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Search Results: 1 - 10 of 18423 matches for " Ali Ural "
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Optimization of transfection of green fluorescent protein in pursuing mesenchymal stem cells in vivo
Yusuf Baran,Ali U?ur Ural,Ferit Avcu,Meral Sarper
Turkish Journal of Hematology , 2008,
Abstract: OBJECTIVE: Green Fluorescent Protein (GFP) has been used as a marker of gene expression and a single cell marker in living organisms in cell biology studies. The important areas that GFP is used are expression levels of different genes in different organisms by inserting GFP in these genes and as a marker in living cells. In this study, we tried to optimize transfection of mesenchymal stem cells, (MSCs) used for regeneration of damaged tissues in animals, by GFP containing plasmid vector by which MSCs can be followed in vivo.METHODS: To this aim, phM-GFP plasmid vector carrying GFP gene and effectene transfection reagent were used. RESULTS: The data revealed that twice transfection of MSCs resulted in higher expression of GFP for longer times as compared to once transfected MSCs. On the other hand, leaving the chemical transfection agents in the medium induced apoptosis after a while. CONCLUSION: As a conclusion we suggest the transfection of MSCs twice with 48 hours interval and removal of transfection agents after 8 hours which removed toxic and apoptotic effects of the chemicals.
A rare urogenital myiasis caused by Psychoda albipennis: a case report
Ural O?uz,Berkan Re?orlu,Zeynep ?izmeci,Ali ünsal
Turkish Journal of Urology , 2012,
Abstract: Myiasis is the infestation of body tissues or organs by dipterous fly species and is often associated with poor hygiene. Urogenital myiasis is uncommon, and Psychoda albipennis-induced urogenital myiasis is very rare. In this article, we present a case of urinary myiasis caused by Psychoda albipennis. The patient claimed that he had observed more than 10 black-grayish-colored mobile particles in his urine. We identified them as the fourth stage of the moth fly Psychoda albipennis. The patient was a farmer and lived in Ankara, Turkey. He was treated with antibiotics, and there were no complications during or after treatment.
Anaerobic Glycolysis is the Main Pathway for Energy Generation in HL-60 Acute Promyelocytic Leukemia Cells
Hakan Boyunaga,Hatice Keles,Levent Kenar,Ali Ural
Journal of Clinical and Analytical Medicine , 2010, DOI: 10.4328
Abstract: Aim: In physiological conditions, normal cells use mainly the glycolytic aerobic pathway to provide energy. However, most cancer cells utilize anaerobic glycolytic way for energy generation. Aim of this study was to investigate the carbohydrate metabolic pathways of HL-60 acute promyelocytic leukemia cells for energy production. Material and Methods: Leukemia cells as well as normal leukocytes were incubated with radiolabelled glucose in aerobic and anaerobic conditions and glycogen consumptions and the ratios of radiolabelled glucose catabolized into CO2 or lactate, that is, the rates of aerobic or anaerobic glycolysis, were determined. Results: The glycogen consumption was significantly higher in aerobic leukemia cell culture than normal leukocyte culture (p<0.01). The rate of anaerobic glycolysis was 93.8% in leukemia cells in aerobic conditions and it increased to 96.6% while utilization of glycogen increased by 7.31% in anaerobic conditions. Conclusion: In conclusion, principally anaerobic glycolysis is effective for energy generation in HL-60 promyelocytic leukemia cells. This result may be important for the development of new therapeutic approaches in the treatment of promyelocytic leukemia, requiring further comprehensive studies.
