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Search Results: 1 - 10 of 225 matches for " Allayee Hooman "
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CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults
Beitelshees Amber L,Aquilante Christina L,Allayee Hooman,Langaee Taimour Y
Human Genomics , 2012, DOI: 10.1186/1479-7364-6-9
Abstract: Objective Leukocyte count has been associated with blood pressure, hypertension, and hypertensive complications. We hypothesized that polymorphisms in the CXCL5 gene, which encodes the neutrophilic chemokine ENA-78, are associated with blood pressure in cardiovascular disease (CVD)-free adults and that these polymorphisms are functional. Methods and results A total of 192 community-dwelling participants without CVD or risk equivalents were enrolled. Two CXCL5 polymorphisms ( 156 G > C (rs352046) and 398 G > A (rs425535)) were tested for associations with blood pressure. Allele-specific mRNA expression in leukocytes was also measured to determine whether heterozygosity was associated with allelic expression imbalance. In 156 C variant carriers, systolic blood pressure (SBP) was 7 mmHg higher than in 156 G/G wild-type homozygotes (131 ± 17 vs. 124 ± 14 mmHg; P = 0.008). Similarly, diastolic blood pressure (DBP) was 4 mmHg higher in 156 C variant carriers (78 ± 11 vs. 74 ± 11 mmHg; P = 0.013). In multivariate analysis of SBP, age, sex, body mass index, and the 156 G > C polymorphism were identified as significant variables. Age, sex, and the 156 G > C SNP were further associated with DBP, along with white blood cells. Allelic expression imbalance and significantly higher circulating ENA-78 concentrations were noted for variant carriers. Conclusion CXCL5 gene polymorphisms are functional and associated with variable blood pressure in CVD-free individuals. The role of CXCL5 as a hypertension- and CVD-susceptibility gene should be further explored.
Prevalence of common disease-associated variants in Asian Indians
Trevor J Pemberton, Niyati U Mehta, David Witonsky, Anna Di Rienzo, Hooman Allayee, David V Conti, Pragna I Patel
BMC Genetics , 2008, DOI: 10.1186/1471-2156-9-13
Abstract: We investigated the prevalence of common polymorphisms that have been associated with diseases, such as atherosclerosis (ALOX5), hypertension (CYP3A5, AGT, GNB3), diabetes (CAPN10, TCF7L2, PTPN22), prostate cancer (DG8S737, rs1447295), Hirschsprung disease (RET), and age-related macular degeneration (CFH, LOC387715). In addition, we examined polymorphisms associated with skin pigmentation (SLC24A5) and with the ability to taste phenylthiocarbamide (TAS2R38). All polymorphisms were studied in a cohort of 576 India-born Asian Indians sampled in the United States. This sample consisted of individuals whose mother tongue is one of 14 of the 22 "official" languages recognized in India as well as individuals whose mother tongue is Parsi, a cultural group that has resided in India for over 1000 years. Analysis of the data revealed that allele frequency differences between the different Indian language groups were small, and interestingly the variant alleles of ALOX5 g.8322G>A and g.50778G>A, and PTPN22 g.36677C>T were present only in a subset of the Indian language groups. Furthermore, a latitudinal cline was identified both for the allele frequencies of the SNPs associated with hypertension (CYP3A5, AGT, GNB3), as well as for those associated with the ability to taste phenylthiocarbamide (TAS2R38).Although caution is warranted due to the fact that this US-sampled Indian cohort may not represent a random sample from India, our results will hopefully assist in the design of future studies that investigate the genetic causes of these diseases in India. Our results also support the inclusion of the Indian population in disease-related genetic studies, as it exhibits unique genotype as well as phenotype characteristics that may yield new insights into the underlying causes of common diseases that are not available in other populations.India is currently the second most populous country in the world after China with a population of 1,087 million that is predicted to expand to 1
Drilling Operation and Formation Damage  [PDF]
Hooman Fallah, Sara Sheydai
Open Journal of Fluid Dynamics (OJFD) , 2013, DOI: 10.4236/ojfd.2013.32005

Transport of particle suspensions in oil reservoirs is an essential phenomenon in many oil industry processes. Solid and liquid particles dispersed in the drilling fluid (mud) are trapped by the rock (porous medium) and permeability decline takes place during drilling fluid invasion into reservoir resulting in formation damage. The formation damage due to mud filtration is explained by erosion of external filter cake. Nevertheless, the stabilization is observed in core floods, which demonstrates internal erosion. A new mathematical model for detachment of particles is based on mechanical equilibrium of a particle positioned on the internal cake or matrix surface in the pore space. In the current work the analytical solution obtained to mud filtration with one particle capture mechanism with damage stabilization. The particle torque equilibrium is determined by the dimensionless ratio between the drag and normal forces acting on the particle. The maximum retention function of the dimensionless ratio closes system of governing equations for colloid transport through porous medium.

An Exploration on the Effective Factors of Tourism Industry on Protection of the Environment in the Historical City Ghoumas  [PDF]
Hooman Mesgarian, Leili Alaei
Open Journal of Ecology (OJE) , 2014, DOI: 10.4236/oje.2014.49048

According to the world tourism organization (WHO) in 2005, the number of tourists has increased up to 36 times. In a way that it has maximized from 25 million in 1950 to 1018 million in 2010. The sustainable tourism, thus, because of making a balance between different environmental, economic, cultural and social dimensions of the tourism development, plays a considerable role in protection of species diversity, and benefits the tourism activists in order to reduce its destructive impact on the environment and the local cultures and being kept for the future generations. Accordingly, the present research first examines the relationship between tourism, sustainable development and the ecology, for measurement of different aspects of the industry effect on the environment. Secondly, the present study uses from some parameters like the average monthly minimum and maximum temperatures, the average relative humidity, the average maximum and minimum temperatures in day and at night in the Semnan station as well as using the common diagram in the experimental methods like Olegi to assess day and night Climatourism in the region. Finally, on the basis of the performed analysis, the strengths and weak points of tourist attractions for the protection of the environment are considered.

