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Protective Effect of Dendrosomal Curcumin Combination on Colon Cancer in Rat
Sarbolouki MN,Alizadeh AM,Khaniki M,Azizian S
Tehran University Medical Journal , 2012,
Abstract: Background: Cancer is a multistep process that develops very rapidly after its onset. Previous studies have confirmed antitumor effects of curcumin (1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; diferuloylmethane) that can potentially prevent colon cancer development with low side-effects. Different methods have been performed to increase the efficiency and effectiveness of curcumin among which dendrosome, a nanoparticle created by Sarbolouki et al. was used in this study. The present study was undertaken to evaluate the effects of dendrosomal curcumin on rat colon cancer. Methods: In this study which was performed in Cancer Research Center of Tehran University of Medical Sciences in 2010 year, forty rats were equally divided into control, curcumin and curcumin-dendrosome groups. Animals received azoxymethane (15 mg/kg s.c.), a carcinogen, once a week for two weeks. Curcumin (0.2%) and curcumin-dendrosome were administered to the respective animals 2 weeks before the first and 14 weeks after the last azoxymethane injections. Eventually, colorectal specimens from tumoral and adjacent non-tumoral mucosal tissues were fixed in 10% formaldehyde, and passaged and embedded in paraffin. Histopathological and immunohistochemical studies were performed on the specimens. Results: The mean number of lesions, nuclear/cytoplasmic ratio, epithelial stratification, loss of nuclear polarity, goblet depletion, structural abnormality and beta-catenin expression were higher in the control group compared to curcumin and curcumin-dendrosome groups. These parameters had significantly decreased in the dendrosomal curcumin group (P<0.05). Conclusion: The present study shows that dendrosome can be used as a suitable nanoparticle to increase curcumin efficiency in the prevention or treatment of colon cancer.
Effects of Fumonisin B1 on the Stomach and Colon Cell Lines in Vitro
Mahmoodi M,Alizadeh AM,Amini-Najafi M,Khosravi AR
Tehran University Medical Journal , 2012,
Abstract: Background: Fumonisins, a family of mycotoxins, are mainly found in wheat, corn and their products. Previous studies have shown that fumonisin B1 (FB1), the most abundant and toxic of known fumonisins, has been associated with many animal and human diseases including cancer. In the present study, the effects of FB1 were examined on the production of inflammatory cytokines in intestine and stomach cell lines.Methods: This study was performed in the Cancer Research Center of Tehran University of Medical Sciences in 2010. The cell lines of colon adenocarcinoma (SW742) and gastric epithelium (AGS) were purchased from the Pasteur Institute of Iran. The cells were pretreated with different concentrations of FB1 (0 to 100 μM) for 3 days. The cells were later stimulated by lipopolysaccharides. Twenty-four hours after cell induction, the cytokines including tumor necrosis factor-alpha (TNF-α), interlukin-1 beta (IL-1β) and interlukin-8 (IL-8) were measured by ELISA. Results: Treatment with FB1 induced a dose-dependent decrease in IL-8 production (P<0.05). This decrease was seen in both SW742 and AGS cell lines. Moreover, FB1 induced a dose-dependent increase in the production of TNF-α and IL-1β in both cell lines (P<0.05). Conclusion: The results of this study indicated that FB1 could increase the inflammatory cytokines including TNF-α and IL-1β in gastric and intestinal celllines. These effects might result in the development of inflammatory responses and subsequent mucosal atrophy in in-vivo conditions.
Stress among medical students of Gorgan (South East of Caspian Sea), Iran
A Marjani,AM Gharavi,M Jahanshahi,A Vahidirad,F Alizadeh
Kathmandu University Medical Journal , 2008, DOI: 10.3126/kumj.v6i3.1726
Abstract: Objective: This study aims to estimate the prevalence of psychological stress and association between the levels of stress and study variables among Gorgan medical students. Materials and methods: All three year medical students (129 basic sciences students) in Gorgan Faculty of Medicine, Golestan University of medical Sciences, were asked to complete the Kessler 10 questionnaire. Results: The findings showed mild, moderate and severe stress among 26.22%, 20.50% and 14.75% study subjects. 39.35% of medical students had no stress. There was statistically significant association between year of study and stress levels (p= 0.040). Conclusion : The results indicate that there is a decrease in the psychological health of first year medical students. Provided that stress management courses are organised by medical schools, when the students arrive, they will cope up with the stress in coming years. These courses may reduce the negative effects of stress on medical students. By providing such courses and reducing stress level, medical students may improve their medical education. Key words : Medical students, stress, Gorgan ??? doi: 10.3126/kumj.v6i3.1726 ? Kathmandu University Medical Journal (2008), Vol. 6, No. 3, Issue 23, 421-425
Alteration in T-Cell Cytokine Production by Vitamin A and Zinc Supplementation in Mice  [PDF]
Sorayya Kheirvari, Mohammad Alizadeh
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.38141
Abstract: Simultaneous zinc and vitamin A deficiency are common health problems in developing countries. The objective of this study was to assess effect of supplementation of high zinc or vitamin A on immune function. After three months of feeding with a zinc and vitamin A deficient diet, mice were assigned into four groups which, for additional two months, received a normal or high zinc along with vitamin A deficient diet and a normal or high vitamin A along with zinc deficient diet. Serum and intestinal mucosa immunoglobulin A (IgA) were determined and supernatants of splenocytes were used to assess interlukin (IL)-2, IL-5, IFN-γ. Mice maintained on zinc deficient diet with normal or high vitamin A resulted in significantly lower production of IFN-γ. Also, supplementation of high dose vitamin A augmented production of the cytokine as compared to normal intake of the vitamin. Supplementation of either normal or high zinc along with low vitamin A diet significantly led to higher production of IFN-γ as compared to those receiving zinc limited but adequate vitamin A. High intake of zinc along with vitamin A deficient diet significantly enhanced secretion of IL-2. Levels of serum and mucosal IgA and IL-5 were not be significantly modulated. Moreover, animals fed with high doses of zinc showed increased IL-2 production than those that had normal intake of zinc. Results indicated that zinc and vitamin A supplementation up-regulates production of T-cell cytokines, IFN-γ and IL-2.