In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells
A Ugur Ural, Ferit Avcu, Muhammed Candir, Metin Guden, M Ali Ozcan
Breast Cancer Research , 2006, DOI: 10.1186/bcr1543
Abstract: Human MCF-7 breast cancer cells were treated with up to 100 μM zoledronic acid, were irradiated with up to 800 cGy or were exposed to combinations of both treatments to determine the antiproliferative effects of zoledronic acid and radiation.Zoledronic acid and radiation caused a dose-dependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 μM and 20 μM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation). A synergistic cytotoxic effect of the combination of zoledronic acid and radiation was confirmed by isobologram analysis.These data constitute the first in vitro evidence for synergistic effects between zoledronic acid and radiation. This combination therapy might thus be expected to be more effective than either treatment alone in patients with metastatic breast carcinoma.Breast cancer metastases in bone account significantly for morbidity and mortality, and can cause intractable pain, spinal cord compression and hypercalcemia. The survival of women who have solely bone metastases as the predominant, or only, metastatic site may be measured in years, indicating the important therapeutic need for an effective bone-specific palliative treatment [1]. This also signifies that the malignant process is incurable since, once tumor cells become lodged in the skeleton, therapy can only be given with palliative intent. This includes analgesics, radiation therapy and systemic treatments such as bisphosphonates (BPs) or chemotherapy.Metastases from most cancer types are predominantly osteolytic, except for those from prostate cancer, which at least radiographically appear as sclerotic secondary lesions. Osteolysis is primarily a result of increased activity in osteoclasts, resulting in elevated calcium levels in blood. The BPs are pyrophosphate analogs used to treat osteoclast-mediated bone diseases, including osteoporosis, Paget's disease, hypercalcemia of malignancy, bone metastases and bon
A Giant Ureteral Stone without Underlying Anatomic or Metabolic Abnormalities: A Case Report
Selcuk Sarikaya,Berkan Resorlu,Ekrem Ozyuvali,Omer Faruk Bozkurt,Ural Oguz,Ali Unsal
Case Reports in Medicine , 2013, DOI: 10.1155/2013/236286
Abstract: A 28-year old man presented with left flank pain and dysuria. Plain abdominal film and computed tomography showed a left giant ureteral stone measuring 11.5?cm causing ureteral obstruction and other stones 2.5?cm in size in the lower pole of ipsilateral kidney and 7?mm in size in distal part of right ureter. A left ureterolithotomy was performed and then a double J stent was inserted into the ureter. The patient was discharged from the hospital 4 days postoperatively with no complications. Stone analysis was consistent with magnesium ammonium phosphate and calcium oxalate. Underlying anatomic or metabolic abnormalities were not detected. One month after surgery, right ureteral stone passed spontaneously, left renal stone moved to distal ureter, and it was removed by ureterolithotomy. Control intravenous urography and cystography demonstrated unobstructed bilateral ureter and the absence of vesicoureteral reflux. 1. Introduction Stones may be located in different anatomical locations of urinary tract; however, ureteral stones are usually located in three anatomic stenotic sites of ureter [1, 2]. Stone size, in particular the maximum diameter, is the most important factor dictating how a stone should be managed [2–4]. In general, ureteral stones larger than 10?mm in diameter are less likely to be passed and the majority of these patients require intervention [5]. Extracorporeal shock wave lithotripsy (SWL) and ureteroscopy (URS) are the main treatment modalities for these stones [6]. However some ureteral calculi show silent progression to reach a large size and can be larger than 10?cm in length or weighing more than 50 gram. These stones are called giant ureteral stones and seen extremely rare [5, 7]. In this study we report a case of giant ureteral calculi with ipsilateral renal calculi and contralateral distal ureteral calculi without underlying metabolic or anatomic abnormalities, which to our knowledge has not been reported before. 2. Case Report A 28-year-old man presented with bilateral flank pain and dysuria. Urinalysis revealed microscopic hematuria and pyuria. Urine culture was positive for Proteus mirabilis and was treated with ceftriaxone 1?g twice a day for 5 days. The urine culture became negative before the operation. Serum creatinine level was 1.9?mg/dL and other laboratory studies revealed no significant abnormalities. Physical examination did not yield anything apart from tenderness in left costovertebral angle location. Ultrasound (US) detected hydronephrosis and hydroureter on the left side. A plain abdominal film (KUB) and computed
