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Search Results: 1 - 10 of 6818 matches for " Alison Chan "
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Course‐Integrated Learning Outcomes for Library Database Searching: Three Assessment Points on the Path of Evidence
Dianne Cmor,Alison Chan,Teresa Kong
Evidence Based Library and Information Practice , 2010,
Abstract: Objective ‐ This study aims to assess student learning with respect to basic database searching at three different points within a required first year course. Methods ‐ Three methods were employed at three different points to identify evidence of successful learning: 1. Analysis of in‐class exercises from the initial library workshop, e.g. how many students showed evidence of satisfactorily achieving the stated learning outcomes. 2. Participant observation of student presentations, noting themes, strengths and weaknesses of student research strategy; written observation reports from librarians were coded and quantified to identify major themes. 3. Interviews with course instructors responsible for grading the final submitted projects, focusing on both student achievement and instructor perceptions of the impact of library involvement. Results ‐ Though performance on in‐class exercises showed evidence of successful learning in over 70% of students, observational data indicated that very few students showed evidence of applying new knowledge and new search skills to their own topics two weeks later. Instructor interviews revealed a perception of similar difficulties in final project submissions, and instructors suggested that students did not appreciate the need for library resources. Conclusion ‐ In this study, students showed evidence of learning in a simulated environment, but were unable or unwilling to demonstrate this learning in authentic situations. Multiple assessment methods reveal a lack of student ability to apply search skills.
Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial
Lindsay S. Nagamatsu,Alison Chan,Jennifer C. Davis,B. Lynn Beattie
Journal of Aging Research , 2013, DOI: 10.1155/2013/861893
Change in Body Fat Mass Is Independently Associated with Executive Functions in Older Women: A Secondary Analysis of a 12-Month Randomized Controlled Trial
Elizabeth Dao, Jennifer C. Davis, Devika Sharma, Alison Chan, Lindsay S. Nagamatsu, Teresa Liu-Ambrose
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0052831
Abstract: Objectives To investigate the independent contribution of change in sub-total body fat and lean mass to cognitive performance, specifically the executive processes of selective attention and conflict resolution, in community-dwelling older women. Methods This secondary analysis included 114 women aged 65 to 75 years old. Participants were randomly allocated to once-weekly resistance training, twice-weekly resistance training, or twice-weekly balance and tone training. The primary outcome measure was the executive processes of selective attention and conflict resolution as assessed by the Stroop Test. Sub-total body fat and lean mass were measured by dual-energy x-ray absorptiometry (DXA) to determine the independent association of change in both sub-total body fat and sub-total body lean mass with Stroop Test performance at trial completion. Results A multiple linear regression model showed reductions in sub-total body fat mass to be independently associated with better performance on the Stroop Test at trial completion after accounting for baseline Stroop performance, age, baseline global cognitive state, baseline number of comorbidities, baseline depression, and experimental group. The total variance explained was 39.5%; change in sub-total body fat mass explained 3.9% of the variance. Change in sub-total body lean mass was not independently associated with Stroop Test performance (P>0.05). Conclusion Our findings suggest that reductions in sub-total body fat mass – not sub-total lean mass – is associated with better performance of selective attention and conflict resolution.
A Case Study of Water Education in Australia  [PDF]
Alison J. Sammel
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.513129

What does it mean to be scientifically literate in relation to water? Is this understanding the same for water literacy? And what implications do these two concepts have for water education in Australia? In addressing these questions, this paper provides a snapshot of the similar and competing educational ideologies that underpin the concepts of scientific literacy in relation to water, and water literacy. An investigation of the Australian Curriculum (Science), and a small case study of pre-service education students highlight the degree to which one concept is favored over the other. This bias ultimately raises questions for water education in Australia, as it is not about whether the ACS or [future] teachers should be addressing issues associated with water, but rather how and to what end goal. This necessitates exploring the partial and political nature of any approach to educating about water, and highlights that not all approaches are equally as politically neutral or challenging.

Science as a Human Endeavour: Outlining Scientific Literacy and Rethinking Why We Teach Science  [PDF]
Alison J. Sammel
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.510098
Abstract: What does it mean to be scientifically literate? Historically, dominant understandings of scientific literacy focus on science content acquisition. However, new understandings imply more genuine and authentic interactivity between science content knowledge/skills and understanding of the economic, sociocultural, religious, ecological, ideological, political and temporal connections upon which the science is based: this is the task of Science as a Human Endeavour. This paper presents a snapshot of what Science as a Human Endeavour is, its purpose and factors to consider. Science as a Human Endeavour doesn’t just necessitate that we change our teaching practices: it forces us to rethink the teaching and learning of science and the reason why we are doing it.

