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Search Results: 1 - 10 of 18998 matches for " Ali SR "
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The regulatory effects of interleukin-12 on interleukin-18 and interferon-γ production in Egyptian breast cancer patients
SR Demian, M Hamdy, IM Ali
Alexandria Journal of Medicine , 2011,
Abstract: Background: Breast cancer is the commonest form of cancer in women throughout the world. The outcome of malignant neoplasia in human is often accompanied by defective cellular immunity. Objective: To investigate the regulatory effects of IL-12 on IL-18 and IFN-c production in patients with breast cancer. In addition, the correlations between IL-18 and IFN-c levels with different prognostic factors. Methods: This study included 40 female patients with histologically proved breast cancer. They were divided into two groups metastatic and non-metastatic. Peripheral blood mononuclear cells were isolated from freshly drawn heparinized blood of each subject and cultured with and without recombinant IL-12 supplementation. IL-18 and IFN-c levels assessed using ELISA before and after the addition of IL-12. Results: The level of IL-18 in culture supernatants ranged from 0.69 to 0.95 ng/ml with mean value of 0.8 ng/ml in non-metastatic patients, whereas IL-18 in metastatic patients levels varied from 0.5 to 0.7 ng/ml with a mean value of 0.6 ng/ml after supplementation with IL-12. In non-metastatic patients the levels of IFN-c ranged from 1.2 to 1.9 ng/ml with mean value 1.4 ng/ml while in metastatic patients the levels ranged from 0.7 to 1.2 ng/ml. Statistical analysis of data revealed that the supplementation of culture with IL-12 significantly increased the mean values of IL-18 IFN-c in different clinicopathological parameters. Univariate analysis by age, tumor size, grade, number of lymph nodes, ER-PR, IL-18 level, and HER2 neu. Indicated that patients with IL-18 level higher than the median at the diagnosis had higher survival results than those with lower IL-18 concentration. In multivariate analysis IL-18 did not have an independent influence on the survival. Conclusion: Findings provide insights that interleukin-12 may be a potent stimulant of the immune response by enhancing the production of IL-18 and IFN-c. We can suggest that, IL-12 could be used as a therapeutic agent for improving prognosis associated with breast cancer.
An overwhelming post-splenectomy infection (OPSI)
Elbadawi O,Ali SR,Waheed A,Khan S
Journal of Emergency Medicine, Trauma and Acute Care , 2012, DOI: 10.5339/jemtac.2012.13
Abstract: We present the case of a 25 year old man who had a splenectomy five years previously following a road traffic accident (RTA). He presented to our A&E department one evening with fever and upper abdominal pain associated with nausea and vomiting. Clinical examination was unremarkable. Initial investigations revealed only pyuria. He was treated symptomatically along with parenteral antibiotic and admitted to the general medical ward. Within few hours he deteriorated rapidly with septic shock, multi-organ failure, disseminated intravascular coagulation (DIC) and eventually cardio-respiratory arrest. Despite all resuscitative measures he died within few hours of admission. Splenectomized patients are prone to develop severe infection, including sepsis and meningitis, due to OPSI, or overwhelming post-splenectomy infection. Presentation may be mild, but the course is rapid and the prognosis is very poor, even in young people. It is important that splenectomized patients receive vaccines according to guidelines, take antibiotic prophylaxis and are educated to seek medical attention at the earliest sign of even minor infections.
Functionalized carbon nanotubes: biomedical applications
Vardharajula S, Ali SZ, Tiwari PM, Ero lu E, Vig K, Dennis VA, Singh SR
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S35832
Abstract: nctionalized carbon nanotubes: biomedical applications Review (2236) Total Article Views Authors: Vardharajula S, Ali SZ, Tiwari PM, Ero lu E, Vig K, Dennis VA, Singh SR Published Date October 2012 Volume 2012:7 Pages 5361 - 5374 DOI: http://dx.doi.org/10.2147/IJN.S35832 Received: 11 July 2012 Accepted: 22 August 2012 Published: 09 October 2012 Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Ero lu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh1 1Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, India Abstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.
The effects of inflammatory arthritis on bone remodeling
SR Goldring
Arthritis Research & Therapy , 2005, DOI: 10.1186/ar1518
Positron emission tomography and X-ray computed tomography: tools for mouse phenotyping?