Rule of Structural Factors in Formation of Porphyry Copper Deposits in South Western Part of Kerman Area, Iran  [PDF]
Hasan Alizadeh, Mehran Arian
Open Journal of Geology (OJG) , 2015, DOI: 10.4236/ojg.2015.57045
Abstract: Kerman area is located in southern parts of central Iranian volcanic belt. The area under study is located in the southern part of this complex copper mineralization in the area, which is mainly porphyry type and is associated with extensive hydrothermal alteration. This area has a great potential as far as tertiary porphyry copper deposits are concerned. To the exploration of porphyry copper deposits in study area, we have analyzed the lineaments. The lineaments interpreted out from ETM + (band8) data is recognized as another method for locating porphyry type copper mineralization. There is a close correlation between photo lineament factor values and the known copper mineralization in the area. The relationship between 16 porphyry copper deposits with faults and fractures in the area is studied. Photo lineament factor assessments by using satellite photos indicate a strong relationship between a number of lineation intersection in each cell refer to an amount of average lineation in whole map (c/C ratio). In the study area, ratio of c/C even has more relationship refers to PF factor that has previously described in the papers.
(2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline-κ2N,N′)bis(thiocyanato-κS)mercury(II)
Robabeh Alizadeh
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809023228
Abstract: In the molecule of the title compound, [Hg(NCS)2(C26H20N2)], the HgII atom is four-coordinated in a distorted tetrahedral configuration by two N atoms from a chelating 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline ligand and by two S atoms from two thiocyanate anions. The ligand ring system is not planar. The dihedral angle between the phenyl rings is 53.20 (3)° . In the crystal structure, π–π contacts between phenanthroline rings [centroid–centroid distance = 3.981 (1) ] may stabilize the structure.
Mixed cropping of annual feed legumes with barley improves feed quantity and crude protein content under dry-land conditions
Khoshnood Alizadeh
Maejo International Journal of Science and Technology , 2013,
Abstract: The objective of this research is to determine a suitable mixture of annual feed legumes and barley as a winter crop under dry-land conditions. Seeds of Hungarian vetch (cv. 2670), smooth vetch (cv. Maragheh), and local varieties of grass pea and field pea were mixed with barley (cv. Abidar) in a 1:1 ratio and were tested, along with related monoculture. All legumes in the mixture survived winter while legumes alone, except Hungarian vetch, did not survive in the cold areas. The maximum fresh and dry forage yields (56 and 15 ton ha-1 respectively) were obtained from a mixture of smooth vetch and barley in provinces with mild winter and more than 400 mm of rainfall. The mixture of barley and smooth vetch resulted in the highest mean crude protein content (17%). Autumn seeding of smooth vetch and barley in a 1:1 ratio produced more than 2 ton ha-1 of dry biomass with good quality in all studied areas and thus could serve as an alternative cropping system after wheat/barley in cold and semi-cold dry land.
Some algorithms for normality testing irreducible polynomials and computing complexity of the normal polynomials over finite fields
M. Alizadeh
Applied Mathematical Sciences , 2012,
Abstract:
Prevalence of Subcallosal Striation as A Radiologic Finding in Multiple Sclerosis Patients Sagital with FLAIR MR Imaging
A. Alizadeh
Iranian Journal of Radiology , 2008,
Abstract: Background/Objective: Multiple sclerosis is one of the debilitating neurological diseases. MRI findings play a major role in diagnosis of diseases, but unfortunately are non-specific. This study was conducted to deter-mine the prevalence of Subcallosal Striation as an early MR finding in MS patients."nPatients and Methods: In this case series, patients re-ferred to our imaging center, Poursina hospital, Rasht, Guilan University of medical sciences with multiple Sclerosis, selected with census method, were studied. For evaluation of subcallosal striation, sagital FLAIR imaging, added to routine MR studies of the brain. The images were reviewed for presence of sub-callosal striation which is linear 1-2 mm thick foci of hyperintensities, perpendicular to epandyma, like stack of coins. Data were reviewed in Excel program and descriptive statistical indicators were extracted."nResults: Most of the patients with Multiple Sclerosis (more than 90%) had subcallosal striations. Also we found pericallosal region, subcortical region, hemi-spheric white matter, posterior fossa, brain stem, proximal cervical spinal cord and optic nerves as the most common locations for MS plaques."nConclusion: Subcallosal Striation is a common early radiological finding in MS patients and could help us in differential diagnosis of the disease.
Role of VCUG in Secondary Vesicoureteral Reflux
H Alizadeh
Iranian Journal of Radiology , 2009,
Abstract: "nVesicoureteral reflux (VUR) still remains one of the most common causes of severe renal damage or sometimes end-stage kidneys in children. Although in some cases prenatal suggestion may happen, especially in secondary VUR, most of them are detected during childhood after episodes of urinary tract infection. "nDespite new modern imaging modalities in the recent years, standard VCUG still has an important role in the evaluation of voiding dysfunction, primary and secondary VUR. "nParticularly in male children it is mandatory for the evaluation of lower urinary tract. "nThis article is a review that describes the proper technique of VCUG, normal variations and some common pathological findings in secondary VUR.
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