Climatic Effects on the Formation and Function of Architectures Based on the Climate in Semnan Province, Iran  [PDF]
Saeid Kamyabi, Hooman Mesgarian
Open Journal of Ecology (OJE) , 2014, DOI: 10.4236/oje.2014.49044

Semnan province is one of the vast provinces of the country that has a variety of topographical and clamatorial conditions. This province plays a key role in industrial, agricultural and animal husbandry activities. The study of its climate potential with respect to its natural limitations like lack of water resources, soil types, droughts and desertification problems has been considered as a necessity in the province annual planning. In this study, the climatic regionalization of the province is done through using empirical and quantitative methods on climatic data of meteorological stations of the area in statistical period of 1982-2005. Methods of Koppen empirical, De Martonne, Emberger and Dr Karimi have divided the province into 3, 2, 4 and 6 climactic types, respectively. Using principle components and the cluster analysis on 14 climatic elements of 21 stations, 5 climatic types have been specified for the province. Based on this method, temperature, its Diurnal Temperature Range (DTR), precipitation and its type, and humidity contribute a great deal to the climate of the Semnan Province. The main results of this identification of 5 climatic types include hot & dry, dry & hot semi-dry, dry & cold semi-dry, mountainous, and Caspian climate.

Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
Thomas M Morgan, John A House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L Hazen, Yesha Patel, Riyaz S Patel, Danny J Eapen, Salina P Waddy, Arshed A Quyyumi, Marcus E Kleber, Winfried M?rz, Bernhard R Winkelmann, Bernhard O Boehm, Harlan M Krumholz, John A Spertus
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-127
Abstract: We examined 95 polymorphisms in 69 distinct gene regions identified in a GWAS for premature myocardial infarction for their association with post-ACS mortality among 811 whites recruited from university-affiliated hospitals in Kansas City, Missouri. We then sought replication of a positive genetic association in a large, racially diverse cohort of myocardial infarction patients (N = 2284) using Kaplan-Meier survival analyses and Cox regression to adjust for relevant covariates. Finally, we investigated the apparent association further in 6086 additional coronary artery disease patients.After Cox adjustment for other ACS risk factors, of 95 SNPs tested in 811 whites only the association with the rs6922269 in MTHFD1L was statistically significant, with a 2.6-fold mortality hazard (P = 0.007). The recessive A/A genotype was of borderline significance in an age- and race-adjusted analysis of the entire combined cohort (N = 3095; P = 0.052), but this finding was not confirmed in independent cohorts (N = 6086).We found no support for the hypothesis that the GWAS-identified variants in this study substantially alter the probability of post-ACS survival. Large-scale, collaborative, genome-wide studies may be required in order to detect genetic variants that are robustly associated with survival in patients with coronary artery disease.Genome-wide association studies (GWAS) have identified robust genetic associations in a variety of common diseases [1], including myocardial infarction (MI) [2-6]. The GWAS approach, with its emphasis on large sample sizes and inclusion of hundreds of thousands of genetic markers, has produced a degree of reproducibility that was generally lacking in earlier candidate gene studies of MI [7]. However, nine GWAS-identified genetic susceptibility markers, all meeting criteria for genome-wide statistical significance, collectively account for only 3% of the estimated heritability of early-onset myocardial infarction (MI), raising questions about t
A Probabilistic Analysis on the Harmonic Cancellation Characteristics of the Scott Transformer  [PDF]
Hooman Erfanian MAZIN, Joey GALLANT
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.21003
Abstract: The Scott transformer is widely used in electric railway systems when there are two unbalanced single-phase loads as this transformer can reduce unbalance currents. This paper investigates whether or not the Scott transformer can also reduce harmonic current. Our study shows that it can reduce the harmonic current when single-phase loads have identical harmonic characteristics. This harmonic reduction occurs through the cancellation of harmonic currents of single-phase loads in the transformer windings. Our studies also show that there is some degree of cancelation even when the loads do not have identical harmonic characteristics. The cancellation depends on load balance factor and harmonic order.
The Little Randall-Sundrum Model at the LHC
Davoudiasl, Hooman
High Energy Physics - Phenomenology , 2008,
Abstract: We present a predictive warped model of flavor, cut off at an ultraviolet scale O(10^3) TeV, called the "Little Randall-Sundrum (LRS)" model. This model corresponds to a volume-truncation, by a factor y \approx 6, of the RS scenario and is holographically dual to dynamics with number of colors larger by y. With separate gauge and flavor dynamics, several unwanted contributions to precision electroweak, Z b \bar b, and flavor observables are suppressed in the LRS framework, compared with the corresponding RS case. The LRS truncation leads to a significant enhancement of the clean (golden) di-lepton LHC signals, by O(y^3).
Constraining Unparticle Physics with Cosmology and Astrophysics
Davoudiasl, Hooman
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevLett.99.141301
Abstract: It has recently been suggested that a scale invariant "unparticle" sector with a non-trivial infrared fixed point may couple to the Standard Model (SM) via higher dimensional operators. The weakness of such interactions hides the the unparticle phenomena at low energies. We demonstrate how cosmology and astrophysics can place significant bounds on the strength of unparticle-SM interactions. We also discuss the possibility of a having a non-negligible unparticle relic density today.
Taxonomy of Trypanosoma cruzi: a commentary on characterization and nomenclature
Momen Hooman
Memórias do Instituto Oswaldo Cruz , 1999,
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