative of the diversity in the R. solanancearum species complex.The rapidly accumulating complete genomes in databases provide unique opportunities to study relationships among organisms. Since DNA sequences are conserved between closely related organisms, comparative genomic analyses are a powerful tool for understanding the complex evolutionary events in specific phylogenetic lineages.R. solanacearum, formerly known as Pseudomonas solanacearum and Bu
Analyzing Small Industrial and Commercial User Demand for Electricity  [PDF]
Keighton R. Allen, Thomas M. Fullerton, Jr.
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.814193
Abstract: This study employs duality theory to develop a theoretical model for small commercial and industrial (CIS) electricity usage. The CIS production function is posited such that output is a function of three variable inputs (electricity, natural gas, and labor) and one fixed input (capital). A profit function dual to this production function is specified using a normalized quadratic functional form. CIS profits are functionally dependent upon output price, an electricity input price, and natural gas and labor input prices for a fixed quantity of capital. The derived input-demand equation results from differentiating the profit function with respect to the price of electricity. The input-demand equation for electricity is dependent upon the own-price of electricity, the CIS output price, and input cross-prices. The model may be of use to utilities and regulators for the analysis of CIS electricity usage.
Shoulda’ Put a Ring on It: Investigating Adult Attachment, Relationship Status, Anxiety, Mindfulness, and Resilience in Romantic Relationships  [PDF]
Aileen M. Pidgeon, Alexandra C. Giufre
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.211005

This study aimed to investigate the predictive ability of relationship status, anxiety, mindfulness, and resilience in relation to the two orthogonal dimensions of adult attachment: attachment anxiety and attachment avoidance. 156 participants completed measures assessing relationship status, adult attachment, anxiety, mindfulness and resilience. The results showed that resilience and the relationship status of single significantly predicted attachment anxiety, whereas anxiety and being either single or divorced significantly predicted attachment avoidance. A significant mediating role of resilience in the prediction of attachment anxiety from being single was also observed. The main implications of this study provided preliminary support for the significant predictive value of resilience in attachment anxiety.

Genomes of uncultured eukaryotes: sorting FACS from fiction
Alexandra Z Worden, Christopher Dupont, Andrew E Allen
Genome Biology , 2011, DOI: 10.1186/gb-2011-12-6-117
Abstract: Uncultured unicellular eukaryotes have critical roles in global CO2 fixation in the oceans. The dilemma is that as earth systems undergo climate change, the responses of these elusive organisms and other uncultured taxa are nearly impossible to study or predict. Researchers are now investigating uncultured microbes by sequencing their genomes directly from the environment. The approach itself sounds straightforward: use fluorescently activated cell sorting (FACS) to separate populations, amplify their DNA by multiple displacement amplification (MDA), and sequence individual genes or genome fragments. But artifacts can be introduced at each step in the process and careful consideration is required during the data interpretation phase.For many years, oceanographers inferred from pigment distributions that a group of unicellular eukaryotic phytoplankton belonging to the prymnesiophytes were important - and that these prymnesiophytes were tiny (picoplankton, up to 2 to 3 μm in diameter). Yet no such prymnesiophyte existed in culture - at least none that matched the 18S rDNA sequences commonly retrieved from the ocean by PCR. Two recent publications showed that uncultured pico-prymnesiophytes are responsible for 25 ± 9% of the overall primary production (photosynthetic uptake of CO2 into plant-like biomass) in the North Atlantic [1,2]. Moreover, pico-prymnesiophytes form a significant portion of picoplanktonic photosynthetic biomass in biogeographical provinces stretching from the tropics to high latitude seas [1,2].In 2010 we sequenced a targeted metagenome from a wild pico-prymnesiophyte population using their natural photosynthetic pigments and size characteristics, at-sea FACS and MDA [2], a non-PCR based DNA amplification technique that uses random hexamer primers and the bacteriophage-derived Ф29 polymerase. The resulting partial genome assemblies revealed densely packed genomes with sparse intergenic regions and novel features for phytoplankton. Since then, a seco
A constrained optimization framework for compliant underactuated grasping
M. Ciocarlie,P. Allen
Mechanical Sciences (MS) , 2011, DOI: 10.5194/ms-2-17-2011
Abstract: This study focuses on the design and analysis of underactuated robotic hands that use tendons and compliant joints to enable passive mechanical adaptation during grasping tasks. We use a quasistatic equilibrium formulation to predict the stability of a given grasp. This method is then used as the inner loop of an optimization algorithm that can find a set of actuation mechanism parameters that optimize the stability measure for an entire set of grasps. We discuss two possible approaches to design optimization using this framework, one using exhaustive search over the parameter space, and the other using a simplified gripper construction to cast the problem to a form that is directly solvable using well-established optimization methods. Computations are performed in 3-D, allow arbitrary geometry of the grasped objects and take into account frictional constraints. This paper was presented at the IFToMM/ASME International Workshop on Underactuated Grasping (UG2010), 19 August 2010, Montréal, Canada.
Population growth and environment as a self-organizing system
Peter M. Allen
Discrete Dynamics in Nature and Society , 1998, DOI: 10.1155/s102602269900014x
Abstract: Over recent years a new understanding of complex systems, and their dynamics and evolution has emerged, and these have been shown to provide a new basis for models of the changing patterns of population and economic activities that shape the landscape. In this paper we make clear the necessarily partial description that any particular model must provide, and show the importance of a multidisciplinary, holistic understanding, linking any particular model to the co-evolution of its environment. In addition, we show how evolutionary processes link the microscopic level of molecules through successive scales of structure and organization ultimately to the biosphere itself, to issues of climatic change, of biomes at the continental scale and atmospheric and oceanic circulation patterns. Some very recent results will be shown which demonstrate that the world climate has already been modified considerably by human activities, particularly agriculture, underlining the vital need to understand better the on-going interaction between human activities and the biosphere.
On the Life Cycle and Natural History ofHymenitis Nero (Lepidoptera: Ithomiinae)in Costa Rica
Allen M. Young
Psyche , 1972, DOI: 10.1155/1972/13681
Notes on the Population Ecology of Cicadas(Homoptera: Cicadidae) in the Cuesta AngelForest Ravine of Northeastern Costa Rica
Allen M. Young
Psyche , 1981, DOI: 10.1155/1981/51602
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