Emergent Intervention Criterias for Controlling Sever Bleeding after Percutaneous Nephrolithotomy
Ural Oguz,Berkan Resorlu,Mirze Bayindir,Tolga Sahin,Omer Faruk Bozkurt,Ali Unsal
ISRN Urology , 2013, DOI: 10.1155/2013/760272
Abstract: Objectives. To determine when emergent intervention for bleeding after percutaneous nephrolithotomy (PCNL) is required. Methods. We reviewed analysis data of 850 patients who had undergone PCNL in our center. Blood transfusion was needed for 60 (7%) patients during and/or after surgery. We routinely performed followup of the urine output per hour, blood pressure, and hemoglobin levels after PCNL. Five (0.6%) of them had severe bleeding that emergent intervention was needed. Results. The mean age of the 5 patients who had emergent surgery due to severe bleeding was 42.2 (19–56) years. Mean duration of surgery was 44.75 (25–65)?minutes. Mean stone size was 27 (15–38)?mm. Mean decrease of hemoglobin was 4.8 (3.4–5.8)?ng/dL, and unit of transfused blood was 4.4 (3–6). Mean blood pH was 7.21. There were metabolic acidosis and anuria/oliguria in all these patients. One of 5 patients suffered from cardiopulmonary arrest because of massive bleeding four hours after the PCNL, and despite cardiac resuscitation, he died. Hemorrhaging was controlled by open surgery in the other 4?patients. Two patients experienced cardiac arrest during the open surgery but they responded to cardiac resuscitation. There were no metabolic asidosis and anuria/oliguria, and bleeding was managed only with blood transfusion for the other 55?patients. Conclusion. Severe bleeding after PCNL is rare and can be mortal. If metabolic asidosis and anuria/oliguria accompanied the drop of hemoglobin, emergent surgical intervention should be performed because vascular collapse may follow, and it may be too difficult to stabilise the patient. 1. Introduction Urolithiasis is a common disease, and the prevalence of this disease is increasing everyday [1]. Percutaneous nephrolithotomy (PCNL) is an effective and common treatment technique for especially large and complex renal calculi. Although PCNL is a common procedure, it can be associated with some mortal or morbid complications such as septicemia, severe bleeding, and pleural or colonic injury. With this study, we documented patients who needed blood transfusion and patients who had renal hemorrhaging requiring emergent intervention after PCNL. We aimed to answer questions including “how long conservative therapy for bleeding after PCNL takes?” and “when emergent intervention should be performed?” To our knowledge, this is the first paper to investigate this topic regarding PCNL. 2. Material and Methods 2.1. Patients We performed a retrospective analysis of 850 patients who underwent PCNL in the urology department of our institute. Before the
Ozana URAL
The Turkish Online Journal of Distance Education , 2007,
Abstract: ABSTRACT Distance education systems are being used in along with the traditional education systems in order to respond to the demand for higher education. Technological advancements, interactive learning possibilities are forcing the traditional universities to make more use of the distance education systems and technologies. Most of the traditional universities to create the opportunity for their students to be independent learners and learners who can organize their learning processes by using distance education systems and technologies. It is thought that students who can learn on their own and who can organize their learning processes will be more likely to use lifelong learning opportunities. In Turkey where there is a great demand for higher education, the use of distance education systems and technologies in traditional universities is not common. These traditional universities can make use of the distance education systems and technologies in certain lectures and cope with the pressure of the increasing number of students. Successful implementation of the distance education applications in traditional universities will affect the mega Turkish education system in a positive way. In this study, the views of the doctoral students at traditional universities on the use of distance education systems and technologies and independent learning are determined. Findings indicate that doctoral students do not have a positive attitude towards the use of distance education systems and technologies, and they do not agree with the idea that distance education systems can support independent learning.