SR Cherry
Breast Cancer Research , 2003, DOI: 10.1186/bcr671
Molecular pathology of breast cancer
SR Lakhani
Breast Cancer Research , 2002, DOI: 10.1186/bcr464
A clinical approach to dysuria in women
SR Ramphal
Continuing Medical Education , 2004,
Tectonic setting of gabbroic rocks in the western part of the Lupa Gold Field, south-west Tanzania
SR Mnali
Tanzania Journal of Science , 2002,
Abstract: There is a pronounced occurrence of gabbroic rocks in the western part of the Lupa gold field, SW Tanzania. These rocks occur in the peripheral part around the Saza-Chuya granodiorite with which it makes a gradiational, unchilled contact. The rocks have been altered or metamorphosed to low-grade greenschist facies as indicated by the presence of secondary epidote, penninite, chlorite, sericite and calcite. The majority of major-element oxides show scattered variation trends against immobile elements such as Zr, indicating some degree of element mobility during post-crystallization processes of alteration or metamorphism. Major-trace-element data show that the gabbroic rocks in the study area are calc-alkaline. REE patterns show that the rocks are highly evolved with a high (La/Yb)N ratio of about 30 and (La/Sm)N ratios of between 18-40. The highly evolved nature of the studied rocks is shown also by low values of magnesium between 56-62%. The gabbroic rocks in the western part of the Lupa gold field seem to have been formed in the continental arc setting. Tanzanian Journal of Science Vol. 28(1) 2002: 99-113
Assessment of heavy metal pollution in the Lupa gold field, SW Tanzania
SR Mnali
Tanzania Journal of Science , 2001,
Abstract: The concentrations of AS, Cd, Cr, Cu, Hg and Pb were determined in water, stream sediments, soil, and mine tailings from Lupa Gold Field (LGF), SW Tanzania, in order to assess their pollution levels. As, Cd and Cr were determined by automated Graphite Furnace Absorption Spectrophotometry. Cu and Pb were analysed by Air-Acetylene Flame, while Hg was analysed by Cold Vapour Atomic Absorption Spectrophotometry. The mean concentrations obtained were: As: 0.44 ppb (water), 1.2 ppm (sediments), 0.44 ppm (soil) and 5.2 ppm (tailings); Cd: 0.03 ppb (water), 0.03 ppm (sediments), 0.03 ppm (soil) and 0.50 ppm (tailings); Cr: 1.4 ppb (water), 70 ppm (stream sediments), 250 ppm (soil) and 270 ppm (tailings); Cu: 30 ppb (water), 68 ppm (sediments), 66 ppm (soil) and 455 ppm (tailings); Hg: 0.25 ppb (water), 1.1 ppm (sediments), 0.10 ppm (soil) and 8.70 ppm (tailings) and Pb: 0.50 ppb (water), 85 ppm (sediments), 22 ppm (soil) and 275 ppm (tailings). Leaching of As-based mineral flotation reagents as well as the decomposition of accessory As minerals such as arsenopyrite (FeAsS), enargite (Cu3AsS4) and tennantite (Cu12As4S13) most likely contributed to some high As concentrations in the mine tailings. The low Cd content in all samples reflects the low content of sphalerite (in which Cd replaces Zn) typical of the LGF ores. Cromium was low in water, most likely because of its low mobility; it was high in soils and tailings derived from mafic-ultramafic rocks. High Cu levels in tailings came from dissolution of chalcopyrite and bornite. Neutral to alkaline pH conditions (6.5-8.5) of water was most likely responsible for its low Cu levels. Amalgamation of Au concentrate likely introduced Hg into the environment. Dissolution of galena and anglesite was likely the source of Pb into the soils, sediments and tailings. The range of concentrations of the six heavy metals recorded in the Lupa gold field is of great concern to human health. Tanzania Journal of Science Volume 27A (Special Issue) 2001, pp. 15-22
Breast conditions during pregnancy and lactation: An understanding of unique breast conditions associated with pregnancy and lactation is essential for evaluation and management of breast problems in pregnant or lactating women
SR Cacala
Continuing Medical Education , 2010,
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