Equilibrium in Classical Confucian “Economy”  [PDF]
Shirley Chan
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.22015
Abstract: In a modern economy, “equilibrium” means that supply and demand is equal. It is at this point that the allocation of goods and services is at its most efficient, this being because the amount of goods and the amount of goods in demand are equally balanced. The market equilibrium therefore is determined by supply and demand. This paper looks at the concept of “equilibrium” in some of the early Confucian texts and its possible implications in economic activities. In the Confucian context equilibrium, or what can be termed as the ultimate equilibrium, is to be understood in a broader sense where balances and harmony at different levels (e.g. individual and society) need to be sought in order to achieve a model of sustainable development. The ultimate equilibrium may provide an alternative approach to social welfare and economic prosperity creating universal harmony and better living for humans. In Confucian ideology, governing for the welfare of the people is not merely a question of increasing personal income and wealth; it requires implementation on a priority basis, taking into consideration the formation of an orderly society based on the enforcement of moral and ethical standards with the existence of a benevolent government which appropriates things according to the principles of harmony and order to achieve what can be termed as the “great equilibrium”—equilibrium that is not simply defined by balanced economic forces as in modern economic theory; but rather is used to suggest an ideal state of harmony in self fulfilment and socio-political order through incentives and by appropriate means.
Language Learner Autonomy and Learning Contract: A Case Study of Language Majors of a University in Hong Kong  [PDF]
Mable Chan
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.52013
Abstract: With the aim of developing first year undergraduate students’ awareness and ability of autonomous learning, they were asked to do self-access work in an academic English proficiency course through drafting a learning contract outlining their learning objectives and submitting learning evidence regularly in the course of the semester. This study examines the content of the learning contract and the English language learning beliefs reflected from the learning objectives formulated, plus questionnaire results, and determines whether university students in Hong Kong are ready for autonomous learning or not. Based on the findings, the study examines whether Hong Kong university students are ready for autonomous learning, and discusses ways to deal with the challenges which might impede implementation of language learner autonomy in Hong Kong.
Teachers’ Cognition about Teaching and Learning of Simple Past Tense: Can Processing Instruction Help?  [PDF]
Mable Chan
Open Journal of Modern Linguistics (OJML) , 2016, DOI: 10.4236/ojml.2016.64033
Abstract: This study examines how teachers perceive the difficulties and strategies of acquiring simple past tense, and the pedagogical implications. Findings show that teachers’ understanding of the nature of the acquisition problem of tense, and their use of teaching approach are instrumental in shaping students’ learning outcomes. What is fortunate is that they understand the need to improve the existing teaching approach which is too form-oriented. Unfortunately, they do not seem to have much knowledge about how to do so. Findings in the literature should not be limited to researchers; there is a pressing need for teachers to understand the nature of the acquisition problem, possible reasons leading to the difficulty, and ways to help students master both the forms and meaning of simple past tense.
Assessment of Metagenomic Assembly Using Simulated Next Generation Sequencing Data
Daniel R. Mende, Alison S. Waller, Shinichi Sunagawa, Aino I. J?rvelin, Michelle M. Chan, Manimozhiyan Arumugam, Jeroen Raes, Peer Bork
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031386
Abstract: Due to the complexity of the protocols and a limited knowledge of the nature of microbial communities, simulating metagenomic sequences plays an important role in testing the performance of existing tools and data analysis methods with metagenomic data. We developed metagenomic read simulators with platform-specific (Sanger, pyrosequencing, Illumina) base-error models, and simulated metagenomes of differing community complexities. We first evaluated the effect of rigorous quality control on Illumina data. Although quality filtering removed a large proportion of the data, it greatly improved the accuracy and contig lengths of resulting assemblies. We then compared the quality-trimmed Illumina assemblies to those from Sanger and pyrosequencing. For the simple community (10 genomes) all sequencing technologies assembled a similar amount and accurately represented the expected functional composition. For the more complex community (100 genomes) Illumina produced the best assemblies and more correctly resembled the expected functional composition. For the most complex community (400 genomes) there was very little assembly of reads from any sequencing technology. However, due to the longer read length the Sanger reads still represented the overall functional composition reasonably well. We further examined the effect of scaffolding of contigs using paired-end Illumina reads. It dramatically increased contig lengths of the simple community and yielded minor improvements to the more complex communities. Although the increase in contig length was accompanied by increased chimericity, it resulted in more complete genes and a better characterization of the functional repertoire. The metagenomic simulators developed for this research are freely available.
A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen
Sergei Rudchenko, Matthew Scanlan, Gavreel Kalantarov, Victoria Yavelsky, Chen Levy, Alison Estabrook, Lloyd Old, Gerald L Chan, Leslie Lobel, Ilya Trakht
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-248
Abstract: The current study employs immunocytochemistry, immunohistochemistry, Western blot analysis as well as Northern blots, Scatchard binding studies and finally SEREX analysis for target antigen identification.By application of an expression cloning technique known as SEREX, we determined that the target antigen for two monoclonal antibodies, 27.B1 and 27.F7, derived from lymph node B-cells of a breast cancer patient, is the PDZ domain-containing protein known as GIPC1. This protein is highly expressed not only in cultured human breast cancer cells, but also in primary and metastatic tumor tissues and its overexpression appears to be cancer cell specific. Confocal microscopy revealed cell membrane and cytoplasmic localization of the target protein, which is consistent with previous studies of this protein.We have determined that GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer. Its role, however, in the initiation and/or progression of breast cancer remains unclear and needs further clarification.In patients with cancer, the body mounts an immune response following the onset of malignant disease since the new cells are recognized as non-self. It is composed of both immune cells that mediate innate, non-specific immunity, and adaptive, antigen-specific immunity [1-3]. Tumor cell proteins can elicit an immune response for various reasons; aberrant gene expression (e.g. cancer-testis antigens) [4-10], overexpression (neu/Her2) [11,12], aberrant processing (mucin) [13,14] and mutation events (p53) [11,15]. Although it is evident that a natural humoral response to cancer exists, tumor-associated antigens (TAAs) are generally notoriously bad immunogens. This is likely due to systemic tolerance to the autoantigens and, as a result, the natural humoral immune response against tumor antigens fails to reach high antibody titers and is not effective [16].During the last decade, the search for TAAs that can be targeted by the immun
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