Cardiovascular risk assessment and risk stratification- guided therapy: Predict, prevent and individualize
Dilek Ural
Anadolu Kardiyoloji Dergisi , 2011,
Abstract: Modern concept in primary prevention of cardiovascular diseases (CVD) entails assessing the person’s global risk and making the right management in accordance with these results. Correspondingly, 3 steps recommended for the prevention of CVD under risk guidance are: (a) risk assessment via a proper system like Framingham Risk Score, SCORE, QRISK, PROCAM; (b) decision-making in the proper management in terms of informing the patient about lifestyle changes that he or she can cope and drug selection; and (c) evaluation of treatment decision in terms of cost effectiveness. Although, a significant decline is observed in CVD morbidity and mortality, particularly in the western countries, we still are trying to approach to competent quality measures about management under CV risk guidance. This review summarizes the main challenges regarding risk stratification-guided management strategy in primary prevention of CVD.
On the field of differential rational invariants of a subgroup of affine group (Ordinary differential case)
Ural Bekbaev
Mathematics , 2006,
Abstract: An ordinary differential field $(F,d)$ of characteristic zero, a subgroup $H$ of affine group $ GL(n,C)\propto C^n$ with respect to its identical representation in $F^n$ and the following two fields of differential rational functions in $x=(x_1,x_2,...,x_n)$-column vector, $$C< x, d>^H=\{f^d< x> \in C< x, d> : f^d< hx+ h_0> = f^d< x> {for any} (h,h_0)\in H \},$$ $$C< x, d>^{(F^*,H)}=\{f^d< x> \in C< x, d> : f^{g^{-1}d}< hx+ h_0> = f^d< x> {for any} g\in F^* {and} (h,h_0)\in H \}$$ are considered, where $C$ is the constant field of $(F,d)$ and $C< x, d>$ is the field of differential rational functions in $x_1,x_2,...,x_n$ over $C$. The field $C< x, d>^H$ ($C< x, d>^{(F^*,H)}$) is an important tool in the equivalence problem of paths(respect. curves) in Differential Geometry with respect to the motion group $H$. In this paper an pure algebraic approach is offered to describe these fields. The field $C< x, d>^{(F^*,H)}$ and its relation with $C< x, d>^H$ are investigated. It is shown also that $C< x, d>^H$ can be derived from some algebraic (without derivatives) invariants of $H$. Key words: Differential field, differential rational function, invariant, differential transcendent degree. 2000 Mathematics Subject Classification: 12H05, 53A04, 53A55
On the field of differential rational invariants of a subgroup of affine group (Partial differential case)
Ural Bekbaev
Mathematics , 2006,
Abstract: An differential field $(F;\partial_1,...,\partial_m)$ of characteristic zero, a subgroup $H$ of affine group $ GL(n,C)\propto C^n$ with respect to its identical representation in $F^n$ and the following two fields of differential rational functions in $x=(x_1,x_2,...,x_n)$-column vector, $$C< x, \partial >^H=\{f^{\partial}< x> \in C< x, \partial> : f^{\partial}< hx+ h_0> = f^{\partial}< x> {whenever} (h,h_0)\in H \},$$ $$C< x, \partial>^{(GL^{\partial}(m,F),H)}=\{f^{\partial}< x> \in C< x, \partial> : f^{g^{-1}\partial}< hx+ h_0> = f^{\partial}< x> {whenever} g\in GL^{\partial}(m,F) {and} (h,h_0)\in H \}$$ are considered, where $C$ is the constant field of $(F,\partial)$, $C< x, \partial>$ is the field of $\partial$-differential rational functions in $x_1,x_2,...,x_n$ over $C$ and $$GL^{\partial}(m,F)= \{g=(g_{jk})_{j,k=\bar{1,m}}\in GL(m,F): \partial_ig_{jk}= \partial_jg_{ik} {for} i,j,k=\bar{1,m}\}$$, $\partial$ stands for the column-vector with the "coordinates" $\partial_1,. . >.,\partial_m$. In the paper these two fields are described.
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